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1 week ago • Cellular signalling

Blocking the ETS1/DRP1 pathway may reduce disc degeneration by limiting excessive mitochondrial splittingInhibition of ETS1/DRP1 axis attenuates intervertebral disc degeneration by suppressing excessive mitochondrial fission.

📖 Top 20% JournalArticle

1 week ago • Aging cell

Comparing Natural and Measurement Reliability of Epigenetic Clocks and Their Links to Disease Outlook and Treatment ResponseBiological Versus Technical Reliability of Epigenetic Clocks and Implications for Disease Prognosis and Intervention Response.

🥉 Top 5% JournalArticle

1 week ago • GeroScience

Using DNA-based aging markers in diet and aging studies: practical steps, participant views, and study planningEpigenetic aging biomarkers in dietary geroscience: feasibility, participant perceptions, and trial design considerations.

🎖️ Top 10% JournalArticle

1 week ago • The Journal of cell biology

Overactive PARP1 slows protein production and causes stress granules after DNA damagePARP1 hyperactivity stalls translation and triggers stress granule formation following DNA damage.

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1 week ago • Nature reviews. Genetics

How Genes and Their Regulation Control Cell AgingGenomic, epigenomic and transcriptomic regulation of cellular senescence.

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1 week ago • International immunopharmacology

Dehydrodiisoeugenol may improve ulcerative colitis by reducing cell aging through AKT inhibition and GSK3B activationDehydrodiisoeugenol ameliorates DSS-induced ulcerative colitis by suppression of cellular senescence through inhibiting AKT and activating GSK3B.

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1 week ago • Animal genetics

Changes in Cell Aging Markers and Stress Hormones in Grazing Goats: Early Insights for Welfare MonitoringTelomere Dynamics and Cortisol Response in Grazing Goats: Preliminary Insights Into Welfare Monitoring.

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1 week ago • Nature aging

Different types of aging cells show the variety of senescent cellsSenotypes define the diverse landscape of senescent cells.

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1 week ago • Nature

Energy use in cells and gene regulation together influence the aging-related secretionsMitochondrial metabolism and epigenetic crosstalk drive SASP.

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1 week ago • Nature neuroscience

Build-up of damaged energy parts and recycling problems create harmful clumps in Alzheimer's diseaseMitochondrial accumulation and lysosomal dysfunction result in mitochondrial plaques in Alzheimer's disease.

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1 week ago • The Journal of pharmacology and experimental therapeutics

Changes in Alzheimer's disease linked to M1 muscarinic receptor activity differ between male and female APPswe/PSEN1ΔE9 miceM1 muscarinic receptor modulation drives sex-specific alterations of Alzheimer's pathophysiology in APPswe/PSEN1ΔE9 mice.

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1 week ago • Nutrients

How Diet Changes Fat Molecules That May Lead to Heart Metabolism ProblemsDiet-Induced Ceramide Remodeling as a Mechanistic Link to Cardiac Metabolic Dysfunction.

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1 week ago • Molecules (Basel, Switzerland)

Organic Germanium (Ge-132) Lowers Sugar-Related Cell Damage While Keeping Stress Signals Active, Showing Limited Link Between Chemical and Cell ResponsesOrganic Germanium (Ge-132) Reduces Glycative Damage While Maintaining Cellular Stress Signaling, Revealing Limited Coordination Between Biochemical and Cellular Responses.

📖 Top 20% JournalArticle

1 week ago • Cancers

How CDK4/6 Inhibitors Cause Cancer Cells to Stop Growing and What This Means for TreatmentCDK4/6 Inhibitor-Induced Senescence in Cancer: Mechanisms and Therapeutic Implications.

🎖️ Top 10% JournalArticle

1 week ago • Frontiers in immunology

Cell cleanup of the protein-making system in inflammatory diseasesEndoplasmic reticulum autophagy in inflammatory diseases.

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1 week ago • Frontiers in cellular and infection microbiology

How the cell’s recycling process affects infections by single-celled parasitesThe role of autophagy in protozoan infections.

