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1 week ago • European journal of pharmacology

Cycloastragenol may lengthen lifespan and boost stress resistance in worms by reducing insulin signaling and activating immune defense through p38 MAPKCycloastragenol extends lifespan and enhances stress resistance in Caenorhabditis elegans by inhibiting IIS pathway and activating p38 MAPK-mediated innate immunity.

📖 Top 20% JournalArticle

1 week ago • Journal of molecular histology

Cell-level sirtuin signaling networks as key controllers of heart function and repairSubcellular sirtuin signaling networks: pivotal regulators of cardiovascular homeostasis and remodeling.

📖 Top 30% JournalArticle

1 week ago • Journal of clinical anesthesia

Surgery and its link to biological aging in a UK population studySurgical exposure and biological aging: A population-based study from the UK Biobank.

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1 week ago • Journal of photochemistry and photobiology. B, Biology

Pomegranate peel extract in bilophytosome form protects skin from UVB aging by reducing inflammation, cell damage, aging signs, and tissue breakdownPomegranate peel extract bilophytosome protects against UVB- induced skin photoaging through pleiotropic modulation of inflammation, mitophagy, senescence, and metalloproteinases.

📖 Top 30% JournalArticle

1 week ago • Experimental gerontology

Aging immune decline, chronic inflammation, and metabolism-related diseases: Understanding their connections from an aging biology viewImmunosenescence, inflammaging, and metabolic disease: A geroscience perspective on mechanisms and links.

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1 week ago • Biology of reproduction

Problems in Galectin-1 Signaling May Disrupt Tissue Aging and Preparation for Pregnancy in Repeated Implantation FailureGalectin-1 Signaling Dysregulation Impairs Stromal Senescence and Decidualization in Recurrent Implantation Failure.

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1 week ago • Mechanisms of ageing and development

How Fasting May Influence Aging by Changing Gene Control to Support Healthy LifespanFasting and aging: Mechanistic insights into epigenomic and transcriptional regulation of healthspan.

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1 week ago • Renal failure

Mitochondrial vesicles as new messengers between the heart and kidneys in cardiorenal syndromeMitochondrial extracellular vesicles in cardiorenal syndrome: emerging mediators of mitochondrial signaling and inter-organ crosstalk.

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1 week ago • GeroScience

A type of HDL with high apolipoprotein(a) speeds up blood vessel aging and artery disease by causing blood vessel lining cells to ageApolipoprotein(a)-rich electronegative HDL accelerates vascular aging and atherosclerosis by inducing endothelial senescence.

🎖️ Top 10% JournalArticle

1 week ago • Pathology, research and practice

Targeting the Sigma-1 Receptor to Improve Treatment for Blood Flow Loss in TissuesSigma-1 receptor (S1R): Advancing therapeutic strategies in targeting ischemia.

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1 week ago • Cardiovascular drugs and therapy

Changes in Sugar Metabolism in Immune and Blood Vessel Cells Linked to AtherosclerosisVascular Immunometabolism in Atherosclerosis: Emerging Roles of Glycometabolic Reprogramming in Immune and Vascular Cells.

Systematic Review

1 week ago • GeroScience

Markers of Aging and DNA Changes in Women Receiving Chemotherapy for Early Breast Cancerp16INK4a and DNA methylation clocks in women treated with chemotherapy for early breast cancer.

🎖️ Top 10% JournalArticle

1 week ago • Annals of human genetics

Genetic Links Between White Blood Cell Telomere Length, Faster Biological Aging, and HealthspanGenetically Proxied Leukocyte Telomere Length and Epigenetic Age Acceleration in Relation to Healthspan: A Mendelian Randomization Study.

📖 Top 50% JournalArticle

1 week ago • Cell metabolism

Blocking PD-L2 may reduce buildup of aging cells and related declineBlocking PD-L2 prevents senescent cell accumulation and age-related dysfunction.

🥇 Top 1% JournalArticle

1 week ago • JCI insight

Muscle growth and endurance after eating are controlled by feeding-activated mTORC1 signaling, but muscle size is not affectedFeeding-induced muscle mTORC1 signaling regulates postprandial protein synthesis and endurance but not muscle size.

