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1 week ago • Kidney & blood pressure research

Changes in Blood Vessel Lining Cells in Chronic Kidney Disease: Causes and Possible TreatmentsEndothelial-to-Mesenchymal Transition in Chronic Kidney Disease: Mechanisms and Therapeutic Targets.

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1 week ago • iScience

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1 week ago • Ageing research reviews

Is amyloid beta peptide a cause of age-related chronic inflammation?Is amyloid beta peptide a driver of inflammaging?

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1 week ago • Cardiovascular drugs and therapy

Cell Aging in Diabetes-Related Heart Disease: How It Happens and Possible TreatmentsCellular Senescence in Diabetic Cardiomyopathy: Mechanistic Insights and Therapeutic Perspectives.

Article

1 week ago • iScience

Chromatin pieces with TRF2 in the cell fluid trigger cGAS-STAT1 inflammation during cell agingTRF2 enriched cytoplasmic chromatin drives cGAS-STAT1-mediated inflammation in senescence.

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1 week ago • PeerJ

Understanding biological aging using metabolism markersDecoding aging clocks from a metabolomic perspective.

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1 week ago • Journal of immunoassay & immunochemistry

Understanding the interaction between key cell growth and energy pathways and their role in metabolism and treatment of human diseasesDecoding the PI3K/Akt/mTOR-AMPK signalling nexus: molecular crosstalk, metabolic reprogramming and therapeutic targeting in human disease.

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1 week ago • Immunogenetics

Genetic links between aging immune cells and immune system declineGenetic association of immunosenescence to immune decline.

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1 week ago • Signal transduction and targeted therapy

How cells keep mitochondria healthy and possible treatments for related diseasesMitochondrial quality control in health and disease: mechanisms and therapeutic targets.

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1 week ago • European heart journal

Activation of the AMPK/USP10 cycle increases ACE2 and its possible link to lung high blood pressureAMPK/USP10 loop activation of ACE2: implications for pulmonary hypertension.

🥇 Top 1% JournalArticle

1 week ago • The Journal of biological chemistry

Sugar-Modified CD147 Triggers Cell Cleanup to Reduce Fibroblast Activation and TransformationAutophagy Induced by Glycosylated CD147 Attenuates Fibroblast Activation and Myofibroblast Differentiation.

🎖️ Top 10% JournalArticle

1 week ago • Journal of assisted reproduction and genetics

MAFF may cause aging in womb lining cells by reducing antioxidant defenses in repeated pregnancy lossMAFF promotes decidual stromal cell senescence by suppressing NRF2-mediated antioxidant responses in recurrent pregnancy loss.

📖 Top 20% JournalArticle

1 week ago • Experimental gerontology

Muscle Signals Connecting Muscle Loss to Thinking Decline and Possible Prevention in AgeingMyokines as molecular mediators of the muscle-brain axis: Mechanisms linking sarcopenia to cognitive decline and implications for preventive strategies in ageing - A narrative review.

Article

1 week ago • Fitoterapia

Comparing five Indian spices for lifespan extension and anti-aging effects using chemical analysis and biological tests in yeastChronological lifespan extension evaluation-driven comparative study of five Indian dietary spices for geroprotective action via phytochemical profiling, bioactivity screening and network pharmacology in Saccharomyces cerevisiae.

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1 week ago • Neurology international

New Treatment Approaches and Challenges for Major Brain Iron Accumulation DisordersTherapeutic Advances in Major NBIA Disorders: Current Strategies and Translational Challenges.

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1 week ago • Journal of cardiovascular development and disease

Blood Vessel Lining Mitochondria Problems in INOCA and Small Heart Vessel Dysfunction: Causes, Differences Between Men and Women, and Treatment PossibilitiesEndothelial Mitochondrial Dysfunction in INOCA and Coronary Microvascular Dysfunction: Mechanisms, Sex Differences, and Therapeutic Implications.

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1 week ago • Membranes

How Disordered Proteins Help Clear Cell Waste Without Membranes and Inside Membrane CompartmentsA New Anatomy of Autophagic Clearance: On the Roles of Intrinsic Disorder in the Membrane-Less on Membrane-Encapsulated Mechanism.

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1 week ago • Metabolites

Precise Measurement of Aging: Basics and UsesPrecision Gerontometry: Introduction, Fundamentals and Areas of Application.

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1 week ago • iMeta

Hyperoside may reduce aging of uterine lining cells in unexplained recurrent miscarriage by helping resolve DNA-RNA structures through DHX9Hyperoside alleviates endometrial stromal cell senescence in unexplained recurrent spontaneous abortion via DHX9-mediated R-loop resolution.

🥇 Top 1% JournalArticle

1 week ago • Journal of cell science

Vimentin filaments help form cell cleaning structures at contact points between energy and recycling systems during starvationVimentin intermediate filaments support autophagosome biogenesis at ER-endosome contact sites in response to starvation.

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1 week ago • Diseases (Basel, Switzerland)

Gut Microbes as a Possible Cause of DiseaseThe Microbiota as a Potential Cause of Disease.

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1 week ago • eLife

Cell imaging shows type I and type II kinase inhibitors differently affect LRRK2 filament formation and their binding to cell movement structuresIn-cell cryo-electron tomography reveals differential effects of type I and type II kinase inhibitors on LRRK2 filament formation and microtubule association.

🥈 Top 2% JournalArticle

1 week ago • Journal of inflammation research

SIRT1’s role in rheumatic diseases and its connection to traditional Chinese medicineSIRT1 as a Key Regulator in Rheumatic Diseases: Integrating Molecular Insights with Traditional Chinese Medicine Approaches.

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1 week ago • Redox biology

The complex role of energy-producing cell molecules in controlling aging and its signsThe nuanced role of mitochondrial ROS in modulating aging and aging hallmarks.

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1 week ago • Molecular biology reports

How Piper retrofractum may protect blood vessel energy systems and mitochondria in high blood pressure and oxidative damageMolecular biology of vascular bioenergetics rewiring: Mitochondrial protective mechanisms of Piper retrofractum in hypertension and oxidative injury.

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1 week ago • Journal of studies on alcohol and drugs

High-Intensity Interval Training May Reduce Heart Cell Stress and Repair Problems in Healthy Rats After Taking Methylphenidate and AlcoholHigh-Intensity Interval Training Ameliorates Oxidative Stress and Mitophagy in Heart Tissue of Healthy Rats Following the Combination Use of Methylphenidate and Ethanol.

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1 week ago • Biochimica et biophysica acta. Gene regulatory mechanisms

NMN may reduce hair loss damage by activating a protective protein and boosting glutamine useNMN alleviates oxidative stress damage in alopecia areata by activating SIRT7 and promoting glutamine metabolism.

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1 week ago • Progress in neuro-psychopharmacology & biological psychiatry

Targeting specific HSP90 protein types as a precise treatment approach for brain and metabolic diseasesIsoform-selective HSP90 inhibition as a precision therapeutic strategy for neurodegenerative and metabolic diseases.

Article

1 week ago • Protein & cell

Gene editing screen finds GNPTAB activates a cell defense pathway that causes cell agingCRISPR screening identifies GNPTAB as a noncanonical STING activator driving cellular senescence.

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1 week ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Movement of Bacteroides Uniformis from Gut to Liver May Reduce Severe Fatty Liver Disease by Stopping Liver Cell Damage Through Propionic AcidGut-Liver Translocation of Bacteroides Uniformis Alleviates Advanced Metabolic Dysfunction-Associated Steatotic Liver Disease by Suppressing Hepatocyte Ferroptosis via Propionic Acid Secretion.

🥈 Top 2% JournalArticle

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