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4 weeks ago • Pharmacological research

Mitochondria-focused control networks in fatty liver disease: linking cell cleanup, organ interactions, and gut-liver communicationMitochondrial-centric regulatory networks in MASLD: Integrating quality control, organelle interactions, and gut-liver communication.

🥉 Top 5% JournalArticle

4 weeks ago • European journal of pharmacology

Early resveratrol exposure causes different blood vessel effects in adult rats: protective in high blood pressure rats but harmful in normal ratsDevelopmental exposure to resveratrol induces context-dependent vascular effects in adult offspring: protection in SHR and adverse remodeling in normotensive rats.

📖 Top 20% JournalArticle

4 weeks ago • GeroScience

Using DNAm PhenoAge as an epigenetic marker to predict risk in adult spinal deformity surgeryExamination of DNAm PhenoAge as an epigenetic biomarker for perioperative risk in adult spinal deformity surgeries.

🎖️ Top 10% JournalArticle

4 weeks ago • Molecular medicine reports

📖 Top 30% JournalArticle

4 weeks ago • Molecular medicine reports

How Cell Recycling Works and Its Treatment Potential in Intestinal Tissue ChangesAutophagy: Mechanisms and therapeutic perspectives in intestinal metaplasia (Review).

📖 Top 30% JournalArticle

4 weeks ago • Experimental eye research

Lycium barbarum polysaccharides may reduce fat buildup and aging caused by a high-fat diet by activating fat recycling in cellsLycium barbarum polysaccharides ameliorates high-fat diet induced lipid accumulation and aging through triggering lipophagy.

📖 Top 20% JournalArticle

4 weeks ago • Ageing research reviews

Lasting effects of aging cells on tissue repair may cause ongoing organ problems in chronic diseaseSenescent repair memory in chronic disease: Failed resolution as a driver of persistent organ dysfunction.

🥈 Top 2% JournalArticle

4 weeks ago • Child development

Peer bullying, feeling accepted at school, and biological aging in children of Latino immigrantsPeer victimization, school belonging, and epigenetic aging among children of Latino immigrants.

🥉 Top 5% JournalArticle

4 weeks ago • Molecular & cellular proteomics : MCP

Nicotinamide mononucleotide and glucose together reduce iron-related energy problems in mice under low oxygen pressureNicotinamide mononucleotide combined glucose counteracts iron overload induced mitochondrial dysfunction in mice under hypobaric hypoxia.

🥉 Top 5% JournalArticle

4 weeks ago • Spinal cord

Challenges and considerations for using NAD+ supplements and PARP blockers after spinal cord injury in miceNAD+ supplementation and PARP inhibition following spinal cord injury in mice: Hurdles and considerations for therapeutic use.

📖 Top 20% JournalArticle

4 weeks ago • Chinese journal of natural medicines

Natural compounds targeting mitochondria with potential to treat mitochondrial diseasesMitochondria-targeted natural products with potential for the treatment of mitochondria-related diseases.

📖 Top 20% JournalArticle

4 weeks ago • Autophagy

Handling Cell Membrane Stress Using CASMDealing with membrane stress through CASM.

🥈 Top 2% JournalArticle

4 weeks ago • Chemico-biological interactions

PGAM5 helps form VDAC1 clusters that may increase ponatinib heart damage by disrupting the combined mitochondrial cleanup and stress responsePGAM5-mediated VDAC1 oligomerization facilitates ponatinib-induced cardiotoxicity via disrupting the mitophagy-mitochondrial unfolded protein response synergistic defense crosstalk.

📖 Top 20% JournalArticle

4 weeks ago • Molecular biology reports

EGCG's role in controlling cell recycling to treat heart and blood vessel diseasesEGCG targeting autophagy in cardiovascular diseases: mechanisms and therapeutic potential.

📖 Top 30% JournalArticle

4 weeks ago • Aging cell

hTERT Immortalization Keeps Human Umbilical Cord Stem Cells Stable and Preserves Their Small Vesicles’ Ability to Regulate Immunity and Activate Early Egg FollicleshTERT Immortalization Stabilizes Human Umbilical Cord MSCs and Maintains Their Small Extracellular Vesicles With Preserved Immunomodulatory Activity and Primordial Follicle-Activating Capacity.

