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3 weeks ago • Journal of controlled release : official journal of the Controlled Release Society

Improving insulin sensitivity by lowering fat cell aging with targeted nanoparticles in obese mice on a high-fat dietEnhancing insulin sensitivity by reducing adipocyte senescence using uPAR-targeted nanoparticles in high-fat-diet-induced obese mice.

3 weeks ago • Acta diabetologica

Using single-cell machine learning to find how PINK1-related mitochondrial recycling affects metabolism in type 2 diabetesInterpretable single-cell machine learning identifies PINK1-centred mitophagy as a determinant of metabolic fitness in type 2 diabetes.

3 weeks ago • Environmental toxicology and pharmacology

Antioxidant strength relates to different damage and aging rates in skin and lung cells exposed to workplace-level glyphosateAntioxidant efficiency is associated with differential susceptibility to oxidative damage and senescence progression in dermal and lung fibroblasts exposed to occupationally relevant glyphosate concentrations.

📖 Top 20% Journal

3 weeks ago • Journal of controlled release : official journal of the Controlled Release Society

Using Nanoparticles to Remove Aging Cells in Brain Blood VesselsNanoparticles as an efficient strategy to eliminate senescent brain endothelial cells.

3 weeks ago • Cellular and molecular life sciences : CMLS

How aging and cell aging relate through shared molecular processesCellular senescence and aging: molecular mechanisms and convergent pathways.

🥉 Top 5% Journal

3 weeks ago • JBRA assisted reproduction

Obesity and weight loss have different effects on cell recycling in mouse ovarian support cellsObesity and weight loss differentially regulate autophagy in mouse ovarian granulosa cells.

📖 Top 50% Journal

3 weeks ago • International urology and nephrology

A global analysis of aging cells in kidney diseases and new treatment directionsCellular senescence in kidney diseases: a bibliometric analysis of global trends, knowledge bases, and emerging therapeutic frontiers.

📖 Top 50% Journal

3 weeks ago • The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Understanding the mTOR Pathway in Lung Transplants: Could Biomarkers Guide Personalized Treatment?MAPPING THE MTOR PATHWAY IN LUNG TRANSPLANTATION: IS IT TIME FOR A BIOMARKER-DRIVEN PRECISION THERAPY?

🥉 Top 5% Journal

3 weeks ago • ACS applied materials & interfaces

A Nanoparticle System Carrying Donepezil for Alzheimer's Disease that Boosts Cell Cleanup and Reduces Brain InflammationA Multitarget Nanosystem Loaded with Donepezil for Alzheimer's Disease Treatment by Activating Mitophagy and Reshaping the Inflammatory Microenvironment.

🎖️ Top 10% Journal

3 weeks ago • Biogerontology

Silymarin reduces aging-related increases in brain inflammation, protein buildup, and oxidative stress linked to memory problems in miceSilymarin attenuates senescence-exacerbated amyloidogenesis, neuroinflammation, and oxidative stress in lipopolysaccharide-induced memory impairment in aging mice.

📖 Top 20% Journal

3 weeks ago • Chinese medical journal

Understanding tiny cell particles in age-related long-term lung diseasesInsights into extracellular vesicles in senescence-associated chronic lung diseases.

3 weeks ago • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

PFDA exposure may speed up heart aging and scarring by over-activating the MTORC1 signaling pathwayPFDA exposure promotes myocardial aging and fibrosis via hyperactivation of the MTORC1 signaling axis.

3 weeks ago • The journals of gerontology. Series A, Biological sciences and medical sciences

Tracking Aging Patterns Over Time Using Urine Metabolism Measured by Detailed NMRUrinary Metabolic Age from High-Resolution NMR Reveals Longitudinal Aging Patterns.

3 weeks ago • Neurochemical research

Combined Elamipretide and NMN Treatment May Reduce Brain Damage After Stroke by Targeting TREM2 in MiceElamipretide (SS-31) and Nicotinamide Mononucleotide (NMN) Combination Therapy Targets TREM2 to Mitigate Post-ischemic Brain Injury in Mice.

📖 Top 20% Journal

3 weeks ago • Neurochemical research

A Mix of Four Natural Compounds May Reduce Memory Area Damage and Disease Signs in an Alzheimer's ModelA Combination of Artemisinin, N-acetylcysteine, Resveratrol, and Hesperidin Ameliorates Hippocampal Damage and Pathological Features in an Experimental Model of Alzheimer's Disease.

