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1 week ago • Proceedings of the National Academy of Sciences of the United States of America

How eIF4E-binding proteins control microglial energy use, inflammation, and survivalTranslational control of microglial metabolism, inflammatory responses, and survival by the eIF4E-binding proteins.

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1 week ago • Biochimica et biophysica acta. Molecular basis of disease

How heart and diabetes drugs affect mitochondria to protect or harm the diseased heartMitochondrial pharmacology of cardiovascular and antidiabetic drugs: Mechanistic basis of cardioprotection and cardiotoxicity in the diseased heart.

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2 weeks ago • Toxicology and applied pharmacology

Aging of lung immune cells in smoke-exposed versus naturally aged mice and how P2X7R may affect smoke-related airway inflammationComparison of alveolar macrophages senescence between cigarette smoke-exposed and naturally aged mice and the role of P2X7R in CS-induced airway inflammation.

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2 weeks ago • Biochimica et biophysica acta. Molecular cell research

High salt stress in kidney tube cells may trigger self-cleaning processes in nearby support cells through released glutamateHyperosmotic stress in renal tubular epithelial cells promotes TFEB-dependent autophagy in interstitial fibroblasts by involving extracellular glutamate.

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2 weeks ago • Pathology, research and practice

Disrupted Cell Cleanup Processes in Osteoarthritis: How Non-Coding RNAs Control Them and Possible TreatmentsDysregulated autophagy in osteoarthritis: Mechanisms, regulation by non-coding RNAs, and therapeutic implications.

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2 weeks ago • Archives of gerontology and geriatrics

Exercise training and changes in energy-producing parts of aging muscles: A combined review and analysisExercise training and mitochondrial remodeling in aging skeletal muscle: A translational systematic review and meta-analysis.

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2 weeks ago • Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology

Biomarker patterns that change with size in zebra mussels and what they mean for monitoring freshwater healthSize-dependent biomarker profiles in the zebra mussel Dreissena polymorpha: implications for freshwater biomonitoring.

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2 weeks ago • Cureus

How Sugars Contribute to Acne and Oily Skin InflammationMolecular Role of Carbohydrates in Acne and Seborrheic Dermatitis.

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2 weeks ago • Mechanisms of ageing and development

Cell Aging, Chronic Inflammation, and Gene Changes Linked to Blood Vessel Aging and AtherosclerosisThe triad of vascular ageing: Cellular senescence, inflammaging, and epigenetic remodelling in atherosclerosis.

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2 weeks ago • FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Protein RNF126 may contribute to obesity by triggering removal of damaged cell power sources through the PINK1/Parkin pathwayE3 Ubiquitin Ligase RNF126 Contributes to Pathogenesis of Obesity by Induction Mitophagy Mediated by PINK1/Parkin Pathway.

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2 weeks ago • Medicine and science in sports and exercise

Sleep Loss Changes Cell Stress Responses During Hot Exercise Differently in Young and Older MenSleep Deprivation Selectively Alters Cellular Stress Responses During Exercise in the Heat in Young and Older Males.

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2 weeks ago • Mechanisms of ageing and development

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2 weeks ago • The Journal of bone and joint surgery. American volume

How Molecular Processes Contribute to Osteoarthritis and New Treatment PossibilitiesMolecular Mechanisms of Osteoarthritis: A Review and Opportunities for Novel Therapeutics.

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2 weeks ago • Progress in neuro-psychopharmacology & biological psychiatry

The possible role of the gephyrin-CNTNAP4 connection in brain aging: How problems in inhibitory brain circuits may relate to memory and thinking declineThe potential role of the gephyrin-CNTNAP4 interface in brain aging: Mechanisms of inhibitory circuit dysfunction and cognitive decline.

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3 weeks ago • FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Neferine may protect against rat osteoarthritis by increasing cell cleanup processesNeferine Exerts a Protective Effect on Rat Osteoarthritis by Upregulating Autophagy.

