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2 weeks ago • Epigenomics

How DNA methylation data cleaning and removed values affect epigenetic age estimatesDNA methylation quality control decisions, removed beta values, and their influence on epigenetic clocks.

📖 Top 30% Journal

3 weeks ago • Journal of bioenergetics and biomembranes

The role of the mitochondrial sodium-calcium exchanger in brain cell agingThe role of mitochondrial Na⁺/Ca²⁺ exchanger in brain cell aging.

📖 Top 30% Journal

3 weeks ago • World journal of pediatric surgery

Loss of NAD+ metabolism linked to stopped skin lining growth in Hirschsprung diseaseNAD+ metabolic collapse and arrest of epithelial development in Hirschsprung disease.

📖 Top 50% Journal

4 days ago • bioRxiv : the preprint server for biology

Boosting Beclin1 by genes or drugs may prevent heart and blood vessel damage caused by aldosteroneGENETIC AND PHARMACOLOGIC ACTIVATION OF BECLIN1 PREVENTS ALDOSTERONE-INDUCED CARDIOVASCULAR DAMAGE.

Preprint

4 days ago • bioRxiv : the preprint server for biology

KIF1A protein is needed for waste removal inside human nerve cellsKIF1A-mediated trafficking is required for neuronal autophagy in human neurons.

Preprint

yesterday • Clinical and experimental nephrology

How Kidney Energy Use Relates to Chronic Kidney DiseaseEnergy metabolism in the kidney and its role in chronic kidney disease.

Article

1 week ago • FASEB journal : official publication of the Federation of American Societies for Experimental Biology

The Protein POC5 Controls Fat Cell Development and Aging in a Rare Metabolic DisorderCentriolar Protein POC5 Regulates Human Adipogenesis and Cellular Senescence: Insights From a Novel Metabolic Ciliopathy.

Article

1 week ago • EMBO reports

How E3 Ubiquitin Ligases Help Selective Forms of Cellular Self-CleaningThe role of E3 ubiquitin ligases in selective types of macroautophagy.

2 weeks ago • Clinical science (London, England : 1979)

How a Sugar-Based Change on CaMKII Affects Heart Cell Mitochondria Cleanup Through HSPB8 in Diabetic Heart DiseaseO-GlcNAc Modification of CaMKII-Mediated Mitophagic Flux Regulation via HSPB8 in Diabetic Cardiomyopathy.

2 weeks ago • Proceedings of the National Academy of Sciences of the United States of America

Single-cell map of the mouse ovary shows molecular changes linked to aging during the transition to reduced fertilitySingle-cell atlas of the mouse ovary reveals molecular drivers of aging and senescence during the estropausal transition.

2 weeks ago • Aging clinical and experimental research

Faster biological aging linked to muscle size, strength, and function in the Hertfordshire CohortBiological age-acceleration in relation to muscle mass, strength and function: findings from the Hertfordshire Cohort Study.

2 weeks ago • The journals of gerontology. Series A, Biological sciences and medical sciences

How Tiny Cell Particles and Epigenetic Clocks Relate to Tissue Aging, Focusing on SkinExtracellular Vesicles and Epigenetic Aging Clocks in Tissue Aging: An Exosome-Focused Conceptual Framework with a Focus on Skin.

2 weeks ago • Annals of medicine

Support cells protect the retina from low blood flow damage through a calcium signal and cell cleanup processAstrocyte exosomes shield retina from ischemia via CaMKII-autophagy.

2 weeks ago • Mathematical medicine and biology : a journal of the IMA

Estimating biological age using a brain marker for toxic amyloid Beta clustersPredicting biological age using an accumulated neurotoxicity biomarker for amyloid Beta oligomers.

3 weeks ago • Experimental physiology

How aging and risk factors contribute to irregular heartbeats in atrial fibrillationA new approach to an old disease: Ageing, arrhythmogenic substrate and the role of risk-factor modification in atrial fibrillation.

