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1 week ago • Aging and disease

Using Worms and Mice to Find and Rank Treatments for Age-Related Muscle LossA C. elegans-to-Mouse Discovery Framework for Prioritizing Sarcopenia Interventions.

🥉 Top 5% JournalArticle

1 week ago • Molecular biology reports

Royal jelly reduces aging-related harmful secretions in old human skin cellsRoyal jelly suppresses senescence-associated secretory phenotype in senescent human epidermal keratinocytes.

📖 Top 30% JournalArticle

1 week ago • Autophagy

How cell cleanup and nitric oxide change immune metabolism: a possible new approach for asthma treatmentAutophagy-nitric oxide reprogramming of immune metabolism: a potential avenue for asthma therapeutic advancement.

🥈 Top 2% JournalArticle

1 week ago • FASEB journal : official publication of the Federation of American Societies for Experimental Biology

The Protein POC5 Controls Fat Cell Development and Aging in a Rare Metabolic DisorderCentriolar Protein POC5 Regulates Human Adipogenesis and Cellular Senescence: Insights From a Novel Metabolic Ciliopathy.

Article

1 week ago • Aging

A short overview of the theory that overactive processes cause aging and ideas for future researchA brief history of the hyperfunction theory of aging and future directions.

📖 Top 20% JournalHistorical Article

1 week ago • Cureus

Genes Involved in Cell Recycling May Be Linked to Obsessive-Compulsive Disorder Through Energy-Related Cell MaintenanceAutophagy-Related Gene-Set Signals in the Genetic Architecture of Obsessive-Compulsive Disorder: A Hypothesis-Generating Link to Nicotinamide Adenine Dinucleotide-Associated Cellular Maintenance Biology.

1 week ago • Cell cycle (Georgetown, Tex.)

Gene and data analysis finds fat metabolism and protein tagging patterns and suggests ATG5, ASB4, LDLR, and CD36 as possible markers for insulin resistanceIntegrated multi-level transcriptomic and bioinformatics analysis identifies lipid metabolism-ubiquitination signatures and reveals ATG5, ASB4, LDLR, and CD36 as Candidate biomarkers in insulin resistance.

📖 Top 20% Journal

1 week ago • Aging cell

How AcSirt2 and FOXO Control Mitochondrial Cleanup to Help Slow Aging in Asian Honey BeesUnveiling the AcSirt2-FOXO-Mitophagy Axis: Insights Into Mitochondrial Quality Control and Delayed Aging in Apis cerana.

🥉 Top 5% Journal

1 week ago • Neurotoxicology

How Perfluorooctanoic Acid May Cause Brain Cell Loss and Thinking Problems by Disrupting Cell Energy Management and Blood-Brain Barrier FunctionMechanisms Underlying Perfluorooctanoic Acid-Induced Neuronal Loss and Cognitive Deficits: Disruption of Mitochondrial Dynamics, Impaired Mitophagy, and Blood-Brain Barrier Dysfunction.

📖 Top 20% Journal

1 week ago • Food science & nutrition

Health Benefits and How Urolithin A Works: From Gut Bacteria Product to Medical UsesHealth Benefits and Molecular Mechanisms of Urolithin A: From a Gut Microbiota-Derived Metabolite to Translational Applications.

📖 Top 20% Journal

1 week ago • Phytomedicine : international journal of phytotherapy and phytopharmacology

How complex sugars change cell energy systems and relate to chemotherapy resistance in digestive system cancersPolysaccharides-mediated mitochondrial remodeling: role in chemotherapy resistance of gastrointestinal tumors.

🎖️ Top 10% Journal

1 week ago • Journal of advanced research

Using a special chemical method to attach tightly packed DNA to the cell's outer nucleus layer reverses aging and joint diseaseBioorthogonal epigenetic anchoring of heterochromatin to the nuclear lamina reverses senescence and osteoarthritis.

🥉 Top 5% Journal

1 week ago • Advanced materials (Deerfield Beach, Fla.)

Biomimetic Skin Inspired by Turritopsis nutricula May Help Heal Aged Wounds by Changing Mitochondrial Metabolism Through DAZAP1 Phase SeparationTurritopsis nutricula-Inspired Engineered Biomimetic Skin Promoting Aged Wound Repair via DAZAP1 Phase Separation-Related Mitochondrial Metabolism Reprogramming.

