OpenScience.ink

4 days ago • Molecular neurobiology

Fixing Energy Problems in Brain Immune Cells as a New Approach to Treat Brain Degenerative DiseasesTargeting Mitochondrial Dysfunction in Microglia: A New Frontier for Treating Neurodegenerative Diseases.

🎖️ Top 10% JournalArticle

4 days ago • Stem cells (Dayton, Ohio)

Using Stem Cells and Empagliflozin to Improve Cell Recycling and Protective Proteins in Diabetic Kidney DiseaseMesenchymal Stem Cells and Empagliflozin: a potential therapeutic approach for autophagy and Klotho modulation in Diabetic Kidney Disease.

📖 Top 20% JournalArticle

4 days ago • Biogerontology

Advances in Traditional Chinese Medicine for Nervous System Diseases Related to AgingResearch progress of traditional Chinese medicine interventions for aging-related nervous system diseases.

📖 Top 20% JournalArticle

4 days ago • Sports medicine and health science

How exercise changes waste recycling systems in skeletal muscleExercise-induced lysosomal adaptations in skeletal muscle.

📖 Top 30% JournalArticle

4 days ago • Molecular neurobiology

How Waste Removal and Inflammation in Brain Support Cells Are Linked in Alzheimer's DiseaseThe Glial Autophagy-Lysosomal-Inflammation Axis in Alzheimer's Disease: a Unifying Mechanistic Framework.

🎖️ Top 10% JournalArticle

4 days ago • Genetics

Protein helpers linked to ribosomes coordinate mitochondrial protein import, stress signals, and protein balance in yeastRibosome-associated chaperones integrate co-translational mitochondrial protein import, stress signaling and proteostasis in Saccharomyces cerevisiae.

Article

4 days ago • bioRxiv : the preprint server for biology

Autophagy helps maintain tight junction barriers by controlling claudin-2 and reducing stress in the cell's protein factoryAutophagy prevents ER stress-induced Tight Junction barrier disruption via claudin-2 homeostasis.

Preprint

5 days ago • International journal of molecular medicine

Brazilin reduces blood vessel cell damage caused by methylglyoxal by boosting a protein modification and blocking a cell recycling and death pathway in lab and animal studiesBrazilin attenuates methylglyoxal‑induced endothelial injury by enhancing eIF5A hypusination and inhibiting the AMPK/mTOR‑mediated autophagy/apoptosis axis in vitro and in vivo.

Article

5 days ago • Zoological research

Lack of DNAJB6a may cause tau buildup by triggering cell stress that harms mitochondriaDNAJB6a deficiency induces tau pathology through IRE1α-Xbp1-induced mitochondria dysfunction.

📖 Top 20% JournalArticle

5 days ago • Immunity & ageing : I & A

Cell aging as a hidden cause of long-lasting skin inflammationCellular senescence: the "hidden driver" in chronic inflammatory skin disorders.

🎖️ Top 10% JournalArticle

5 days ago • Phytomedicine : international journal of phytotherapy and phytopharmacology

Galangin reduces UVB-caused skin aging by activating a protein that controls cell cleaningGalangin attenuates UVB-induced skin photoaging through SIRT1-dependent LC3 deacetylation and autophagy modulation.

🎖️ Top 10% JournalArticle

5 days ago • Phytomedicine : international journal of phytotherapy and phytopharmacology

Naringin reduces damage to brain cell energy structures and overactive cleanup after stroke by affecting specific protein pathwaysNaringin reduces mitochondrial fragmentation and excessive mitophagy in cerebral ischemia-reperfusion injury via the S-nitrosylated Dynamin-related protein 1 (SNO-DRP1) / Leucine-rich repeat kinase 2 (LRRK2) / Mitochondrial Calcium Uniporter (MCU) pathway.

🎖️ Top 10% JournalArticle

5 days ago • Frontiers in pharmacology

How empagliflozin and nebivolol may interact in aging-related oxidative stress and inflammationMechanistic intersections of empagliflozin and nebivolol in aging-associated redox and inflammatory pathways.

📖 Top 20% JournalArticle

5 days ago • Biochemical pharmacology

How a cell growth pathway increases cholesterol receptor and fat buildup in bone cells during hip bone tissue death after injurymTORC1-regulated LDL receptor increasing and oxidized lipid accumulation in osteocytes participate in trauma-induced osteonecrosis of the femoral head.

