OpenScience.ink

2 weeks ago • Free radical biology & medicine

Controlling cell cleanup and inflammation from mitochondrial DNA to treat bone loss caused by inflammationDual-regulation of mitophagy and cytosolic mtDNA-induced inflammation for the treatment of inflammatory bone loss.

🥉 Top 5% Journal

2 weeks ago • Molecular neurobiology

How DNA Detection Triggers Brain Inflammation and Potential Treatments for Age-Related Brain DiseasesDNA Sensing and Neuroinflammation: Mechanistic Insights into cGAS-STING Biology and Therapeutic Translation in Age-Related Neurodegenerative Diseases.

🎖️ Top 10% Journal

2 weeks ago • Molecular biology reports

How Exercise May Influence a Key Protein That Affects Joint Health in OsteoarthritisThe role of exercise in MFN2 regulation in osteoarthritis.

📖 Top 30% Journal

2 weeks ago • Molecular biology reports

Nicotinamide mononucleotide may reduce testicular cell death and improve mitochondrial function in rats treated with doxorubicinInvestigating the effects of nicotinamide mononucleotide administration on testicular apoptosis, and mitochondrial function in doxorubicin-treated rats.

📖 Top 30% Journal

2 weeks ago • Aging clinical and experimental research

Faster biological aging linked to muscle size, strength, and function in the Hertfordshire CohortBiological age-acceleration in relation to muscle mass, strength and function: findings from the Hertfordshire Cohort Study.

2 weeks ago • Ageing research reviews

Aging of brain blood vessel support cells linked to blood-brain barrier problems in Alzheimer's disease: causes, effects, and treatment possibilitiesNeurovascular unit senescence as a driver of blood-brain barrier dysfunction in Alzheimer's disease：Mechanisms, consequences, and therapeutic implications.

🥈 Top 2% Journal

2 weeks ago • Cell reports

TTYH3 controls chloride flow in lysosomes and affects their fusion, cell recycling, and agingTTYH3 regulates a lysosomal chloride conductance and controls lysosomal fusion, autophagy and senescence.

🥈 Top 2% Journal

2 weeks ago • Journal of controlled release : official journal of the Controlled Release Society

Nanozyme-Enhanced Gel Helps Mitochondria Manage Stress to Reduce Inflammation and Damage in Disc DegenerationNanozyme-integrated hydrogel orchestrates mitochondrial quality control to counter inflammatory and oxidative milieu during disc degeneration.

2 weeks ago • Translational stroke research

PIP4K2A may reduce brain damage after stroke by lowering harmful protein buildup and adjusting cell survival signalsPIP4K2A Attenuates Cerebral Ischemia/Reperfusion Injury by Reducing the TRIB3-p62 Complex Burden and Modulating AKT/mTOR Signaling.

🎖️ Top 10% Journal

2 weeks ago • Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance

Faster Heart Ageing in Heart Disease: Findings from Heart Imaging and Electrical TestsAdvancing Heart Ageing in Ischemic Heart Disease: Insights from CMR and ECG Analysis.

🎖️ Top 10% Journal

2 weeks ago • Ecotoxicology and environmental safety

Spermidine reduces egg cell damage from chemical exposure by restoring normal cell cleanup processes in miceSpermidine alleviates 2,2-dichloroacetamide/ 2,2-dibromoacetamide-exposed mouse oocyte toxicity by restoring autophagic homeostasis.

🎖️ Top 10% Journal

2 weeks ago • International journal of molecular medicine

Fixing lung cell problems in unexplained lung scarring: How it happens and new treatment ideasTargeting alveolar type II cell dysfunction in idiopathic pulmonary fibrosis: Molecular mechanisms and emerging therapeutic strategies (Review).

2 weeks ago • Cellular signalling

How the USP5-MATN3 pathway helps protect spine disc cells from aging and degenerationThe USP5-MATN3 axis in nucleus pulposus cell senescence: A Deubiquitination mechanism protecting against intervertebral disc degeneration.

📖 Top 20% Journal

2 weeks ago • Molecular medicine reports

How Key Gene Control Networks Linked to Super-Enhancers May Influence AgingFrom cell to disease: Regulatory networks and mechanisms of super‑enhancers in aging (Review).

📖 Top 30% Journal

2 weeks ago • Cell death & disease

LARS controls aging and self-cleaning processes in liver cancer cellsLARS regulates cellular senescence and autophagy in liver cancer cells.

