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5 days ago • Cell

Calorie restriction changes mutation rate independently of lifespanCalorie restriction uncouples mutation rate from lifespan.

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5 days ago • Neural regeneration research

How the Sirtuin 1/PGC-1α Pathway Controls Mitochondria and May Help Treat Neurodegenerative DiseasesSirtuin 1/peroxisome proliferator-activated receptor gamma coactivator 1α signaling pathway: Molecular mechanisms from mitochondrial function regulation to the treatment of neurodegenerative diseases.

📖 Top 20% JournalArticle

5 days ago • Neural regeneration research

Changes in nerve cell receptors in the aging bone lining: From detailed cell maps to repair targetsNeuronal receptor remodeling in the aging periosteum: From single-cell atlases to regenerative targets.

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5 days ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

A Fat Cell Signaling Pathway Helps Keep Insulin Working in Mice and Changes in Human ObesityAn Adipocyte MKK3-p38β Axis Preserves Insulin Responsiveness in Mice and Is Reciprocally Altered in Human Obesity.

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6 days ago • Aging cell

Aging Support Cells May Cause Stem Cell Aging by Producing Imbalanced Signaling MoleculesSenescent Mesenchymal Stromal Cells Drive Stem Cell Aging Through Dysregulated Chemokine Synthesis.

🥉 Top 5% JournalArticle

6 days ago • Chinese journal of natural medicines

CCA, a natural compound from Caesalpinia bonduc, improves memory problems in Alzheimer's mice by reducing brain inflammation and supporting cell cleanupCCA, a cassane diterpene from Caesalpinia bonduc ameliorates cognition impairment in Alzheimer's disease mice by regulating neuroinflammation and autophagy.

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6 days ago • Cellular immunology

How aging changes the function of neutrophils in peopleEffect of aging on neutrophil function in humans.

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6 days ago • JMIR dermatology

Using AI to Grade Facial Aging Signs and Estimate Visible Age from Standard PhotosAI-Based Grading of Facial Aging Signs and Prediction of Visible Age From Standardized Facial Images: Algorithm Development and Internal Evaluation Study.

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6 days ago • Translational research : the journal of laboratory and clinical medicine

Removing TRPV4 in appetite-controlling neurons worsens diet-induced obesity through calcium-linked mitochondrial recyclingDeletion of TRPV4 in the POMC neurons exacerbates diet-induced obesity via Ca2+-dependent PGAM5-mediated mitophagy.

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6 days ago • Autophagy

Exercise causes a chemical change in WDR41 that starts cell cleaning and helps improve fatty liver diseaseExercise-induced lactylation in WDR41 initiates autophagy and improves fatty liver diseases.

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6 days ago • Research (Washington, D.C.)

Making Cell Communication Channels Using a Chinese MicroneedlePositioning Creation of Cell Communication Channels via Chinese Microneedle.

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6 days ago • Journal of agricultural and food chemistry

How DEHP May Promote Liver Scarring by Activating Fat Breakdown in Liver Support CellsExploring the Mechanism of DEHP Promoting Hepatic Fibrosis Based on Network Toxicology by Triggering Lipophagy-Dependent Hepatic Stellate Cell Activation.

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6 days ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Serine Metabolism Controlled by PHGDH in Spine Disc Cells May Be a Treatment Target for Disc DegenerationPHGDH-Mediated Serine Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration.

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6 days ago • Seminars in respiratory and critical care medicine

Lymphangioleiomyomatosis (LAM): From Genetic Causes to Treatment ApproachesLymphangioleiomyomatosis (LAM): From Genetics to Management.

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6 days ago • Chimia

How mTOR and Small Cell Particles Connect Chemical Stress to Communication Between OrganismsmTOR and Extracellular Vesicles: Linking Chemical Stress to Ecological Communication.

Article

6 days ago • Journal of visualized experiments : JoVE

Isolating Heart Muscle Cells from the Annual Killifish for Detailed Electrical RecordingIsolation of Ventricular Cardiomyocytes from the Annual Killifish Nothobranchius furzeri for Whole-Cell Patch Clamp Recordings.

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6 days ago • Signal transduction and targeted therapy

Ginsenoside Rb1 may reduce uterine aging by blocking a key cell growth pathwayGinsenoside Rb1 alleviates uterine aging via AMPK-mediated mTOR inactivation.

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6 days ago • Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology

Leukocyte Telomere Length and Telomerase Gene Variant Linked to Cannabis and Synthetic Cannabinoid Use DisorderExploring the Role of Leukocyte Telomere Length and Human Telomerase Reverse Transcriptase MNS16A Variant in Cannabis or Synthetic Cannabinoid Use Disorder.

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6 days ago • Autophagy

Overview of the human protein maintenance system: the cell’s recycling pathwaySurvey of the human proteostasis network: the autophagy-lysosome pathway.

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6 days ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

DUSP26 Controlled by YY1 Lactylation Links Bone Formation and Blood Vessel Growth by Activating Cell Cleaning in Bone Stem CellsDUSP26 Regulated by YY1 Lactylation Couples Osteogenesis and Angiogenesis by Dephosphorylating PMPCB at Y141 and Activating Mitophagy in BMSCs.

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6 days ago • Journal of visualized experiments : JoVE

Long Non-Coding RNA H19 May Protect Diabetic Mice Hearts from Blood Flow Damage Through Low-Oxygen Response SignalingLong Non-Coding RNA H19 Protection Against Myocardial Ischemia/Reperfusion Injury in Diabetic Mice Through Hypoxia-Inducible Factor 1 Alpha Signaling.

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1 week ago • Autophagy

Overview of the human protein maintenance system: making, folding, and organelle-specific processesSurvey of the human proteostasis network: translation, protein folding, and organelle-specific systems.

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1 week ago • Signal transduction and targeted therapy

The AMPK pathway's role in cell energy use and human diseasesThe AMPK signaling pathway in cell metabolism and human diseases.

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1 week ago • Genetics and molecular biology

Active Vitamin D supports bone cell precursor recycling and development by increasing BECN1 gene activity1α,25-(OH)2-D3 promotes osteoclast-precursor autophagy and osteoclast differentiation by promoting BECN1 transcription.

Article

1 week ago • Cellular signalling

Moxibustion may help bone cell growth in osteoporotic rats by controlling stem cell signals that affect cell energy cleanupMechanistic study on the promotion of osteogenic differentiation in osteoporotic rats by moxibustion via regulation of BMSCs-derived exosomal miR-27a-3p-mediated mitophagy.

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1 week ago • Current opinion in pediatrics

Telomere biology disorders seen through clinical geneticsTelomere biology disorders: recognizing the underrecognized through the lens of clinical genetics.

📖 Top 30% JournalArticle

1 week ago • Medical science monitor : international medical journal of experimental and clinical research

Thermosensitive Ion Channels and Their Possible Role in Diabetes and TreatmentReview of the Roles of Thermosensitive Transient Receptor Potential Channels in Diabetes Mellitus and Their Potential as Therapeutic Targets.

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1 week ago • Experimental neurology

Exosomes from stem cells may improve memory and Alzheimer-like brain changes in mice by altering metabolismhucMSC-derived exosomes rescue cognitive impairment and Alzheimer-like pathology in APP/PS1 mice via metabolic remodeling.

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1 week ago • Molecules and cells

Updated methods for measuring cell aging in mammalsUpdated guide to the assessment of mammalian cellular senescence.

Letter

1 week ago • Journal of Ayurveda and integrative medicine

How Rasayana may protect cells and support healthy agingMolecular mechanisms and therapeutic potential of Rasayana in cellular protection and healthy aging.

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