Latest Longevity & Aging Research Papers | Page 6 | OpenScience.ink

1 week ago • Autophagy

Timing and location of Atg9 vesicle fusion during autophagosome formationSpatiotemporal control of Atg9 vesicle fusion in autophagosome formation.

🥈 Top 2% JournalArticle

1 week ago • International journal of radiation biology

Resveratrol reduces radiation damage and oxidative stress in rats, possibly through activating the body's antioxidant defense systemResveratrol mitigates radiation-induced oxidative stress and tissue injury in rats: potential involvement of the Nrf2-ARE antioxidant pathway.

Article

1 week ago • Journal of visualized experiments : JoVE

Qi-fu-yin's effects on memory problems and brain cell aging in a mouse model of Alzheimer'sEffects of Qi-fu-yin on Improving Cognitive Impairment and Reducing Cellular Senescence in the Brains of 5xFAD Mice.

📖 Top 50% JournalVideo-Audio Media

1 week ago • iScience

Early high-fat diet changes adult metabolism in fruit fliesEarly life high-fat diet exposure modulates adult metabolic phenotypes in Drosophila.

🎖️ Top 10% JournalArticle

1 week ago • Journal of the American Heart Association

Faster Aging in Fontan Patients Linked to Right-Sided Heart Pumps and Poor Blood FlowAccelerated Aging Fontan Phenotype Is Associated With Systemic Right Ventricles and Adverse Hemodynamics.

🥉 Top 5% JournalArticle

1 week ago • Molecular neurobiology

Muscarinic M1 and Histamine H1 Receptor Signals Working Together Through the PI3K/Akt/mTOR Pathway in Brain Inflammation and Myelin Repair in Multiple SclerosisGPCR-Driven Muscarinic M1 and Histamine H1 Receptor Signaling Converging on the PI3K/Akt/mTOR Pathway: Functional Integration in Neuroinflammation and Myelin Repair in Multiple Sclerosis.

🎖️ Top 10% JournalArticle

1 week ago • Cell

Calorie restriction changes overall mutation levels in mouse body cellsCaloric restriction modulates genome-wide somatic mutation in mice.

🏆 Top 0.1% JournalArticle

1 week ago • Science advances

Androgen receptor helps muscle stem cells stay active and maintain their supply for life-long repairAndrogen receptor imprints satellite cell stemness and preserves their reservoir for lifelong regeneration and optimal repair.

🥈 Top 2% JournalArticle

1 week ago • Signal transduction and targeted therapy

Disulfidptosis: how it works at the molecular level and possible treatment targetsDisulfidptosis: molecular mechanisms and therapeutic targets.

🥇 Top 1% JournalResearch Support, Non-U.S. Gov't

1 week ago • PLoS genetics

A protein complex in fission yeast helps lengthen chromosome ends and prevent their rearrangementFission yeast RPA-TERT-Tpz1TPP1 complex promotes telomere extension and suppresses telomere recombination.

🥉 Top 5% JournalArticle

1 week ago • HemaSphere

Mitochondrial DNA mutations linked to weaker energy production and better imatinib response in chronic myeloid leukemiaMitochondrial DNA mutations are associated with impaired oxidative phosphorylation and enhanced imatinib response in chronic myeloid leukemia.

🎖️ Top 10% JournalArticle

1 week ago • Ageing research reviews

Cellular Aging as a Breakdown in Hormone SignalingCellular senescence as endocrine information failure in aging.

🥈 Top 2% JournalArticle

1 week ago • Autophagy

Increasing amino acid levels inside cells reduces problems in cells lacking autophagyAugmenting intracellular amino acid pools suppresses the phenotypes of autophagy-deficient cells.

🥈 Top 2% JournalArticle

1 week ago • Reproduction & fertility

Mouse egg cell types show different blastocyst responses to resveratrol and vitamin B12Mouse oocyte phenotypes differ in blastocyst response to resveratrol and vitamin B12.

📖 Top 20% JournalArticle

1 week ago • JCI insight

SMURF2 reduces the cell’s ability to clear tuberculosis bacteria in immune cellsSMURF2 inhibits autophagic control of Mycobacterium tuberculosis in macrophages.

