OpenScience.ink

3 weeks ago • Chinese medical journal

How Mesenchymal Stem Cells May Help Regulate and Signal in Diabetic Kidney DiseaseMesenchymal stem cells in diabetic kidney disease: Potential regulatory mechanisms and related signaling pathways of mesenchymal stem cells.

Article

3 weeks ago • The FEBS journal

Specific cell cleaning processes in aging and brain diseases: New roles for mitochondrial and nuclear removalSelective autophagy pathways in ageing and neurodegeneration: Emerging roles for mitophagy and nucleophagy.

🥉 Top 5% JournalArticle

3 weeks ago • Open medicine (Warsaw, Poland)

Stem cells with extra ATG5 help ligament healing by promoting healing-type immune cells in older ratsATG5-overexpressing MSCs improve ligament healing with an associated shift toward M2 macrophage polarization in aged rats.

📖 Top 50% JournalArticle

3 weeks ago • Journal of bioenergetics and biomembranes

APPL1 reduces DHEA-caused cell damage in ovarian support cells by improving mitochondrial cleanup and preventing iron-related cell death: implications for polycystic ovary syndromeAPPL1 attenuates DHEA-induced oxidative injury in granulosa cells by enhancing mitophagy and suppressing ferroptosis: implications for polycystic ovary syndrome.

📖 Top 30% JournalArticle

3 weeks ago • Ageing research reviews

How Diet May Slow Brain Aging and Neurodegenerative DiseasesThe mechanism of dietary intervention in delaying brain aging and neurodegenerative diseases.

🥈 Top 2% JournalArticle

3 weeks ago • Experimental cell research

Mechanical support from OPTN-TRIP6 and actin helps close cell structures needed for face and skull developmentOPTN-TRIP6-mediated F-actin mechanical support regulates phagophore closure to govern craniofacial skeletal development.

Article

3 weeks ago • Ageing research reviews

How Daily Eating Patterns Affect Metabolism, Stress Resistance, and Healthy AgingChrononutrition in the aging era: Circadian regulation of metabolism, resilience, and healthy longevity.

🥈 Top 2% JournalArticle

3 weeks ago • BMJ open

Effects of HMB and 2-HOBA supplements on health markers in older adults: protocol for a Canadian clinical trialEffects of β-hydroxy-β-methylbutyrate (HMB) and/or 2-hydroxybenzylamine (2-HOBA) on markers of healthspan in older adults (H2AGE trial): study protocol of a randomised controlled trial at the Canadian Translational Geroscience Network.

📖 Top 20% JournalArticle

3 weeks ago • Molecular biomedicine

Protein recycling and balance in the ear's hearing system and its link to hearing lossThe ubiquitin-proteasome system and proteostasis in the cochlea and sensorineural hearing disorders.

🥉 Top 5% JournalArticle

3 weeks ago • Neuroinformatics

Using Natural Plant Compounds to Influence Mitochondrial Splitting and Recycling Processes in Brain Disorders by Targeting ROCK ProteinsTargeting ROCK Isoforms by Natural Phytocompounds: An In-Silico Approach to Modulate Mitochondrial Fission and Mitophagy in Neurological Diseases.

📖 Top 20% JournalArticle

3 weeks ago • Ageing research reviews

How Exercise May Affect DNA Changes Linked to Alzheimer's Across GenerationsExercise, DNA methylation, and Alzheimer's disease: Mechanistic links and future directions in intergenerational research.

🥈 Top 2% JournalArticle

3 weeks ago • International immunopharmacology

How Aging of the Immune System Relates to Rheumatoid Arthritis and Its TreatmentThe role of immune aging in rheumatoid arthritis and its clinical and therapeutic significance.

Article

3 weeks ago • Progress in neurobiology

How a Protein Network Involving Parkin and Cell Cleanup Controls Cell Death in Parkinson's Disease and Possible TreatmentsThe mechanism of the parkin-CMA-NLRP3-PANoptosis signaling axis in Parkinson's disease: From molecular basis to therapeutic strategies.

Article

3 weeks ago • International journal of pharmaceutics: X

Lactoferrin-modified stem cell vesicles help cross the brain barrier and boost gastrodin’s nerve protection in Parkinson’s disease through cell cleanup processesLactoferrin-modified MSC-derived extracellular vesicles facilitate BBB penetration and enhance gastrodin-induced neuroprotection in Parkinson's disease: involvement of mitophagy.

📖 Top 20% JournalArticle

3 weeks ago • Glia

Autophagy in Schwann Cells May Protect Nerve Insulation in a Mouse Model of Krabbe DiseaseSchwann Cell-Specific ATG7-Dependent Autophagy Protects Myelin in a Mouse Model of Krabbe Disease.

