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2 weeks ago • Behavioural brain research

Electroacupuncture may reduce memory problems from heart-lung bypass by helping cell cleanup and brain connection repairElectroacupuncture mitigates cognitive impairment caused by CPB by facilitating PINK1-dependent mitophagy and synaptic plasticity.

2 weeks ago • STAR protocols

Method for identifying aging cells using single-cell and single-nucleus RNA sequencing dataProtocol for classifying cellular senescence from single-cell and single-nucleus RNA sequencing data.

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2 weeks ago • Epigenomics

Using epigenetic markers to guide chronic pain treatment and predict health outcomesClinical applications of epigenetic signatures in chronic pain management and health outcome prediction.

📖 Top 30% Journal

2 weeks ago • European journal of pharmacology

A key protein controlling cell cleaning and brain inflammation in Alzheimer's diseaseRepressor Element 1 Silencing Transcription Factor as a central regulator of autophagy and neuroinflammation in Alzheimer's disease.

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2 weeks ago • Biogerontology

CD44 as a key controller of aging-related inflammation, cell cleanup, and tissue balanceFrom matrix to nucleus: CD44 as a central regulator of inflammaging, autophagy, and tissue homeostasis.

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2 weeks ago • Clinical science (London, England : 1979)

How a Sugar-Based Change on CaMKII Affects Heart Cell Mitochondria Cleanup Through HSPB8 in Diabetic Heart DiseaseO-GlcNAc Modification of CaMKII-Mediated Mitophagic Flux Regulation via HSPB8 in Diabetic Cardiomyopathy.

2 weeks ago • Functional & integrative genomics

ANGPTL4 as a diagnostic marker linked to placental aging in gestational diabetesANGPTL4 in gestational diabetes: a diagnostic biomarker linked to placental senescence.

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2 weeks ago • Zeitschrift fur Gerontologie und Geriatrie

Miscommunication between cells in aging and long-term inflammation[Misdirected intercellular communication in aging and chronic inflammation].

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2 weeks ago • Life medicine

SIRT1 reduces lactate production by modifying PKM2 to help prevent early ovarian failureSIRT1 deacetylates PKM2 to constrain lactate production and protect against premature ovarian insufficiency.

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2 weeks ago • Molecular biology reports

Stress between cell energy centers and their partners in asthmaER-mitochondria contact sites and organelle stress in asthma.

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2 weeks ago • GeroScience

How cell stress affects aging, cell aging, and brain degenerationThe PERK paradox in aging: how ER stress shapes senescence and neurodegeneration.

🎖️ Top 10% Journal

2 weeks ago • The Journal of steroid biochemistry and molecular biology

Estrogen’s role in controlling key inflammation and repair systems to protect the brain during aging and neurodegenerationEstrogen's master switch: NFκB-NLRP3, SIRT1-HMGB1, and TLR4 triad tamed for brain rescue in ageing and neurodegeneration.

📖 Top 30% Journal

2 weeks ago • Biochimica et biophysica acta. Molecular cell research

Lack of RSL1D1 weakens iron storage and triggers cell death and aging in eye support cells in diabetic retinopathyRSL1D1 deficiency reduces FTH1 stability and induces ferroptosis and senescence in retinal pigment epithelial cells in diabetic retinopathy.

2 weeks ago • Neuron

Different types of aging cells in the brain and their links to brain aging and neurodegenerative diseasesSenescent cell heterogeneity in brain aging and neurodegenerative disease.

2 weeks ago • Aging cell

Different impacts of Nicotinamide Riboside and Intense Exercise on Age-Related Changes in Muscle DNAThe Divergent Effects of Nicotinamide Riboside and High-Intensity Exercise Training on Skeletal Muscle Epigenetic Aging.

🥉 Top 5% Journal

2 weeks ago • Nature aging

Aging cells gather CTCF protein at nuclear speckles to control alternative RNA splicingSenescent cells cluster CTCF on nuclear speckles to instruct an alternative splicing program.

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2 weeks ago • GeroScience

A metabolic measure of aging linked to frailty and thinking skills across different groupsA metabolomic clock of population ageing: cross-cohort validation and associations with frailty and cognitive function.

