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1 week ago • Cell reports

Early problems in mitochondrial cleanup and energy use may drive organ damage progression in Fabry heart diseaseEarly mitophagy defects and impaired mitochondrial energy metabolism drive target organ damage progression: Lessons from the Fabry heart.

🥈 Top 2% JournalArticle

1 week ago • Circulation research

Natural Killer Cell Signals Control Lung Growth After BirthNatural Killer Cell TGF-β Signaling Regulates Postnatal Lung Development.

🥇 Top 1% JournalArticle

1 week ago • Acta pharmaceutica (Zagreb, Croatia)

Relaxin-2 helps protect brain connections through inflammation and cell recycling pathways in the memory area in an age-related Alzheimer’s modelRelaxin-2 protects synaptic integrity via hippocampal NLRP3-mTOR-autophagy pathways in an age-dependent Alzheimer-like model.

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1 week ago • Expert opinion on therapeutic targets

Therapeutic potential of different sirtuin proteinsWhat are the potentials of the different sirtuin proteins as therapeutic targets?

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1 week ago • npj aging

Using Biological Age and Artificial Intelligence in Health CareThe use of biological age and artificial intelligence in health care.

🥉 Top 5% JournalLetter

1 week ago • Reproduction (Cambridge, England)

Early puberty linked to egg supply and aging signs in young adultsEarly menarche in association with ovarian reserve and biological aging in young adults: a cross-sectional study.

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1 week ago • iScience

How specific cell types in memory and hormone control areas respond to nutrition and metabolism in Alzheimer's diseaseHippocampal and hypothalamic cell-type specific mechanisms underlying nutritional and metabolic modulation of Alzheimer's disease.

🎖️ Top 10% JournalArticle

1 week ago • Cytotechnology

CDKN1B forms liquid droplets and reduces fat buildup and inflammation by boosting damaged mitochondria removal in non-alcoholic fatty liver diseaseCDKN1B undergoes liquid-liquid phase separation and attenuates lipid accumulation and inflammatory response by promoting mitophagy in non-alcoholic fatty liver disease.

📖 Top 50% JournalArticle

1 week ago • GeroScience

Interaction between Sonic Hedgehog and Matrix Metalloproteinases in Brain Blood Vessel Aging and Stroke: A Possible MechanismSonic hedgehog-matrix metalloproteinase crosstalk in neurovascular ageing and stroke: a potential mechanistic link.

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1 week ago • IBRO neuroscience reports

Protective effects of Klotho signals in Huntington's disease from molecules to treatmentNeuroprotective roles of Klotho signaling in Huntington's disease: From molecular insights to clinical translation.

📖 Top 30% JournalArticle

1 week ago • Developmental biology

Blood cells as nutrient sensors that influence immunity, lifespan, and offspring health in fruit fliesHemocytes as nutrient-sensing regulators of immune function, lifespan, and intergenerational fitness in Drosophila melanogaster.

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1 week ago • International journal of cosmetic science

Chemical and gene studies reveal multiple skin-aging benefits of a triple-fermented extractIntegrated chemical profiling, transcriptomics and functional validation elucidate the multifunctional benefits of a triple-ferment filtrate complex for skin aging intervention.

📖 Top 30% JournalArticle

1 week ago • Ecotoxicology and environmental safety

Mitochondria quality control during cadmium brain poisoning: helpful cleanup, uneven removal, and blocked processingMitochondrial quality-control states in cadmium neurotoxicity: Adaptive clearance, disproportionate elimination and stalled flux.

🎖️ Top 10% JournalArticle

1 week ago • Current biology : CB

The buildup of antimicrobial peptides helps gut cells shed to keep the aging fruit fly's gut healthyThe antimicrobial peptide pileup promotes enterocyte shedding to maintain gut homeostasis in aging Drosophila.

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1 week ago • Aging cell

Changes in Gene Packaging Linked to Aging, Brain Inflammation, and Metabolism in Alzheimer's DiseaseHistone Modifications at the Intersection of Aging, Neuroinflammation and Metabolism in Alzheimer's Disease.

🥉 Top 5% JournalArticle

1 week ago • Trends in molecular medicine

Understanding Kidney Cancer by Studying MiT/TFE ProteinsRethinking kidney cancer through the lens of microphthalmia (MiT)/transcription factor E (TFE) Biology.