🥉 Top 5% JournalArticle

3 weeks ago • Acta diabetologica

The cGAS-STING pathway’s role in memory loss linked to Type 2 diabetes: from sensing damaged cell DNA to brain cell damageThe cGAS-STING signaling axis in Type 2 diabetes-associated cognitive decline: from mitochondrial DNA sensing to neurodegeneration.

Article

3 weeks ago • Aging

Multiple Aging Processes with Epigenetic Control as a Key Limit to Human LifespanThe polycentric aging framework: epigenetic regulation as a dominant lifespan-limiting center in human aging.

📖 Top 20% JournalArticle

3 weeks ago • Ageing research reviews

Cell Aging in Heart Failure with Normal Pumping: Causes and Possible TreatmentsCellular senescence in heart failure with preserved ejection fraction: Mechanisms and therapeutic opportunities.

🥈 Top 2% JournalArticle

3 weeks ago • Biochemical and biophysical research communications

Targeting tau protein acetylation in Alzheimer's disease: how it works, its harmful effects, and possible treatments from plant-based compoundsTargeting tau acetylation in Alzheimer's disease: Molecular mechanisms, pathological consequences, and therapeutic opportunities of dietary phytochemicals.

📖 Top 30% JournalArticle

3 weeks ago • Diabetes & metabolism journal

Development and Testing of New STK3/4 Blockers That May Help Reduce ObesityDevelopment and Preclinical Evaluation of Novel STK3/4 Inhibitors with Anti-Obesity Potential.

Article

3 weeks ago • Neuroscience

Humanin reduces brain cell aging and keeps nerve signal release stable in mature nerve-like cellsHumanin attenuates neuronal cellular senescence and preserves neurotransmitter release in differentiated PC12 cells.

📖 Top 20% JournalArticle

3 weeks ago • Journal of inherited metabolic disease

Inherited Metabolic Diseases and the Role of Selective Cell RecyclingRevisiting Inherited Metabolic Diseases (IMDs) Through the Lens of Selective Autophagy.

📖 Top 20% JournalArticle

3 weeks ago • Ecotoxicology and environmental safety

Possible ways the chemical DEHP may cause bone loss, shown by combining network analysis and lab testsElucidation of the potential mechanisms of di-2-ethylhexyl phthalate (DEHP)-associated osteoporosis by integrating network toxicology and in vitro validation.

🎖️ Top 10% JournalArticle

3 weeks ago • Renal failure

Faster Biological Aging Linked to Progression of Heart, Kidney, and Metabolic Problems in UK and US PopulationsBiological age acceleration and cardiovascular-kidney-metabolic syndrome progression: evidence from UK Biobank and NHANES.

📖 Top 30% JournalArticle

3 weeks ago • Molecular biology reports

Oxidized mitochondrial DNA as a possible marker and cause of disrupted cell cleanup in pulmonary arterial hypertensionOxidized mitochondrial DNA as a potential biomarker and mechanistic driver of autophagy-mitophagy dysregulation in pulmonary arterial hypertension: a narrative review.

📖 Top 30% JournalArticle

3 weeks ago • Stem cells (Dayton, Ohio)

Senescent Bone Cell Signals Linked to Localized Tissue Changes and Stiffness in Human Brain ModelsParacrine Bone-Derived Senescent Secretome is Associated with Spatially Patterned ECM Remodeling and Altered Biomechanics in Human Brain Organoids.

📖 Top 20% JournalArticle

3 weeks ago • Epilepsia

Detailed gene and protein patterns in epilepsy linked to mTOR systemComprehensive transcriptomic and proteomic profiling of mTOR-related epilepsy.

Article

3 weeks ago • Exploration (Beijing, China)

Bazi Bushen Formula may reverse chronic stress-related aging and inflammation by activating energy and cell maintenance pathways and renewing immune cellsReversal of Chronic Stress-Induced Inflammaging by Bazi Bushen Formula Through AMPK-Sirtuins Axis Activation and Myeloid Reset.

🥈 Top 2% JournalArticle

3 weeks ago • Skin pharmacology and physiology

Using a Yeast Protein Extract to Activate SIRT6 and Improve Skin Aging by Targeting Key Aging ProcessesActivation of SIRT6 Using a Hydrolyzed Yeast Protein Extract to Enhance Skin Longevity by Targeting Multiple Hallmarks of Aging.

📖 Top 30% JournalArticle

3 weeks ago • Toxicology mechanisms and methods

Metformin partly reduces nerve cell aging caused by cisplatin but does not stop increased sensitivity in rat peripheral nervesMetformin Partially Modulates Cisplatin-Induced Neuronal Senescence but Does Not Prevent Rat Peripheral Sensory Hypersensitivity.

📖 Top 30% JournalArticle

← prevpage 12 of 16next →

Latest Longevity & Aging Research Papers