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5 days ago • Experimental gerontology

Using n-acetylcysteine to reduce cell aging in human blood vessel cells through the HuR pathwayFrom antioxidant to senotherapeutic: Repurposing n-acetylcysteine to counteract senescence via the HuR pathway in human endothelial cells.

Article

6 days ago • Autophagy

Turning off V-ATPase triggers cell recycling and abnormal Notch signaling to help intestinal stem cells develop in adult fruit fliesInactivation of V-ATPase induces autophagy and ectopic Notch activation to promote intestinal stem cell differentiation in adult drosophila midgut.

🥈 Top 2% JournalArticle

6 days ago • RSC medicinal chemistry

Testing pyrazolo-pyrimidines as inhibitors of the SIRT2 enzyme using computer models and lab experimentsProbing pyrazolo-pyrimidines as SIRT2 inhibitors via molecular modelling and biological assays.

📖 Top 30% JournalArticle

6 days ago • medRxiv : the preprint server for health sciences

Changes in Biological Aging Markers and Brain Health in Middle AgeEpigenetic Clock Trajectories and Brain Health in Midlife.

Preprint

6 days ago • Frontiers in immunology

Autophagy’s two roles in gouty arthritis: underlying processes and treatment possibilitiesDual role of autophagy in gouty arthritis (GA): molecular mechanisms and therapeutic potential.

🥉 Top 5% JournalArticle

6 days ago • Frontiers in cell and developmental biology

Two-Way Links Between Cell Membrane Transport Problems and Fat Metabolism DisordersThe endo-lysosomal-lipid axis: bidirectional interactions between membrane trafficking dysfunction and lipid metabolic disorders.

🎖️ Top 10% JournalArticle

6 days ago • Frontiers in immunology

🥉 Top 5% JournalArticle

6 days ago • Phytomedicine : international journal of phytotherapy and phytopharmacology

Salidroside may reduce liver scarring from fatty liver disease by controlling cell cleanup through the PI3K/AKT/mTOR pathwaySalidroside alleviates metabolic dysfunction-associated steatohepatitis-induced fibrosis by regulating PI3K/AKT/mTOR pathway-mediated hepatocyte mitophagy.

🎖️ Top 10% JournalArticle

6 days ago • Frontiers in allergy

From Chronic Inflammation to Steroid Resistance: Rethinking the Causes of Neutrophil-Driven AsthmaFrom inflammaging to steroid resistance: reframing the pathogenesis of neutrophilic asthma.

📖 Top 20% JournalArticle

6 days ago • Frontiers in aging

Automated creation of personalized aging patterns using DyViA-GANAutomated generation of personalized trajectories of aging phenotypes with DyViA-GAN.

🎖️ Top 10% JournalArticle

6 days ago • Frontiers in cell and developmental biology

Stress and its link to brain cell cleaning processes that may affect lifelong disease riskThe embedding of stress: mitophagy as a mechanism for the central nervous system (CNS) programming and lifelong disease vulnerability.

🎖️ Top 10% JournalArticle

6 days ago • Phytomedicine : international journal of phytotherapy and phytopharmacology

Poricoic acid A reduces ulcerative colitis by blocking cell aging through the AMPK/PPARγ pathway and changing gut bacteria and their metabolismPoricoic acid a ameliorates ulcerative colitis via AMPK/PPARγ pathway-dependent cellular senescence inhibition and concomitant gut microbiota-metabolome modulation.

🎖️ Top 10% JournalArticle

6 days ago • Nature aging

Chemotherapy-caused cell aging releases factors that help cancer cells detach and spread by changing their metabolismThe chemotherapy-induced senescence-associated secretome promotes cell detachment and metastatic dissemination through metabolic reprogramming.

🥇 Top 1% JournalArticle

6 days ago • eLife

A muscle protein complex limits muscle length growth when stretchedThe titin N2A-MARP signalosome constrains muscle longitudinal hypertrophy in response to stretch.

🥈 Top 2% JournalArticle

6 days ago • Autophagy

Using diet to improve cell cleanup reduces age-related heart scarring and stiffnessTargeting chaperone-mediated autophagy by nutritional interventions mitigates age-related cardiac fibrosis and diastolic dysfunction.

