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1 week ago • CNS drugs

Additional Drug Treatments for Major Depression with Anxiety: From Traditional Brain Chemicals to New Clinical FindingsAdjunctive Pharmacotherapy for Major Depressive Disorder with Anxiety Symptoms: from Monoamines to Recent Clinical Evidence.

Article

1 week ago • Biomedicines

Psilocybin: Current Knowledge, Safety Concerns, and Challenges in Studying Its Possible Effects on Multiple OrgansPsilocibin: Current Evidence, Safety Signals, and Challenges in Assessing Potential Multi-Organ Effects.

📖 Top 20% JournalArticle

1 week ago • Frontiers in psychiatry

How psychedelic research reveals healing processes in brain systems linked to mental healthSystems-based psychiatry: insights from psychedelic research on mechanisms of healing.

📖 Top 20% JournalArticle

1 week ago • Journal of music therapy

Participants’ Music Experiences During Psychedelic Therapy for Life-Threatening IllnessParticipants' Music Experiences Associated With Psychedelic-Assisted Psychotherapy for Life-Threatening Illness: Interpretivist Research.

Randomized Controlled Trial

1 week ago • Analytical and bioanalytical chemistry

Sensitive test using glowing particles to detect mescaline and LSD in hair samplesHigh-sensitivity immunochromatographic assay based on time-resolved fluorescence microspheres for the simultaneous detection of mescaline and LSD in hair.

📖 Top 30% JournalArticle

1 week ago • Biomolecules

A Six-Point Guide to the Evidence, Safety, and Benefits of Natural Psilocybin for Therapy and PolicyNaturally Derived Psilocybin for Therapeutic Use: A Six-Criterion Framework for Evidence, Safety, and Benefit-Risk Considerations in Policy and Clinical Development.

🎖️ Top 10% JournalArticle

1 week ago • Pharmaceuticals (Basel, Switzerland)

Assessing the Brain Toxicity of NBOH Chemical VariantsEvaluation of Neurotoxicity of NBOH Derivatives.

📖 Top 20% JournalArticle

1 week ago • Journal of clinical psychopharmacology

Liver safety of ketamine and esketamine in hard-to-treat depression in real-world patientsHepatic Safety of Ketamine and Esketamine for Treatment-Resistant Depression: A Real-World Cohort Study.

Article

1 week ago • Psychopharmacology

Long-term low-dose psilocybin causes gene regulation changes in the thinking areas of rat brainsLong- term administration of low doses of psilocybin causes epigenetic changes in the rat medial prefrontal cortex.

📖 Top 20% JournalArticle

1 week ago • Therapeutic advances in psychopharmacology

Understanding how psychedelic clinical trials are designed and studiedConceptual analysis of mechanisms and methods in psychedelic clinical trial design: a narrative review.

📖 Top 20% JournalArticle

1 week ago • L'Encephale

Use of classic psychedelics and links to suicidal thoughts and behaviors: A review of research[Illicit use of classic psychedelics and suicidality: A systematic literature review].

📖 Top 50% JournalEnglish Abstract

1 week ago • Neural computation

Brain Wave Interactions as a Basis for Evaluating Prediction ErrorsCross-Frequency Coupling as a Neural Substrate for Prediction Error Evaluation: A Laminar Neural Mass Modeling Approach.

📖 Top 30% JournalArticle

1 week ago • Cell reports

How GluN2D-targeting drugs and ketamine influence inhibitory signals, long-term brain strengthening, and motivationBidirectional control of vesicular GABA release, LTP, and amotivation by GluN2D-selective allosteric modulators and ketamine.

🥈 Top 2% Journal

1 week ago • Psychiatric research and clinical practice

Real-World Benefits and Costs of Nasal Esketamine Compared to Muscle-Injected KetamineReal-World Effectiveness and Cost-Differential of Intranasal Esketamine Versus Intramuscular Ketamine.

📖 Top 20% Journal

1 week ago • Addictive behaviors

Patterns and effects of using vaping and hallucinogens together: a review and analysisPatterns and implications of co-use between vaping and hallucinogens: a systematic review and meta-analysis.