🥉 Top 5% JournalArticle

4 weeks ago • Hematological oncology

Changes in Gene Control and Treatment Weaknesses That Vary by Situation in Blood Cell CancersEpigenetic Rewiring and Context-Dependent Therapeutic Vulnerabilities in Myeloproliferative Neoplasms.

Article

4 weeks ago • Ageing research reviews

How E3 Ubiquitin Ligases Help Fix Protein Balance Problems in AgingE3 Ubiquitin ligases molecular strategies against proteostasis defects of imperfect ageing.

🥈 Top 2% JournalArticle

4 weeks ago • American journal of nephrology

How Control of CCN1 Protein May Contribute to Muscle Loss in Chronic Kidney DiseaseThe Regulation of CCN1 Contributes to Skeletal Muscle Wasting in Chronic Kidney Disease.

🎖️ Top 10% JournalArticle

1 month ago • Nature aging

Blocking cyclin D1-CDK6 reduces age-related inflammation and loss of functionInhibiting cyclin D1-CDK6 suppresses senescence-associated inflammatory gene expression and age-related functional decline.

🥇 Top 1% JournalArticle

1 month ago • bioRxiv : the preprint server for biology

17α-Estradiol Provides Limited Protection Against APOE4-Related Traits in Middle-Aged Female Mice17α-Estradiol Confers Limited Protection Against APOE4 Phenotypes in Middle-Aged Female Mice.

Preprint

1 month ago • Phytomedicine : international journal of phytotherapy and phytopharmacology

Apigenin-7-O-glucoside from Gualou-Xiebai may reduce artery plaque by promoting fat-cleaning in vessel muscle cells through Rab7 and SNAP29Gualou-Xiebai-derived Apigenin-7-O-glucoside inhibits VSMCs foam cell formation and alleviates atherosclerosis by targeting Rab7 to drive SNAP29-dependent lipophagy.

🎖️ Top 10% JournalArticle

1 month ago • Phytomedicine : international journal of phytotherapy and phytopharmacology

Indole-3-propionic acid boosts cell cleanup and reduces cell death in blood vessel disease by targeting the 14-3-3θ proteinTargeting the 14-3-3θ protein with indole-3-propionic acid restores PINK1/Parkin mediated mitophagy and suppresses endothelial PANoptosis in atherosclerosis.

🎖️ Top 10% JournalArticle

1 month ago • bioRxiv : the preprint server for biology

The longevity-linked enzyme UBE3C controls lamin B1 levels by selective cell recycling and slows agingA longevity-associated ubiquitin E3 ligase UBE3C governs lamin B1 homeostasis through selective autophagy and delay senescence.

Preprint

1 month ago • bioRxiv : the preprint server for biology

Genetic factors linked to protein changes over time in large health study groupsGenetic drivers of protein changes over time: Findings, considerations, and approaches in TOPMed cohorts and UK Biobank.

Preprint

1 month ago • Advanced healthcare materials

Nanoparticle Treatments Targeting Cell Energy Centers in Age-Related Brain Diseases: New Possibilities and Clinical PromiseMitochondria-Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential.

🥉 Top 5% JournalArticle

1 month ago • Ageing research reviews

Mitochondrial Problems in Brain Diseases: Causes and New TreatmentsMitochondrial dysfunction in neurodegenerative diseases: Mechanisms and therapeutic advances.

🥈 Top 2% JournalArticle

1 month ago • bioRxiv : the preprint server for biology

Senescent cell groups connect tissue changes and blood vessel problems in human fibroidsSenescent cell networks link matrix remodeling and vascular dysfunction in human fibroids.

Preprint

1 month ago • mSystems

Age-adjusted machine learning finds facial skin microbes linked to skin quality in Korean womenAge-adjusted machine learning identifies facial skin microbes associated with skin quality among Korean women.

🎖️ Top 10% JournalArticle

1 month ago • iScience

Faster biological aging is linked to worse outcomes in frail ICU patientsAccelerated biological aging predicts poor outcomes in frail ICU patients.

🎖️ Top 10% JournalArticle

1 month ago • Genes & diseases

CCN1 may control microglia placement by region-specific cell interactionsSpatial transcriptomics revealed the regulatory role of CCN1 to microglia distribution through region-specific cellular interactions.

🎖️ Top 10% JournalArticle

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