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3 days ago • Journal of visualized experiments : JoVE

Cell Death Processes in Stroke: From How They Work to Possible TreatmentsMolecular Networks of Cell Death in Ischemic Stroke: From Mechanisms to Interventions.

📖 Top 50% JournalVideo-Audio Media

3 days ago • Medical science monitor : international medical journal of experimental and clinical research

Mitochondrial Splitting by Drp1 Helps Control Mineral Transport and Mitochondrial Balance During Bone FormationDrp1-Mediated Mitochondrial Fission Coordinates Mineral Precursor Transport and Mitochondrial Homeostasis During Osteogenesis.

📖 Top 50% JournalArticle

4 days ago • Nature

Diet at the start of disease affects how tissues remember inflammationDiet at disease onset determines tissue inflammatory memory.

Article

4 days ago • Aging cell

A New Peptide Activates SIRT1 by Targeting Its Interaction with USP25 to Reduce Cell AgingA Novel Peptide Targeting the USP25-SIRT1 Interaction Activates SIRT1 to Suppress Cell Senescence.

🥉 Top 5% JournalArticle

4 days ago • Science advances

LAMP2A gene therapy reduces Parkinson's disease symptoms in primatesLAMP2A gene therapy mitigates Parkinson's disease-related pathology in nonhuman primates.

🥈 Top 2% JournalArticle

4 days ago • Immunity

Amount of mitochondrial DNA influences immune-triggered cancer cell deathMitochondrial DNA abundance is a determinant of immunogenic cell death in cancer.

🥇 Top 1% JournalArticle

4 days ago • Calcified tissue international

Drugs Targeting Cell Aging for Age-Related Muscle and Bone Disorders: A Review of Laboratory StudiesSenotherapeutics for Age-Related Musculoskeletal Disorders: A Systematic Review of Preclinical Evidence.

📖 Top 20% JournalSystematic Review

4 days ago • Journal of cell science

🎖️ Top 10% JournalArticle

4 days ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

A Small Molecule That Detects Damaged Mitochondria and Selectively Boosts Their Removal by AutophagyA Damage-Gated Small-Molecule Chimera Selectively Enhances Mitophagy by Coupling Dysfunctional Mitochondria to Autophagy.

🥈 Top 2% JournalArticle

4 days ago • International journal of molecular medicine

The role of sugar breakdown in lung scarring and potential treatmentsGlycolysis in pulmonary fibrosis: From drivers to therapeutic opportunities (Review).

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4 days ago • Molecular neurobiology

Exercise and the removal of damaged cell parts in brain stroke: how it works, exercise approaches, and challenges for real-world useExercise and Mitophagy in Cerebral Ischemia: Mechanistic Evidence, Exercise Strategies, and Translational Challenges.

🎖️ Top 10% JournalArticle

4 days ago • Molecular medicine reports

Mitochondria problems in fatty liver disease linked to metabolism: Causes and possible treatmentsMitochondrial dysfunction in metabolic dysfunction-associated steatotic liver disease: Mechanistic insights and therapeutic horizons (Review).

📖 Top 30% JournalArticle

4 days ago • Cardiovascular research

Restoring NAD+ lowers heart muscle aging and improves heart relaxation in older menNAD+ replenishment reduces cardiomyocyte senescence and improves diastolic function in the aged male heart.

Article

4 days ago • Food science & nutrition

Nicotinamide Mononucleotide's Protective Effect on Fatty Liver Disease Caused by High-Fat Diet in MiceHepatoprotective Effect of Nicotinamide Mononucleotide on High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice.

📖 Top 20% JournalArticle

4 days ago • Journal of Alzheimer's disease : JAD

Levels of p62 protein in spinal fluid linked to tau buildup, brain changes, and thinking problems in adults without dementiaCerebrospinal fluid p62/SQSTM1 is associated with tau pathology, brain structural alterations, and cognitive impairment in adults without dementia.

📖 Top 20% JournalArticle

4 days ago • Journal of Alzheimer's disease : JAD

How SGLT2 Inhibitors May Protect Brain Cells in Alzheimer's DiseaseDeciphering the neuroprotective signaling of SGLT2 inhibitors in Alzheimer's disease.

