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1 week ago • Molecular biology reports

Saikosaponin A may help heal diabetic wounds by reducing inflammatory cell death and adjusting cell cleanup processesSaikosaponin A promotes diabetic wound healing by suppressing NLRP3 inflammasome-associated macrophage pyroptosis and modulating mitophagy-related signaling.

📖 Top 30% JournalArticle

1 week ago • Autophagy

ATG9 and ATG2 as lipid regulators linking cell recycling and vesicle releaseATG9 and ATG2 as lipid managers at the crossroads of autophagy and extracellular vesicle secretion.

🥈 Top 2% JournalArticle

1 week ago • Autophagy

Mitochondrial membrane rupture allows prohibitin 2 to link bacteria and attract E3 ligase to trigger mitochondrial bacterial clearanceMitochondrial membrane rupture licenses prohibitin 2-mediated bacterial tethering and E3 ligase recruitment to drive mito-xenophagy.

🥈 Top 2% JournalArticle

1 week ago • EULAR rheumatology open

Signs of Aging in Systemic Sclerosis and Their Links to Disease Cause, Multiple Health Problems, and Treatment OptionsHallmarks of aging in systemic sclerosis: implications for pathogenesis, multimorbidity, and therapeutic development.

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1 week ago • Neural regeneration research

Rapamycin helps injured nerves recover by affecting the communication between the brain, body, and musclesTargeting the central-peripheral-effector muscle axis: Rapamycin promotes functional recovery in injured peripheral nerves.

📖 Top 20% JournalArticle

1 week ago • Journal of visualized experiments : JoVE

Links, Causes, and Health Impacts of Eating Ultra-Processed Foods in Inflammatory Bowel DiseaseEpidemiological Evidence, Underlying Mechanisms, and Public Health Implications of Ultra-Processed Food Consumption in Inflammatory Bowel Disease.

📖 Top 50% JournalVideo-Audio Media

1 week ago • Journal of Alzheimer's disease : JAD

Cell-free DNA changes in spinal fluid reflect disease biology in tau-related brain disordersCerebrospinal fluid cell-free DNA methylation captures disease-specific biology in tauopathies.

📖 Top 20% JournalArticle

1 week ago • Journal of Alzheimer's disease : JAD

A possible iron-related process in Alzheimer's disease: from iron imbalance and aging to iron-driven cell deathA putative iron-related evolving framework in Alzheimer's disease: From iron dyshomeostasis and ferro-aging to ferroptosis.

📖 Top 20% JournalArticle

1 week ago • Autophagy

How gene activity controls cell cleanup: processes, timing, and drug effectsTranscriptional control of autophagy: mechanisms, dynamics, and pharmacological modulation.

🥈 Top 2% JournalArticle

1 week ago • Free radical biology & medicine

Dioscin reduces liver damage from aniline by targeting a fat-processing pathway, lowering harmful molecules, and restoring cell energy and cleanup systemsDioscin attenuates aniline-induced liver injury by targeting the ACOT2-mediated ROS-JAK2/STAT3-CLN5 axis and restoring mitochondrial fatty acid oxidation and lysosomal lipophagy.

🥉 Top 5% JournalArticle

1 week ago • Human mutation

Potential Biomarkers Linked to Mitochondrial Cleanup in AtherosclerosisCCR5, CD163, CSF1R, and FCGR3A as Candidate Biomarkers Associated With Mitophagy in Atherosclerosis.

🎖️ Top 10% JournalArticle

1 week ago • Aging cell

Partial Cell Reprogramming with Yamanaka Factors May Reduce Stroke Damage in Older MiceIn Vivo Partial Cell Reprogramming With Yamanaka Factors Reduced Ischemic Brain Damage in Aging Mice.

🥉 Top 5% JournalArticle

1 week ago • Molecular medicine reports

How Aging and Obesity Affect the Male Reproductive System and Ways to Manage ThemMechanisms of the interaction between aging of the male reproductive system and obesity, and clinical management strategies (Review).

📖 Top 30% JournalArticle

1 week ago • MedComm

Blocking Leptin Reduces Age-Related Inflammation in Blood Vessel and Immune CellsLeptin Neutralization Attenuates Inflammaging in Endothelial and Immune Cell Models.

🥉 Top 5% JournalArticle

1 week ago • Cardiovascular research

MAPK15 may cause heart cell aging and irregular heartbeat by increasing calcium overload in mitochondria through modifying Mcub proteinMAPK15 induces cardiomyocyte senescence and atrial fibrillation by promoting mitochondrial calcium overload via palmitoylating Mcub at the C91 residue.

