Latest Longevity & Aging Research Papers | Page 15 | OpenScience.ink

4 weeks ago • Microbial physiology

Improving Nicotinamide Mononucleotide Production by Engineering CpNampt Enzyme Mutants in YeastSemi-Rational Design of CpNampt Mutants for Enhanced Nicotinamide Mononucleotide (NMN) Synthesis in Saccharomyces cerevisiae.

📖 Top 20% JournalArticle

4 weeks ago • Cell reports

Mitochondria transfer may protect against hearing loss from cisplatin by activating cell cleanup through fumarateMitochondrial transfer protects against cisplatin-induced hearing loss by fumarate-mediated activation of mitophagy.

🥈 Top 2% JournalArticle

4 weeks ago • Journal of physiology and biochemistry

New processes of non-standard cell self-cleaning without ATG8Emerging mechanisms of ATG8-independent non-canonical autophagy.

📖 Top 20% JournalArticle

4 weeks ago • Journal of cellular biochemistry

Chronic Stress May Worsen Bone Loss in Mice Without Ovaries Showing Anxiety and Depression by Activating Bone Breakdown and Blocking Cell CleanupChronic Stress Exacerbates Osteoporosis in Ovariectomized Mice With Anxiety- and Depression-Like Symptoms by Activating Cathepsin K and Impairing Autophagy.

📖 Top 30% JournalArticle

4 weeks ago • FASEB journal : official publication of the Federation of American Societies for Experimental Biology

SIRT1 Controls the Final Step of Cell Recycling and Mitochondria Cleanup in Heart Muscle CellsSIRT1 Regulates Late Stage of Autophagy and Mitophagy via Autophagosome-Lysosome Fusion in Cardiomyocytes.

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4 weeks ago • Glia

Light Therapy May Improve Alexander Disease by Boosting Cell Cleanup Through Energy RegulationPhotobiomodulation Ameliorates Alexander Disease Through AMPK/mTOR-Mediated Mitophagy.

🥉 Top 5% JournalArticle

4 weeks ago • Biogerontology

Sex differences in immune patterns across dog lifespans and short-term effects of anti-aging treatmentsSex-stratified immune patterns across the canine lifespan and short-term responses to geroprotective interventions.

📖 Top 20% JournalArticle

4 weeks ago • PLoS medicine

An AI-based aging score linked to risk and death prediction in heart, kidney, and metabolic conditionsA machine learning-derived aging index for risk stratification and mortality prediction in cardiovascular-kidney-metabolic syndrome: A retrospective cohort study.

🥈 Top 2% JournalArticle

4 weeks ago • GeroScience

Links between overall aging, frailty, and changes in the retina using combined environmental and metabolic dataAssociation of systemic aging and frailty with retinal alterations: insights from an integrated exposome and metabolome framework.

🎖️ Top 10% JournalArticle

4 weeks ago • Molecular reproduction and development

Jujuboside A may improve polycystic ovary syndrome by boosting cell cleanup in ovarian support cells through SIRT3 and PINK1/Parkin pathwaysJujuboside a Improves Polycystic Ovary Syndrome Through SIRT3-Mediated PINK1/Parkin-Dependent Mitochondrial Autophagy in Ovarian Granulosa Cells.

📖 Top 30% JournalArticle

4 weeks ago • The Journal of clinical investigation

Movement of USP15 between the cell nucleus and cytoplasm promotes harmful cell recycling that disrupts neural stem cell balance and brain developmentNucleocytoplasmic shuttling of USP15 promotes pathological autophagy that disrupts neural stem cell homeostasis and neurodevelopment.

🥈 Top 2% JournalArticle

4 weeks ago • Proceedings of the National Academy of Sciences of the United States of America

Late-onset preeclampsia is linked to faster aging of the placentaLate-onset preeclampsia is characterized by accelerated placental aging.

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4 weeks ago • Regenerative therapy

Stem cell aging limits bone and joint repair in aging: underlying processes and possible treatmentsStem cell senescence as a regenerative bottleneck in age-related skeletal degeneration: Mechanistic crosstalk and translational strategies.

📖 Top 20% JournalArticle

4 weeks ago • Mechanisms of ageing and development

Resveratrol helps liver cells resist aging caused by harmful natural toxinsResveratrol protects primary hepatocytes against senescence induced by endogenous toxic metabolites.

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4 weeks ago • Journal of the Endocrine Society

Angiotensin II and cAMP signals control the creation and function of energy-producing parts in human adrenal gland cellsAngiotensin II and cAMP signaling pathways regulate mitochondrial biogenesis and activity in human adrenocortical cells.