🎖️ Top 10% Journal

2 weeks ago • Ageing research reviews

Changes in Gut Microbes with Aging and Their Links to Immune and Metabolic Control Over Time and Body AreasMicrobiome remodeling during aging: Integrative multi-omics and spatiotemporal perspectives on immune and metabolic regulation.

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2 weeks ago • Comparative biochemistry and physiology. Toxicology & pharmacology : CBP

SIRT Genes Help Protect Zebrafish Ovaries from Damage Caused by Plastic NanoparticlesThe SIRT gene family protects against oxidative stress and mitochondrial dynamic dysfunction induced by polystyrene nanoplastics in the ovaries of zebrafish (Danio rerio).

📖 Top 20% Journal

2 weeks ago • Journal of medicinal chemistry

Improving p62-Targeting AUTOTACs to Better Break Down Cancer-Related Proteins EGFR and VEGFR2 and Fight TumorsStructure-Guided Optimization of p62-Directed AUTOTACs for Efficient EGFR/VEGFR2 Degradation and Antitumor Efficacy.

🎖️ Top 10% Journal

2 weeks ago • Cardiovascular research

KMT2B increases inflammation and artery disease by controlling cell cleanup in blood vessel lining cellsKMT2B drives inflammation in endothelial cells and promotes atherosclerosis via histone H3 lysine 4 trimethylation-mediated autophagy.

2 weeks ago • Biochemical pharmacology

Higher MYH11 levels may reduce autophagy problems by adjusting ATG4A in fatty liver disease linked to metabolismMYH11 upregulation attenuates autophagy dysfunction through modulation of ATG4A in metabolic dysfunction-associated steatotic liver disease.

2 weeks ago • Translational research : the journal of laboratory and clinical medicine

How SGLT2 inhibitors and GLP-1 receptor agonists work together in treating chronic kidney diseaseFrom FLOW to translational positioning in chronic kidney disease: mechanistic complementarity of SGLT2 inhibitors and GLP-1 receptor agonists.

🥉 Top 5% Journal

2 weeks ago • GeroScience

DNA methylation patterns linked to high blood pressure and inherited biological aging markers in Korean adultsHypertension-associated DNA methylation signatures and multi-generational epigenetic clocks in Korean adults.

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2 weeks ago • Stem cell research & therapy

Miro1 helps stem cell treatment for muscle loss by restoring healthy mitochondriaMiro1-mediated mitochondrial transfer boosts stem cell therapy for muscle atrophy via restoring mitochondrial homeostasis.

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2 weeks ago • Journal of agricultural and food chemistry

18β-Glycyrrhetinic Acid may protect fat tissue from age-related inflammation in diet-induced obese miceProtective Effects of 18β-Glycyrrhetinic Acid against Inflammaging in Adipose Tissue of Diet-Induced Obese Mice.

📖 Top 20% Journal

2 weeks ago • Proceedings of the National Academy of Sciences of the United States of America

Single-cell map of the mouse ovary shows molecular changes linked to aging during the transition to reduced fertilitySingle-cell atlas of the mouse ovary reveals molecular drivers of aging and senescence during the estropausal transition.

2 weeks ago • Aging cell

Platelet-Coated Resveratrol Nanoparticles May Improve Mitochondrial Problems and Aging in Blood Vessel Cells During Atherosclerosis by Activating FOXM1Mechanistic Study of Platelet Membrane-Coated Resveratrol Nanosystem in Mitochondrial Dysfunction and Endothelial Senescence During Atherosclerotic Lesion Development via FOXM1 Activation.

🥉 Top 5% Journal

2 weeks ago • Neurology

Senescence Gene Activity Linked to 90-Day Recovery Outcomes in Stroke PatientsSenescence Gene Expression Profiles and 90-Day Outcome in Stroke Patients.

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2 weeks ago • Aging cell

Lower Levels of a Cell Cleanup Regulator and Faulty Cell Recycling Linked to Older Kidneys' Vulnerability to Infection-Related InjuryDown-Regulation of TFEB With Defective Autophagy in the Susceptibility of Aging Kidneys to Septic Acute Kidney Injury.

🥉 Top 5% Journal

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