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2 weeks ago • International journal of biological macromolecules

Seaweed Sugars Help Reduce UV Skin Aging by Repairing Outer Skin and Rebuilding Support LayersPolysaccharides from Sargassum fusiforme attenuate UV-induced skin photoaging via epidermal repair and dermal matrix reconstruction.

📖 Top 20% JournalArticle

2 weeks ago • Smart molecules : open access

A pH-sensitive fluorescent probe shows how a key enzyme groups together to help cells avoid agingA pH-Responsive fluorescence lifetime probe reveals GOT1 phase separation in cellular anti-senescence.

Article

2 weeks ago • Reproduction (Cambridge, England)

Changing Fertility Timing in Women with Reduced Egg SupplyBeyond the Clock: Reprogramming Fertility in Diminished Ovarian Reserve.

Article

2 weeks ago • Clinical science (London, England : 1979)

Lack of IRAP helps protect kidney function and reduce damage in older miceIRAP deficiency preserves renal function and attenuates pathology in aged mice.

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2 weeks ago • Mechanisms of ageing and development

Metformin treatment may increase immune cell aging markers and longevity genes in Asian Indians with prediabetes over 24 weeksMetformin therapy increases leukocyte telomere length, telomerase activity, and longevity gene expression in Asian Indians with prediabetes: A 24-week participant-blind, outcome-assessor-blinded randomized controlled trial.

Article

2 weeks ago • Biogerontology

Stress and metabolic ageing in older adults during long crises, shown by UkraineStress biology and metabolic ageing in older adults during prolonged crises: Ukraine as an example.

📖 Top 20% JournalArticle

2 weeks ago • microPublication biology

Deguelin may increase lifespan and health in C. elegans through the fmo-4 geneErratum: Corrigendum: Deguelin promotes longevity and healthspan through C. elegans fmo-4.

Published Erratum

2 weeks ago • Carbohydrate polymers

How Cichorium glandulosum polysaccharides may protect against muscle loss and obesity by triggering cell cleanup through the butyrate-GPR43-AMPK pathwayStructure and protection of Cichorium glandulosum polysaccharides against sarcopenic obesity through activating mitophagy via butyrate-GPR43-AMPK pathway.

🥉 Top 5% JournalArticle

2 weeks ago • The journal of gene medicine

Lysosome Problems Linked to Spinal Disc Wear: Molecular Types and Key Genes Found Using Advanced AnalysisLysosomal Dysfunction Is Associated With Intervertebral Disc Degeneration: Multiomics and Machine Learning Identify Molecular Subtypes and Hub Genes.

📖 Top 30% JournalArticle

2 weeks ago • International journal of rheumatic diseases

Faster Biological Aging and Its Link to Osteoarthritis Risk Over TimeCross-Sectional and Longitudinal Association Between Biological Aging Acceleration and the Risk of Osteoarthritis: A Cohort Study From UK Biobank.

📖 Top 50% JournalArticle

2 weeks ago • Biochemical and biophysical research communications

Ivermectin’s potential to affect a key protein pathway in Alzheimer’s diseaseTargeting the protein tyrosine phosphatase 1B signaling axis in Alzheimer's disease: Emerging therapeutic potential of ivermectin.

📖 Top 30% JournalArticle

2 weeks ago • Stroke

Blocking Immune Checkpoint B7-H3 May Change Early Brain Inflammation and Protect the Brain After StrokeImmune Checkpoint B7-H3 Inhibition Reprograms Acute Neuroinflammation and Protects the Brain After Acute Ischemic Stroke.

🥉 Top 5% JournalArticle

2 weeks ago • Aging cell

How Aging Cells and Immune Cells InteractInsights Into the Interplay Between the Senescent Cells and Immune Cells.

🥉 Top 5% JournalArticle

2 weeks ago • Neurochemical research

Mild Cooling May Reduce Tissue Damage After Blood Flow Loss by Triggering Cell Cleanup ProcessesMild Hypothermia Alleviates Ischemia and Reperfusion Injury by Activating PINK1/Parkin Mitophagy.

📖 Top 20% JournalArticle

2 weeks ago • Journal of Huntington's disease

Selective cleanup of damaged proteins with helper molecules in polyglutamine diseases: from how it works to possible treatmentsChaperone-assisted selective autophagy (CASA) in polyglutamine-related diseases: From mechanisms to therapeutic perspectives.

🎖️ Top 10% JournalArticle

2 weeks ago • Chemistry & biodiversity

Egg Peptides from American Shad May Extend Lifespan and Health in Worms by Changing Fat Metabolism and Boosting Antioxidant DefensesEgg Peptides From American Shad Extend Lifespan and Healthspan in Caenorhabditis elegans via Lipid Metabolism Remodeling and Antioxidant Defense.

