OpenScience.ink

3 weeks ago • Acta pharmacologica Sinica

Lack of RNF10 in heart muscle cells weakens mitochondrial cleanup and leads to harmful heart enlargementRNF10 deficiency in cardiomyocytes impairs mitophagy and drives pathological hypertrophy.

🥉 Top 5% Journal

3 weeks ago • Molecular biology of the cell

Removal and release of alpha-synuclein through RTN3L-controlled cell cleanup processClearance and secretion of α-synuclein by RTN3L-mediated endoplasmic reticulum autophagy.

📖 Top 20% Journal

3 weeks ago • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Chemical exposure worsens amyloid-beta toxicity in Alzheimer's model worms through impaired cell cleanup and increased oxidative stressDi(2-ethylhexyl) phthalate exposure aggravates amyloid-beta-induced toxicity in transgenic AD Caenorhabditis elegans via lysosomal dysfunction and oxidative stress.

3 weeks ago • NPJ science of food

Differences in biological aging linked to instant versus filtered coffee in UK Biobank dataDiscrepancies between instant and filtered coffee in biological aging: evidence from the UK Biobank.

📖 Top 20% Journal

3 weeks ago • ACS applied materials & interfaces

Using a Tiny Enzyme Carrier with Resveratrol to Treat Osteoarthritis by Regulating Cell Signaling and Joint EnvironmentNanozyme Loaded with Resveratrol for Osteoarthritis Therapy via Wnt/β-Catenin Pathway and Microenvironment Regulation.

🎖️ Top 10% Journal

3 weeks ago • Nature communications

The SIRT5-SUCLG2 interaction slows ovarian aging through mitochondrial and gene regulationThe SIRT5-SUCLG2 desuccinylation axis delays ovarian aging via a mitochondrial-epigenetic regulatory mechanism.

🥈 Top 2% Journal

3 weeks ago • Acta biomaterialia

Exact methods to remove aging cells to fight aging and related diseasesPrecise strategies for targeted elimination of senescent cells to combat aging and age-related diseases.

🥉 Top 5% Journal

3 weeks ago • Nature communications

Cellular features and aging signs in the human lung tissueCellular hallmarks and aging clock of the human lung parenchyma.

🥈 Top 2% Journal

3 weeks ago • Neuropharmacology

Enavogliflozin improves movement problems in Parkinson's disease mice by reducing cell damage and brain inflammation and activating protective cell pathwaysEnavogliflozin alleviates motor deficits in rotenone-induced Parkinson's disease mice via attenuation of oxidative stress and neuroinflammation as well as activation of the SIRT1/PINK1/Parkin pathway.

🎖️ Top 10% Journal

3 weeks ago • Cardiovascular toxicology

Welding Metals Linked to Heart Disease Risk in Male Welders Through Faster Biological AgingAssociations Between Welding-Related Metals and Atherosclerotic Cardiovascular Disease Risk in Male Welders: The Mediating Role of Accelerated Biological Aging.

📖 Top 30% Journal

3 weeks ago • Nanomedicine : nanotechnology, biology, and medicine

Nanoceria particles protect mitochondria to reduce oxidative damage in light-related eye cell lossMitochondrial preservation underlies the antioxidant activity of nanoceria particles in light-induced retinal degeneration.

📖 Top 20% Journal

3 weeks ago • Cell death discovery

Piceatannol as a safe treatment to reduce aging signs in mice after radiationPiceatannol as a safe senotherapeutic: ameliorating senescence-associated markers in a radiation-induced murine model.

🥉 Top 5% Journal

3 weeks ago • GeroScience

Faster biological aging linked to muscle aging signs in young and middle-aged adultsAssociation of biological age acceleration with muscle aging phenotype in young and middle-aged adults: a prospective cohort study.

🎖️ Top 10% Journal

3 weeks ago • Autophagy reports

New roles of the Arp2/3 complex and WHAMM in cell cleanup and recycling systemsDamage control: new functions for the Arp2/3 complex and WHAMM in autophagy and lysosomal homeostasis.

3 weeks ago • Cellular and molecular life sciences : CMLS

Chaperone-Mediated Cell Cleanup Controls Notch Signaling and Neural Stem Cell DevelopmentLAMP2A-dependent chaperone mediated autophagy regulates Notch signaling and controls neural stem cell differentiation.