📖 Top 20% Journal

3 weeks ago • Journal of controlled release : official journal of the Controlled Release Society

Tiny particles from hairyvein agrimony in microneedles kill hidden bacteria and reverse cell aging to heal diabetic foot bone infectionsHairyvein agrimony-derived nanovesicles in microneedles eradicate intracellular bacteria and reverse senescence to heal diabetic foot osteomyelitis.

3 weeks ago • Journal of agricultural and food chemistry

Astragaloside IV May Reduce Long-Term Kidney Damage from Tacrolimus by Controlling a Key Cellular Stress PathwayAstragaloside IV Mitigates Tacrolimus-Induced Chronic Nephrotoxicity by Regulating the mTOR-TFEB-GADD45α Pathway.

📖 Top 20% Journal

3 weeks ago • Journal of biomolecular structure & dynamics

Natural compounds that adjust a protein involved in heart function: a computer simulation studyAllosteric modulation of Drp1 by natural compounds for cardiac therapeutics: a molecular docking and dynamics study.

📖 Top 50% Journal

3 weeks ago • Journal of the science of food and agriculture

Using Caenorhabditis elegans as a model to study aging in food and nutrition researchPractical guideline for applying Caenorhabditis elegans as an aging model in food and nutritional research.

📖 Top 30% Journal

3 weeks ago • International immunopharmacology

Changes in immune and metabolism systems in lung scarring: New treatment targets beyond inflammationImmuno-metabolic reprogramming in pulmonary fibrosis: Emerging therapeutic targets beyond inflammation.

3 weeks ago • Inflammopharmacology

How Tau Protein Affects Cell Structures and Links to Brain DiseasesTau physiology and pathology: impacts on cellular structures and neurodegenerative diseases.

📖 Top 20% Journal

3 weeks ago • Zhongguo zhen jiu = Chinese acupuncture & moxibustion

Eye acupuncture's effects on nerve cell cleanup in damaged brain tissue of rats after blood flow returns, involving energy and recycling signals[Effect of eye acupuncture on mitophagy in neurons of ischemic cortical brain tissue in rats with cerebral ischemia reperfusion injury based on AMPK/ULK1/FUNDC1 signaling axis].

3 weeks ago • Mechanisms of ageing and development

Biological Age and Mortality Risk Estimated from Common Blood Test ResultsBlood Biochemistry Age Clock - an interpretable estimate of biological age and predictor of all-cause-mortality derived from routinely ordered blood biomarkers.

3 weeks ago • Mechanisms of ageing and development

Biological limits to lifespan extension: evidence that control shifts from specific pathways to whole-system protection across speciesBiological limits of lifespan extension: evidence for a shift from pathway leverage to system-level buffering across species.

3 weeks ago • Journal of affective disorders

Trouble Sleeping and Faster Biological Aging Linked to Depressive Symptoms in Three GroupsThe associations of trouble sleeping, biological age acceleration with depressive symptoms: Evidence from three cohorts.

🥉 Top 5% Journal

3 weeks ago • Molecular biology reports

How GABARAPL2 and Alix control cell recycling and communication to maintain cell balanceGABARAPL2 and Alix mediate reciprocal regulation of autophagy and exosome pathways to facilitate cellular homeostasis.

📖 Top 30% Journal

3 weeks ago • Biochemical and biophysical research communications

Creating a lasting human hair follicle skin cell line that can still produce hairGeneration of an immortalized human hair follicle keratinocyte cell line retaining trichogenic potential.

📖 Top 30% Journal

3 weeks ago • Open medicine (Warsaw, Poland)

Sorghum plant compounds may influence aging-related inflammation pathways, shown by computer and lab studiesComputational and experimental evidence supports the modulation of inflammaging-related pathways by Sorghum bicolor 3-deoxyanthocyanidins.

📖 Top 50% Journal

3 weeks ago • Open medicine (Warsaw, Poland)

SMP30 as a potential cancer marker and treatment targetSMP30: a promising cancer biomarker with therapeutic potential.

📖 Top 50% Journal

3 weeks ago • Journal of cachexia, sarcopenia and muscle

A Redox-Sensitive Role of Dnajb5 in Antarctic Fish Muscle Repair Involving mTORC1 and HDAC4Dnajb5 From Antarctic Fish Reveals a Redox-Sensitive Mechanism Coordinating Muscle Regeneration via mTORC1 and HDAC4.

🥈 Top 2% Journal

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