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2 weeks ago • Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences

Trehalose's overlooked roles in Alzheimer's: gut, brain, and cell cleanup signals beyond common targetsTrehalose's untapped mechanisms in alzheimer's: gut-brain-autophagy signalling beyond the usual targets.

📖 Top 30% JournalArticle

2 weeks ago • Phytotherapy research : PTR

Using Natural Supplements in Heart Failure, Irregular Heartbeats, and Related Heart ConditionsIntegrative Approaches in Cardiovascular Disease: The Role of Nutraceuticals in Heart Failure, Atrial Fibrillation, and Related Conditions.

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2 weeks ago • International journal of oral science

PFKM triggers donut-shaped changes in energy structures to support bone formationPFKM acts as a metabolic switch initiating donut-shaped mitochondrial remodeling to promote osteogenesis.

🥉 Top 5% JournalArticle

2 weeks ago • Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

Biological aging clocks as markers of human aging: their basis, design, and population impactBiological aging clocks as biomarkers of human aging: Biological basis, methodological design, and epidemiological implications.

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2 weeks ago • International journal of general medicine

How p38 MAPK Signaling May Contribute to Heart Damage from DoxorubicinMechanisms and the Role of p38 MAPK Signaling in Doxorubicin-Induced Cardiotoxicity: A Review.

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2 weeks ago • Biogerontology

📖 Top 20% JournalArticle

2 weeks ago • Journal of sport and health science

Short-term passive heat exposure changes cell recycling and stress responses in older active adultsShort-term passive heat acclimation modulates autophagy and cellular stress responses in older active adults.

🥉 Top 5% JournalArticle

2 weeks ago • Journal of Alzheimer's disease : JAD

Terpenoids may reduce Alzheimer's symptoms by boosting cell antioxidants and clearing damaged mitochondria through the Keap1/Nrf2/ARE pathwayResearch progress on terpenoids alleviating Alzheimer's disease through the Keap1/Nrf2/ARE pathway by exerting antioxidant effects and promoting mitophagy.

📖 Top 20% JournalArticle

2 weeks ago • Lupus science & medicine

Changes in MLKL crotonylation linked to RAB1A-mTOR signaling and cell recycling in kidney tubule cells in lupus nephritisCrotonylome profiling identifies MLKL crotonylation in lupus nephritis associated with RAB1A-mTOR signalling and autophagy changes in tubular epithelial cells.

🎖️ Top 10% JournalArticle

2 weeks ago • Advances in pharmacological and pharmaceutical sciences

How PCSK9 Influences Inflammation in Fat-Building Cells and Natural Compounds That May Affect This ProcessPCSK9-Mediated Inflammation in Foam Cell Formation and Exploring the Biologically Active Compounds Derived From Natural Resources.

📖 Top 30% JournalArticle

2 weeks ago • Autophagy

Cell self-cleaning of RAB8A may increase iron uptake problems that lead to ferroptosisAutophagic degradation of RAB8A promotes ferroptosis through dysregulation of TFRC-mediated iron uptake.

🥈 Top 2% JournalArticle

2 weeks ago • iScience

How the shape and role of actin affect its condition and the aging processForm and function of actin impacts actin health and aging.

🎖️ Top 10% JournalArticle

2 weeks ago • International journal of pharmaceutics: X

Nanovesicles carrying SRT1720 may improve diabetic brain stroke by boosting cell cleanup through SIRT1 and PARKIN in ratsSRT1720-loaded exosome-mimetic nanovesicles promote mitophagy via SIRT1/PARKIN activation to ameliorate diabetic cerebral infarction in a preclinical rat model.

📖 Top 20% JournalArticle

2 weeks ago • Aging cell

SIRT1 May Turn Off L1 Mobile DNA by Supporting Chromatin-Stabilizing ComplexesSIRT1 Silences L1 Retrotransposons by Stabilizing Heterochromatin-Modifying Complexes.

🥉 Top 5% JournalArticle

2 weeks ago • Molecular carcinogenesis

Combined Genetic and Molecular Study of Aging-Related Genes Linked to Cancer RiskMulti-Omic Analysis of Putative Cellular Senescence-Associated Genes on the Risk of Pan-Cancer.

