Trending Psychedelic Science Research Papers | OpenScience.ink

3 days ago • Depression and anxiety

Oral Esketamine for Hard-to-Treat Depression: Patient Results from an Unapproved Treatment ProgramOral Esketamine Maintenance Treatment for Treatment-Resistant Depression: Clinical Outcomes During an Off-Label Treatment Program.

🥉 Top 5% JournalObservational Study

4 days ago • Translational psychiatry

Genes responding quickly to psychedelics are linked to serotonin receptors and specific brain cell types in the thinking areas of humans and other speciesCross-species mapping of acute psychedelic-responsive genes links HTR2A cortical expression, cell-type enrichment, and human cortical expression modules.

🥉 Top 5% JournalArticle

5 days ago • Frontiers in psychiatry

Participant experiences and suggestions for psychedelic clinical trials and future treatments from expert advocatesParticipant experiences and recommendations for psychedelic clinical trials and future treatment delivery: a qualitative study with experts by experience from the Psychedelic Participant Advocacy Network.

📖 Top 20% JournalArticle

4 days ago • Journal of affective disorders

Psilocybin with psychological support may reduce loss of pleasure in hard-to-treat depression: A small controlled trialEffects of psilocybin with psychological support on anhedonia in treatment-resistant depression: A randomized controlled pilot trial.

🥉 Top 5% JournalArticle

4 days ago • Molecular psychiatry

How serotonin-affecting psychedelics work across species and their links to consciousness and therapyEvolutionary neuropharmacology of serotonergic psychedelics: a cross-species perspective on mechanisms, consciousness, and therapeutic potential.

🥈 Top 2% JournalArticle

4 days ago • Science advances

The Fireside Database: Evidence from Over 25,000 Support Sessions for Psychedelic ExperiencesThe Fireside Database: Large-scale evidence from 25,419 psychedelic support interactions.

🥈 Top 2% JournalArticle

3 days ago • Psychiatry and clinical psychopharmacology

Therapeutic Potential of Traditional Psychedelics and Non-Hallucinogenic Brain-Change Drugs in Mental Health DisordersTherapeutic Potential of Classical Psychedelics and Non-Hallucinogenic Psychoplastogens in Psychiatric Disorders.

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1 week ago • Microbiology and molecular biology reviews : MMBR

The genes and enzymes involved in making psilocybinMagic pathways: the genes and enzymes of psilocybin biosynthesis.

🥉 Top 5% JournalArticle

3 days ago • Methods in molecular biology (Clifton, N.J.)

Measuring Tryptamine Compounds in Body SamplesDetermination of Tryptamines in Biological Specimens.

📖 Top 50% JournalArticle

yesterday • Journal of psychopharmacology (Oxford, England)

Ongoing mental health problems after using classic psychedelics: Stories from people seeking helpPersisting psychological complications following the use of classic psychedelics: A qualitative study of help-seeking experiences.

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1 week ago • International journal of molecular sciences

Similar Fast Antidepressant Effects of Two Low Ketamine Doses Linked to Different Molecular Changes in Brain Areas After Teen StressComparable Acute Antidepressant-like Effects of Two Subanesthetic Ketamine Doses Are Associated with Divergent Region-Specific Molecular Responses After Adolescent Chronic Stress.

📖 Top 20% JournalArticle

4 days ago • Journal of psychopharmacology (Oxford, England)

Effectiveness and safety of LSD for treating depression symptoms: A combined review and analysisEfficacy, safety, and tolerability of lysergic acid diethylamide for the treatment of depressive symptoms: A meta-analysis and systematic review.

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4 days ago • Alcohol (Fayetteville, N.Y.)

MDMA-Assisted Therapy and Clinical Results for Veterans with Both PTSD and Alcohol Use Disorder in an Initial Open-Label TrialMDMA-Assisted Therapy for Veterans with Comorbid Posttraumatic Stress Disorder and Alcohol Use Disorder: Clinical Outcomes from the First Open-Label Pilot Trial.

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1 week ago • Journal of psychopharmacology (Oxford, England)

Psychedelics and psychosis: A review of recent studies from 1984 to 2025Psychedelics and psychosis: A systematic review of recent-era studies (1984-2025).

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4 days ago • Journal of psychiatric research

Fast antidepressant effects of ketamine combined with common antidepressants: How they work and future possibilitiesRapid antidepressant effects of ketamine combined with selective serotonin reuptake inhibitors: Mechanisms and outlook.

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1 week ago • In silico pharmacology

Computer study of Desmodium gangeticum compounds as dual regulators of MAO-B and 5-HT2A in Parkinson's diseaseIn silico characterization of Desmodium gangeticum compounds as dual modulators of MAO-B and 5-HT2A in Parkinson's disease: an integrated approach combining molecular docking, ADMET profiling, MM-GBSA, QSAR modeling, and molecular dynamics simulation.

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