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2 weeks ago • Nature neuroscience

Disrupted cholesterol movement by ABCA1 may lead to nerve cell damage in Parkinson's diseaseDysregulated cholesterol trafficking through ABCA1 drives neurodegeneration in Parkinson's disease.

🥇 Top 1% JournalArticle

2 weeks ago • Toxicology and applied pharmacology

Aging of lung immune cells in smoke-exposed versus naturally aged mice and how P2X7R may affect smoke-related airway inflammationComparison of alveolar macrophages senescence between cigarette smoke-exposed and naturally aged mice and the role of P2X7R in CS-induced airway inflammation.

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2 weeks ago • Frontiers in molecular biosciences

Communication between fat storage and energy systems in osteoarthritis linking fat use to energy imbalanceLipid droplet-mitochondria crosstalk in osteoarthritis: linking lipid routing to metabolic mismatch.

📖 Top 20% JournalArticle

2 weeks ago • Bioactive materials

Controlled RNA delivery using charged gelatin nanoparticles may protect against spinal disc degeneration by targeting mTORC1Cationized gelatin nanosphere-mediated release-controlled RNA interference targeting mTORC1 protects against intervertebral disc degeneration.

🥈 Top 2% JournalArticle

2 weeks ago • Diabetes

Faster Biological Aging in Diabetic Kidney Disease Compared Using 10 Epigenetic Clocks in People with Type 1 DiabetesAccelerated Epigenetic Ageing in Diabetic Kidney Disease: A Comparison of 10 Epigenetic Clock Measures in Individuals With Type 1 Diabetes.

🥉 Top 5% JournalArticle

2 weeks ago • Frontiers in endocrinology

Immune Cells and Metabolism Changes Linked to Reduced Ovarian Reserve: Disease Features and Possible TreatmentsMacrophages and immunometabolism in diminished ovarian reserve: pathological features and therapeutic implications.

🎖️ Top 10% JournalArticle

2 weeks ago • eLife

Human brain organoid shows immune cell recruitment by microglia and immune problems linked to Alzheimer's diseaseAn integrated human forebrain organoid reveals microglia-mediated CD8+ T cell recruitment and neuroimmune dysfunction in Alzheimer's disease pathology.

🥈 Top 2% JournalArticle

2 weeks ago • Genes & diseases

Glis1 supports cell metabolism by increasing H3K18 lactylation to reduce nerve cell aging after spinal cord injuryGlis1 regulates metabolic programming by promoting H3K18 lactylation to alleviate neuronal senescence following spinal cord injury.

🎖️ Top 10% JournalArticle

2 weeks ago • Odontology

Cell aging and its secretions in the mouth-body connection: a possible link between gum disease and type 2 diabetesCellular senescence and the SASP in the oral-metabolic axis: a putative link between periodontitis and type 2 diabetes mellitus.

📖 Top 30% JournalArticle

2 weeks ago • GeroScience

Metformin's effects on blood gene activity in older adults with age-related vision lossAn exploratory study of the effect of metformin on the whole blood transcriptome of nondiabetic older adults with age-related macular degeneration.

🎖️ Top 10% JournalArticle

2 weeks ago • Plastic and reconstructive surgery

Partial Cell Reprogramming as a New Approach in Plastic SurgeryA New Frontier: Partial Cellular Reprogramming in Plastic Surgery.

📖 Top 20% JournalArticle

2 weeks ago • Biochimica et biophysica acta. Molecular cell research

High salt stress in kidney tube cells may trigger self-cleaning processes in nearby support cells through released glutamateHyperosmotic stress in renal tubular epithelial cells promotes TFEB-dependent autophagy in interstitial fibroblasts by involving extracellular glutamate.

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2 weeks ago • Autoimmunity reviews

Long-lasting antibody-producing cells in rheumatic and certain autoimmune diseases: biology, evidence, and treatment optionsLong-lived plasma cells in rheumatic and selected antibody-mediated autoimmune diseases: biology, evidence, and therapeutic opportunities.

🥉 Top 5% JournalArticle

2 weeks ago • International journal of stem cells

TAOK1 may protect older mice from kidney injury after blood flow returns by activating a cell cleanup processTAOK1 Protects against Renal Ischemia-Reperfusion Injury in Aged Mice through the STK3/BNIP3 Mitophagy Pathway.