📖 Top 20% JournalArticle

4 weeks ago • Circulation

The Oxidized Lipid PGPC Reduces New Blood Vessel Growth by Blocking Cell Cleanup Fusion Through NPC1-Triggered Changes in Syntaxin 17The Oxidized Phospholipid PGPC Impairs Angiogenesis by Inhibiting Endothelial Autophagosomal-Lysosomal Fusion Through NPC1-Induced Syntaxin 17 Acetylation and Ubiquitination.

🥇 Top 1% JournalArticle

4 weeks ago • Stem cell research & therapy

Potential of aging-targeting treatments for xeroderma pigmentosumSenotherapeutic potential against xeroderma pigmentosum.

🥉 Top 5% JournalArticle

4 weeks ago • Acta neurologica Belgica

Shorter immune cell DNA length as a sign of aging in relapsing-remitting multiple sclerosisShorter Leukocyte telomere length as a marker of biological aging in relapsing-remitting multiple sclerosis.

📖 Top 50% JournalArticle

4 weeks ago • Experimental gerontology

Blood levels of TNF-α, CCL2, and IL-6 are linked to biological aging and specific DNA changes in aging miceCirculating TNF-α, CCL2 and IL-6 are associated with blood-based epigenetic age and targeted CpG methylation signatures in aging mice.

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4 weeks ago • Theriogenology

SIRT2 helps fix damaged mitochondria in older cow egg cells by changing SQSTM1 at a specific siteSIRT2-dependent SQSTM1 decrotonylation at K100 rescues impaired mitophagy in aged bovine oocytes.

📖 Top 30% JournalArticle

4 weeks ago • Aging cell

New Flavonoid Drugs That Target Aging Cells May Reduce Aging Signs and Improve HealthNovel Flavonoid Senotherapeutics Identified by Phenotypic Drug Discovery Reduce Senescence and Improve Multiple Markers of Healthspan.

🥉 Top 5% JournalArticle

4 weeks ago • Small methods

Predicting Cell Aging Caused by Oxidative Stress and Cancer Drugs Using 3D Imaging and Explainable AIPrediction of Oxidative Stress- and Anticancer Drug-Induced Cellular Senescence Using Holotomography and Interpretable Attention-Based Contrastive Learning.

🥉 Top 5% JournalArticle

1 month ago • EMBO reports

TBK1 helps remove clumping-prone TDP-43 protein using an immune pathway in ALS modelsTBK1 eliminates aggregation-prone monomeric TDP-43 through an IFNβ-immunoproteasome pathway in ALS models.

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1 month ago • Nature reviews. Molecular cell biology

Selective Cell Cleanup and Recycling in Health, Disease, and AgingChaperone-mediated autophagy in physiological homeostasis, disease and ageing.

🏆 Top 0.1% JournalArticle

1 month ago • British journal of clinical pharmacology

Treatments that may reverse cell aging: Review of drugs and therapies tested in peopleTherapeutic reversal of cellular senescence: A systematic review of senolytics, senomorphics and anti-ageing therapies in human clinical trials.

📖 Top 20% JournalArticle

1 month ago • Nature aging

Reduced cell cleanup by support proteins in aging weakens immune cell removal of old cellsDecline of chaperone-mediated autophagy in aging impairs macrophage clearance of senescent cells.

🥇 Top 1% JournalArticle

1 month ago • Neurochemical research

Electroacupuncture's effects on inflammation linked to aging-related memory loss: Combined analysis of clinical trialsElectroacupuncture Targeting the NLRP3 Inflammasome in Senescence‑associated Cognitive Impairment: Mechanistic Synthesis and Meta‑analysis of Clinical Randomized Controlled Trials.

📖 Top 20% JournalMeta-Analysis

1 month ago • Best practice & research. Clinical rheumatology

New understanding of how osteoporosis develops and personalized treatment approachesNew insights into the pathogenesis of osteoporosis and the translational approach to personalized therapy.

🎖️ Top 10% JournalArticle

1 month ago • Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association

How Cell Recycling and Gene Regulation in Brain Hunger Centers May Explain Ongoing Obesity and Treatment ChallengesThe Autophagy-Epigenome Axis in Hypothalamic Neurons: A Unified Framework for Understanding Obesity Persistence and Therapeutic Resistance.

📖 Top 50% JournalArticle

1 month ago • Neurobiology of disease

Blood levels of PINK1/Parkin ratio and ATF5 linked to movement problems in Parkinson's diseasePlasma PINK1/Parkin ratio and ATF5 as potential biomarkers associated with dyskinesia in Parkinson's disease.

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