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3 weeks ago • Pharmacology & therapeutics

Molecular causes of natural heart pacemaker problems, resulting irregular heartbeats, and paths toward targeted treatmentsSinoatrial node dysfunction: molecular mechanisms, arrhythmogenesis, and translational pathways toward precision therapy.

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3 weeks ago • Reproduction (Cambridge, England)

Nicotinamide mononucleotide helps cow embryos develop by improving energy production in early-stage cellsNicotinamide mononucleotide supports the development of bovine embryo through enhancement of mitochondrial function in morula.

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3 weeks ago • Molecular and cellular biochemistry

Exercise may improve heart failure by controlling heart cell cleanup through the ILF3/lncRNA NEAT1 pathwayExercise improves heart failure by regulating cardiomyocyte autophagy via the ILF3/lncRNA NEAT1 axis.

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3 weeks ago • Chinese medical journal

How Mesenchymal Stem Cells May Help Regulate and Signal in Diabetic Kidney DiseaseMesenchymal stem cells in diabetic kidney disease: Potential regulatory mechanisms and related signaling pathways of mesenchymal stem cells.

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3 weeks ago • Experimental cell research

Mechanical support from OPTN-TRIP6 and actin helps close cell structures needed for face and skull developmentOPTN-TRIP6-mediated F-actin mechanical support regulates phagophore closure to govern craniofacial skeletal development.

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3 weeks ago • International immunopharmacology

How Aging of the Immune System Relates to Rheumatoid Arthritis and Its TreatmentThe role of immune aging in rheumatoid arthritis and its clinical and therapeutic significance.

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3 weeks ago • Progress in neurobiology

How a Protein Network Involving Parkin and Cell Cleanup Controls Cell Death in Parkinson's Disease and Possible TreatmentsThe mechanism of the parkin-CMA-NLRP3-PANoptosis signaling axis in Parkinson's disease: From molecular basis to therapeutic strategies.

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3 weeks ago • Acta diabetologica

The cGAS-STING pathway’s role in memory loss linked to Type 2 diabetes: from sensing damaged cell DNA to brain cell damageThe cGAS-STING signaling axis in Type 2 diabetes-associated cognitive decline: from mitochondrial DNA sensing to neurodegeneration.

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3 weeks ago • Diabetes & metabolism journal

Development and Testing of New STK3/4 Blockers That May Help Reduce ObesityDevelopment and Preclinical Evaluation of Novel STK3/4 Inhibitors with Anti-Obesity Potential.

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3 weeks ago • Epilepsia

Detailed gene and protein patterns in epilepsy linked to mTOR systemComprehensive transcriptomic and proteomic profiling of mTOR-related epilepsy.

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3 weeks ago • Expert opinion on drug delivery

Using Tiny Particles to Restore Cell Cleanup in Brain DegenerationNanotechnology meets neurodegeneration: restoring lysosomal function with nanovectors.

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3 weeks ago • Cytokine

Strength training reduces liver inflammation and boosts energy cell changes in mice lacking IL-10Strength training attenuates hepatic inflammation and potentiates mitochondrial adaptations in IL-10-deficient mice.

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3 weeks ago • Phytotherapy research : PTR

Astragaloside IV may protect kidney filtering cells in diabetic kidney disease by restoring cell recycling and preventing cell death through blocking Notch1 signaling via SIRT6 activityAstragaloside IV Restores Autophagy and Inhibits Apoptosis for Podocyte Protection in Diabetic Nephropathy by Inhibiting Notch1 Signaling via SIRT6-Mediated Deacetylation.

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3 weeks ago • Nutrition (Burbank, Los Angeles County, Calif.)

Metabolism problems in long-term critical illness: causes, effects, and possible treatmentsMetabolic dysfunction in chronic critical illness: mechanisms, clinical consequences and therapeutic perspectives.

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3 weeks ago • Journal of cellular physiology

Sestrin1 Reduces Aging Signs and Helps Exercise Protect the Liver in MiceSestrin1 Ameliorates Senescence and Mediates the Protective Effects of Exercise Against Hepatic Abnormality in C57BL/6J Mice.

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Longevity & Aging Research Papers