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3 weeks ago • Circulation research

Removal of damaged mitochondria helps maintain protein balance in cells to protect heart functionMitophagy Facilitates Cytosolic Proteostasis to Preserve Cardiac Function.

🥇 Top 1% JournalArticle

3 weeks ago • Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Lanthionine Ketenamine Derivative May Improve Early Muscle Recovery After Blood Flow Injury by Regulating Cell Cleanup and StressLanthionine Ketenamine Derivative Enhances Early Functional Recovery Following Skeletal Muscle Ischemia-Reperfusion Injury Through Modulation of Autophagy and Oxidative Stress.

Article

3 weeks ago • Functional & integrative genomics

Key genes linked to cell aging and tissue changes in muscle loss identified by combined gene analysisIntegrated bulk and single-cell transcriptomic analyses identify senescence-related hub genes and microenvironmental remodeling in sarcopenia.

📖 Top 30% JournalArticle

3 weeks ago • Biogerontology

An important aging topic: connecting aging science with the publicAn aging essential 8: closing the gap between geroscience and the public it serves.

📖 Top 20% JournalArticle

3 weeks ago • Biochimica et biophysica acta. Molecular basis of disease

Rapamycin may reduce age-related changes and irregular heartbeat in the heart by improving metabolism controlled by HIF-1αRapamycin attenuates age-related atrial remodeling and fibrillation by targeting HIF-1α-mediated metabolic dysregulation.

Article

3 weeks ago • Nature aging

A probiotic and its active compound may reduce age-related inflammation to improve healthy agingA geroprotective probiotic and its functional metabolite counteract inflammaging to extend healthspan.

🥇 Top 1% JournalArticle

3 weeks ago • Biogerontology

How gut bacteria may influence aging: molecular clues from a tiny wormAging regulation by gut microbiota: molecular insights from Caenorhabditis elegans.

📖 Top 20% JournalArticle

3 weeks ago • Biochemical and biophysical research communications

Fibroblast activation protein promotes heart support cell activity linked to reduced cell cleanupFibroblast activation protein (FAP) promotes cardiac fibroblast activation in association with impaired ER-phagy.

📖 Top 30% JournalArticle

3 weeks ago • Acta neuropathologica communications

Lower small blood vessel coverage connects low-oxygen areas to microglia recycling problems in Parkinson's diseaseReduced microvascular coverage links a hypoxia-associated niche to microglial autophagic dysfunction in Parkinson's disease.

🥉 Top 5% JournalArticle

3 weeks ago • BMC medicine

JP1 peptide may reduce cell damage and support cell cleanup systems through antioxidant pathways in ALS model miceJP1 peptide modulates oxidative stress and autophagy via Keap1-Nrf2-ARE in ALS model mice.

🥉 Top 5% JournalArticle

3 weeks ago • Journal of inherited metabolic disease

A Modern Classification of Inherited Lysosomal Diseases Based on Their Underlying CausesA Contemporary Pathomechanistic Nosology of Inherited Lysosomal Disorders.

📖 Top 20% JournalArticle

3 weeks ago • Drug design, development and therapy

Remimazolam May Reduce Brain Injury After Trauma by Boosting Mitochondrial Cleanup and Lowering Cell Inflammation in Brain Immune CellsRemimazolam Attenuates Neurological Injury After TBI: A Potential Role of α7nAChR-Associated Mitophagy Enhancement and Pyroptosis Suppression in BV2 Cells.

📖 Top 20% JournalArticle

3 weeks ago • Protein & cell

LMNA R527C mutation may cause a premature aging syndrome with inflammation by activating DNA detection pathwaysLMNA R527C pathogenic variant causes an inflammation-driven segmental progeroid syndrome via triggering DNA-sensing pathways.

🥇 Top 1% JournalArticle

3 weeks ago • Neuroscience

Resveratrol improves liver failure-related thinking and movement problems in rats by affecting brain glutamate signalingSIRT1 activator resveratrol improves the ALF-induced cognitive and motor function deficits in rats via modulating glutamate-NMDAR-NOS-cGMP pathway.

📖 Top 20% JournalArticle

3 weeks ago • Aging

Blocking insulin signaling in worms greatly extends male lifespan and improves late-life reproductive healthDisruption of the insulin/IGF-1 signaling pathway in Caenorhabditis elegans dramatically increases male longevity and enhances reproductive health late in life.

