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1 week ago • Experimental gerontology

Epigenetic clocks and faster biological aging in people with HIV: New insights and health consequencesEpigenetic clocks and accelerated biological aging in people living with HIV: Emerging mechanisms and clinical implications.

Article

1 week ago • Experimental gerontology

Protein patterns linked to body-wide inflammation in aging, multiple diseases, and risk of deathProteomic signatures of systemic inflammation in aging, multimorbidity, and mortality.

Article

1 week ago • Phytotherapy research : PTR

Research trends and key insights into natural treatments for Alzheimer's diseaseResearch Trends and Mechanistic Insights Into Natural Medicines for Alzheimer's Disease: A Bibliometric Analysis and Narrative Review.

Article

1 week ago • Archives of biochemistry and biophysics

Blocking ITIH3 reduces cell stress and self-cleaning processes in kidney cells by controlling the HSP90B1/STAT3 pathway, helping to ease diabetic kidney damageTargeting ITIH3 inhibits oxidative stress and autophagy in renal tubular epithelial cells by regulating the HSP90B1/STAT3 axis, thereby alleviating diabetic nephropathy injury.

📖 Top 20% JournalArticle

1 week ago • Molecular neurodegeneration

Therapies targeting cell recycling systems for neurodegenerative diseasesRetromer-targeted therapy for neurodegenerative diseases.

🥇 Top 1% JournalArticle

1 week ago • Molecular neurobiology

Fructooligosaccharides improve gut function and boost brain fatty acids to reduce nerve cell death caused by mitochondrial recycling in rats with long-term reduced brain blood flowFructooligosaccharides Restore Gut Function and Increase Hippocampal Short-Chain Fatty Acids to Alleviate Neuronal Apoptosis Induced by Mitochondrial Autophagy in rats with Chronic Cerebral Hypoperfusion.

🎖️ Top 10% JournalArticle

1 week ago • Pharmacological research

Balance of Cell Energy Centers in Muscle and Bone Diseases: Causes and Targeted TreatmentsMitochondrial homeostasis in musculoskeletal diseases: From pathogenic mechanisms to precision therapies.

🥉 Top 5% JournalArticle

1 week ago • Journal of diabetes investigation

Protein Balance in Controlling Pancreatic Islet Cell FlexibilityProteostasis in the regulation of pancreatic islet cell plasticity.

📖 Top 20% JournalArticle

1 week ago • Calcified tissue international

PAI-1's role in bone breakdown and repair may depend on different conditionsSERPINE1/PAI-1 in Skeletal Degeneration: A Proposed Context-Dependent Framework for Bone Remodeling Regulation.

📖 Top 20% JournalArticle

1 week ago • Cureus

Telomerase Mutation Linked to Blood Cell Loss and Liver Damage Needing TransplantTelomerase Reverse Transcriptase (TERT) Mutation at a Price: Telomere Biology Disorder Presenting With Pancytopenia and Cirrhosis Requiring Liver Transplantation.

Case Reports

1 week ago • Food & function

Comparison of weight-loss effects of popular natural products in animal studies using data analysisComparative anti-obesity efficacy of high-interest natural products in preclinical models: a bibliometric and network meta-analysis.

📖 Top 20% JournalArticle

1 week ago • Molecular therapy : the journal of the American Society of Gene Therapy

D-Amino Acid Prodrug DLMEH May Activate Cell Growth Pathway Through Sestrin2 to Improve Muscle Protein Production in Age-Related Muscle LossD-Amino Acid Prodrug DLMEH Activates mTORC1 via Sestrin2 to Restore Muscle Protein Synthesis in Sarcopenia.

🥈 Top 2% JournalArticle

1 week ago • Metabolic brain disease

Nicotinamide riboside and metformin may protect the memory area of the brain in male rats with diet-related obesityNeuroprotective impact of nicotinamide riboside and metformin on the hippocampus of male rats with diet-induced obesity.

📖 Top 20% JournalArticle

1 week ago • PloS one

Network analysis finds genes linked to two types of cell death involved in rheumatoid arthritisIntegrative network analysis identifies candidate genes shared between ferroptosis and cuproptosis pathways in rheumatoid arthritis pathogenesis.

📖 Top 30% JournalArticle

1 week ago • Biochemical and biophysical research communications

Esculetin that targets cell energy centers may reduce age-related heart changes by activating energy and repair pathways and blocking stress signalsMitochondria-targeted esculetin mitigates age-associated cardiac remodeling through coordinated activation of AMPK-SIRT1 and inhibition of p38 MAPK signaling.

