Latest Psychedelic Science Research Papers

yesterday • Journal of psychopharmacology (Oxford, England)

Ongoing mental health problems after using classic psychedelics: Stories from people seeking helpPersisting psychological complications following the use of classic psychedelics: A qualitative study of help-seeking experiences.

Article

2 days ago • Translational psychiatry

Transcriptional profiling of antidepressant ketamine and electroconvulsive therapy treatment.Transcriptional profiling of antidepressant ketamine and electroconvulsive therapy treatment.

🥉 Top 5% JournalArticle

3 days ago • Psychiatry and clinical psychopharmacology

Therapeutic Potential of Traditional Psychedelics and Non-Hallucinogenic Brain-Change Drugs in Mental Health DisordersTherapeutic Potential of Classical Psychedelics and Non-Hallucinogenic Psychoplastogens in Psychiatric Disorders.

Article

3 days ago • Depression and anxiety

Oral Esketamine for Hard-to-Treat Depression: Patient Results from an Unapproved Treatment ProgramOral Esketamine Maintenance Treatment for Treatment-Resistant Depression: Clinical Outcomes During an Off-Label Treatment Program.

🥉 Top 5% JournalObservational Study

3 days ago • Methods in molecular biology (Clifton, N.J.)

Measuring Tryptamine Compounds in Body SamplesDetermination of Tryptamines in Biological Specimens.

📖 Top 50% JournalArticle

4 days ago • Molecular psychiatry

How serotonin-affecting psychedelics work across species and their links to consciousness and therapyEvolutionary neuropharmacology of serotonergic psychedelics: a cross-species perspective on mechanisms, consciousness, and therapeutic potential.

🥈 Top 2% JournalArticle

4 days ago • Journal of psychiatric research

Fast antidepressant effects of ketamine combined with common antidepressants: How they work and future possibilitiesRapid antidepressant effects of ketamine combined with selective serotonin reuptake inhibitors: Mechanisms and outlook.

Article

4 days ago • Journal of affective disorders

Psilocybin with psychological support may reduce loss of pleasure in hard-to-treat depression: A small controlled trialEffects of psilocybin with psychological support on anhedonia in treatment-resistant depression: A randomized controlled pilot trial.

🥉 Top 5% JournalArticle

4 days ago • Science advances

The Fireside Database: Evidence from Over 25,000 Support Sessions for Psychedelic ExperiencesThe Fireside Database: Large-scale evidence from 25,419 psychedelic support interactions.

🥈 Top 2% JournalArticle

4 days ago • Alcohol (Fayetteville, N.Y.)

MDMA-Assisted Therapy and Clinical Results for Veterans with Both PTSD and Alcohol Use Disorder in an Initial Open-Label TrialMDMA-Assisted Therapy for Veterans with Comorbid Posttraumatic Stress Disorder and Alcohol Use Disorder: Clinical Outcomes from the First Open-Label Pilot Trial.

Article

4 days ago • Translational psychiatry

Genes responding quickly to psychedelics are linked to serotonin receptors and specific brain cell types in the thinking areas of humans and other speciesCross-species mapping of acute psychedelic-responsive genes links HTR2A cortical expression, cell-type enrichment, and human cortical expression modules.

🥉 Top 5% JournalArticle

4 days ago • Journal of psychopharmacology (Oxford, England)

Effectiveness and safety of LSD for treating depression symptoms: A combined review and analysisEfficacy, safety, and tolerability of lysergic acid diethylamide for the treatment of depressive symptoms: A meta-analysis and systematic review.

Article

5 days ago • Frontiers in psychiatry

Participant experiences and suggestions for psychedelic clinical trials and future treatments from expert advocatesParticipant experiences and recommendations for psychedelic clinical trials and future treatment delivery: a qualitative study with experts by experience from the Psychedelic Participant Advocacy Network.

📖 Top 20% JournalArticle

1 week ago • International journal of molecular sciences

📖 Top 20% JournalArticle

1 week ago • Journal of psychopharmacology (Oxford, England)

Psychedelics and psychosis: A review of recent studies from 1984 to 2025Psychedelics and psychosis: A systematic review of recent-era studies (1984-2025).

