OpenScience.ink

3 weeks ago • Cureus

Nicotinamide Mononucleotide (NMN) May Prevent Age-Related Gene Changes Differently Across Tissues Through Protein Transport and Fatty Acid BreakdownNicotinamide Mononucleotide (NMN) Prevents Age-Associated Transcriptional Drift in a Tissue-Dependent Manner: Mechanistic Leads From Ras-Related Protein Rab-11A-Mediated Trafficking and Carnitine Palmitoyltransferase 2-Linked Fatty Acid Oxidation.

Article

3 weeks ago • Ageing research reviews

The Grandmother Hypothesis and How Heart and Blood Vessel Aging Relate to ItThe Grandmother Hypothesis: A perspective from cardiovascular aging.

🥈 Top 2% JournalArticle

3 weeks ago • Food research international (Ottawa, Ont.)

Gut bacteria-produced short-chain fatty acids help the anti-aging effects of a plant fiber by regulating immune cells in the intestines of miceGut microbiota-derived SCFAs mediate the intestinal anti-aging effect of structurally characterized Dendrobium officinale glucomannan via Treg immune regulation in mice.

🎖️ Top 10% JournalArticle

3 weeks ago • The Journal of biological chemistry

How ERα and SIRT1 signals help pterostilbene improve metabolismERα/SIRT1 signaling mediates the metabolic regulatory benefits of pterostilbene.

🎖️ Top 10% JournalArticle

3 weeks ago • Food & function

Resveratrol from food helps several generations of C. elegans resist infection through p38 MAPK and DAF-16 pathwaysFood-derived resveratrol confers multigenerational host defense against PA14 via p38 MAPK and DAF-16 signaling in C. elegans.

📖 Top 20% JournalArticle

3 weeks ago • Autophagy

A signaling network linked to cell structure growth connects extra centrosomes with cell cleaning processesConnecting the dots: a centrosome-associated RAC1 signaling network links centrosome amplification with autophagy.

🥈 Top 2% JournalArticle

3 weeks ago • Open life sciences

How SIRT1 helps protect blood vessels from aging caused by stressProtective effect and mechanism of SIRT1 under stress-induced vascular senescence.

📖 Top 50% JournalArticle

3 weeks ago • Mechanisms of ageing and development

Body’s balance problems and internal clocks from a distance-based viewHomeostatic dysregulation and clocks: a distance-based perspective.

Article

3 weeks ago • Basic & clinical pharmacology & toxicology

Low-dose fisetin supplements and their link to long-term inflammation in middle-aged and older adultsLow-Dose Fisetin Supplementation and Its Association With Chronic Inflammation in Middle-Aged and Older Adults: Study Protocol for a Triple-Blind, Randomised, Placebo-Controlled Trial.

Randomized Controlled Trial

3 weeks ago • Metabolism open

Gene activity and genetics point to EHHADH in a FUNDC1-linked mitochondrial system in diabetic kidney diseaseTranscriptomic and genetic evidence highlights EHHADH in a FUNDC1-associated mitochondrial network in diabetic nephropathy.

Article

4 weeks ago • Biochemical and biophysical research communications

Low levels of a key receptor weaken the brain's protective barrier and speed up cell aging in the memory areaLow expression of PDGFR-β impairs the blood-brain barrier and accelerates cellular aging in the hippocampal region.

📖 Top 30% JournalArticle

4 weeks ago • Translational stroke research

MCC950, an NLRP3 inhibitor, may improve stroke recovery in aging miceTherapeutic Potential of NLRP3 Inhibitor MCC950 in Aging Mice Stroke Outcomes.

🎖️ Top 10% JournalArticle

4 weeks ago • Current obesity reports

🥉 Top 5% JournalArticle

4 weeks ago • GeroScience

Using biological aging measures in healthcare to improve personalized long-term healthIntegrating biological aging into clinical practice: a review and path forward for precision longevity medicine.

🎖️ Top 10% JournalArticle

4 weeks ago • Mechanisms of ageing and development

DNA Methylation Clock Reveals Immune and Metabolic Aging Patterns Linked to MortalityEnsemble DNA methylation clock demonstrates Immune-metabolic aging signatures associated with mortality.