🥉 Top 5% Journal

2 weeks ago • Neuromolecular medicine

STAT6 Controls Cell Cleanup to Affect Brain Immune Cell Aging in Thinking Problems from Small Blood Vessel DiseaseSTAT6 Targets the Autophagy Pathway to Regulate Microglial Senescence in Cognitive Impairment Caused by Cerebral Small-Vessel Disease.

📖 Top 20% Journal

2 weeks ago • Molecular neurobiology

Sirtuin Signaling in Parkinson's Disease and Brain Cell Loss: Molecular Understanding and Possible TreatmentsTargeting Sirtuin Signaling in Parkinson's Disease and Neurodegeneration: Molecular Insights and Translational Potential.

🎖️ Top 10% Journal

2 weeks ago • The journals of gerontology. Series A, Biological sciences and medical sciences

How Tiny Cell Particles and Epigenetic Clocks Relate to Tissue Aging, Focusing on SkinExtracellular Vesicles and Epigenetic Aging Clocks in Tissue Aging: An Exosome-Focused Conceptual Framework with a Focus on Skin.

2 weeks ago • Archives of medical research

Physical Activity Linked to Faster Aging Measured by Body-Based Age in Older Mexican AdultsAssociation between Physical Activity and Accelerated Aging Using S-Anthropoage: A Secondary Analysis of the Mexican Health and Aging Study.

📖 Top 20% Journal

2 weeks ago • Molecular neurodegeneration

Human stem cell–derived brain immune cells improve brain damage and circuit problems in mice lacking progranulinTransplantation of human iPSC-derived microglia ameliorates neuropathology and circuit dysfunction in progranulin-deficient mice.

🥇 Top 1% Journal

2 weeks ago • Environmental geochemistry and health

How Microplastics Affect the Gut Microbiome and Ageing: Causes and Possible TreatmentsMicroplastics, the gut microbiome and ageing: mechanisms and intervention strategies.

📖 Top 20% Journal

2 weeks ago • Ageing research reviews

How Palmitoylation Relates to Heart and Blood Vessel Aging and Disease, and Possible TreatmentsPalmitoylation in cardiovascular aging and disease: Mechanistic insights and therapeutic opportunities.

🥈 Top 2% Journal

2 weeks ago • Immunologic research

How two key cell signaling pathways interact in multiple sclerosis and their potential for treatmentDecoding the PI3K/Akt/mTOR-JAK/STAT signaling axis in multiple sclerosis: mechanistic crosstalk and therapeutic opportunities.

📖 Top 20% Journal

2 weeks ago • Aging

Including Healthspan Improvement Plans in the Italian National Health ServiceTowards integration of healthspan strategies into the Italian National Health Service.

📖 Top 20% Journal

2 weeks ago • Neurotoxicology

Manganese buildup may trigger cell aging, with the natural drug quercetin helping to reverse itManganese overload as a previously underappreciated trigger of cellular senescence: unraveling mechanisms and therapeutic rescue by the senolytic quercetin.

📖 Top 20% Journal

2 weeks ago • Molecular metabolism

SAMM50 gene variant linked to energy problems in cells and worsening fatty liver disease related to metabolismSAMM50 rs3761472 causes mitochondrial dysfunction and progression of metabolic dysfunction-associated steatotic liver disease.

🥉 Top 5% Journal

2 weeks ago • Neurochemistry international

Can Urolithin A Work as a Brain-Boosting Supplement? A Review of How It Acts, Reaches the Brain, and What Is Unknown in Alzheimer’s and Parkinson’s DiseaseIs Urolithin A(UA) a Pharmacologically Credible Neuro-Nutraceutical? A Critical Review of Mechanisms, Brain Exposure, and Evidence Gaps in Alzheimer's and Parkinson's Disease.

2 weeks ago • Annals of medicine

Support cells protect the retina from low blood flow damage through a calcium signal and cell cleanup processAstrocyte exosomes shield retina from ischemia via CaMKII-autophagy.

2 weeks ago • Clinical epigenetics

Faster biological aging linked to slow heart rhythms: clinical and genetic evidenceBiological age acceleration and bradyarrhythmia: evidence from clinical and epigenetic perspectives.

🎖️ Top 10% Journal

2 weeks ago • Discover oncology

Using data analysis and machine learning to find potential cell recycling targets for treating prostate cancerIntegrated bibliometric and machine learning analyses identify candidate autophagy related therapeutic targets for prostate cancer.

📖 Top 20% Journal

← prevpage 11 of 18next →

Latest Longevity & Aging Research Papers