📖 Top 30% JournalArticle

2 weeks ago • Autophagy

How PTEN-L controls PRKN to link reduced removal of damaged mitochondria with lower inflammatory cell deathPRKN dephosphorylation by PTEN-L couples mitophagy inhibition to GSDME pyroptosis suppression.

🥈 Top 2% JournalArticle

2 weeks ago • Experimental neurology

How exercise training may improve energy control in the memory area of the brain in Alzheimer's diseaseEffectiveness of exercise training on hippocampal mitochondrial regulation in Alzheimer's disease: A mechanistic systematic review.

🎖️ Top 10% JournalArticle

2 weeks ago • Translational neurodegeneration

Exercise may reduce brain immune cell activity to boost fat breakdown and improve thinking in Alzheimer's diseaseExercise promotes lipophagy and mitigates cognitive impairment in Alzheimer's disease through downregulating microglial TMEM9.

🥈 Top 2% JournalArticle

2 weeks ago • Discover nano

Using plant-based compounds to improve muscle loss by boosting mitochondrial cleanup and cell survivalTargeting ubiquitin-dependent mitochondrial autophagy and apoptosis in sarcopenia: the therapeutic potential of phytochemicals.

📖 Top 30% JournalArticle

2 weeks ago • RSC advances

Chemical comparison of tea and coffee extracts finds a green tea component that may block two digestive enzymesComparative biochemical analysis of tea (Camellia sinensis) and coffee (Coffea arabica) extracts identifies the ethyl acetate fraction of green tea as a potential dual digestive enzyme inhibitor: an in vitro and in silico study.

📖 Top 30% JournalArticle

2 weeks ago • Pathology, research and practice

Disrupted Cell Cleanup Processes in Osteoarthritis: How Non-Coding RNAs Control Them and Possible TreatmentsDysregulated autophagy in osteoarthritis: Mechanisms, regulation by non-coding RNAs, and therapeutic implications.

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2 weeks ago • Aging cell

Activating SIRT6 may improve aging spine disc healthSIRT6 Activation Improves Intervertebral Disc Health in the Aging Spine.

🥉 Top 5% JournalFulltext (Open License)Article

2 weeks ago • Archives of gerontology and geriatrics

Exercise training and changes in energy-producing parts of aging muscles: A combined review and analysisExercise training and mitochondrial remodeling in aging skeletal muscle: A translational systematic review and meta-analysis.

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2 weeks ago • Signal transduction and targeted therapy

Mitochondria cleanup helps communication between cell parts in health and diseaseMitophagy coordinates organelle crosstalk in health and diseases.

🥇 Top 1% JournalArticle

2 weeks ago • eLife

Bruce reduces self-cleaning enzyme activity and wing growth in fruit fliesBruce suppresses autophagy-regulated caspase activity and wing tissue growth in Drosophila.

🥈 Top 2% JournalArticle

2 weeks ago • Toxicology mechanisms and methods

Resveratrol's role in reducing reproductive damage: evidence and underlying mechanismsResveratrol as a Modulator of Reproductive Toxicity: Evidence and Mechanistic Perspectives.

📖 Top 30% JournalArticle

2 weeks ago • Food & function

Gene activity differences show unique anti-aging roles and teamwork among three probiotics in a worm modelComparative transcriptomics reveals distinct anti-aging specificities and functional complementarity among three probiotic strains in Caenorhabditis elegans.

📖 Top 20% JournalArticle

2 weeks ago • The Lancet. Digital health

Using AI to Identify Health Conditions from Face Photos: Developing and Testing a New ModelFoundation artificial intelligence models for health recognition by use of face photographs (FAHR-Face): a model development and validation study.

🥇 Top 1% JournalArticle

2 weeks ago • BMC complementary medicine and therapies

Resveratrol's effects on memory-related brain areas in a chemical model of epilepsyThe effect of resveratrol on the hippocampus in the pentylenetetrazol (PTZ) - dependent kindling model of epilepsy.

📖 Top 30% JournalArticle

2 weeks ago • Cureus

How Sugars Contribute to Acne and Oily Skin InflammationMolecular Role of Carbohydrates in Acne and Seborrheic Dermatitis.

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2 weeks ago • Veterinary and animal science

Clodronate and trehalose together unexpectedly reduce growth of dog mammary tumor cellsClodronate and trehalose exhibit a paradoxical antagonistic interaction that suppresses proliferation of canine mammary tumour cells.

📖 Top 50% JournalArticle

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