📖 Top 30% JournalArticle

1 week ago • Neurochemical research

Aging-like changes in hypothalamus support cells from rats with chemically induced dementiaThe Senescent Phenotype of Cultured Hypothalamic Astrocytes from Rats with Streptozotocin-Induced Dementia.

📖 Top 20% JournalArticle

1 week ago • Acta neuropathologica

Molecular processes in the brain's arousal center connect APOE and pigment buildup to Alzheimer's riskMolecular programs in human locus coeruleus link APOE and neuromelanin to Alzheimer's vulnerability.

🥈 Top 2% JournalArticle

1 week ago • International journal of pharmaceutics: X

Using tiny immune-targeting particles to change joint inflammation and help repair cartilage in osteoarthritisNanoimmunomodulation for cartilage repair in osteoarthritis: reprogramming the inflammatory joint microenvironment.

📖 Top 20% JournalArticle

1 week ago • Cardiovascular toxicology

Cell Aging from Replication and Air Pollution: Telomere Damage, Mitochondrial Stress, and Protective Effects of Astragaloside IV in Blood Vessel CellsReplicative and Air Pollution-Induced Senescence: Telomere Dysfunction, Mitochondrial Stress, and Modulatory Effects of Astragaloside IV in Endothelial and Vascular Smooth Muscle Cells.

📖 Top 30% JournalResearch Support, Non-U.S. Gov't

1 week ago • International journal of molecular medicine

Rapamycin may slow aging of blood vessel cells by lowering miR-30a and affecting cell recycling protein Beclin1[Expression of Concern] Rapamycin‑induced miR‑30a downregulation inhibits senescence of VSMCs by targeting Beclin1.

Expression of Concern

1 week ago • Biochemical pharmacology

Ambrisentan may reduce heart cell death and energy problems caused by doxorubicin by affecting p53 and mTOR pathwaysAmbrisentan rescues doxorubicin-induced cardiac apoptosis and mitochondrial bioenergetic dysfunction: Mechanistic insights into p53 and mTOR signaling.

Article

1 week ago • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Rapamycin may increase brain blood flow and change metabolism, inflammation, and gut bacteria in healthy middle-aged people with APOE4EXPRESS: Rapamycin increases cerebral blood flow and modulates metabolic, inflammatory, and microbiome profiles in healthy middle-aged APOE4 carriers: a pilot single-arm trial.

🥉 Top 5% JournalArticle

1 week ago • The Journal of physiology

Mitochondria keep working despite stress and lower numbers after 10 days of bed rest in older adultsPreserved mitochondrial respiration in presence of oxidative stress and reduced mitochondrial mass after 10-day bed rest in older adults.

🎖️ Top 10% JournalArticle

1 week ago • Trends in pharmacological sciences

Proteins that remove tags controlling the cleanup of damaged mitochondria for therapyDeubiquitinases in mitophagy: therapeutic control of mitochondrial quality.

🥈 Top 2% JournalArticle

1 week ago • Nature reviews. Nephrology

How the kidney heals or worsens after sudden injuryMechanisms of regeneration and maladaptive repair in acute kidney injury.

🥇 Top 1% JournalArticle

1 week ago • Nature immunology

AMBRA1 activates NLRP3 by lifting its self-blocking mechanismAMBRA1 allosterically activates NLRP3 by releasing its autoinhibition.

🥇 Top 1% JournalArticle

1 week ago • Communications biology

How a harmful cell aging process and chronic inflammation may speed up aging and related diseasesThe vicious cycle of SASP and inflammaging promotes aging and age-related diseases.

🥉 Top 5% JournalArticle

1 week ago • International journal of general medicine

Changes in Bone Marrow Immune and Metabolic Function in Osteoporosis: From Overall Risk to Targeted TreatmentBone Marrow Immunometabolic Remodeling in Osteoporosis: From Systemic Risk Factors to Precision Intervention.

Article

1 week ago • Nature

TM184C is a receptor-like protein that controls cell communication and self-cleaning processesTM184C is a GPCR-like regulator of intercellular exchange and autophagy.

Article

1 week ago • GeroScience

High-intensity interval training may preserve body, brain, and heart health in older female miceHigh-intensity interval training in aged female mice preserves physical, cognitive, and cardiovascular function.

🎖️ Top 10% JournalArticle

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