Article

1 week ago • Seminars in nephrology

Intestinal Phosphate Absorption and Phosphate Metabolism in Chronic Kidney Disease: Direct and Indirect Toxicity of Phosphate Additives in Ultra-processed Diets.Intestinal Phosphate Absorption and Phosphate Metabolism in Chronic Kidney Disease: Direct and Indirect Toxicity of Phosphate Additives in Ultra-processed Diets.

📖 Top 20% JournalArticle

1 week ago • Archives of gerontology and geriatrics

Links between infections and differences in organ aging in UK Biobank participantsAssociations between infection and organ age gaps: results from the UK Biobank.

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1 week ago • European journal of clinical investigation

Mitochondrial DNA Levels and Related Genes in Sudden and Stable Heart Artery DiseaseMitochondrial DNA Copy Number and Mitochondrial Homeostasis Genes in Acute and Stable Coronary Artery Disease.

📖 Top 20% JournalObservational Study

1 week ago • Experimental gerontology

Matching changes in biological aging measures with health outcomes in aging treatment studies: A systematic reviewConcordance between changes in epigenetic clocks and changes in clinical outcomes in geroscience intervention trials: A systematic review.

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1 week ago • International journal of molecular medicine

How ferritin breakdown affects tissue scarring and its potential for treatmentMechanisms and therapeutic implications of ferritinophagy in fibrotic diseases (Review).

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1 week ago • Autophagy

Understanding Cell Death That Depends on the Body’s Recycling Process: Key Ideas, Signs, and How It HappensA Guide to autophagy-dependent cell death: concepts, criteria, and mechanisms.

🥈 Top 2% JournalArticle

1 week ago • Experimental eye research

How Cellular Recycling Affects Eye Health and Disease, and Possible TreatmentsAutophagy in ocular health and disease: From mechanistic insights to therapeutic perspectives.

📖 Top 20% JournalArticle

1 week ago • Journal of Alzheimer's disease : JAD

How immune cell waste processing problems may cause brain inflammation in Alzheimer's and potential treatment targetsPathogenesis and therapeutic targets of neuroinflammation in Alzheimer's disease mediated by microglia lysosomal dysfunction.

📖 Top 20% JournalArticle

1 week ago • Archives of toxicology

How HDAC6 activity weakens cell cleanup by disrupting microtubule stability and fusion in PBDE-47 brain toxicityHistone deacetylase 6 (HDAC6)-mediated α-tubulin (K40) deacetylation and microtubule destabilization disrupt autophagosome-lysosome fusion in PBDE-47-induced neurotoxicity.

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1 week ago • Cell death and differentiation

Fhl2 increases cartilage cell death in osteoarthritis by disrupting mitochondrial cleanup through microtubule disorganizationFhl2 promotes chondrocyte ferroptosis in osteoarthritis by impairing mitophagic flux through microtubule disorganization.

🥇 Top 1% JournalArticle

1 week ago • Molecular neurobiology

β-Asarone reduces brain inflammation after stroke and improves mitochondrial health through a specific cellular cleanup processβ-Asarone Alleviates Post-stroke Neuroinflammation and Improves Mitochondrial Quality Via the BNIP3/BNIP3L-dependent Mitophagy Pathway.

🎖️ Top 10% JournalArticle

1 week ago • Nature aging

Key gene activity patterns linked to aging in blood vessel lining cells revealed by single-cell analysisUncovering the transcriptional hallmarks of endothelial cell aging via integrated single-cell analysis.

🥇 Top 1% JournalArticle

1 week ago • EMBO reports

Lck controls T cell activation by modifying p62Lck regulates T cell activation through phosphorylation of p62.

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1 week ago • Biochemical pharmacology

Mots-c reduces diabetic kidney damage by lowering LARS1 to boost fat recycling and prevent kidney tubule agingMots-c attenuates diabetic nephropathy by downregulating LARS1 to promote lipophagy and suppress tubular senescence.

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1 week ago • Experimental neurology

NEFL helps DJ-1 protect nerve cells and regulate cell cleanup in Alzheimer's-like damageNEFL contributes to DJ-1-mediated neuroprotection and autophagic flux regulation in Alzheimer's disease-like injury.

🎖️ Top 10% JournalArticle

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