🥈 Top 2% JournalArticle

1 week ago • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Finding compounds that target bitter taste receptors to slow metabolic decline using a new lab method measuring hormone and inflammation signalsIdentification of TAS2R-targeting bioactive compounds against metabolic decline: A novel ex vivo methodology based on enteroendocrine and inflammatory readouts.

🎖️ Top 10% JournalArticle

1 week ago • Nature reviews. Cardiology

Heart and blood vessel strength in people aged 100 and olderCardiovascular resilience in centenarians.

🥇 Top 1% JournalArticle

1 week ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

A Nanoparticle System Inspired by Nature Boosts Cell Cleaning and Recovery After Spinal Cord InjuryA Biomimetic PLK1 Nanodelivery System Promotes Migrasome-Mediated Mitocytosis to Restore Efferocytosis and Functional Recovery After Spinal Cord Injury.

🥈 Top 2% JournalArticle

1 week ago • Food & function

Energy-regulating pathways help grape waste extract protect against obesity-related chronic kidney disease in miceAMPK-dependent mechanisms mediate the protective effects of grape pomace extract in obesity-associated chronic renal disease in mice.

📖 Top 20% JournalArticle

1 week ago • Proceedings of the National Academy of Sciences of the United States of America

Natural DNA copying errors help control chromosome end length in normal yeastSpontaneous replication fork collapse regulates telomere length homeostasis in wild-type yeast.

Article

1 week ago • FASEB journal : official publication of the Federation of American Societies for Experimental Biology

How Cell Recycling Controls Collagen I and Tissue Balance: From Basic Processes to Scarring Problems and TreatmentsAutophagy-Controlled Collagen I Metabolism and ECM Homeostasis: From Molecular Mechanisms to Fibrotic Dysregulation and Therapy.

Article

1 week ago • The Journal of nutrition

Hydroxyproline boosts the positive effects of branched-chain amino acids on lifespan and health in C. elegansHydroxyproline Enhances Branched-Chain Amino Acid Effects on Lifespan and Healthspan in Caenorhabditis elegans.

Article

1 week ago • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Using protective blood pressure system pathways to reduce inflammation and restore lung balance in emphysemaTargeting protective renin-angiotensin system pathways in pulmonary emphysema: Preclinical evidence for resolving inflammation and restoring lung homeostasis.

🎖️ Top 10% JournalArticle

1 week ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Aging donor cells shift damaged mitochondria from recycling to small vesicle release using a protein-stabilizing processDonor-Cell Senescence Redirects PINK1-Marked Mitochondrial Cargo From Mitophagy to Microvesicle Transfer Through SUMO3-Stabilized HSPA9.

🥈 Top 2% JournalArticle

1 week ago • Journal of cardiovascular translational research

Protein Modifications Linked to Irregular Heartbeats in Atrial FibrillationPost-Translational Protein Acylation in Atrial Fibrillation.

📖 Top 30% JournalArticle

1 week ago • Autophagy

A specific protein modification helps build a gene-regulating complex that controls cell cleanup and protein balance in non-dividing eye support cellsAKT1-phosphorylated TERT assembles a FOXO3-MYC transcriptional complex that drives ERphagy and proteostasis in post-mitotic RPE.

🥈 Top 2% JournalArticle

1 week ago • International immunopharmacology

How Proton Pump Inhibitors May Affect Brain Inflammation, Protection, and Damage in Alzheimer's DiseaseImmunopharmacology of proton pump inhibitors in Alzheimer's Disease: An evidence-weighted mechanistic review of Neuroinflammation, neuroprotection, and neurodegeneration.

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1 week ago • Biogerontology

Ginsenoside Rg1 may slow aging by boosting cell cleanup through DAF-16 in C. elegansGinsenoside Rg1 promotes mitophagy and delays aging through the DAF-16 in Caenorhabditis elegans.

📖 Top 20% JournalArticle

1 week ago • Materials today. Bio

Nanoparticles that renew aged LepR+ cells to improve old bone marrowAged microenvironment-triggered nanoreactors rejuvenate senescent LepR+ cells to remodel aged bone marrow.

🥉 Top 5% JournalArticle

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