OpenScience.ink

1 week ago • Biochemical pharmacology

How NMN affects the structure and grouping of digestive enzymes (Trypsin, Pepsin, α-Amylase) studied by simulations and spectroscopyRevealing NMN-induced biomacromolecular complex and conformational regulation of digestive enzymes (Trypsin, Pepsin, α-Amylase): Insights from molecular dynamics simulation and multi-spectroscopy.

Article

1 week ago • Oral diseases

RIPK3 may increase gum cell death and gum inflammation by disrupting cell cleanupRIPK3 Promotes Gingival Fibroblast Apoptosis and Periodontal Inflammatory Injury by Impairing Mitophagy.

📖 Top 20% JournalArticle

1 week ago • Advanced healthcare materials

Nanoparticles Targeting Cell Energy Centers May Reduce Cell Aging by Restoring Energy Balance in OsteoarthritisMitochondria-Targeted Supramolecular Nanoparticles Alleviate Cellular Senescence by Restoring Mitochondrial Homeostasis in Osteoarthritis.

🥉 Top 5% JournalArticle

1 week ago • Journal of inflammation research

Autophagy as a Possible Control Point Between Gut Microbes and Heart HealthAutophagy as a Proposed Regulatory Interface in the Gut Microbiota-Cardiovascular Axis.

📖 Top 20% JournalArticle

1 week ago • Cell communication and signaling : CCS

Iron buildup as a possible cause of aging-related bone and joint diseasesFerro-aging: a potential driver of degenerative bone and joint diseases.

🥉 Top 5% JournalArticle

1 week ago • Environment & health (Washington, D.C.)

Using Tiny Gold Nanoparticles to Reduce Early Ovarian Failure Caused by Environmental Pollutants by Controlling Cell Stress and Mitochondrial CleanupMitigating Environmental Pollutant-Induced Premature Ovarian Insufficiency by Rationally Designed Ultrasmall Gold Nanoparticles via Dual Regulation of ROS and Mitophagy.

🎖️ Top 10% JournalArticle

1 week ago • Clinical and translational medicine

A lysosomal protein helps protect the heart from injury after blood flow returns by promoting removal of damaged mitochondria through the NEDD4-LC3 pathwayLysosomal protein transmembrane 5 protects against myocardial ischemia-reperfusion injury by promoting mitophagy via the NEDD4-LC3 axis.

🥉 Top 5% JournalArticle

1 week ago • hLife

Former Regulatory T Cells: From Misunderstood Artifact to Potential Treatment TargetEx-Tregs: From controversial artifact to therapeutic target.

📖 Top 20% JournalArticle

1 week ago • Immunobiology

Removing immune cells reduces inflammation and aging signs in old mouse kidneysPharmacological depletion of macrophages leads to a reduction in inflammation and senescence in aged murine kidneys.

📖 Top 30% JournalArticle

1 week ago • Plastic and reconstructive surgery. Global open

Fast Wound Healing Linked to Taking NAD+ Supplements by Mouth: A Case StudyRapid Wound Healing Observed Following Oral LathMized NAD+ Supplementation: A Case Study.

📖 Top 30% JournalCase Reports

1 week ago • Annals of neurology

Faster Biological Aging in Frontotemporal Dementia Linked to Smoking, Inflammation, and MetabolismAccelerated Epigenetic Aging in Frontotemporal Dementia Highlights Smoking, Inflammation, and Metabolic Signals.

🥈 Top 2% JournalArticle

1 week ago • Anesthesia and pain medicine

📖 Top 50% JournalArticle

1 week ago • Nano letters

Tiny Polymer Dot Reactors for Highly Sensitive Detection of Various Metabolites and On-the-Spot DiagnosisNanoconfined Polymer Dot Reactors for Ultrasensitive Monitoring of Diverse Metabolites and Point-of-Care Diagnosis.

🥉 Top 5% JournalArticle

1 week ago • Pharmacological research

A modified chalcone compound reduces Alzheimer's Aβ and Tau problems by affecting energy control and cell cleanup processesA trifluoromethylated chalcone derivative attenuates Alzheimer disease-related Aβ/Tau pathology by modulating the AMPK-dependent autophagy-proteostasis axis.

🥉 Top 5% JournalArticle

1 week ago • Cardiovascular toxicology

How Air Pollution May Speed Up Heart and Blood Vessel Aging: Key Processes, Biomarkers, and the PACA ApproachParticulate Matter Exposure and Accelerated Cardiovascular Aging: Mechanistic Evidence, Biomarker Integration, and the PACA Framework.

