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2 weeks ago • Biogerontology

Using nanoparticles to improve treatments for aging-related cell declineClosing the gap in aging science: unlocking the potential of nanoparticles in senescence therapy.

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2 weeks ago • Molecular and cellular endocrinology

Glucose and blood factors adjust nerve cell metabolism and influence insulin signalingGlucose and serum availability fine-tune neuronal metabolic adaptations and direct insulin signaling.

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2 weeks ago • Science advances

Fluorescent protein ticker tape: Recording multiple gene activity patterns in living cells and animalsFluorescent protein ticker tape (FPTT): Multiplexed recording of transcriptional dynamics in living cells and in vivo.

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2 weeks ago • Cell

A complete map of gene activity in human cell typesTabula Sapiens 2.0: A comprehensive transcriptomic atlas of human cell types.

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2 weeks ago • Antioxidants & redox signaling

Mitochondrial Microautophagy as a New Way Cells Keep Mitochondria BalancedMitochondrial Microautophagy: An Emerging Pathway in Maintaining Mitochondrial Homeostasis.

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2 weeks ago • Free radical biology & medicine

Metformin may slow disc degeneration by triggering a cell stress response through energy regulation pathwaysMetformin activates the mitochondrial unfolded protein response via the AMPK/SIRT1 pathway to delay intervertebral disc degeneration.

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2 weeks ago • Inflammopharmacology

How lithium, magnesium, and zinc affect protein balance linked to Alzheimer's disease under stressThe lithium-magnesium-zinc axis under stress: regulation of N-glycosylation-linked proteostasis and Alzheimer's disease.

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2 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Nanoparticles Targeting Mitochondria Reduce Inflammation Caused by Damaged Mitochondrial DNAMitochondria-Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA-Driven Inflammation at the Source.

🥈 Top 2% JournalArticle

2 weeks ago • The Journal of animal ecology

How males and females respond differently to warming over time, linked to aging markers, enzyme activity, and cell stressSex-specific responses to warming: A longitudinal study linking life-history variation to telomere dynamics, telomerase expression and oxidative stress.

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2 weeks ago • Histochemistry and cell biology

Higher DNA 5-hydroxymethylation helps stem cells become cartilage cells by lowering hTERT through TET enzymesElevated DNA 5-hydroxymethylation promotes chondrocyte differentiation via TET-mediated epigenetic downregulation of hTERT in human mesenchymal stem cells.

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2 weeks ago • Experimental gerontology

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2 weeks ago • Orthopaedic surgery

Osteoarthritis Treatments: Progress from Understanding Joint Environment to Using RegenerationOsteoarthritis Therapeutics: From Microenvironment Understanding to Regenerative Intervention-Current Advances and Future Perspectives.

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2 weeks ago • Cell metabolism

Understanding Actual Age versus Body’s Biological Age in Age Reversal ClaimsAging vs. biological age: Conceptual considerations for age reversal claims.

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2 weeks ago • Proceedings of the National Academy of Sciences of the United States of America

A Hox-controlled process keeps autophagy genes turned off near the cell nucleusA Hox-dependent anchoring mechanism mediates transcriptional repression of autophagy-related genes at the nuclear periphery.

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2 weeks ago • Medicine

Faster biological aging linked to death risk in U.S. adults with heart, kidney, and metabolic problems at early to moderate stagesBiological age acceleration and mortality risk among U.S. adults with cardio-kidney-metabolic syndrome, stages 0-3: An NHANES cohort study.

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2 weeks ago • Ageing research reviews

New Approaches to Treat Aging by Targeting Cell Aging MarkersTargeting senescence-associated biomarkers: Emerging strategies for anti-ageing therapy.

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2 weeks ago • Neurochemistry international

Amyloid-beta linked to overactive CaMKII and problems in cell waste recycling and damaged mitochondria removalAβ-induced CaMKII hyperactivation is associated with impaired lysosomal maturation and mitophagy.

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2 weeks ago • Journal of environmental sciences (China)

Brain cell damage in rats from 2,5-hexanedione linked to a process where damaged mitochondria trigger iron-related cell deathMitophagy-mediated ferroptosis involved in 2,5-hexanedione-induced neurotoxicity in rats.

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2 weeks ago • Molecular biomedicine

Glutamine Transport by SLC1A5 Controls Macrophage Aging and Cleanup Function During Liver RepairSolute Carrier Family 1 Member 5 (SLC1A5)-dependent glutamine transport regulates macrophage senescence and efferocytosis during liver regeneration.

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2 weeks ago • Metabolic brain disease

Changes in Fat Molecules Affecting Brain Cell Membranes in Obesity-Linked Alzheimer's Disease: How They Involve Immune Responses and Potential TreatmentsPhosphatidylethanolamine-mediated metabolic membrane remodeling in obesity-associated Alzheimer's disease: mechanisms, neuroimmune crosstalk, and therapeutic potential.

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2 weeks ago • International immunopharmacology

Diosgenin glucoside may support platelet production by promoting cell recycling through the AMPK/mTOR/ULK1 pathwayThe role and mechanism of diosgenin glucoside in modulating megakaryopoiesis through promotion of autophagy via the AMPK/mTOR/ULK1 signaling pathway.

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2 weeks ago • Journal of environmental sciences (China)

Common levels of DCOIT reduce lifespan and health in Caenorhabditis elegansEnvironmentally relevant concentrations of DCOIT impaired lifespan and healthspan in Caenorhabditis elegans.

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2 weeks ago • Cell reports

MGRN1 helps protect temporarily damaged energy centers in cells for antioxidant repairMGRN1 preserves transiently damaged mitochondria for antioxidant-mediated repair.

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2 weeks ago • The journals of gerontology. Series A, Biological sciences and medical sciences

Biological Aging Measures and Long Healthy Thinking in Older WomenEpigenetic Clocks of Biological Aging and Cognitively Healthy Longevity: The Women's Health Initiative Memory Study.

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2 weeks ago • Acta physiologica (Oxford, England)

Increasing AS160 Protects Insulin-Producing Cells in High Blood Sugar Mice by Working with HSPA8 to Control Mitochondrial CleanupAS160 Overexpression Protects Against β-Cell Failure in Hyperglycemic Mice by Interacting With HSPA8 to Regulate Mitophagy.

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2 weeks ago • The Journal of clinical investigation

How the brain’s process for clearing damaged cell parts affects neuron health and nerve diseasesMitophagy in neuronal health and disease: from mechanisms to neurodegeneration.

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2 weeks ago • Cardiovascular drugs and therapy

Empagliflozin may reduce artery plaque by boosting cell cleanup in blood vessel liningEmpagliflozin Improves Atherosclerosis by Promoting Mitophagy in Endothelial Cells.

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2 weeks ago • Food research international (Ottawa, Ont.)

Resveratrol improves high-fat diet caused ovarian damage by changing gut bacteria and restoring ovarian energy use and gene activityResveratrol ameliorates High-Fat Diet induced ovarian damage by reshaping gut microbiota and reversing aberrant ovarian energy metabolism and gene expression.

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2 weeks ago • Nature aging

Aging patterns vary across human tissues and show coordinated declineMapping structural aging across human tissues reveals tissue-specific trajectories and coordinated deterioration.

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2 weeks ago • Neuromolecular medicine

New Treatments to Restore α-Synuclein Removal in Parkinson's DiseaseRebalancing α-Synuclein Clearance: Novel Therapeutic Frontiers in Parkinson's Disease.

📖 Top 20% JournalArticle

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