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1 month ago • EMBO reports

TBK1 helps remove clumping-prone TDP-43 protein using an immune pathway in ALS modelsTBK1 eliminates aggregation-prone monomeric TDP-43 through an IFNβ-immunoproteasome pathway in ALS models.

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2 days ago • The journals of gerontology. Series A, Biological sciences and medical sciences

Article

2 days ago • Journal of controlled release : official journal of the Controlled Release Society

Testing cell aging as a treatment target in fatty liver disease linked to metabolism using navitoclaxValidation of senescence as a therapeutic target in metabolic dysfunction-associated steatohepatitis (MASH) through navitoclax delivery.

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4 days ago • Cardiovascular research

Energy metabolism decline caused by LncAAT is key to aging of blood vessel lining cellsLncAAT-mediated decline in energy metabolism is essential for vascular endothelial senescence in advancing age.

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4 days ago • Experimental gerontology

Disrupted protein balance in aging muscles: Causes and possible treatments for muscle loss and weaknessProteostasis network dysregulation in aging skeletal muscle: Mechanisms and therapeutic targets in sarcopenia and muscle wasting.

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4 days ago • Experimental gerontology

Changes in 5hmC DNA Marks in Aging Beyond 5mCBeyond 5mC: 5hmC in the aging epigenome.

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5 days ago • International journal of molecular medicine

The role of sugar breakdown in lung scarring and potential treatmentsGlycolysis in pulmonary fibrosis: From drivers to therapeutic opportunities (Review).

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5 days ago • Cardiovascular research

Restoring NAD+ lowers heart muscle aging and improves heart relaxation in older menNAD+ replenishment reduces cardiomyocyte senescence and improves diastolic function in the aged male heart.

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6 days ago • Molecular and cellular biochemistry

Trehalose reduces cell aging caused by oxidative stress and is linked to changes in cell growthTrehalose alleviates oxidative stress-induced senescence and is associated with cell-cycle remodeling.

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1 week ago • Molecules and cells

Updated methods for measuring cell aging in mammalsUpdated guide to the assessment of mammalian cellular senescence.

Letter

1 week ago • Reproduction (Cambridge, England)

Early puberty linked to egg supply and aging signs in young adultsEarly menarche in association with ovarian reserve and biological aging in young adults: a cross-sectional study.

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1 week ago • Developmental biology

Blood cells as nutrient sensors that influence immunity, lifespan, and offspring health in fruit fliesHemocytes as nutrient-sensing regulators of immune function, lifespan, and intergenerational fitness in Drosophila melanogaster.

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1 week ago • Current biology : CB

The buildup of antimicrobial peptides helps gut cells shed to keep the aging fruit fly's gut healthyThe antimicrobial peptide pileup promotes enterocyte shedding to maintain gut homeostasis in aging Drosophila.

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1 week ago • Proceedings of the National Academy of Sciences of the United States of America

Natural DNA copying errors help control chromosome end length in normal yeastSpontaneous replication fork collapse regulates telomere length homeostasis in wild-type yeast.

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1 week ago • FASEB journal : official publication of the Federation of American Societies for Experimental Biology

How Cell Recycling Controls Collagen I and Tissue Balance: From Basic Processes to Scarring Problems and TreatmentsAutophagy-Controlled Collagen I Metabolism and ECM Homeostasis: From Molecular Mechanisms to Fibrotic Dysregulation and Therapy.

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1 week ago • International immunopharmacology

How Proton Pump Inhibitors May Affect Brain Inflammation, Protection, and Damage in Alzheimer's DiseaseImmunopharmacology of proton pump inhibitors in Alzheimer's Disease: An evidence-weighted mechanistic review of Neuroinflammation, neuroprotection, and neurodegeneration.

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1 week ago • The Journal of nutrition

Hydroxyproline boosts the positive effects of branched-chain amino acids on lifespan and health in C. elegansHydroxyproline Enhances Branched-Chain Amino Acid Effects on Lifespan and Healthspan in Caenorhabditis elegans.

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1 week ago • EULAR rheumatology open

Signs of Aging in Systemic Sclerosis and Their Links to Disease Cause, Multiple Health Problems, and Treatment OptionsHallmarks of aging in systemic sclerosis: implications for pathogenesis, multimorbidity, and therapeutic development.

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1 week ago • Archives of gerontology and geriatrics

Links between infections and differences in organ aging in UK Biobank participantsAssociations between infection and organ age gaps: results from the UK Biobank.

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1 week ago • Cardiovascular research

MAPK15 may cause heart cell aging and irregular heartbeat by increasing calcium overload in mitochondria through modifying Mcub proteinMAPK15 induces cardiomyocyte senescence and atrial fibrillation by promoting mitochondrial calcium overload via palmitoylating Mcub at the C91 residue.

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1 week ago • Experimental gerontology

Matching changes in biological aging measures with health outcomes in aging treatment studies: A systematic reviewConcordance between changes in epigenetic clocks and changes in clinical outcomes in geroscience intervention trials: A systematic review.

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1 week ago • International journal of molecular medicine

How ferritin breakdown affects tissue scarring and its potential for treatmentMechanisms and therapeutic implications of ferritinophagy in fibrotic diseases (Review).

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1 week ago • Biochemical pharmacology

Mots-c reduces diabetic kidney damage by lowering LARS1 to boost fat recycling and prevent kidney tubule agingMots-c attenuates diabetic nephropathy by downregulating LARS1 to promote lipophagy and suppress tubular senescence.

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1 week ago • Progress in neuro-psychopharmacology & biological psychiatry

Cell aging in normal ageing and brain diseases: causes, signs, and possible treatmentsCellular senescence in ageing and neurodegenerative disorders: Molecular mechanisms, biomarkers, and therapeutic strategies.

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1 week ago • Archives of toxicology

How HDAC6 activity weakens cell cleanup by disrupting microtubule stability and fusion in PBDE-47 brain toxicityHistone deacetylase 6 (HDAC6)-mediated α-tubulin (K40) deacetylation and microtubule destabilization disrupt autophagosome-lysosome fusion in PBDE-47-induced neurotoxicity.

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1 week ago • Experimental gerontology

Blood from people after fermented whey protein intake may boost muscle cell growth and protein productionHuman serum collected after fermented whey protein supplementation stimulates myocellular growth and protein synthesis: A randomized, double-blind, active-controlled crossover trial.

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1 week ago • Biochemical pharmacology

How NMN affects the structure and grouping of digestive enzymes (Trypsin, Pepsin, α-Amylase) studied by simulations and spectroscopyRevealing NMN-induced biomacromolecular complex and conformational regulation of digestive enzymes (Trypsin, Pepsin, α-Amylase): Insights from molecular dynamics simulation and multi-spectroscopy.

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1 week ago • Neuroscience letters

Zinc may trigger cell cleaning by controlling a key protein after brain blood flow injuryZinc activates autophagy by regulating HDAC6 expression following cerebral ischemia/reperfusion injury.

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1 week ago • Experimental gerontology

New inflammation marker and aging signs in diabetes: the possible role of platelets in age-related inflammationNovel inflammation index and biological aging indicators in diabetes: unveiling the role of platelets in inflammaging in a population-based observational study.

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1 week ago • The Journal of bone and joint surgery. American volume

How Biological Age Relates to Adult Spinal Deformity SurgeryThe Role of Biological Age in Adult Spinal Deformity Surgery.

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Longevity & Aging Research Papers