OpenScience.ink

1 week ago • Biogerontology

LSD may lengthen lifespan in a type of wormLysergic acid diethylamide extends lifespan in Caenorhabditis elegans.

📖 Top 20% JournalArticle

1 week ago • Frontiers in pharmacology

Activation of serotonin 5-HT2A receptors causes long-lasting presynaptic inhibition in the reward system depending on cannabinoid CB1 receptors5-HT2A receptor activation induces CB1-dependent presynaptic inhibitory long-term depression in the nucleus accumbens core.

📖 Top 20% JournalArticle

1 week ago • Drug and alcohol dependence

Safety and effectiveness of psilocybin therapy for alcohol use disorder in an extended open-label trialSafety and efficacy of psilocybin-assisted therapy for alcohol use disorder: Open-label extension of a phase II randomized controlled trial.

🎖️ Top 10% JournalArticle

1 week ago • Frontiers in public health

New Public Health Ideas Inspired by Traditional Use of PsychedelicsBreaking psychedelic boundaries in public health: emerging ideas with ancient roots.

📖 Top 20% JournalHistorical Article

1 week ago • Psychedelic medicine (New Rochelle, N.Y.)

Lysergic Acid Diethylamide (LSD) Use in U.S. Sexual Minorities from 2015 to 2019Past-Year Lysergic Acid Diethylamide Use in United States Sexual Minorities from 2015 to 2019.

Article

1 week ago • Psychiatric services (Washington, D.C.)

Cost-effectiveness of Ketamine Compared to Electroconvulsive Therapy for Nonpsychotic Treatment-Resistant DepressionKetamine Versus Electroconvulsive Therapy for Nonpsychotic Treatment-Resistant Depression: A Cost-Effectiveness Analysis.

Article

1 week ago • Psychedelic medicine (New Rochelle, N.Y.)

How Psychedelic Drugs Affect the Brain's Serotonin Movement SystemDorsal Raphe Revisited: A Systems Neuroscience Lens on Psychedelic Drug Action.

Article

1 week ago • Journal of psychiatric research

Psilocybin’s effects on loss of pleasure in unipolar and bipolar depression: A review of clinical and laboratory studiesPsilocybin for anhedonia in unipolar and bipolar depression: A systematic review of clinical and preclinical evidence.

Article

1 week ago • Psychedelic medicine (New Rochelle, N.Y.)

Psychedelics Helping Psychotherapy: A Look Back at Psycholytic TherapyWhat About Psycholytic Therapy? A Historical Revisiting of Psychedelics Assisting Psychotherapy.

Article

1 week ago • Journal of affective disorders

Suicidal thoughts and behaviors during treatment with nasal esketamine: A look back at patient recordsSuicidality during intranasal (es)ketamine treatment: A retrospective cohort study.

🥉 Top 5% JournalArticle

1 week ago • JAMA psychiatry

Psilocybin and its links to inflammation and cell energy stress in Parkinson's disease patientsPsilocybin and Inflammatory and Mitochondrial Stress Markers in Parkinson Disease: A Nonrandomized Clinical Trial.

🥇 Top 1% JournalArticle

1 week ago • Psychedelic medicine (New Rochelle, N.Y.)

The role of patient-therapist connection in psilocybin treatment for hard-to-treat depression: a critical commentStrong Alliance, Weak Conclusions: Comment on Goodwin et al. (2026) "The Role of Therapeutic Alliance in Psilocybin Treatment for Treatment-Resistant Depression".

Article

1 week ago • Psychedelic medicine (New Rochelle, N.Y.)

Balancing new methods and proof: Comparing structured protocols with flexible, patient-led approaches in MDMA therapyBalancing Innovation and Evidence: Reflections on Structured Protocols in MDMA-Assisted Therapy Versus a Principle-Guided, Patient-Directed Approach.

Article

1 week ago • Psychedelic medicine (New Rochelle, N.Y.)

Links Between Ketamine, Classic Psychedelics, and Brain Connections Related to PainCorrelation of Ketamine and Classic Psychedelics with Pain-Related Neural Connectivity: A Scoping Review of Clinical Experiments on a Potential Therapeutic Target Concerning Ketamine and Classical Psychedelics Administration for Pain Relief.

Article

1 week ago • Chemistry & biodiversity

Lab and computer tests of new chemical compounds made from a natural plant extract for fighting malariaSynthesis of 1,2,3-Triazole Derivatives of N,N-Dimethyltryptamine Isolated From Mimosa tenuiflora Root Bark: Antiplasmodial Activity In Silico and In Vitro.

