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1 week ago • Frontiers in psychiatry

Adding rapamycin to long-term ketamine use may improve various symptomsNon-randomized rapamycin augmentation of chronic self-administered ketamine provides subjective improvement in diverse phenotypes.

📖 Top 20% JournalArticle

1 week ago • JAMA

PsilocybinPsilocybin.

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1 week ago • Neuroscience research

Psilocybin improves spatial memory but not communication between thinking and memory areas in a rat model of Alzheimer's diseasePsilocybin restores spatial memory but not fronto-hippocampal synchrony in a rat model of Alzheimer's disease.

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1 week ago • Molecular psychiatry

Psychedelic 4-AcO-DMT reduces fear-freezing by activating decision-area neurons in micePsychedelic 4-AcO-DMT attenuated looming-induced freezing behaviors by activating PrL CaMKIIα neurons in mice.

🥈 Top 2% JournalArticle

1 week ago • The International journal on drug policy

Why removing the psychedelic experience from psychedelic medicine may be a mistakeWhy taking the trip out of psychedelic medicine is a mistake.

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1 week ago • Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

Craving Reduction and Smoking Results with Psilocybin-Assisted Compared to Standard Quit ProgramsCraving Reduction and Smoking Outcomes in Psilocybin-Assisted and Standard Cessation Care.

📖 Top 20% JournalArticle

1 week ago • Cureus

Severe Serotonin Syndrome Causing Sudden Breathing Failure After Using Ayahuasca and DextromethorphanSevere Serotonin Syndrome With Acute Respiratory Failure Following Ayahuasca and Dextromethorphan Use: A Case Report.

Case Reports

1 week ago • Progress in neuro-psychopharmacology & biological psychiatry

Psilocybin reduces new-environment grooming through 5-HT2B receptors in ratsPsilocybin selectively suppresses novelty-induced grooming via 5-HT2B receptors: A microstructure analysis in Wistar rats.

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1 week ago • Journal of psychopharmacology (Oxford, England)

Psychedelic therapy shows no lasting effects: Review of controlled studies from 1965 to 1977Psychedelic therapy without durable effects: A review and re-evaluation of controlled studies between 1965 and 1977.

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1 week ago • Proceedings of the National Academy of Sciences of the United States of America

Breaking Down the Chemical Structure of LSDDeconstruction of lysergic acid diethylamide.

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1 week ago • Harvard review of psychiatry

MDMA-Assisted Therapy May Reduce PTSD Symptoms, Dissociation, Depression, and DisabilityMDMA-Assisted Therapy May Decrease PTSD Symptoms, Dissociation, Depression, and Functional Disability: A Systematic Review and Meta-Analysis.

📖 Top 20% JournalArticle

1 week ago • Brain research

Increased brain signal variety, network disruption, and improved well-being during DMT use measured by EEGHigher signal diversity, network dysregulation, and increased well-being under DMT administration: An EEG study.

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1 week ago • Journal of psychopharmacology (Oxford, England)

Ketamine's effects on cell energy production, survival, and function: A systematic reviewThe effect of ketamine on mitochondrial bioenergetics, viability, and function: A systematic review.

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1 week ago • Journal of clinical psychopharmacology

TS-161, a drug blocking mGlu2/3 receptors, may help treat hard-to-treat depression: Early clinical trial resultsThe Antidepressant Effects of the mGlu2/3 Receptor Antagonist TS-161 in Treatment-Resistant Depression: A Phase IIa Proof-of-Concept Clinical Trial.

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1 week ago • Journal of psychoactive drugs

Users’ Reported Experiences with 5-MeO-DMT on Reddit: A Thematic OverviewExploratory Insights into 5-MeO-DMT Experiences on Reddit: A Thematic Analysis.

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1 week ago • Neuroscience and biobehavioral reviews

How Psychedelics May Affect Learning to Link Ideas: A Systematic ReviewThe Effect of Psychedelics on Associative Learning: a Systematic Review.