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1 week ago • Biomedicines

Corneal Nerve Shape and Biological Age in Healthy AdultsCorneal Nerve Fiber Morphology and Biological Age in Healthy Adults.

📖 Top 20% JournalArticle

1 week ago • Frontiers in immunology

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1 week ago • International journal of molecular sciences

Mitochondrial Genetic Diseases and Their Eye Symptoms: Causes, Genetics, and TreatmentMitochondrial Genetic Diseases and Ophthalmic Manifestations: Molecular Pathophysiology, Genetics, and Clinical Management.

📖 Top 20% JournalArticle

1 week ago • Microorganisms

Interaction Between Gut Bacteria and Ageing in Alcohol-Related Liver DiseaseGut Microbiota and Ageing: A Critical Crosstalk in Alcohol-Related Liver Disease.

📖 Top 20% JournalArticle

1 week ago • International journal of molecular sciences

Exercise changes liver cell energy production through muscle, gut, and thyroid system interactions in fatty liver diseaseExercise-Induced Hepatic Mitochondrial Reprogramming Across Muscle-Gut-Thyroid Axes in MASLD/MASH.

📖 Top 20% JournalArticle

1 week ago • Frontiers in immunology

How the Immune System Controls Normal Body FunctionsThe immune system as a regulator of normal physiology.

🥉 Top 5% JournalArticle

1 week ago • Biomedicines

Mitochondrial Problems: From How They Happen to New Research Methods for Lab and Medical StudiesMitochondrial Dysfunction: From Molecular Mechanisms to Modern Approaches for Basic and Clinical Research.

📖 Top 20% JournalArticle

1 week ago • Biomolecules

Links Between Chronic Inflammation, Oxidative Stress, and Inflammation-Related MicroRNAs in Metabolic Aging: From Diagnostic Groups to Combined Risk ProfilesThe Inflammaging-Redox-InflammamiR Axis in Metabolic Aging: From Diagnostic Clusters to Integrated Risk Phenotypes.

🎖️ Top 10% JournalArticle

1 week ago • Healthcare (Basel, Switzerland)

Gut Bacteria and Ageing: How They Affect Age-Related Diseases and Possible TreatmentsGut Microbiota and Ageing: Mechanisms, Age-Related Diseases, and Therapeutic Perspectives.

📖 Top 30% JournalArticle

1 week ago • Frontiers in aging neuroscience

🎖️ Top 10% JournalArticle

1 week ago • International journal of molecular sciences

A Specific Synbiotic Creates Immune-Regulating Metabolites, Activates Gut-Immune Pathways Linked to Age-Related Inflammation, and Supports Healthy Aging in a Worm ModelA Defined Synbiotic Produces Immunomodulatory Metabolites, Engages Gut-Immune Pathways Relevant to Inflammaging, and Supports Healthy Aging in a Nematode Model.

📖 Top 20% JournalArticle

1 week ago • Biomolecules

Using Non-Mammal Models to Study Energy Systems in Brain DisordersNon-Mammalian Models for Mitochondria Research in CNS Disorders.

🎖️ Top 10% JournalArticle

1 week ago • International journal of molecular sciences

Early Signs and Causes of Muscle Loss: Key Roles of Energy Problems, Chronic Inflammation, Cell Aging, and Nerve-Muscle DamageBiomarkers and Early Mechanisms of Sarcopenia: Central Roles of Mitochondrial Dysfunction, Inflammaging, Cellular Senescence, and Neuromuscular Degeneration.

📖 Top 20% JournalArticle

1 week ago • International journal of molecular sciences

Faulty Cell Cleanup Causes Heart Muscle Disease in Lysosomal Storage Disorders: From Disease Understanding to Targeted TreatmentsAutophagy-Lysosomal Dysfunction as a Converging Mechanism of Cardiomyopathy in Lysosomal Storage Disorders: From Pathobiology to Targeted Therapy.

📖 Top 20% JournalArticle

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