🥉 Top 5% JournalArticle

1 week ago • International journal of biological macromolecules

A plant sugar from Anemarrhena asphodeloides may extend lifespan in worms through a key longevity proteinA homogalacturonan polysaccharide from Anemarrhena asphodeloides promotes longevity in Caenorhabditis elegans with involvement of DAF-16/FOXO.

📖 Top 20% JournalArticle

1 week ago • Pharmacological research

Possible Anti-Aging Benefits of Diabetes Medicines Linking Type 2 Diabetes and Faster AgingSenotherapeutic Potential of Anti-Diabetic Medications: Bridging Type 2 Diabetes and Accelerated Aging.

🥉 Top 5% JournalArticle

1 week ago • Cell chemical biology

Studying key histone-modifying enzymes using peptide toolsInvestigation of the classical histone deacetylases and sirtuins using peptide technologies.

🥉 Top 5% JournalArticle

1 week ago • Molecular and cellular biochemistry

Nanoplastics may disrupt cell skeleton and transport, linked to cell aging and declineNanoplastics as disruptors of microtubule dynamics and intracellular trafficking: implications for cellular senescence and ageing.

Article

1 week ago • PloS one

Using artificial intelligence to find and understand combined anti-aging compounds in Dengzhan Shengmai formulaArtificial intelligence-driven identification and mechanistic exploration of synergistic anti-aging compounds from Dengzhan Shengmai formulation.

📖 Top 30% JournalArticle

1 week ago • Biochimie

Selenium's Role in Aging and LifespanSelenium in Aging and Longevity.

Article

1 week ago • GeroScience

LAPTM5 is linked to retinal cell aging and scarring through a mitochondrial cleanup process and immune activation in an aging modelLAPTM5 correlates with RPE senescence and subretinal fibrosis through the LAPTM5-WWP2-OPTN mitophagy cascade and cGAS/STING activation in a D-galactose-induced aging model.

🎖️ Top 10% JournalArticle

1 week ago • American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

NLRP3-driven liver immune cell death worsens injury after transplant from older donors through a CD38-NAD+-Sirt1 pathway affecting ERRα functionNLRP3 Mediated Kupffer Cell Pyroptosis Aggravated Ischemia-reperfusion Injury After Aging Donor Liver Transplantation Through CD38-NAD+-Sirt1 Dependent Acetylation of ERRα.

🥉 Top 5% JournalArticle

1 week ago • Translational psychiatry

Health Habits and Cell Aging in Severe Mental IllnessHealth behaviours and telomere biology in severe mental disorders.

🥉 Top 5% JournalArticle

1 week ago • Nature reviews. Drug discovery

New treatments to build muscle and support healthy agingStrengthening muscle for healthy ageing: innovative treatments for sarcopenia.

Article

1 week ago • Nature biotechnology

Using protein-based aging measures in a phase 2a clinical trial to support testing of anti-aging treatmentsIntegration of proteomic aging clocks in a phase 2a clinical trial supports simultaneous geroprotective assessment.

🏆 Top 0.1% JournalArticle

1 week ago • Clinical science (London, England : 1979)

Activating Beclin1 by Genes or Drugs May Prevent Heart and Blood Vessel Damage Caused by AldosteroneGENETIC AND PHARMACOLOGIC ACTIVATION OF BECLIN1 PREVENTSALDOSTERONE-INDUCED CARDIOVASCULAR DAMAGE.

Article

1 week ago • Aging cell

How Changes in Telomere DNA Packaging Influence Telomere MaintenanceTwisting the End Game: How Telomere Chromatin Modifications Shape Telomere Maintenance.

🥉 Top 5% JournalArticle

1 week ago • Journal of molecular histology

Thymoquinone and intermittent fasting may protect rat memory areas from aluminum-induced Alzheimer's-like damage by affecting brain cell growth and cleanupThe neuroprotective potential of thymoquinone and intermittent fasting on aluminum chloride-induced Alzheimer's disease like model in rat hippocampus: insights into neurogenesis and autophagy.

📖 Top 30% JournalArticle

1 week ago • Aging cell

Blocking Growth Hormone Receptors May Extend LifespanGrowth Hormone Receptor Antagonism Extends Lifespan.

🥉 Top 5% JournalArticle

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