🥇 Top 1% Journal

1 week ago • Bioorganic & medicinal chemistry letters

Creation and early testing of resveratrol-like compounds that may affect cell aging proteins and reduce inflammationSynthesis and preliminary biological evaluation of resveratrol-like carbostyril derivatives as sirtuin 1 modulators and cyclooxygenase inhibitors.

📖 Top 50% Journal

1 week ago • Pediatric research

Changing role of energy-making cell problems and their cleanup in severe intestinal tissue damageEvolving role of mitochondrial dysfunction and mitophagy in necrotizing enterocolitis.

📖 Top 20% Journal

1 week ago • Ecotoxicology and environmental safety

Cadmium may cause kidney damage through a daily rhythm-related inflammation and aging process that can be reduced by goji berry extract and melatoninCadmium induces renal injury via a BMAL1-dependent inflammatory and senescence cascade: Attenuation by Lycium barbarum polysaccharide and melatonin.

🎖️ Top 10% Journal

1 week ago • Ageing research reviews

Targeting a Key Immune Trigger in Alzheimer's Disease: Understanding How It Works and New Treatment ApproachesTargeting the NLRP3 inflammasome in Alzheimer's disease: Mechanistic insights and therapeutic advances.

🥈 Top 2% Journal

1 week ago • Journal of Huntington's disease

Early treatment with 4',5,7-trihydroxyisoflavone may prevent severe Huntington's disease symptoms in a mouse modelPrevention of appearance of severe Huntington's disease symptoms in the R6/1 mouse model by early administration of 4',5,7-trihydroxyisoflavone.

🎖️ Top 10% Journal

1 week ago • Journal of dental research

A Dual-Function Barrier Membrane May Improve Bone Healing in Older AdultsA Bioactive Janus Barrier Membrane Rejuvenates Bone Regeneration in Aging.

1 week ago • Nature aging

Long-term low valine intake improves health and lifespan differently in male and female miceLifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice.

🥇 Top 1% Journal

1 week ago • Autoimmunity reviews

Aging of the immune system in lupus: causes, health effects, and treatment possibilitiesImmunosenescence in systemic lupus erythematosus: Mechanisms, clinical consequences, and therapeutic implications.

🥉 Top 5% Journal

1 week ago • GeroScience

Blood factors from time-restricted eating may change metabolism in blood vessel lining cellsCirculating factors induced by time-restricted eating drive metabolic reprogramming in endothelial cells.

🎖️ Top 10% Journal

1 week ago • npj aging

🥉 Top 5% Journal

1 week ago • Brain research bulletin

Reducing DYNC1I1 lessens nerve cell loss and harmful protein buildup in Parkinson's disease modelsTargeting DYNC1I1 attenuates Parkinsonian neurodegeneration and α-synuclein accumulation in cellular and mouse models.

📖 Top 20% Journal

1 week ago • Neurotoxicology

Aluminum and Alzheimer's Disease: A Review of Current Evidence and DebatesAluminum and Alzheimer's disease in the 21st century: An umbrella review of evidence and controversies.

📖 Top 20% Journal

1 week ago • Experimental gerontology

Drugs targeting multiple pathways to reduce harmful cell aging signals for healthier agingSenomorphic agents: Multi-target strategies to tame the senescence-associated secretory phenotype for healthy ageing.

1 week ago • Journal of biochemistry

New Connections Between Cell Recycling Centers and Supersulfides in Cell Energy and BalanceLysosomes and Supersulfides: Emerging Links in Cellular Metabolism and Homeostasis.

📖 Top 30% Journal

1 week ago • Epigenomics

Understanding differences between biological age estimates from various aging clocksUnderstanding and making sense of epigenetic age misalignment across different aging clocks.

📖 Top 30% Journal

1 week ago • Cellular signalling

Poor mitochondrial cleanup and stress response affect cell aging after DNA damageImpaired mitochondrial quality control and stress signalling machinery modulate senescence induction by genotoxic challenge.

📖 Top 20% Journal

1 week ago • Autophagy

IL17A may disrupt cell waste recycling and lysosome renewal through a specific signaling pathway in Huntington diseaseIL17A disrupts autophagy-lysosomal function and lysosome reformation through the GSK3B-TFE3 signaling pathway in Huntington disease.

🥈 Top 2% Journal

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