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1 week ago • GeroScience

Blood factors from time-restricted eating may change metabolism in blood vessel lining cellsCirculating factors induced by time-restricted eating drive metabolic reprogramming in endothelial cells.

🎖️ Top 10% Journal

1 week ago • npj aging

🥉 Top 5% Journal

1 week ago • Brain research bulletin

Reducing DYNC1I1 lessens nerve cell loss and harmful protein buildup in Parkinson's disease modelsTargeting DYNC1I1 attenuates Parkinsonian neurodegeneration and α-synuclein accumulation in cellular and mouse models.

📖 Top 20% Journal

1 week ago • Neurotoxicology

Aluminum and Alzheimer's Disease: A Review of Current Evidence and DebatesAluminum and Alzheimer's disease in the 21st century: An umbrella review of evidence and controversies.

📖 Top 20% Journal

1 week ago • Experimental gerontology

Drugs targeting multiple pathways to reduce harmful cell aging signals for healthier agingSenomorphic agents: Multi-target strategies to tame the senescence-associated secretory phenotype for healthy ageing.

1 week ago • Journal of biochemistry

New Connections Between Cell Recycling Centers and Supersulfides in Cell Energy and BalanceLysosomes and Supersulfides: Emerging Links in Cellular Metabolism and Homeostasis.

📖 Top 30% Journal

1 week ago • Epigenomics

Understanding differences between biological age estimates from various aging clocksUnderstanding and making sense of epigenetic age misalignment across different aging clocks.

📖 Top 30% Journal

1 week ago • Cellular signalling

Poor mitochondrial cleanup and stress response affect cell aging after DNA damageImpaired mitochondrial quality control and stress signalling machinery modulate senescence induction by genotoxic challenge.

📖 Top 20% Journal

1 week ago • Autophagy

IL17A may disrupt cell waste recycling and lysosome renewal through a specific signaling pathway in Huntington diseaseIL17A disrupts autophagy-lysosomal function and lysosome reformation through the GSK3B-TFE3 signaling pathway in Huntington disease.

🥈 Top 2% Journal

1 week ago • Behavioural brain research

Lidocaine may reduce postoperative delirium by triggering removal of damaged mitochondria to lower harmful molecules and prevent inflammatory microgliaActivation of Mitophagy by Lidocaine Limits mROS and Prevents Microglial M1 Polarization to Alleviate Postoperative Delirium.

1 week ago • JACC. Basic to translational science

Problems in Mitochondrial Cleanup and Movement in AtherosclerosisDisrupted Mitochondrial Quality Control in Atherosclerotic Disease: Mitophagy and Dynamics in Focus.

🥉 Top 5% Journal

1 week ago • Nature communications

Short-term rapamycin treatment shows different ways inflammation during pregnancy causes problems in miceAcute rapamycin treatment reveals distinct mechanisms of dysfunction in a maternal inflammation mouse model.

🥈 Top 2% Journal

1 week ago • EMBO reports

How E3 Ubiquitin Ligases Help Selective Forms of Cellular Self-CleaningThe role of E3 ubiquitin ligases in selective types of macroautophagy.

1 week ago • American journal of physiology. Lung cellular and molecular physiology

How FCCP Triggers Mitochondrial Cleanup in Human Airway Muscle CellsMolecular Mechanisms Underlying FCCP-Induced Mitophagyin Human Airway Smooth Muscle Cells.

📖 Top 20% Journal

1 week ago • Immunological investigations

How the ATG14-SIRT1 Interaction May Influence Inflammation and Immune Response in Sudden Lung InjuryThe ATG14-SIRT1 Axis Modulates NF-Κb Pathway Activation and Inflammatory Responses in Acute Lung Injury.

📖 Top 30% Journal

1 week ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

A Blood Protein May Help ALS by Triggering Cell Cleanup to Remove Harmful Protein Clumps Without Using the Usual PathwayA Blood-Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN-Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1.

🥈 Top 2% Journal

1 week ago • Molecular biology reports

How NAD+ works in the body and its potential benefits from supplements to treatmentsNAD⁺ biology and supplementation: From mechanisms to clinical perspectives.

📖 Top 30% Journal

1 week ago • Science advances

mTOR signaling helps control daily gene activity rhythms in mouse livermTOR signaling contributes to system-driven rhythmic gene expression in mouse liver.

🥈 Top 2% Journal

1 week ago • Pathology, research and practice

Precision approaches to control T cell activation, movement, and self-cleaning by targeting the CD31 immune-metabolism pathwayTargeting the CD31 immunometabolic axis: Precision strategies for modulating T cell activation, migration, and autophagy.

1 week ago • MedComm

Biological Roles and Treatment Potential of SIRT ProteinsSIRT Family: Biological Functions and Therapeutic Targets.

🥉 Top 5% Journal

1 week ago • International immunopharmacology

Luteolin may reduce cell aging and inflammation caused by cigarette smoke in mice through a specific cell protection pathwayLuteolin is associated with alleviation of cigarette smoke-induced cellular senescence and inflammation in mice involving the CREB/c-Fos/NQO1 pathway.

1 week ago • Biogerontology

Cell Aging and Chronic Inflammation: How They Work and Possible TreatmentsCellular senescence and inflammageing: from mechanisms to senotherapeutic interventions.

📖 Top 20% Journal

1 week ago • Journal of community health

Frequent Nighttime Urination Is Linked to Biological Age, Not Actual AgeNocturia is Associated with Biological Age not Chronological Age.

📖 Top 20% Journal

1 week ago • Experimental cell research

Bone marrow stem cell exosomes may reduce bone loss by blocking bone-breakdown cells through RBM15B/YAP1-triggered cell recyclingExosomes from bone marrow mesenchymal stem cells inhibit osteoclast differentiation and alleviate osteoporosis via RBM15B/YAP1 to induce autophagy.

1 week ago • Carbohydrate polymers

Recent progress and potential treatments using cyclodextrin to deliver resveratrolCyclodextrin-mediated delivery of resveratrol: Recent advances, therapeutic potential, and future perspectives.

🥉 Top 5% Journal

1 week ago • Science advances

Different roles of COPI proteins reduced during cell agingDistinct roles of COPI proteins attenuated in cell senescence.

🥈 Top 2% Journal

1 week ago • Journal of Alzheimer's disease : JAD

Chemical agents that change brain connections: New possibilities for Alzheimer's treatmentBiochemical modulators of synaptic plasticity: New horizons in Alzheimer's disease treatment.

📖 Top 20% Journal

1 week ago • Fitoterapia

2-Amino-5-hydroxyhexanoic acid helps prevent muscle loss in diabetes by maintaining protein balance2-Amino-5-hydroxyhexanoic acid mitigates diabetes-induced skeletal muscle atrophy by preserving protein homeostasis.

📖 Top 50% Journal

1 week ago • Cardiovascular toxicology

METTL1 enzyme increases USF2 to speed up septic heart damage by blocking a protective cell cleanup processMethyltransferase METTL1 Upregulates USF2 in a m7G-Dependent Manner to Accelerate Septic Cardiomyopathy by Inactivating PINK1/Parkin-Mediated Mitophagy.

📖 Top 30% Journal

1 week ago • Cellular signalling

Mitochondrial Problems in Disc Degeneration Linked to Oxidative Stress, Cell Changes, and Tissue BreakdownMitochondrial dysfunction in intervertebral disc degeneration: Linking oxidative stress, altered cell fate, and Matrix degeneration.

📖 Top 20% Journal

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