Latest Longevity & Aging Research Papers | Page 5

1 week ago • American journal of obstetrics and gynecology

Faster biological aging linked to endometriosis and adenomyosis in the Norwegian Mother, Father and Child StudyDifferences in epigenetic age acceleration according to a diagnosis of endometriosis/adenomyosis: the Norwegian Mother, Father and Child Cohort Study

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1 week ago • Biogerontology

Lack of a key liver receptor speeds up aging and body decline in male miceFarnesoid X receptor deficiency accelerates aging and systemic functional decline in male mice

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1 week ago • Cell death discovery

How SOCS5 May Link DNA Damage and Cell Aging in Diabetic Eye DiseaseMechanistic insights into SOCS5-related DNA damage and cellular senescence in diabetic retinopathy

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1 week ago • Hepatology (Baltimore, Md.)

HSP72 helps PRDX6 remove tags from mitochondrial PINK1 to activate cell cleanup and improve MASLDHSP72 interacts with PRDX6 to deubiquitinate mitochondrial PINK1, activating mitophagy to treat MASLD

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1 week ago • EMBO molecular medicine

Tomatidine may improve thinking and reduce aging cells in old miceTomatidine is a senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice

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1 week ago • The Journal of clinical investigation

Understanding aging cell types in bone and bone marrowDeconstructing senescence phenotypes in cells of the bone and bone marrow

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1 week ago • The FEBS journal

A protein triggered by progesterone helps stabilize a key cell stress factor to increase mitochondrial recycling and sugar metabolismDecidual protein induced by progesterone enhances HIF ‐1α stability to promote mitophagy and glycolysis

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1 week ago • RSC chemical biology

Improving DNA Repair as a New Treatment Approach for Inflammation and Tissue ScarringFacilitated DNA damage repair as an emerging therapeutic strategy for inflammatory and fibrotic diseases

📖 Top 20% JournalFulltext (Open License)Article

1 week ago • CNS & neurological disorders drug targets

Brain Inflammation, Cell Cleanup, and Nerve Cell Damage: How They Work and Potential TreatmentsNeuroinflammation, Autophagy, and Neurodegeneration: Mechanisms and Therapeutic Insights

📖 Top 30% JournalArticle

1 week ago • Autophagy

Removal of harmful mitochondrial DNA passed from mother depends on cell cleanup and genetic bottleneck sizePurifying selection during maternal inheritance of mammalian mtDNA depends on autophagy and bottleneck size

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1 week ago • Frontiers in bioscience (Elite edition)

How Eating Too Much Fructose Links to Obesity and Diseases Affecting Multiple OrgansFructose Metabolism and Disease Mechanisms: From Nutritional Excess to Obesity and Multiorgan Pathophysiology

📖 Top 50% JournalArticle

1 week ago • ACS applied bio materials

Bamboo-Inspired Bone Repair Scaffold That Restores Damaged Bone and Supports Stem Cell GrowthBiomimetic Bamboo-Inspired Bone Repair Scaffold: Reversing Degraded States and Promoting Mesenchymal Stem Cell Differentiation

📖 Top 20% JournalArticle

1 week ago • Nature communications

Removal of cell nucleus parts is helped by two recycling receptors and blocked by DNA attachment to the nucleus lining in fission yeastNucleophagy is promoted by two autophagy receptors and inhibited by chromatin-nuclear envelope tethering in fission yeast

🥈 Top 2% JournalArticle

1 week ago • Nature communications

Homoharringtonine may reduce obesity and insulin resistance linked to diet and aging and help mice live longerHomoharringtonine exhibits senotherapeutic activity that mitigates diet- and age-associated obesity and insulin resistance and extends lifespan in mice

🥈 Top 2% JournalFulltext (Open License)Article

1 week ago • Trends in biochemical sciences

How the mTORC1 Pathway Detects Nutrients Through Molecular and Structural ProcessesMolecular and structural mechanisms of nutrient sensing in the mTORC1 pathway

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1 week ago • Nature communications

A harmful Tau mutation may cause problems in cell waste removal that reduce Tau breakdown in frontotemporal dementiaA pathogenic Tau mutation drives autophagy-lysosome dysfunction that limits Tau degradation in a model of frontotemporal dementia

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1 week ago • The Journal of neuroscience : the official journal of the Society for Neuroscience

How two cell-based mTOR systems control epilepsy-related brain problemsCell-intrinsic regulation of epilepsy-associated pathology by mTORC1 and mTORC2

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1 week ago • Biochemical pharmacology

Improving cell power supply cleanup by targeting small mitochondrial vesicles in Parkinson's diseaseRevitalizing mitochondrial quality control: targeting mitochondria-derived vesicles in Parkinson’s disease

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1 week ago • Nucleic acids research

Reversible RNA modification involving ADP-ribose added to uracil basesReversible RNA ADP-ribosylation on uracil bases

🥇 Top 1% JournalArticle

1 week ago • Nature communications

How a protein-modifying enzyme linked to ribosomes helps plants control protein balance and recyclingThe ribosome-associated N-terminal acetyltransferase B coordinates global proteostasis and autophagy in plants by creating Ac/N-degrons

🥈 Top 2% JournalFulltext (Open License)Article

1 week ago • Communications biology

Lisinopril may restore cell cleaning and change fat use by activating BI1 in ALSLisinopril activates BI1 to reprogram lipid metabolism and restore autophagy in ALS

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1 week ago • Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology

TRPM2's role in controlling bone-forming cell development through mitochondrial recycling in gum disease[Experimental study on the role of TRPM2 in regulating osteoblast differentiation through mitophagy in periodontitis].

English Abstract

1 week ago • International dental journal

Aging of the Mouth Lining: How It Happens and What It Leads ToAgeing of the Oral Mucosa: Mechanisms and Consequences

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1 week ago • Journal of molecular cell biology

How miR-183 and miR-96 control muscle stem cell development by directing NAD+ within cellsNAD+ subcellular partitioning mediated by miR-183 and miR-96 regulates muscle stem cell differentiation

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1 week ago • In vitro cellular & developmental biology. Animal

Ginsenoside F1 improves nonalcoholic fatty liver disease by activating energy regulation and cellular cleaning processesGinsenoside F1 ameliorates nonalcoholic fatty liver disease by activating the AMPK/PGC-1α pathway and autophagy

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1 week ago • Cell chemical biology

Build-up of fat molecules in the cell’s protein-making area may contribute to cell agingER-localized ceramide accumulation contributes to replicative senescence

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1 week ago • Journal of inflammation research

How Cell Recycling Controlled by TFEB May Affect Spinal Disc Degeneration and TreatmentThe Role of TFEB-Regulated Autophagy in Intervertebral Disc Degeneration and Its Therapeutic Potential

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1 week ago • Inflammation and regeneration

Timing and location of aging-related cell signals during bone healing: stages and treatment opportunitiesA spatiotemporal atlas of senescence-associated secretory phenotype in fracture healing: stage-dependent mechanisms and therapeutic windows

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1 week ago • NPJ Parkinson's disease

Problems with cell recycling in nerve cells and midbrain models made from stem cells with extra copies of the SNCA geneAutophagy dysfunction in iPSCs-derived neurons and midbrain organoids carrying a SNCA triplication

🥉 Top 5% JournalArticle

1 week ago • Poultry science

Combined gene and metabolite analysis reveals molecular changes in ovarian aging of laying hensIntegrated analysis of transcriptome and metabolomic uncover molecular mechanisms of ovarian aging in laying hens

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