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3 weeks ago • Journal of neurochemistry

Balance of Synapse Maintenance in Health and IllnessSynaptic Proteostasis in Health and Disease.

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3 weeks ago • Journal of cellular physiology

Sestrin1 Reduces Aging Signs and Helps Exercise Protect the Liver in MiceSestrin1 Ameliorates Senescence and Mediates the Protective Effects of Exercise Against Hepatic Abnormality in C57BL/6J Mice.

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3 weeks ago • Phytotherapy research : PTR

Epigallocatechin-3-Gallate may protect mice from fructose-related fatty liver by controlling cell death and recycling through SIRT5Protective Effect of Epigallocatechin-3-Gallate Against Fructose-Induced Metabolic Associated Fatty Liver Disease in Mice by Regulating Ferroptosis and Autophagy via SIRT5.

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3 weeks ago • Nutrition (Burbank, Los Angeles County, Calif.)

Metabolism problems in long-term critical illness: causes, effects, and possible treatmentsMetabolic dysfunction in chronic critical illness: mechanisms, clinical consequences and therapeutic perspectives.

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3 weeks ago • PLoS biology

The protein RBBP5 controls gene regulation that affects protein balance in cellsThe histone methyltransferase complex subunit RBBP5 serves as a central epigenetic regulator of proteostasis dynamics.

🥉 Top 5% JournalArticle

3 weeks ago • Ageing research reviews

Using Mini-Organs to Study Cell Aging and Age-Related Diseases from Lab Models to Practical UsesOrganoids for modeling cellular senescence and age-related pathology: From experimental reconstruction to mechanistic and translational applications.

🥈 Top 2% JournalArticle

3 weeks ago • PLoS genetics

Stable DNA packaging protects mitochondrial balance and limits TORC1 cell signalingChromatin stability safeguards mitochondrial homeostasis and restrains TORC1 signaling.

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3 weeks ago • Cell chemical biology

Blocking BRD4-BD1-p62 interaction may restore protective cell cleaning processDisrupting BRD4-BD1-p62 engagement restores protective autophagy.

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3 weeks ago • JAMA

Nicotinamide Riboside Treatment in Early Parkinson’s Disease: A Randomized Clinical TrialNicotinamide Riboside for Patients With Early-Stage Parkinson Disease: The NOPARK Randomized Clinical Trial.

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3 weeks ago • PLoS genetics

Lack of ZBED6 causes harmful heart enlargement by disrupting cell cleaning through the MEOX1-ERK1/2 pathwayZBED6 deficiency drives pathological cardiac hypertrophy through MEOX1-ERK1/2-dependent autophagy dysfunction.

🥉 Top 5% JournalArticle

3 weeks ago • Science (New York, N.Y.)

Changes in gene regulation and DNA elements linked to shorter lifespans in larger dogsEpigenetic aging and transposon dysregulation reflect size-related lifespan compression in dogs.

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3 weeks ago • Journal of Parkinson's disease

Overview of immune cells in the blood of people with Parkinson’s diseaseProfiling peripheral immune cells in Parkinson's disease: A scoping review.

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3 weeks ago • Free radical biology & medicine

Phosphodiesterase 4 inhibitors may extend worm lifespan and reduce cell aging in mouse cellsPhosphodiesterase 4 inhibitors extend lifespan of C. elegans and attenuate cellular senescence of mouse embryonic fibroblasts.

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3 weeks ago • Experimental gerontology

Combined delivery of engineered molecules reverses aging in mesenchymal stem cellsSynergistic reversal of mesenchymal stem cell senescence by engineered exosomal delivery of a dual miR-195/miR-188 sponge.

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3 weeks ago • Mitochondrion

Purine levels affect survival of cells lacking energy complex I when relying on oxidative energy productionPurine availability determines survival of complex I-deficient fibroblasts under OXPHOS-reliant condition.

📖 Top 20% JournalArticle

3 weeks ago • Nanomedicine : nanotechnology, biology, and medicine

Combined microRNA and resveratrol treatment targeting cell regulators reverses obesity in high-fat diet miceSynergistic prohibitin-targeted microRNA-resveratrol nanotherapy effectively reverses obesity in high-fat obese mice.