Article

5 days ago • Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics

Metformin’s multiple roles in preventing and treating major eye diseases beyond blood sugar controlBeyond Glycemic Control: Metformin's Multi-Target Role in Preventing and Treating Major Ocular Pathologies.

📖 Top 50% JournalArticle

5 days ago • Rejuvenation research

Biological Age: A New Idea or Just Different Words?Biological Age: A New Concept or a Linguistic Pivot?

Article

5 days ago • Medicine

How Cell Aging Relates to Sepsis and Copper-Induced Cell Death: A Machine Learning AnalysisThe role of cellular senescence in sepsis and its mechanism in copper death: An analysis based on machine learning.

📖 Top 50% JournalArticle

5 days ago • Molecular biology reports

How AMPK controls fat metabolism and its possible use in treatmentsMechanisms and therapeutic potential of AMPK signaling pathway in the regulation of lipid metabolism.

📖 Top 30% JournalArticle

5 days ago • Biophysical chemistry

Using solid-state NMR to study protein clumping, phase changes, and droplet-like assembliesSolid-state NMR methods to investigate biomolecular condensates, protein phase transition, phase separation and coacervates.

📖 Top 30% JournalArticle

5 days ago • Cell reports

Nutrient stress triggers a recycling process controlled by RAB5B to change proteins at nerve connectionsNutrient stress activates RAB5B-mediated autophagy to remodel the synaptic proteome.

🥈 Top 2% JournalArticle

5 days ago • Science advances

Engineered tiny regulators linking heart and liver boost cell recycling and body metabolism to fight artery diseaseEngineered heart-liver axis nanoregulators synergize autophagy activation and systemic metabolic reprogramming against atherosclerosis.

🥈 Top 2% JournalArticle

5 days ago • Research in veterinary science

Blocking histone deacetylase changes gene activity related to cell growth and aging in horse cartilage cellsHistone deacetylase inhibition alters mRNA expression of cell cycle- and senescence-associated genes in primary equine chondrocytes.

📖 Top 50% JournalArticle

5 days ago • Ageing research reviews

Cell Aging Linked to Both Getting Older and Coronary Artery DiseaseCellular senescence at the bidirectional interface between ageing and coronary artery disease.

🥈 Top 2% JournalArticle

5 days ago • European journal of clinical nutrition

Intermittent fasting: Effects, how it works, and important precautions for health and daily lifeIntermittent fasting: Impact, mechanisms and cautions across medical and lifestyle domains.

📖 Top 20% JournalArticle

5 days ago • Ageing research reviews

Physical and Mechanical Features of Cell Aging and Their Use in TreatmentsThe Physical Senotype in cellular senescence: Mechanical and physical strategies for senotherapy.

🥈 Top 2% JournalArticle

5 days ago • Autophagy

Thioredoxin reductase 1 influences the recycling of cell's protein-folding centers during aging through liquid-liquid phase separationTrr1 (thioredoxin reductase 1) modulates ERphagy in aging via liquid-liquid phase separation.

🥈 Top 2% JournalArticle

5 days ago • RNA (New York, N.Y.)

Disease mutations in two parts of dyskerin do not stop it from pairing but disrupt its binding to telomerase RNADisease mutations in the N-terminal extension and α2'-helix of dyskerin do not abolish dimerization but disrupt binding to the telomerase RNA.

🥉 Top 5% JournalArticle

5 days ago • Journal of hazardous materials

Swallowed microplastics that don’t enter the brain may harm nerves by disturbing gut bacteria, tryptophan metabolism, and brain immune cell cleanupOral exposure to non-brain-penetrable microplastics induces neurotoxicity via disrupting the gut microbiota-tryptophan metabolism-microglial autophagy cascade.

🥉 Top 5% JournalArticle

5 days ago • Autoimmunity reviews

Aging of the immune system in lupus: harmful processes and treatment possibilitiesSenescence of the immune system in SLE: Pathogenic mechanisms and therapeutic implications.

🥉 Top 5% JournalArticle

5 days ago • Autophagy

Mitochondrial cleanup in neurodegeneration: interaction between parkin-dependent and independent pathwaysMitophagy in neurodegeneration: crosstalk between PRKN/parkin-dependent and PRKN-independent pathways.

🥈 Top 2% JournalArticle

← prevpage 2 of 18next →

Latest Longevity & Aging Research Papers