🥉 Top 5% JournalArticle

1 week ago • The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

Metabolic changes linked to intravenous ketamine in hard-to-treat major depressionMetabolomic correlates of intravenous racemic ketamine in treatment-resistant major depressive disorder: the Bio-K/NNDC multicenter trial.

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2 weeks ago • Journal of psychopharmacology (Oxford, England)

Brainwave changes caused by psilocybin connect immediate and lasting effectsPsilocybin-induced changes in electroencephalography link acute and long-term effects.

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2 weeks ago • Molecular psychiatry

How Drugs and Other Treatments Influence Dopamine Release in the Movement System: A Meta-Analysis of Brain Imaging StudiesPharmacological and non-pharmacological modulation of striatal dopamine release: a meta-analysis of [11C]raclopride PET studies.

🥈 Top 2% JournalSystematic Review

2 weeks ago • Frontiers in nutrition

Appetite changes during ketamine treatment in hard-to-treat mood disordersAppetite measures during ketamine administration in treatment-resistant mood disorders: a naturalistic study.

📖 Top 20% JournalArticle

2 weeks ago • The American journal of clinical hypnosis

Using Hypnosis to Explore Mystical Experiences: A Qualitative StudyHypnosis-based intervention for mystical experiences: a qualitative analysis.

📖 Top 50% JournalArticle

2 weeks ago • Alpha psychiatry

How Ketamine May Help Improve Thinking Problems in Depression, Revealed by Network PharmacologyNetwork Pharmacology Reveals the Potential Mechanism of Ketamine in Improving Cognitive Impairment in Patients With Depression.

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2 weeks ago • Alpha psychiatry

Low Dose Ketamine Prepares Brain Support Cells' Energy Systems for Antidepressant Effects by Increasing Adenosine, Humanin, and MelatoninLow Dose Ketamine Preconditions Astrocyte Mitochondria to Achieve Antidepressant Efficacy via Adenosine, Humanin, and Melatonin Upregulation and Efflux.

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2 weeks ago • Journal of traumatic stress

Healing Together: Early Results of MDMA-Enhanced Joint Therapy for PTSDHealing together: Results from a pilot trial of 3,4-Methylenedioxymethamphetamine-enhanced cognitive-behavioral conjoint therapy for posttraumatic stress disorder.

📖 Top 20% JournalArticle

2 weeks ago • Human psychopharmacology

Psilocybin’s traditional uses and possible medical benefits: a detailed review of how it works and current viewsPsilocybin, From Ancestral Use to Therapeutic Potential: A Multidimensional Review of Its Pharmacological Basis and Current Perspectives.

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2 weeks ago • Case reports in psychiatry

Ongoing Visual Disturbances After Hallucinogen Use in a Young AdultHallucinogen Persisting Perception Disorder in a Young Adult Case Report.

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2 weeks ago • Science (New York, N.Y.)

Psilocybin may prevent nerve damage from chemotherapy by protecting cell energy transportPsilocybin prevents chemotherapy-induced peripheral neuropathy through mitochondrial trafficking preservation.

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2 weeks ago • Frontiers in psychiatry

A review of microdosing psilocybin mushrooms and trufflesThe subtle science: a systematic review of psilocybin magic mushroom and truffle microdosing.

📖 Top 20% JournalSystematic Review

2 weeks ago • Research square

Medical and Mental Health Consultations to Reduce Risks for Patients Considering Legal Psilocybin Treatment: A Model and Two Case ExamplesMedical and Psychiatric Consultation for Patients Considering State-Regulated Psilocybin Services: A Risk-Reduction Model and Two Illustrative Cases.

Preprint

2 weeks ago • Journal of psychopharmacology (Oxford, England)

Safety and body processing of intravenous deuterated N,N-dimethyltryptamine (CYB004) in healthy volunteersSafety, pharmacokinetics, and pharmacodynamics of intravenously administered deuterated N,N-dimethyltryptamine (CYB004) in healthy volunteers.

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