🥈 Top 2% JournalArticle

6 days ago • iMeta

Bazi Bushen Capsule may improve fertility by supporting energy health in aging womb liningBazi Bushen Capsule restores fertility by targeting mitochondrial health in aging endometrium.

🥇 Top 1% JournalArticle

6 days ago • Neuromolecular medicine

Controlling Brain and Nerve Inflammation After Spinal Cord Injury by Targeting the cGAS-STING Immune PathwayResearch Progress on Regulating Neuroinflammation After Spinal Cord Injury by Targeting the cGAS-STING Pathway.

📖 Top 20% JournalArticle

6 days ago • GeroScience

Oral LNAD+ quickly raises NAD levels inside blood cells and boosts metabolism without increasing NAD in blood plasmaOral LNAD+ rapidly elevates whole blood intracellular NAD and metabolic flux without elevating plasma NAD: evidence from a randomized controlled trial.

🎖️ Top 10% JournalArticle

6 days ago • Cellular signalling

Short-term fasting and exercise together affect energy control in the memory area of healthy miceA combined stimulus of acute fasting and exercise modulates hippocampal mitochondrial quality control in healthy mice.

📖 Top 20% JournalArticle

6 days ago • American journal of physiology. Renal physiology

Too much protein taken up by kidney receptors leads to increased cell growth and aging in kidney tubules of protein-leaking mice, mainly in the outer kidney regionExcessive protein uptake by endocytic receptors causes elevated proliferation and senescence in proximal tubules primarily in outer medulla of proteinuric mice.

Article

6 days ago • Frontiers in cell and developmental biology

Tiny cell membranes that connect organelles influence their movement and cell survivalNanoscale biointerfaces in inter-organelle communication: membrane contact sites, organelle trafficking, and cell fate control.

🎖️ Top 10% JournalArticle

1 week ago • Frontiers in aging

How Omega-3 Fatty Acids May Influence Harmful Sugar-Built Molecules in Aging: Key Processes and Health ImplicationsOmega-3 fatty acids as modulators of advanced glycation end products in aging: mechanistic pathways and clinical implications - a narrative review.

🎖️ Top 10% JournalArticle

1 week ago • Frontiers in public health

Early aging of the placenta and its role in the mother's symptoms in early severe preeclampsiaPremature placental senescence in early-onset preeclampsia: syncytiotrophoblast SASP and the maternal syndrome.

📖 Top 20% JournalArticle

1 week ago • International journal of biological sciences

Cleaning, Repairing, and Soothing: Promising Approaches to Treat Aging-Related DiseasesCleaning, Chasing and Calming: Promising Paradigms of Senotherapy in Aging-Related Diseases.

🥉 Top 5% JournalArticle

1 week ago • Frontiers in immunology

Increased fat-making activity in aging immune cells may contribute to worsening liver scarringUpregulated FASN-mediated lipogenesis in senescent macrophages contributes to liver fibrosis progression.

🥉 Top 5% JournalArticle

1 week ago • bioRxiv : the preprint server for biology

Gene Therapy to Restore Parkin Protein in Early-Onset Parkinson's DiseaseRestoring Parkin Function: An AAV Gene Therapy Approach for Early-Onset Parkinson's Disease.

Preprint

1 week ago • bioRxiv : the preprint server for biology

Blocking Mitochondrial Cleanup Helps Survival and Energy Function in MYC-driven Liver CancerMitophagy Inhibition Promotes Survival and Mitochondrial Function in MYC-driven HCC.

Preprint

1 week ago • bioRxiv : the preprint server for biology

Reducing aged cell buildup helps improve aging in bone marrowTargeting cellular senescence alleviates bone marrow aging.

Preprint

1 week ago • Proceedings of the National Academy of Sciences of the United States of America

Timing and location of Atg2 joining the cell's membrane system during autophagosome formationSpatiotemporal control of Atg2 association with the ER during autophagosome formation.

Article

1 week ago • Nature cell biology

The enzyme PGAM1 controls cell metabolism and recycling to balance growth and stress survivalThe glycolytic enzyme PGAM1 functions as a metabolic-autophagy checkpoint to coordinate growth and stress tolerance.

Article

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