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3 weeks ago • The American journal of the medical sciences

Biological aging and faster aging linked to death risk in patients with heart and kidney problemsAssociations of biological aging and biological age acceleration with mortality in patients with cardiorenal syndrome: A prospective cohort study.

📖 Top 30% JournalArticle

3 weeks ago • Metabolic brain disease

How different intensities of interval training affect brain cell cleanup, metabolism, and inflammation in rats with type 2 diabetesIntensity-dependent effects of interval training on brain mitophagy, metabolic signaling pathways, and neuroinflammation in a rat model of type 2 diabetes.

📖 Top 20% JournalArticle

3 weeks ago • Bioactive materials

Using mRNA nanoparticles to fix cholesterol balance and help heal age-related bone damageA dual-targeting mRNA lipid nanoparticle restores ABCA1-dependent cholesterol homeostasis to promote repair of age-related bone defects.

🥈 Top 2% JournalArticle

3 weeks ago • Naunyn-Schmiedeberg's archives of pharmacology

Propofol may control nerve cell problems and excessive mitochondrial cleanup in the memory area after surgery in older adults by changing a gene regulatorPropofol regulates SLC6A2 expression via NAT10-mediated ac4C modification to modulate excessive mitophagy and hippocampal neuron dysfunction in aged postoperative cognitive dysfunction.

📖 Top 30% JournalArticle

3 weeks ago • Science advances

GGA1 controls enzyme sorting and cell cleanup by changing lipid balance in the cell’s sorting centerSorting of lysosomal enzyme and autophagy are regulated by the GGA1-induced TGN lipid scrambling.

🥈 Top 2% JournalArticle

3 weeks ago • Genetics and molecular biology

Mitochondria’s role in immune response and treatments during long COVIDMitochondria in SARS-CoV-2 infection: Immune interactions and molecular approaches in the Post COVID-19 condition.

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3 weeks ago • Molecular medicine reports

POU2F1 may promote high blood pressure-related heart scarring by controlling mitochondrial cleanup through PINK1/Parkin pathwaysPOU2F1 promotes hypertensive cardiac fibrosis by regulating mitochondrial homeostasis through PINK1/Parkin‑dependent mitophagy.

📖 Top 30% JournalArticle

3 weeks ago • Autophagy

PINK1’s expanded role in monitoring and controlling mitochondriaA New agent in the matrix: PINK1's expanded role in mitochondrial surveillance and Regulation.

🥈 Top 2% JournalArticle

3 weeks ago • Developmental cell

Senescent cells stay alive by breaking apart while attached, which helps spread cell fragmentsSenescent cells maintain viability through adhesion-dependent fragmentation that promotes debris deposition.

🥇 Top 1% JournalArticle

3 weeks ago • The journals of gerontology. Series A, Biological sciences and medical sciences

Biological Age Linked to Long-Term Decline in Frailty-Related AbilitiesBiological Age Associates with Longitudinal Frailty-Related Functional Decline: The Health and Retirement Study.

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3 weeks ago • Aging

Examining how aging may be linked to cell aging and DNA mutationsAssessing mechanisms and evidence of a causal role for cellular senescence and somatic mutations in aging.

📖 Top 20% JournalArticle

3 weeks ago • Journal of ethnopharmacology

Forsythoside A may ease high blood pressure kidney damage by boosting cell cleanup and blocking cell death through the ASCL1-CCNB1/mTOR pathwayForsythoside A alleviates hypertensive nephropathy by promoting mitophagy and inhibiting ferroptosis via ASCL1-CCNB1/mTOR pathway.

📖 Top 20% JournalArticle

3 weeks ago • The journals of gerontology. Series A, Biological sciences and medical sciences

Metabolite profiles linked to telomere length, aging traits, and lifestyle in older Chinese adultsMetabolomic Profiling of Telomere Length: Associations with Aging-related Phenotypes and Modifiable Lifestyle Factors in Chinese Older Adults.

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3 weeks ago • International journal of molecular medicine

New Insights into Sirtuin Proteins in Lung DiseasesAdvances in sirtuin research in lung diseases (Review).

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3 weeks ago • Aging cell

TPP1 Protein Supports Hair Growth by Activating Hair Follicle Stem CellsShelterin TPP1 Promotes Hair Regeneration Through Activating Bulge Hair Follicle Stem Cells.

🥉 Top 5% JournalArticle

3 weeks ago • Science advances

Neuron-produced SPP1 signals microglia to reduce brain cell damageNeuron-derived SPP1 instructs microglia to limit degeneration.