📖 Top 20% JournalArticle

3 weeks ago • Archives of pharmacal research

Plant-based anti-inflammatory compounds from medicinal herbs linked to aging-related inflammation for healthy agingAnti-inflammatory phytochemicals from medicinal herbs based on senoinflammation schema for healthy aging.

🎖️ Top 10% JournalArticle

3 weeks ago • The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry

Roles and Location of NMNAT2 in Controlled Nerve Fiber BreakdownNMNAT2 Functional Landscape and Localization in Programmed Axon Degeneration.

🎖️ Top 10% JournalArticle

3 weeks ago • The Journal of dermatology

Resveratrol May Reduce Age-Related Skin Thinning in Mice by Activating SIRT1SIRT1 Activator Resveratrol Attenuates Age-Related Skin Thinning in Mice.

📖 Top 20% JournalArticle

3 weeks ago • Journal of ethnopharmacology

Herbal combination of Gastrodia elata and Acorus tatarinowii reduces seizures and brain damage in epilepsy rats by affecting cell cleanup and inflammation pathwaysGastrodia elata Blume-Acorus tatarinowii Schott herb pair alleviates seizures and hippocampal injury in TLE rats with alterations in mitophagy and NLRP3 inflammasome pathways.

📖 Top 20% JournalArticle

3 weeks ago • Tissue barriers

Understanding the complex biological processes of skin aging and new methods for diagnosis and treatmentDecoding the multidimensional landscape of skin aging: molecular pathways and next-generation diagnostics & therapeutics.

🎖️ Top 10% JournalArticle

3 weeks ago • Chemical communications (Cambridge, England)

Label-free imaging shows higher water content and stiffness in cell nuclei during agingMultimodal label-free imaging reveals increased nuclear hydration and apparent stiffening during cellular senescence.

📖 Top 20% JournalArticle

3 weeks ago • International journal of ophthalmology

Glucocorticoids may cause damage to retinal pigment cells linked to too much cell recycling and energy control signalsGlucocorticoid-induced RPE injury in ARPE-19 cells: association with excessive autophagy and AMPK/mTOR signaling.

📖 Top 50% JournalArticle

3 weeks ago • Nature neuroscience

How the brain’s cell-cleaning process helps maintain balance and relates to diseaseRoles of autophagy in brain homeostasis and disease.

🥇 Top 1% JournalArticle

3 weeks ago • The EMBO journal

Losing Erbin in kidney tubule cells makes mice more vulnerable to sudden kidney damage and worsens scarringLoss of Erbin in tubular epithelial cells sensitizes mice to acute kidney injury and aggravates renal fibrosis.

🥇 Top 1% JournalArticle

3 weeks ago • International journal of general medicine

New Molecular Signs for Early Detection and Prevention of Age-Related Hearing LossPrecision Diagnostics in Age-Related Hearing Loss: Emerging Molecular Biomarkers for Early Detection and Targeted Prevention.

Article

3 weeks ago • International journal of chronic obstructive pulmonary disease

Biological age linked to risk of death from any cause in COPD patientsPredictive Value of Biological Age for All-Cause Mortality in Patients with COPD.

Comparative Study

3 weeks ago • Journal of ethnopharmacology

Qinghuang Powder May Improve Cell Aging and Energy Problems in Bone Marrow Stem Cells of Myelodysplastic SyndromesQinghuang powder ameliorates cellular senescence and energy metabolism abnormalities in bone marrow mesenchymal stem cells of myelodysplastic syndromes.

📖 Top 20% JournalArticle

3 weeks ago • Biochimica et biophysica acta. Molecular basis of disease

Mfn2-linked mitochondrial problems may cause kidney scarring by triggering cell death in chronic kidney diseaseMfn2-related mitochondrial dysfunction regulates renal fibrosis through ferroptosis in chronic kidney disease.

Article

3 weeks ago • Cellular signalling

Mitochondria-linked processes in lung blood pressure disease: From changes in cell metabolism to blood vessel and heart damageMitochondria-centered signalling in pulmonary hypertension: From metabolic reprogramming to vascular remodeling and right ventricular failure.

📖 Top 20% JournalArticle

3 weeks ago • International journal of biological macromolecules

Protein phosphatase 2A controls cell recycling in spinal disc center and may worsen damage through the AKT/mTOR pathwayProtein phosphatase 2A regulates nucleus pulposus autophagy and aggravates degeneration via the AKT/mTOR pathway.

📖 Top 20% JournalArticle

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