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2 weeks ago • International journal of molecular sciences

Mapping ULK1 Protein Modifications to Show Linked Control of Cell Cleanup and Energy UseIntegrative Phosphoproteomic Characterization of ULK1 Phosphosites Reveals Co-Regulatory Networks in Autophagy and Metabolic Adaptation.

📖 Top 20% JournalArticle

2 weeks ago • Bone research

Stress response systems help cartilage cells adapt and survive in Metaphyseal Chondrodysplasia Type SchmidIntegrated stress signaling pathways promote adaptive reprogramming for chondrocyte survival in Metaphyseal Chondrodysplasia Type Schmid.

🥈 Top 2% JournalArticle

2 weeks ago • Experimental & molecular medicine

Small particles from platelets may cause aging in CD8+ T cells in chronic kidney disease by transferring microRNA-550a-5pPlatelet-derived microparticles induce CD8+ T cell senescence in chronic kidney disease via the transfer of microRNA-550a-5p.

🥈 Top 2% JournalArticle

2 weeks ago • Aging

Key cell death genes linked to immune changes in Duchenne muscular dystrophy and their role in age-related muscle lossFerroptosis-related hub genes and immune infiltration characteristics in Duchenne muscular dystrophy: a molecular framework with implications for aging-related muscle degeneration.

📖 Top 20% JournalArticle

2 weeks ago • FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Protein RNF126 may contribute to obesity by triggering removal of damaged cell power sources through the PINK1/Parkin pathwayE3 Ubiquitin Ligase RNF126 Contributes to Pathogenesis of Obesity by Induction Mitophagy Mediated by PINK1/Parkin Pathway.

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2 weeks ago • Mechanisms of ageing and development

Cell Aging, Chronic Inflammation, and Gene Changes Linked to Blood Vessel Aging and AtherosclerosisThe triad of vascular ageing: Cellular senescence, inflammaging, and epigenetic remodelling in atherosclerosis.

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2 weeks ago • Proceedings of the National Academy of Sciences of the United States of America

S-adenosyl-L-homocysteine may extend lifespan by activating a protective response through the YBT1 transporterS-adenosyl-L-homocysteine triggers an adaptive response that extends lifespan through the YBT1 ABC transporter.

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2 weeks ago • Molecular biology reports

Changing cell cleaning processes to improve skin wound healing: studying molecular steps for new treatmentsRewiring autophagy to target cutaneous wound healing: investigation of molecular mechanisms to therapeutic interventions.

📖 Top 30% JournalArticle

2 weeks ago • International journal of hygiene and environmental health

Day, night, and combined heatwaves linked to faster biological aging in China over timeDaytime, nighttime, and day-night compound heatwaves and accelerated biological ageing: national cross-sectional and longitudinal evidence in China.

🎖️ Top 10% JournalArticle

2 weeks ago • Journal of cardiovascular pharmacology

Targeting Aging Blood Vessel Muscle Cells for Heart and Blood Vessel Drug Treatments: How It Works and Possible TherapiesTargeting Vascular Smooth Muscle Cell Senescence for Cardiovascular Pharmacology: Mechanisms and Therapeutic Perspectives.

📖 Top 30% JournalArticle

2 weeks ago • Molecular biology reports

Lack of Sirt3 weakens fat-blocking signals in female fat cellsSirt3 deficiency impairs AMPK-Acc1 antilipogenic signaling in female adipocytes.

📖 Top 30% JournalArticle

2 weeks ago • Science advances

Astrocyte problems linked to MFN2 may lead to overactive nerve cells and depression-like behaviorsMFN2-associated astrocyte dysfunction contributes to neuronal hyperexcitability and depressive-like behaviors.

🥈 Top 2% JournalArticle

2 weeks ago • Molecular biology reports

miR-486 reduces heart injury after blood flow returns by blocking cell death and self-cleaning through the FOXO1/PTEN/AKT/mTOR pathwaymiR-486 attenuates myocardial ischaemia/reperfusion injury by inhibiting apoptosis and autophagy activation via the FOXO1/PTEN/AKT/mTOR axis.

📖 Top 30% JournalArticle

2 weeks ago • Trends in parasitology

Link between behavior, metabolism, and cell recycling in ticks and mosquitoesBehavior-metabolism-autophagy axis in ticks and mosquitoes.