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3 weeks ago • Autophagy reports

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3 weeks ago • Drug delivery

New niosome method for effective gene delivery in aging umbilical cord stem cellsInnovative niosome screening for efficient gene delivery in senescent primary umbilical cord stroma-derived MSCs.

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4 weeks ago • Experimental & molecular medicine

Macrophage cell death may cause aging and cell changes in prostate growth treated with 5α-reductase inhibitorsMacrophage pyroptosis drives luminal senescence and club-cell reprogramming in 5α-reductase inhibitor-treated prostatic hyperplasia.

🥈 Top 2% JournalArticle

4 weeks ago • GeroScience

How Calorie Restriction Changes Aging-Related Damage and Protein Repair in the Brain and BodyAgainst the "extend healthspan but not lifespan" cliché.

🎖️ Top 10% JournalArticle

4 weeks ago • Signal transduction and targeted therapy

Phospholipid phosphatase 2 supports liver healing and regrowth after sudden liver damagePhospholipid phosphatase 2 drives liver repair and regeneration after acute liver injury.

🥇 Top 1% JournalArticle

4 weeks ago • Journal of biochemical and molecular toxicology

Kidney Tubular Cell Aging Caused by 1-Aminopyrene May Activate Fibroblasts Through BRD4-Linked Aging-Related SignalsRenal Tubular Epithelial Cells Senescence Induced by 1-Aminopyrene Activates Fibroblast via BRD4 Driven Senescence-Associated Secretory Phenotype Signaling.

📖 Top 30% JournalArticle

4 weeks ago • Molecular biology reports

Mitochondria problems in kidney tubule cells linked to scarring and tissue changes in chronic kidney diseaseMitochondrial dysfunction of renal tubular epithelial cells in chronic kidney disease-associated fibrosis: from organelle homeostasis to multicellular remodeling.

📖 Top 30% JournalArticle

4 weeks ago • Aging cell

Long-Term Senolytic Treatment and Aerobic Exercise Reduce Cell Aging and Improve Heart Function in Older AdultsChronic Senolytic Treatment and/or Aerobic Exercise Reduce Senescence and Improve Myocardial Function During Aging in the Heart.

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4 weeks ago • Autophagy

Selective cell cleaning processes preserved across evolutionEvolutionarily conserved selective autophagy pathways.

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4 weeks ago • Molecular neurobiology

Urolithin D Improves Thinking and Behavior in Aging Mice by Helping Cells Clear Damaged Mitochondria Through Energy and Survival PathwaysEllagitannin Metabolite Urolithin D Ameliorates Cognitive Function and Behavioral Performance in Aging Mice Partially via AMPK/PGC-1α/SIRT3-Dependent Regulation of Mitophagy-Related Molecular Machinery.

🎖️ Top 10% JournalArticle

4 weeks ago • Brain : a journal of neurology

Mitochondrial DNA damage may increase PINK1 levels in movement-related brain neurons in Parkinson's diseaseMitochondrial DNA damage elicits PINK1 upregulation in pontine cholinergic neurons in Parkinson's disease.

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4 weeks ago • Ageing research reviews

Could drugs targeting aged cells help treat giant cell arteritis?Is there a role for senotherapeutics in the treatment of giant cell arteritis?

🥈 Top 2% JournalArticle

4 weeks ago • Brain pathology (Zurich, Switzerland)

Muscle control differences in infant and adult Pompe patients revealed by combined molecular and structural analysisIdentifying regulatory muscle processes in infantile and adult Pompe patients using a multi-omic and morphological approach.

🥉 Top 5% JournalArticle

4 weeks ago • Ageing research reviews

Nanoparticle therapies targeting aging cells for healthier aging: design ideas, evidence, and challengesNanoparticle-based senolytic and senomorphic therapies for healthy aging: design principles, translational evidence, and challenges.

🥈 Top 2% JournalArticle

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