Article

1 week ago • In silico pharmacology

Computer study of Desmodium gangeticum compounds as dual regulators of MAO-B and 5-HT2A in Parkinson's diseaseIn silico characterization of Desmodium gangeticum compounds as dual modulators of MAO-B and 5-HT2A in Parkinson's disease: an integrated approach combining molecular docking, ADMET profiling, MM-GBSA, QSAR modeling, and molecular dynamics simulation.

Article

1 week ago • Microbiology and molecular biology reviews : MMBR

The genes and enzymes involved in making psilocybinMagic pathways: the genes and enzymes of psilocybin biosynthesis.

🥉 Top 5% JournalArticle

1 week ago • Journal of personalized medicine

Blood markers linked to response to ketamine and esketamine treatment in depressionPeripheral Biomarkers of Response to Ketamine and Esketamine Treatment in Unipolar Depressive Disorder-A Scoping Review.

📖 Top 20% JournalArticle

1 week ago • Journal of affective disorders

Low-dose ketamine may change brain signal complexity in hard-to-treat depressionLow-dose ketamine modulates brain entropy in treatment-resistant depression: Results from two neuroimaging clinical trials.

🥉 Top 5% JournalArticle

1 week ago • Psychopharmacology

Differences between men and women in responses to psilocybin or escitalopramSex-related differences in outcomes following psilocybin or escitalopram: a Bayesian secondary analysis.

📖 Top 20% JournalArticle

1 week ago • Science China. Life sciences

🥉 Top 5% JournalArticle

1 week ago • Psychopharmacology

Does ketamine treatment in adolescence affect adult risk of drug abuse in rats?Evaluating whether a therapeutic dose of ketamine exposure during adolescence influences adult vulnerability in rats to commonly abused drugs.

📖 Top 20% JournalArticle

1 week ago • JAMA

Single Dose of the Psychedelic Mebufotenin by Nose for Hard-to-Treat Depression: A Randomized Clinical TrialSingle Intranasal Administration of the Psychedelic Mebufotenin for Treatment-Resistant Depression: A Randomized Clinical Trial.

Article

1 week ago • ACS omega

Measuring Psilocybin and Psilocin Levels in Wild Psilocybe Mushrooms from Greece Using Nuclear Magnetic ResonanceDirect Quantitation of Psilocybin and Psilocin by 1H and 31P qNMR in Wild Psilocybe from Greece.

📖 Top 30% JournalArticle

1 week ago • Frontiers in psychiatry

How cancer patients’ awareness of internal body sensations relates to getting ready for psilocybin therapyPreparing the body for psilocybin therapy: receptive and generative interoception in cancer patients.

📖 Top 20% JournalArticle

1 week ago • Frontiers in public health

Using Ayahuasca in Community Care to Support Indigenous Mental Health in the Yaqui Medicine Clinic in Sonora, MexicoIntercultural pathways to indigenous mental health: the integration of ayahuasca in community care in the Yaqui intercultural medicine clinic in Sonora, Mexico.

📖 Top 20% JournalArticle

1 week ago • bioRxiv : the preprint server for biology

Ketamine changes natural opioid signals and lowers heroin-seeking behavior in male ratsKetamine Modulates Endogenous Opioid Peptide Signaling and Reduces Heroin-Seeking in Male Long-Evans Rats.

Preprint

1 week ago • Nature neuroscience

Long-lasting antidepressant-like effects of psychedelics linked to serotonin receptor signalingSustained antidepressant-like effects of psychedelics through 5-HT2AR-β-arrestin signaling.

🥇 Top 1% JournalArticle

1 week ago • The journal of physical chemistry. B

How Terahertz Waves May Change Psychedelic Effects on Serotonin ReceptorsModulating the Thermodynamics and Kinetics of Psychedelics at Serotonin Receptors via Terahertz Waves.

Article

1 week ago • Journal of medicinal chemistry

A Drug-Friendly Water-Repelling Pathway in the 5-HT2A Receptor Targeted by Powerful PhenethylaminesExploring a Druggable Hydrophobic Tunnel in the 5-HT2A Receptor with Potent Phenethylamines.

🎖️ Top 10% JournalArticle

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