📖 Top 20% JournalArticle

4 days ago • Translational neurodegeneration

Disordered proteins linked to problems with cell recycling acidity in brain diseasesThe pathological roles of intrinsically disordered proteins in lysosomal acidification dysfunction in neurodegenerative diseases.

🥈 Top 2% JournalArticle

5 days ago • Neuro-oncology

Standard treatment for childhood BRAF-V600E brain tumors causes cell aging and makes tumors more sensitive to BCL-xL blockingStandard treatment against paediatric BRAF-V600E glioma promotes senescence and sensitizes tumours to BCL-xL inhibition.

🥇 Top 1% JournalArticle

5 days ago • GeroScience

Measuring natural ability and aspirin's impact in older men and women: analysis from a clinical trialValidation of an intrinsic capacity index and the effects of aspirin in older males and females: secondary analysis of a randomized controlled trial.

🎖️ Top 10% JournalArticle

5 days ago • Biomolecules & therapeutics

Nrf2 Activation Causes Aging in Skin Support Cells and Increases Pigment Storage When Skin Cells Grow TogetherNrf2 Activation Induces Fibroblast Senescence and Promotes Melanosome Accumulation in a Fibroblast-Keratinocyte Co-Culture Model.

📖 Top 20% JournalArticle

5 days ago • Autophagy

Overview of the human protein quality control system: the ubiquitin-proteasome pathwaySurvey of the human proteostasis network: the ubiquitin-proteasome system.

🥈 Top 2% JournalArticle

5 days ago • Journal of biochemical and molecular toxicology

Stemonine may reduce skin cell aging caused by UVB light by activating a protective proteinStemonine Alleviates UVB-Induced Keratinocyte Senescence by Activating SIRT3.

📖 Top 30% JournalArticle

5 days ago • Molecular and cellular biochemistry

Trehalose reduces cell aging caused by oxidative stress and is linked to changes in cell growthTrehalose alleviates oxidative stress-induced senescence and is associated with cell-cycle remodeling.

Article

5 days ago • Biogerontology

A task-focused approach to evaluating molecular clocks that estimate biological agingBeyond age prediction: a task-oriented framework for evaluating molecular aging clocks.

📖 Top 20% JournalArticle

5 days ago • In vivo (Athens, Greece)

Urolithin A reduces noise-related hearing loss and is linked to increased cell cleanup in the earUrolithin A Attenuates Noise-induced Hearing Loss and Is Associated With Increased Cochlear Mitophagy Markers.

📖 Top 50% JournalArticle

5 days ago • Molecular metabolism

Immunotherapy against a natural viral element reduces aging signs in insulin-producing cells and helps maintain blood sugar control in a mouse model of type 2 diabetesImmunotherapy targeting an endogenous retrovirus decreases islet senescence markers and preserves glucose control in a mouse model of type 2 diabetes.

🥉 Top 5% JournalArticle

5 days ago • Brain : a journal of neurology

E3 ubiquitin ligases: key proteins for protein balance affected in inherited nerve disordersE3 ubiquitin ligases: a vital component of proteostasis impaired in hereditary neuropathies.

Article

5 days ago • Ecology and evolution

Molecular Changes and Sex Differences in Gene Control During Multi-Year Dormancy of the Cabbage BeetleMolecular Adaptations and Sex-Biased Regulatory Pathways in Multi-Year Diapause of the Cabbage Beetle Colaphellus bowringi: A Duration-Resolved Transcriptomic Analysis.

📖 Top 20% JournalArticle

5 days ago • Cell reports

FXR/Sptlc2 signaling in severe lung injury helps lung immune cells clear damaged mitochondria and reduce inflammationAcute respiratory distress syndrome FXR/Sptlc2 signaling promotes alveolar macrophage mitophagy and limits lung inflammation.

🥈 Top 2% JournalArticle

5 days ago • Molecular neurobiology

Mitochondrial Problems Linked to α-Synuclein Toxicity in Lab Models of Protein ClumpsMitochondrial Dysfunction as a Convergent Mechanism of α-Synuclein Toxicity: A Systematic Review of In Vitro Fibrillar Models.

🎖️ Top 10% JournalSystematic Review

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