📖 Top 50% JournalArticle

2 weeks ago • FASEB journal : official publication of the Federation of American Societies for Experimental Biology

ASIV may reduce kidney cell damage from cisplatin by boosting mitochondrial renewal and cleanup through the ADRA1A/AMPK/FOXO3A pathwayASIV Attenuates Cisplatin-Induced Proximal Tubular Injury by Enhancing Mitochondrial Biogenesis and Mitophagy Through the ADRA1A/AMPK/FOXO3A Pathway.

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2 weeks ago • The Journal of dermatology

Local Low-Frequency Vibration May Improve Wound Healing and Reduce Cell Aging in High Blood Sugar RatsLocal Low-Frequency Vibration Enhances Wound-Healing and Modulates Cellular Senescence in Tissues and Exudates in a Hyperglycemic Rat Model.

📖 Top 20% JournalArticle

2 weeks ago • CNS neuroscience & therapeutics

Melatonin may improve thinking and reduce harmful cell cleanup in rats with blood flow-related dementiaMelatonin Improves Cognitive Function and Suppresses Excessive Mitophagy in Rats With Vascular Dementia.

🎖️ Top 10% JournalArticle

2 weeks ago • JBMR plus

Creating human stem cells with spCAS9 to study gene roles in bone cell developmentGeneration of spCAS9 expressing human mesenchymal stem cell line to study gene function during osteoblast differentiation.

📖 Top 20% JournalArticle

2 weeks ago • Journal of agricultural and food chemistry

Lycopene reduces fat-induced cell damage and death in cow mammary cells by activating cell cleanup processes controlled by TFEBLycopene Alleviates Fatty Acid-Induced Oxidative Stress and Apoptosis in Bovine Mammary Epithelial Cells via the TFEB-Mediated Autophagy Signaling Pathway.

📖 Top 20% JournalArticle

2 weeks ago • The Orthopedic clinics of North America

Osteoarthritis as a Whole-Joint Disease: New Pain, Metabolism, Aging, and Repair Treatment Targets with Ideas for Personalized CareOsteoarthritis as a Whole-Joint Disease, Part II: Emerging Nociceptive, Metabolic, Senescence, and Regenerative Therapeutic Targets, with Perspectives on Precision Care.

📖 Top 30% JournalArticle

2 weeks ago • Seminars in nephrology

How Sudden Kidney Injury May Lead to Long-Term Kidney Disease: Clinical Signs, Underlying Causes, and Potential Use of Traditional Chinese MedicineAcute Kidney Injury-to-Chronic Kidney Disease Transition: Clinical Evidence, Pathophysiologic Mechanisms, and Emerging Role of Traditional Chinese Medicine.

📖 Top 20% JournalArticle

2 weeks ago • Annual review of pathology

Problems with Cell Cleanup in Nerve and Muscle Diseases: From Genetic Causes to Treatment ProgressAutophagy Deficits in Lower Motor Neuron and Striated Muscle Diseases: From Genetics to Therapeutic Advances.

🥇 Top 1% JournalArticle

2 weeks ago • Autophagy

RAB1 helps OPTN control damaged mitochondria removal by bringing in ATG9ARAB1 mediates OPTN-dependent mitophagy via ATG9A recruitment.

🥈 Top 2% JournalArticle

2 weeks ago • GeroScience

Assessing Frailty in Naturally Aging Mice: Types, Challenges, and Future StepsFrailty assessment in naturally aged mouse models: classification, limitations, and future directions.

🎖️ Top 10% JournalArticle

2 weeks ago • The EPMA journal

Changes in biological aging over time and their link to heart disease and stroke riskDynamic reversibility of biological aging and risk of cardiovascular disease and stroke: a longitudinal cohort study.

🎖️ Top 10% JournalArticle

2 weeks ago • Journal of neuroimmunology

Nilotinib reduces inflammation and cell death in brain immune cells by controlling NF-κB signaling and boosting cell cleanup and membrane repairNilotinib attenuates NLRP3 inflammasome activation and GSDMD/NINJ1-mediated pyroptosis via modulation of NF-κB signaling and enhancement of BAG3-dependent aggrephagy and ESCRT-III-mediated plasma membrane repair in microglia.

📖 Top 20% JournalArticle

2 weeks ago • Food science and biotechnology

Broccoli, licorice, and passionflower mix may improve cell energy production and reduce aging-related damageBroccoli-licorice-passionflower blend improves mitochondrial function and exerts senotherapeutic effects.

📖 Top 30% JournalArticle

2 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

How Phase Separation and Material Properties Affect the Behavior of Cellular Cleaning Structures in MammalsPhase Separation, Material State, and Condensate Fate in Mammalian Autophagy.

🥈 Top 2% JournalArticle

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