Article

4 weeks ago • Biochemical pharmacology

Changing the brain's innate immune memory in Alzheimer's disease: From immune cell activation to treatment resistanceImmunopharmacological reprogramming of innate immune memory in Alzheimer's disease: From microglial priming to therapeutic resilience.

Article

4 weeks ago • Ageing research reviews

Elastin Fragments May Promote Aging by Activating the Immune SystemThe Dark Side of the Matrix: Elastin-Derived Fragments Drive Aging by Igniting the Immune System.

🥈 Top 2% JournalArticle

4 weeks ago • Ageing research reviews

How Aging Muscle Limits Cell Therapy: Cell Types, Tissue Environment Problems, and Self-Donor OptionsAgeing of the skeletal muscle as a barrier to cell therapy: Cell sources, microenvironmental failure and autologous alternatives.

🥈 Top 2% JournalArticle

4 weeks ago • Life sciences

Loss of bves causes heart pumping problems and heart muscle energy damage in zebrafishLoss of bves leads to cardiac contractile dysfunction and myocardial mitochondrial damage in zebrafish.

Article

4 weeks ago • Ageing research reviews

Exercise and p21 Signaling in Brain Aging and Cell Aging: Effects Depend on Context and AmountExercise and p21 signaling in central nervous system aging and senescence: A context- and dose-dependent relationship.

🥈 Top 2% JournalArticle

4 weeks ago • Ageing research reviews

How Traditional Chinese Medicine May Slow Blood Vessel Aging at the Cell and Molecular LevelCounteracting vascular ageing with Traditional Chinese Medicine: Mechanisms at the cellular and molecular levels.

🥈 Top 2% JournalArticle

4 weeks ago • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Understanding and Managing the Combined Loss of Bone and MuscleOsteosarcopenia Revisited: From Mechanisms to Management.

Article

4 weeks ago • Nature medicine

How aging biomarkers respond to life-extending treatments in peopleResponsiveness of epigenetic aging biomarkers to longevity interventions in humans.

Article

4 weeks ago • Aging cell

LivAge: An Online Tool to Estimate Mouse Age from Gene ActivityLivAge: An Online Aging Clock for Murine Transcriptomic Age Estimation.

🥉 Top 5% JournalArticle

4 weeks ago • Research (Washington, D.C.)

Overactive PDHA1 Changes Cell Metabolism to Promote Aging in Blood Vessel CellsPDHA1 Hyperactivation Orchestrates Metabolic Reprogramming Promoting Endothelial Senescence.

🥉 Top 5% JournalArticle

4 weeks ago • Redox biology

Changes in blood NAD and glutathione levels in health, disease, aging, and with NAD-boosting treatmentDynamics of blood NAD and glutathione in health, disease, aging, and under NAD+-booster treatment.

🥈 Top 2% JournalArticle

4 weeks ago • Journal of translational medicine

Pirfenidone may improve metabolic hormones and heart cell cleanup through p-AMPK in fatty liver-related heart diseasePirfenidone restores metabolic hormones and cardiac autophagy via p-AMPK in MASH.

🥉 Top 5% JournalResearch Support, Non-U.S. Gov't

4 weeks ago • Autophagy

Loss of BECN1 changes what B cells target and how they present antigens without stopping autophagosome formationLoss of BECN1 does not compromise autophagosome formation but alters cargo selection and HLA-restricted antigen presentation of B cells.

🥈 Top 2% JournalArticle

4 weeks ago • Molecular biology reports

Icaritin may improve pregnancy chances in endometriosis by stopping aging in key ovarian cellsIcaritin improves pregnancy outcomes in endometriosis by inhibiting ovarian granulosa cell senescence.

📖 Top 30% JournalArticle

4 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

How USP30 Prevents Cell Clean-Up to Cause Kidney Tube Damage in DiabetesUSP30-Mediated Deubiquitination of PEX5 Suppresses Pexophagy to Drive Tubular Injury in Diabetic Kidney Disease.

🥈 Top 2% JournalArticle

← prevpage 14 of 16next →

Latest Longevity & Aging Research Papers