3 weeks ago • Biological reviews of the Cambridge Philosophical Society

How heat stress affects sperm development through a network involving oxidative stress, cell cleanup, and controlled cell deathHeat stress in spermatogenesis: a redox-dependent decision network linking ROS, autophagy, and regulated cell death.

3 weeks ago • Cardiovascular diabetology. Endocrinology reports

Obesity linked to shorter telomeres may involve total bilirubin levelsThe association between obesity and telomere shortening is mediated through total bilirubin.

4 weeks ago • The Journal of cell biology

Mitochondria moving between cells and being recycled when protein import failsIntercellular mitochondrial transfer and trans-mitophagy in response to protein import dysfunction.

1 month ago • Cancer chemotherapy and pharmacology

How antibiotics may also fight leukemia: ways they work and treatment possibilitiesOff-target anti-leukemic effects of antibiotics: mechanisms and therapeutic insights.

4 days ago • bioRxiv : the preprint server for biology

Autophagy helps maintain tight junction barriers by controlling claudin-2 and reducing stress in the cell's protein factoryAutophagy prevents ER stress-induced Tight Junction barrier disruption via claudin-2 homeostasis.

Preprint

4 days ago • bioRxiv : the preprint server for biology

Targeting IGFBP5/IGF1, THPO, and P38 MAPK signaling may be effective treatments for mitochondrial energy disorders and bone cancerTargeted modulation of IGFBP5/IGF1, THPO, and P38 MAPK signaling are potent therapeutic strategies generalizable for mitochondrial respiratory chain disease and osteosarcoma.

Preprint

6 days ago • medRxiv : the preprint server for health sciences

Changes in Biological Aging Markers and Brain Health in Middle AgeEpigenetic Clock Trajectories and Brain Health in Midlife.

Preprint

1 week ago • bioRxiv : the preprint server for biology

Gene Therapy to Restore Parkin Protein in Early-Onset Parkinson's DiseaseRestoring Parkin Function: An AAV Gene Therapy Approach for Early-Onset Parkinson's Disease.

Preprint

1 week ago • bioRxiv : the preprint server for biology

Blocking Mitochondrial Cleanup Helps Survival and Energy Function in MYC-driven Liver CancerMitophagy Inhibition Promotes Survival and Mitochondrial Function in MYC-driven HCC.

Preprint

1 week ago • bioRxiv : the preprint server for biology

Reducing aged cell buildup helps improve aging in bone marrowTargeting cellular senescence alleviates bone marrow aging.

Preprint

yesterday • Biochemical pharmacology

RIPK3's structure, unusual roles in different situations, and precise treatment possibilities beyond cell deathBeyond necroptosis: structural determinants, context-dependent non-canonical functions, and precision therapeutic targeting of RIPK3.

Article

2 days ago • Seminars in cell & developmental biology

How nutrient-sensing pathways in adult stem cells help control balance, aging, and diseaseNutrient-sensing pathways in adult stem cells: Orchestrating homeostasis, aging, and disease.

Article

2 days ago • The Journal of endocrinology

Chloroquine reduces rapamycin-caused fatty liver in mice through a pathway involving ERRαRapamycin-induced fatty liver in mice is attenuated by chloroquine co-treatment in an ERRα-dependent manner.

Article

2 days ago • Human reproduction (Oxford, England)

Therapies targeting cell energy centers in assisted reproduction: challenges and possible solutionsMitochondria-targeted therapeutic strategies in assisted reproduction: challenges and potential solutions.

Article

2 days ago • Neurochemistry international

Catalpol May Protect Brain Cells from MPP+ Damage by Boosting Mitochondrial Cleanup and Survival PathwaysCatalpol Protects Against MPP+-Induced Neurotoxicity by Targeting PINK1/DJ-1-Mediated Mitophagy and the TrkB/Akt/BDNF/Bcl-2 Axis.

Article

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Longevity & Aging Research Papers