OpenScience.ink

1 month ago • The Biochemical journal

How different molecules control the mTORC1 pathway through cell surface receptorsSubstrate-specific regulation of the mTORC1 pathway by G protein-coupled receptors.

Article

1 week ago • Cureus

Telomerase Mutation Linked to Blood Cell Loss and Liver Damage Needing TransplantTelomerase Reverse Transcriptase (TERT) Mutation at a Price: Telomere Biology Disorder Presenting With Pancytopenia and Cirrhosis Requiring Liver Transplantation.

Case Reports

1 month ago • bioRxiv : the preprint server for biology

17α-Estradiol Provides Limited Protection Against APOE4-Related Traits in Middle-Aged Female Mice17α-Estradiol Confers Limited Protection Against APOE4 Phenotypes in Middle-Aged Female Mice.

Preprint

1 month ago • bioRxiv : the preprint server for biology

Senescent cell groups connect tissue changes and blood vessel problems in human fibroidsSenescent cell networks link matrix remodeling and vascular dysfunction in human fibroids.

Preprint

1 week ago • Autophagy reports

A new VPS16 gene change blocks cell recycling and causes early-onset DYT-VPS16 movement disorderA de novo VPS16 missense variant blocks autophagic flux and extends DYT-VPS16 into infancy.

Article

yesterday • Neuron

A molecular pathway linking body signals to thinking problems in women during midlifeA miR-10a-5p-γCaMKII axis links periphery-to-brain signaling to cognitive vulnerability during female midlife.

Article

yesterday • Neurobiology of disease

Early signs of cell aging and treatment targets in a mouse model of ALS with TDP-43 mutationCellular senescence is an early feature and therapeutic target in amyotrophic lateral sclerosis TDP-43Q331K mice.

Article

2 days ago • FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Interferon Regulatory Factor 1 May Reduce Fat Cell Formation and Increase Self-Cleaning in Bone Marrow Stem Cells to Help Relieve Bone Loss-related Fat BuildupInterferon Regulatory Factor 1 Inhibits the Adipogenic Differentiation of BMSCs via the AMPK-mTOR Signaling Axis and Induces Their Autophagy to Alleviate Osteoporosis-Related Bone Marrow Adiposity.

Article

3 days ago • Progress in neurobiology

How Sex and Age Affect Brain Differences, Molecular Changes, and Treatment Response in StrokeThe Dimorphic Brain in Ischemic Stroke: How Sex and Age Shape Molecular Pathophysiology and Therapeutic Responsiveness.

Article

3 days ago • Nature medicine

Biological aging clocks differ by sex across organs and molecular dataSex-specific biological aging clocks across organs and omics.

Article

4 days ago • The journal of nutrition, health & aging

Biological aging and blood fat markers linked to pancreatic diseases in UK Biobank participantsBiological aging, circulating lipid biomarkers and pancreatic diseases: a prospective cohort study based on the UK Biobank.

Article

4 days ago • Journal of lipid research

Interaction between energy centers, cell packaging, and fat storage in fat metabolism changes in type 2 diabetesMitochondria-endoplasmic reticulum-lipid droplet crosstalk in lipid metabolic reprogramming in type 2 diabetes mellitus.

Article

4 days ago • Zhongguo zhen jiu = Chinese acupuncture & moxibustion

Moxibustion sensation may influence cell cleanup in the memory area of Alzheimer's model mice[Effect of moxibustion-induced deqi on hippocampal autophagy function in APPswe/PSEN1dE9 transgenic Alzheimer's disease mice].

English Abstract

4 days ago • Nature

RNF213 controls glycogen quality by directly tagging it for breakdownQuality control of glycogen through direct ubiquitylation by RNF213.

Article

4 days ago • International immunopharmacology

Radiation-caused irregular heartbeat linked to cell aging through the GATA4-NF-κB pathway and improved by D/Q cell-removal treatmentRadiation-induced atrial fibrillation is driven by cellular senescence via the GATA4 - NF-κB pathway and rescued by D/Q senolytic therapy.

