Circadian Rhythms, the Gut Microbiome, and Metabolic Disorders

The circadian clock and gut microbiome may each disrupt metabolic homeostasis, potentially leading to metabolic diseases.

• Circadian rhythms regulate various functions in the gastrointestinal tract and liver, including nutrient transport and detoxification.
• The gut microbiota is involved in digestion, inflammation control, and bile acid metabolism.
• Circadian rhythms and gut microbiota influence each other, with gut dysbiosis potentially causing circadian misalignment.
• Disruption of either the circadian clock or gut microbiome can negatively affect metabolic balance.
• Such disruptions are associated with the development of metabolic conditions like obesity, diabetes, and liver diseases.

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