🎖️ Top 10% JournalArticle

2 weeks ago • Cytokine & growth factor reviews

Aging Immune System in Colorectal Cancer: How Gut Bacteria, Chronic Inflammation, and Cell Metabolism InteractImmunosenescence in colorectal cancer: Interplay of microbiota, inflammaging, and metabolic reprogramming.

🥉 Top 5% JournalArticle

2 weeks ago • Ageing research reviews

How FOXO Proteins Relate to Aging Through Gene Regulation and DNA PackagingThe FOXO-aging axis: Epigenetic insights and chromatin mechanisms.

🥈 Top 2% JournalArticle

2 weeks ago • Stem cell research

Creating a human stem cell line with controllable p16INK4a gene activation using doxycyclineEstablishment of a doxycycline-inducible p16INK4a knock-in human embryonic stem cell line, WAe009-A-3Y.

📖 Top 50% JournalArticle

2 weeks ago • Medicine and science in sports and exercise

Sleep Loss Changes Cell Stress Responses During Hot Exercise Differently in Young and Older MenSleep Deprivation Selectively Alters Cellular Stress Responses During Exercise in the Heat in Young and Older Males.

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2 weeks ago • GeroScience

Streptococcus thermophilus changes fat metabolism to extend healthy life in Caenorhabditis elegans through a fat-regulating pathwayStreptococcus thermophilus remodels lipid metabolism to extend healthspan in Caenorhabditis elegans through NHR-49-Delta-9 desaturase axis.

🎖️ Top 10% JournalArticle

2 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Mitochondrial Maintenance in Muscle and Bone Diseases: Key Signals and Treatment OptionsMitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes.

🥈 Top 2% JournalArticle

2 weeks ago • Molecular and cellular biochemistry

Disrupted body clocks worsen alcohol-related heart damage by harming cell cleanup and increasing heart cell deathCircadian disruption exacerbates alcohol-induced cardiac injury through impaired cellular quality control and increased cardiomyocyte death.

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2 weeks ago • Mechanisms of ageing and development

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2 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Bone Marrow Immune Cell Signaling Connects Fat Growth in Bone Marrow to Energy Loss and Bone Formation Decline in AgingBone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging.

🥈 Top 2% JournalArticle

2 weeks ago • Progress in neuro-psychopharmacology & biological psychiatry

The possible role of the gephyrin-CNTNAP4 connection in brain aging: How problems in inhibitory brain circuits may relate to memory and thinking declineThe potential role of the gephyrin-CNTNAP4 interface in brain aging: Mechanisms of inhibitory circuit dysfunction and cognitive decline.

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2 weeks ago • The Journal of bone and joint surgery. American volume

How Molecular Processes Contribute to Osteoarthritis and New Treatment PossibilitiesMolecular Mechanisms of Osteoarthritis: A Review and Opportunities for Novel Therapeutics.

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2 weeks ago • Evolutionary applications

Epigenetic Clocks Can Estimate Age in Largemouth Bass Despite Differences in Location and SexEpigenetic Clocks Can Predict Age in the Largemouth Bass-Complex Despite Spatial and Sexual Variation.

🎖️ Top 10% JournalArticle

2 weeks ago • Cancer letters

Using CRISPR to identify key factors, stress protection, and treatment weaknesses in alternative telomere lengtheningCRISPR-based interrogation of alternative lengthening of telomeres: mapping dependencies, stress-buffering pathways, and therapeutic vulnerabilities.

🥉 Top 5% JournalArticle

2 weeks ago • Cell metabolism

A flexible approach to targeting cell energy metabolism in cancerA context-dependent framework for targeting NAD metabolism in cancer.

🥇 Top 1% JournalArticle

2 weeks ago • Hepatology communications

Liver cell aging linked to metabolic fat-related liver diseaseHepatocyte senescence in metabolic dysfunction-associated steatotic liver disease (MASLD).

🥉 Top 5% JournalArticle

2 weeks ago • Bioactive materials

Targeting aging cells linked to NOX4 with iron-removing treatment to slow spine disc degenerationReprogramming NOX4-associated ferro-aging with an iron-chelating senescent-cell-targeted therapy for intervertebral disc degeneration.

🥈 Top 2% JournalArticle

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