Article

5 days ago • Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

Imaging hydrogen sulfide-related oxidative imbalance in Parkinson’s disease models using near-infrared fluorescence and mass spectrometryCoupled NIR-II fluorescence and mass spectrometry imaging of H2S-associated redox dysregulation in Parkinsonian models.

Article

5 days ago • Mechanisms of ageing and development

Biological Age from DNA Methylation and Its Relationship to Reproductive History: Review and Combined AnalysisBiological age measured by DNA methylation clocks and reproductive history: Systematic review and meta-analysis.

Article

5 days ago • Experimental gerontology

GLP-1 receptor drugs, aging-related gene changes, and possible lifespan extension with medicineGLP-1 receptor agonists, epigenetic aging, and the prospect of pharmacological healthspan extension.

Article

5 days ago • Mechanisms of ageing and development

Loss of Accurate Calcium Signaling with Aging Linked to Mitochondrial Problems, Cell Aging, and Decline in Thinking and MovementLoss of Ca2+ Signaling Fidelity During Aging: Mitochondrial Dysfunction, Senescence, and Cognitive-Motor Decline.

Article

1 week ago • Archives of gerontology and geriatrics

Faster biological aging and problems in multiple body functions linked to higher death risk in NHANES and CHARLS studiesBiological age acceleration and multidomain functional impairment: Mortality associations and incremental value in NHANES and CHARLS.

Article

1 week ago • Experimental gerontology

Epigenetic clocks and faster biological aging in people with HIV: New insights and health consequencesEpigenetic clocks and accelerated biological aging in people living with HIV: Emerging mechanisms and clinical implications.

Article

1 week ago • Progress in neuro-psychopharmacology & biological psychiatry

Resveratrol may improve age-related memory decline by activating cell repair and energy networks that support brain growth and cleanupResveratrol engages SIRT1/AMPK networks to restore BDNF signaling, autophagy, and mitochondrial function in age-related cognitive decline: A geroscience perspective.

Article

1 week ago • Experimental gerontology

Protein patterns linked to body-wide inflammation in aging, multiple diseases, and risk of deathProteomic signatures of systemic inflammation in aging, multimorbidity, and mortality.

Article

1 week ago • International journal of molecular medicine

Rapamycin may slow aging of blood vessel cells by lowering miR-30a and affecting cell recycling protein Beclin1[Expression of Concern] Rapamycin‑induced miR‑30a downregulation inhibits senescence of VSMCs by targeting Beclin1.

Expression of Concern

1 week ago • Biochemical pharmacology

Ambrisentan may reduce heart cell death and energy problems caused by doxorubicin by affecting p53 and mTOR pathwaysAmbrisentan rescues doxorubicin-induced cardiac apoptosis and mitochondrial bioenergetic dysfunction: Mechanistic insights into p53 and mTOR signaling.

Article

1 week ago • Nature

TM184C is a receptor-like protein that controls cell communication and self-cleaning processesTM184C is a GPCR-like regulator of intercellular exchange and autophagy.

Article

1 week ago • Journal of clinical anesthesia

Surgery and its link to biological aging in a UK population studySurgical exposure and biological aging: A population-based study from the UK Biobank.

Article

1 week ago • Experimental gerontology

Aging immune decline, chronic inflammation, and metabolism-related diseases: Understanding their connections from an aging biology viewImmunosenescence, inflammaging, and metabolic disease: A geroscience perspective on mechanisms and links.

Article

1 week ago • Mechanisms of ageing and development

How Fasting May Influence Aging by Changing Gene Control to Support Healthy LifespanFasting and aging: Mechanistic insights into epigenomic and transcriptional regulation of healthspan.

Article

1 week ago • Pathology, research and practice

Targeting the Sigma-1 Receptor to Improve Treatment for Blood Flow Loss in TissuesSigma-1 receptor (S1R): Advancing therapeutic strategies in targeting ischemia.

Article

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Longevity & Aging Research Papers