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1 week ago • Biogerontology

How Mitochondria Balance Their Activity in Ageing: Processes, Strength, and TreatmentsMitochondrial homeodynamics in ageing: mechanisms, resilience, and interventions.

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1 week ago • GeroScience

Copper and iron support cell survival through different metabolic processesCopper and iron engage distinct metabolic programs for cellular survival.

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1 week ago • International immunopharmacology

Stopping a specific cell signaling process prevents immune cell aging and improves bacteria-killing during sepsis-related immune weaknessTargeting the AKT2-NAMPT phosphorylation axis prevents macrophage senescence to enhance bactericidal activity in septic immunosuppression.

Article

1 week ago • Aging

How organisms with exceptionally long lifespans share common traitsHow to live for centuries: common denominators of organisms with exceptional longevity.

📖 Top 20% JournalArticle

1 week ago • Cell death and differentiation

Immune cell receptors CXCR3 and CXCR5 influence nerve cell self-cleaning processCanonical lymphocyte chemokine receptors CXCR3 and CXCR5 modulate neuronal autophagy.

🥇 Top 1% JournalArticle

1 week ago • Scientific reports

Combined analysis of genes and molecules shows disrupted fats and metabolism and timing changes during disease progressionIntegrative multi-omics analysis reveals lipid/metabolite dysregulation and temporal decoupling in disease progression.

📖 Top 20% JournalArticle

1 week ago • Diabetes, metabolic syndrome and obesity : targets and therapy

Yiqi Huoxue Yangyin Decoction may improve diabetic kidney disease by regulating cell recycling through the AMPK/mTOR pathwayYiqi Huoxue Yangyin Decoction Ameliorates Diabetic Nephropathy by Targeting AMPK/mTOR-Mediated Autophagy: A Network Pharmacology-Guided in vivo and in vitro Study.

📖 Top 30% JournalArticle

1 week ago • Experimental gerontology

Changes in Biological Aging and DNA Methylation Patterns in Anderson-Fabry DiseaseEpigenetic aging and autosomal methylation remodeling in Anderson-Fabry disease.

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1 week ago • FASEB journal : official publication of the Federation of American Societies for Experimental Biology

SIRT1's Role, Importance, and Treatment Potential in Brain Degenerative DiseasesSIRT1 in Neurodegenerative Diseases: Molecular Mechanisms, Disease Relevance, and Therapeutic Potential.

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1 week ago • Developmental cell

Senescent cells may leave behind cellular wasteSenescent cells: Leaving cellular waste behind.

🥇 Top 1% JournalComment

1 week ago • Journal of the American Heart Association

Gut Bacteria and Aldosterone Influence Heart Stress Signals to Trigger Cell Cleanup and Energy Changes in a Sepsis-Like Heart Injury ModelGut Microbiota and Aldosterone Regulate Natriuretic Peptide B Expression to Drive Mitophagy and Metabolic Reprogramming in Sepsis-Like Model of Myocardial Injury.

🥉 Top 5% JournalArticle

1 week ago • Cureus

Frailty in Heart and Kidney Care: Older Adults and the 2026 European Heart GuidelinesFrailty in Cardiorenal Care: A Geriatric Perspective on the 2026 European Society of Cardiology Guidelines.

Editorial

1 week ago • The Journal of investigative dermatology

IgG Build-up with Aging May Increase Skin InflammationAging-related IgG accumulation promotes skin inflammation.

🎖️ Top 10% JournalArticle

1 week ago • Journal of the Formosan Medical Association = Taiwan yi zhi

Long-term seizure results and factors linked to response to added everolimus in epilepsy caused by tuberous sclerosis complexLong-term seizure outcomes and factors associated with response to adjunctive everolimus in TSC-associated epilepsy.

📖 Top 30% JournalArticle

1 week ago • MedComm

Combined Analysis Shows That Aβ42-Me3 Clumps Block Mitochondrial Cleanup in Early Alzheimer's DiseaseMulti-Omics Analysis Reveals That Aβ42- Me3 Co-Aggregation Induces Mitophagy Blockade in Early Stages of Alzheimer's Disease.

🥉 Top 5% JournalArticle

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