📖 Top 20% JournalArticle

2 weeks ago • Autophagy

Thyroid hormone helps reshape fat storage and fat recycling in early embryos through KAT2B/PCAF-controlled gene regulationThyroid hormone promotes lipid droplet remodeling and lipophagy through KAT2B/PCAF-dependent histone acetylation in preimplantation embryos.

🥈 Top 2% JournalArticle

3 weeks ago • Environment international

A new two-part AhR process linked to heart aging caused by 6PPDQA novel dual-pathway AhR mechanism underpins cardiac senescence induced by 6PPDQ.

🥉 Top 5% JournalArticle

3 weeks ago • Journal of molecular histology

Schisandra chinensis polysaccharide may reduce diabetic islet cell damage by boosting cell cleanup through blocking the PI3K/AKT/mTOR pathwaySchisandra chinensis polysaccharide attenuates diabetic islet cell injury by promoting autophagy via suppression of the PI3K/AKT/mTOR signaling cascade.

📖 Top 30% JournalArticle

3 weeks ago • Journal of inflammation research

How Inflammation and Metabolism Are Linked in Lung Function Impairment with Normal Breathing Ratios: Causes and Possible TreatmentsThe Inflammation-Metabolism Axis in Preserved Ratio Impaired Spirometry: Pathogenic Mechanisms and Translational Implications.

📖 Top 20% JournalArticle

3 weeks ago • Chinese medical journal

Materials that change metabolism to treat bone and muscle disordersBiomaterials for metabolic reprogramming in skeletal disorders.

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3 weeks ago • Ageing research reviews

Non-Communicable Diseases May Be an Unavoidable Result of Living Longer Than Our Evolution Prepared Us ForLiving Beyond Our Evolutionary Warranty: Why Non-Communicable Diseases May Be The Inevitable Costs of an Extended Lifespan.

🥈 Top 2% JournalArticle

3 weeks ago • MedComm

How the Body Uses Amino Acids in Health and IllnessAmino Acid Metabolism in Health and Disease.

🥉 Top 5% JournalArticle

3 weeks ago • Pharmacological research

Understanding How Bile Acids and Energy Centers in Cells Work Together: Possible Links to Disease and Treatment OptionsDecoding the bile acid-mitochondria axis: Implications for disease management and therapeutic opportunities.

🥉 Top 5% JournalArticle

3 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

How a Fat-Processing Enzyme Links RNA Modification to Breakdown of Spinal Disc TissueACSL4-Dependent Lysosomal Lipid Peroxidation Links WTAP-Mediated m6A Modification to Intervertebral Disc Degeneration.

🥈 Top 2% JournalArticle

3 weeks ago • Pharmacological research

Eriodictyol controls a key enzyme to activate mitochondrial cleaning that reduces inflammation for treating bone lossEriodictyol regulates LDHB to trigger mitophagy-mediated NLRP3 inflammasome inactivation as a therapeutic strategy for bone loss.

🥉 Top 5% JournalArticle

3 weeks ago • Journal of molecular and cellular cardiology plus

Problems in cell structure networks in primary heart muscle disease: Understanding causes and treatmentsOrganelle network dysfunction in primary cardiomyopathy: An integrated perspective on pathogenesis and therapeutics.

📖 Top 30% JournalArticle

3 weeks ago • Experimental physiology

How Cold-Water Recovery Can Both Boost Relaxation and Pain Relief but Slow Muscle Growth Over TimeThe cold-water immersion recovery-adaptation paradox: Reconciling acute parasympathetic and analgesic benefits with chronic hypertrophy attenuation.

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3 weeks ago • Molecular biology reports

The PINK1-Parkin pathway’s role in removing damaged mitochondria during sepsis: helpful or harmful?PINK1-Parkin pathway-mediated mitophagy in sepsis: friend or foe?

📖 Top 30% JournalArticle

3 weeks ago • Talanta

Using DNA nanodevices to gather lysosomes near the cell nucleus to control their functionDNA nanodevice-mediated perinuclear accumulation of lysosomes for functional regulation.

📖 Top 20% JournalArticle

3 weeks ago • Angewandte Chemie (International ed. in English)

Detecting Aging-Related Enzyme Activity at the Single-Molecule LevelIdentification of Senescence-Associated β-Galactosidase With Single-Molecule Resolution.

🥇 Top 1% JournalArticle

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