🥈 Top 2% JournalArticle

3 weeks ago • Aging cell

Anti-Aging Approaches Based on Body Metabolism, Cell Aging Treatments, and Stem Cell TherapiesA Mechanism-Based Framework for Anti-Aging Strategies: From Metabolic Regulation to Senotherapy and Stem Cell-Based Interventions.

🥉 Top 5% JournalArticle

3 weeks ago • International journal of biological macromolecules

Polysaccharides that may improve organelle network problems in Alzheimer's diseasePolysaccharides targeting organelle network dysfunction in Alzheimer's disease: A review.

📖 Top 20% JournalArticle

3 weeks ago • Journal of cardiology

Heart muscle breakdown happens before scarring: the role of heart cell self-cleaning and its disease assessmentMyocardial degeneration precedes fibrosis: The role of myocardial autophagy and its pathological evaluation.

📖 Top 20% JournalArticle

3 weeks ago • Functional & integrative genomics

Identifying aging blood vessel cells in stroke using single-cell and bulk gene analysisDecoding the senescent endothelial landscape in ischemic stroke through single-cell and bulk RNA sequencing.

📖 Top 30% JournalArticle

3 weeks ago • Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

Traditional Chinese Herbal Formula YA3D3 Improves Alzheimer’s-Like Brain Changes and Memory Problems in a Mouse ModelTraditional Chinese Herbal Formula YA3D3 Ameliorates Alzheimer's Disease-Like Pathology and Cognitive Impairment in APP/PS1 Transgenic Mice.

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3 weeks ago • Signal transduction and targeted therapy

How miR-150 controls stem cell fate by regulating SOX2 through mRNA suppression and cell recyclingDual-mode SOX2 regulation by miR-150 via mRNA suppression and autophagy controls stem cell fate.

🥇 Top 1% JournalArticle

3 weeks ago • Ageing research reviews

Brain Aneurysms Linked to Early Blood Vessel Aging, Cell Aging, Chronic Inflammation, and Vessel Wall DamageIntracranial aneurysms as a manifestation of premature vascular aging: Cellular senescence, inflammaging, and wall degeneration.

🥈 Top 2% JournalArticle

3 weeks ago • Life sciences

Genetic differences in kidney cells linked to kidney disease progression, cell damage, aging, and treatment optionsSomatic genomic mosaicism in chronic kidney disease progression: A graded appraisal of renal epithelial injury, cellular senescence, and therapeutic implications.

Article

3 weeks ago • Current opinion in pharmacology

Using mitochondria to treat inflammation and tissue damage: how it works, markers to track, and challenges for medical useMitochondria as a therapeutic platform in inflammatory and degenerative disorders: mechanisms, biomarkers, and translational challenges.

🎖️ Top 10% JournalArticle

3 weeks ago • Bio Systems

Ageing as a Thermodynamic Phase Change: Entropy Production and an Update to Strehler's PrinciplesThe Thermodynamic Phase Transition Hypothesis of Ageing: Entropy Production and a Proposed Extension to Strehler's Postulates.

📖 Top 50% JournalArticle

3 weeks ago • Pharmaceuticals (Basel, Switzerland)

Safety and Action of a Natural Injectable Treatment Targeting Skin Aging PathwaysMechanistic and Preliminary Safety Profiling of a Multicomponent Natural Product-Based Injectable Formulation Targeting Skin Aging-Related Pathways: A Network Pharmacology and Single-Dose Toxicity Study.

📖 Top 20% JournalArticle

3 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Lower KLF5 May Connect Reduced Mitochondrial Cleanup to Inflammation and Valve Changes in Calcific Aortic Valve DiseaseKLF5 Downregulation Links Impaired BNIP3-Mediated Mitophagy to Inflammatory Valve Remodeling in Calcific Aortic Valve Disease.

🥈 Top 2% JournalArticle

3 weeks ago • Omics : a journal of integrative biology

Large-Scale Study of Cell Protein Phosphorylation Suggests a Role for LPIN1 S162 in Metabolic SignalingLarge-Scale Cellular Phosphoproteomic Analysis Reveals a Putative Role for LPIN1 S162 in Metabolic Signaling.

📖 Top 50% JournalArticle

3 weeks ago • Journal of molecular medicine (Berlin, Germany)

SREBF2 supports removal of damaged mitochondria and protects heart cells from iron-related damage through Cav-1 controlled PINK1/Parkin pathway in heart failure caused by low blood flowSREBF2 promotes mitophagy and protects against ferroptosis via Cav-1-regulated PINK1/Parkin signaling in ischemic heart failure.

🎖️ Top 10% JournalArticle

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