📖 Top 50% JournalArticle

1 week ago • Psychedelic medicine (New Rochelle, N.Y.)

Psychedelics and How They Affect the Brain’s Reward System Before and After the 1970 Drug LawPsychedelics and Reward Processing: Before and After the 1970 Controlled Substances Act.

Article

1 week ago • Psychedelic medicine (New Rochelle, N.Y.)

Effects of LSD and 2,5-Dimethoxy-4-Iodoamphetamine on Oral Opioid Use and Withdrawal Symptoms in Male MiceEffects of Psychedelics Lysergic Acid Diethylamide and R(-)-2,5-Dimethoxy-4-Iodoamphetamine on Oral Opioid Consumption and Naloxone-Precipitated Withdrawal in Male C57Bl/6J Mice.

Article

1 week ago • Frontiers in public health

Group psychedelic therapy for mental health conditions: a combined review of studies and experiencesGroup psychedelic-assisted therapy for mental health conditions: a mixed-methods systematic review.

📖 Top 20% JournalSystematic Review

2 weeks ago • Frontiers in psychiatry

Careful Consideration of Psychedelics from Medical and Practical Use PerspectivesCaution before canonisation: a clinical and implementation science perspective on psychedelics.

📖 Top 20% JournalArticle

2 weeks ago • Journal of clinical psychopharmacology

Ayahuasca's effects on thinking and verbal memory at different doses in healthy peopleEvaluation of the Effects of Different Doses of Ayahuasca on Intelligence and Verbal Memory in Healthy Volunteers: A Preliminary, Exploratory, Double-Blind, Randomized, Placebo-controlled Study.

Article

2 weeks ago • Drug testing and analysis

Methods to Identify and Distinguish Similar Chemical Isomers of N-(2-Methoxybenzyl)-2-(Trimethoxyphenyl)ethanamines Using Chromatography and Mass SpectrometryAnalytical Strategies for the Identification and Differentiation of Positional Isomers of N-(2-Methoxybenzyl)-2-(trimethoxyphenyl)ethanamines by Chromatography and Mass Spectrometry.

📖 Top 30% JournalArticle

2 weeks ago • JAMA network open

Clinical studies on psilocybin and how they are shown in the media: a systematic reviewClinical Evidence on Psilocybin and Its Representation in Media Reporting: A Systematic Review.

🥈 Top 2% JournalSystematic Review

2 weeks ago • Nature neuroscience

Changes in the timing and location of activity in the brain's emotion control area mark the start of depression-like behaviorsSpatiotemporal remodeling in habenula marks the onset of depression-related phenotypes.

🥇 Top 1% JournalArticle

2 weeks ago • Frontiers in oncology

Combined approaches to manage anxiety and depression in people with cancerIntegrative options for the management of anxiety and depression in people with cancer.

📖 Top 20% JournalArticle

2 weeks ago • The western journal of emergency medicine

Intravenous Ketamine for Treating Depression and Suicidal Thoughts in Teenagers in the Emergency Room: A Randomized Double-Blind TrialIntravenous Ketamine for Depressed and Suicidal Adolescents in the Emergency Department: A Randomized Double-Blind Trial.

📖 Top 30% JournalRandomized Controlled Trial

2 weeks ago • Neuropharmacology

Low-dose ketamine changes stress-related brain and hormone responses in specific areas of ratsSubanesthetic ketamine modulates region-specific neural and endocrine responses to acute stress in rats.

🎖️ Top 10% JournalArticle

2 weeks ago • Journal of neurotrauma

Brain-Boosting Drugs to Ease Long-Lasting Thinking Problems After Traumatic Brain InjuryPsychoplastogens to Reduce Persistent Cognitive Symptoms for Traumatic Brain Injury as a Chronic Condition.

🎖️ Top 10% JournalArticle

2 weeks ago • Current neuropharmacology

Psilocybin's possible links to depression, inflammation, and pain reliefThe Hidden Therapeutic Bridge: Exploring Psilocybin's Role in Depression, Inflammation, and Pain - A Narrative Review.

🎖️ Top 10% JournalArticle

2 weeks ago • Current biology : CB

Ketamine reduces overactivity in the brain’s emotion control center linked to depressionDepression: Ketamine quiets an unruly habenula.

Comment

2 weeks ago • CNS & neurological disorders drug targets

How Psilocybin May Affect Brain Cell Loss Disorders Through 5-HT2A Receptors and Their SignalsMechanistic Evaluation of Psilocybin in Neurodegenerative Disorders: Relevance of 5-HT2A Receptors and Downstream Pathways.

📖 Top 30% JournalArticle

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