🥉 Top 5% Journal

3 weeks ago • Cell proliferation

Integrin Beta-1 helps stabilize cell structure to reduce stress-induced cell death and disc degeneration by supporting mitochondrial cleanupItgb1-Mediated Stabilization of Vimentin Alleviates Excessive Mechanical Stress-Induced Nucleus Pulposus Cell Pyroptosis and Intervertebral Disc Degeneration via PINK1-Parkin-Dependent Mitophagy.

🥉 Top 5% Journal

3 weeks ago • Ageing research reviews

A Collection of Blood Markers for Aging in Humans: Understanding Their Role in Health and How Treatments May Change ThemA Compendium of Circulating Biomarkers of Senescence in Humans: Insights on Mechanistic Impact Across Health Domains and Modulation by Therapeutic Interventions.

🥈 Top 2% Journal

3 weeks ago • Translational research : the journal of laboratory and clinical medicine

How Physical Forces Affect Aging and Possible TreatmentsMechanical Signals in Aging: Mechanisms and Therapeutic Strategies.

🥉 Top 5% Journal

3 weeks ago • Free radical biology & medicine

Resveratrol Slows Aging in Young but Speeds Aging in Middle-Aged C. elegans through a Key Aging-Related PathwayResveratrol exerts anti-aging effects in young but pro-aging effects in middle-aged C. elegans via a gerosuppressive daf-16/dod-6/sod-3 axis.

🥉 Top 5% Journal

3 weeks ago • Nature communications

Citrulline increases age-related fat buildup linked to healthy agingCitrulline drives age-related lipid deposition for healthspan.

🥈 Top 2% Journal

3 weeks ago • Journal of neuroinflammation

Microglial removal of damaged mitochondria as an immune and metabolic control point in Alzheimer's disease linking cell energy quality to brain inflammationMicroglial mitophagy as an immunometabolic checkpoint in alzheimer's disease: linking mitochondrial quality control to neuroinflammation.

🥉 Top 5% Journal

3 weeks ago • Genes & development

SMARCAL1 as a potential treatment target for tumors using alternative lengthening of telomeresSMARCAL1 is a candidate therapeutic target for ALT-positive tumors.

3 weeks ago • International immunopharmacology

Grx may reduce diabetic cataracts by boosting cell cleaning through a specific energy and recycling pathway in lens cellsGrx attenuates diabetes cataract by activating AMPK/BNIP3/BNIP3L-mediated mitophagy in lens epithelial cells.

3 weeks ago • European journal of pharmacology

Glucosamine may help improve alcoholic liver disease and slow liver aging by activating energy-regulating pathwaysDrug repurposing of Glucosamine to ameliorate alcoholic liver disease and delay liver aging through activation of AMPK signaling pathway.

📖 Top 20% Journal

3 weeks ago • Mechanisms of ageing and development

How ABO Blood Types Are Linked to Aging-Related Health OutcomesABO blood groups and ageing-related outcomes: Insights from a narrative review.

3 weeks ago • Biochimica et biophysica acta. Molecular basis of disease

Neuroglobin lowers stress-related cell damage and amyloid buildup in 3D human nerve cell culturesNeuroglobin reduces stress-induced oxidative damage and amyloid burden in a three-dimensional human neuroblastoma cell culture.

3 weeks ago • Biochemical and biophysical research communications

Ergothioneine reduces age-related weakening of daily body rhythmsErgothioneine attenuates age-related declines in circadian rhythmicity.

📖 Top 30% Journal

3 weeks ago • Neurobiology of disease

Noise exposure triggers immune response in the brain and affects thinking abilities depending on context in rats with long-term hearing lossNoise exposure induces microglial reactivity and context-dependent cognitive vulnerability in chronic noise-induced hearing loss rats.

3 weeks ago • Nature structural & molecular biology

CST complex helps copy the second DNA strand during break-induced replicationCST complex promotes second-strand synthesis in break-induced replication.

🥇 Top 1% Journal

3 weeks ago • The FEBS journal

Fighting Aging by Maintaining Protein Balance Outside CellsCombating ageing beyond the cell: Emerging roles of extracellular proteostasis.

🥉 Top 5% Journal

← prevpage 13 of 18next →

Latest Longevity & Aging Research Papers