🎖️ Top 10% Journal

1 week ago • Molecular psychiatry

How fast-acting antidepressants affect lab-grown brain cells over time from people with treatment-resistant depression and healthy individualsTime-dependent effects of rapid-acting antidepressants in iPSC-derived neurons from treatment-resistant depression and healthy volunteers.

🥈 Top 2% Journal

1 week ago • Frontiers in psychiatry

Real-world results of nasal esketamine and intravenous ketamine treatments for hard-to-treat depression in a community clinicReal-world outcomes of intranasal esketamine and intravenous ketamine induction therapy for treatment-resistant depression in a community clinic: a retrospective cohort study.

📖 Top 20% Journal

1 week ago • iScience

Social rank influences behavior and gene activity responses to long-term stress and ketamine in male miceSocial hierarchy shapes behavioral and transcriptional responses to chronic stress and ketamine in male mice.

🎖️ Top 10% Journal

1 week ago • Progress in neuro-psychopharmacology & biological psychiatry

MDMA as an early treatment after trauma in an animal model of PTSDMDMA as an early post-trauma intervention in a translational animal model of PTSD.

1 week ago • Journal of neuroimmunology

S-ketamine and S-HNK quickly reduce depression-like behavior by targeting inflammation pathways in the thinking areas of the brainTargeting TLR4/PPARα-mediated neuroinflammation in the prefrontal cortex: S-ketamine and S-HNK rapidly alleviate depression-like behaviors.

📖 Top 20% Journal

1 week ago • Frontiers in psychiatry

Using the addictive drug ketamine to treat addiction: revisiting the ketamine paradoxTreating addiction with an addictive drug: the ketamine paradox revisited.

📖 Top 20% Journal

1 week ago • Neuroscience and biobehavioral reviews

How serotonin-based psychedelics affect brain cells by increasing detailed context processingCellular mechanisms of serotonergic psychedelics - apical hypercontextualisation.

🥉 Top 5% Journal

1 week ago • Journal of psychopharmacology (Oxford, England)

No signs of harmful effects of psilocybin and MDMA on working memory or brain activity in healthy adultsNo evidence for deleterious effects of psilocybin and MDMA on working memory or related neurophysiological activity in a non-clinical population: An uncontrolled exploratory study.

2 weeks ago • British journal of clinical pharmacology

Psilocybin as a serotonin-based treatment for epilepsy: potential benefits and challengesPsilocybin as serotonergic therapy in epilepsy: Narrative review of potentials and limitations.

📖 Top 20% Journal

2 weeks ago • Science signaling

A new psychedelic quipazine-like drug designed for therapy with possibly fewer side effectsDesign of a new psychedelic quipazine analog with therapeutic efficacy and potentially fewer side effects.

🥉 Top 5% Journal

2 weeks ago • Nature neuroscience

Adolescent use of the psychedelic 25C-NBOMe in rats leads to lasting avoidance behavior linked to disrupted coordination between memory and decision-making brain areasAdolescent exposure to the psychedelic 25C-NBOMe in rats induces lasting competitive avoidance through disrupted hippocampal-prefrontal synchrony.

🥇 Top 1% Journal

2 weeks ago • European journal of pharmacology

Intranasal Ketamine Reduces Depression-Like Behaviors in Stressed Rats Linked to a Brain Energy EnzymeIntranasal ketamine alleviates depressive-like behaviors in chronic unpredictable mild stress rats in association with hypothalamic NADH:Ubiquinone oxidoreductase subunit A10.

📖 Top 20% Journal

2 weeks ago • Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Psilocybin causes stronger immediate effects and sex-specific long-term improvements in sensory processing in a mouse model of schizophrenia lacking mGlu5Psilocybin produces amplified acute responses and sex-specific long-term increases in sensorimotor gating in the mGlu5 knockout mouse model of schizophrenia.

🥉 Top 5% Journal

2 weeks ago • European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology

New drug and brain stimulation treatments for suicidal thoughts and actionsEmerging pharmacological and neuromodulation interventions for suicidal ideation and behaviour.

🥉 Top 5% Journal

2 weeks ago • Psychopharmacology

How Psychedelic Research Became Influenced by Mystical IdeasThe mystic trip: how psychedelic research fell for mysticism.

📖 Top 20% Journal

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