📖 Top 30% JournalArticle

1 week ago • Aging cell

A Cilia-Based NAD+ Signaling System Controls Lysosome Balance in the Hypothalamus and Metabolic AgingA Cilia-Centered Nicotinamide Adenine Dinucleotide (NAD+) Signaling Network Regulates Hypothalamic Lysosomal Homeostasis and Metabolic Aging.

🥉 Top 5% JournalArticle

1 week ago • Free radical biology & medicine

How nerve cell stress and damaged mitochondria lead to brain immune cell inflammation after radiation injuryNeuronal oxidative stress and mitophagy contribute to microglial inflammation in radiation-induced brain injury.

🥉 Top 5% JournalArticle

1 week ago • Ecotoxicology and environmental safety

Single-cell gene analysis shows dopamine-producing neurons may be vulnerable to self-cleaning process changes after atrazine exposureSingle-cell transcriptomic analysis reveals autophagy-associated transcriptional vulnerability of dopaminergic neurons after atrazine exposure.

🎖️ Top 10% JournalArticle

1 week ago • Annual review of physiology

Aging of Muscle Cells: How It Happens, Its Effects on the Body, and Possible TreatmentsCellular Senescence in Skeletal Muscle: Molecular Mechanisms, Physiological Consequences, and Therapeutic Opportunities.

🥇 Top 1% JournalArticle

1 week ago • Cell structure and function

Cell stress changes mitochondrial amounts and placement of an antioxidant protein during cell agingProteostasis stress alters mitochondrial levels and localization of SOD2 during cellular senescence.

📖 Top 20% JournalArticle

1 week ago • Aging

From Overactive Processes to Widespread Boosts: Rethinking How Aging Can Be ReversedFrom hyperfunction to systemic amplification: reframing the logic of late-life rejuvenation.

📖 Top 20% JournalArticle

1 week ago • European journal of medicinal chemistry

New Lac-Phe Compounds with Better Absorption for Treating Metabolic SyndromeDiscovery of novel Lac-Phe derivatives with improved oral exposure for the treatment of metabolic syndrome.

📖 Top 20% JournalArticle

1 week ago • Channels (Austin, Tex.)

Possible roles of a temperature- and pain-sensing receptor in heart failure with normal pumping functionPotential roles for transient receptor potential vanilloid 1 in heart failure with preserved ejection fraction.

📖 Top 20% JournalArticle

1 week ago • Journal of molecular neuroscience : MN

GBA1 gene variant rs12411216 linked to movement and non-movement problems and worse progression in Parkinson's disease over five yearsThe GBA1-related variant rs12411216 is Associated with Motor and Non-Motor Impairments and Unfavorable Progression in Parkinson's Disease: A Five-Year Longitudinal Study.

📖 Top 20% JournalArticle

1 week ago • Biochimica et biophysica acta. Molecular basis of disease

How heart and diabetes drugs affect mitochondria to protect or harm the diseased heartMitochondrial pharmacology of cardiovascular and antidiabetic drugs: Mechanistic basis of cardioprotection and cardiotoxicity in the diseased heart.

Article

1 week ago • The Journal of bone and joint surgery. American volume

How Biological Age Relates to Adult Spinal Deformity SurgeryThe Role of Biological Age in Adult Spinal Deformity Surgery.

Article

1 week ago • Proceedings of the National Academy of Sciences of the United States of America

How eIF4E-binding proteins control microglial energy use, inflammation, and survivalTranslational control of microglial metabolism, inflammatory responses, and survival by the eIF4E-binding proteins.

Article

1 week ago • Experimental gerontology

New inflammation marker and aging signs in diabetes: the possible role of platelets in age-related inflammationNovel inflammation index and biological aging indicators in diabetes: unveiling the role of platelets in inflammaging in a population-based observational study.

Article

1 week ago • Molecular biomedicine

Using lipid nanoparticles to deliver a gene activator’s instructions for treating fatty liver disease linked to metabolism problemsLipid nanoparticle-mediated transcription factor EB mRNA delivery for the treatment of metabolic dysfunction-associated steatotic liver disease.

🥉 Top 5% JournalArticle

1 week ago • Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Response to 'Intermittent Fasting and Brain Protection After Stroke'EXPRESS: Letter to the Editor Regarding "Much ado about eating: Intermittent fasting and post-stroke neuroprotection".

🥉 Top 5% JournalLetter

← prevpage 7 of 16next →

Latest Longevity & Aging Research Papers