Psychedelic Science Research Papers

4 days ago • Frontiers in psychiatry

Ketamine and its effects on substance use disorders: a combined review and analysisKetamine for substance use disorders: a systematic review and meta-analysis.

📖 Top 20% JournalSystematic Review

4 weeks ago • Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Psilocybin therapy lowers brain chemicals galanin and noradrenaline in major depressionCSF galanin and noradrenaline downregulation by psilocybin therapy in major depressive disorder.

🥉 Top 5% Journal

2 weeks ago • Nature neuroscience

Adolescent use of the psychedelic 25C-NBOMe in rats leads to lasting avoidance behavior linked to disrupted coordination between memory and decision-making brain areasAdolescent exposure to the psychedelic 25C-NBOMe in rats induces lasting competitive avoidance through disrupted hippocampal-prefrontal synchrony.

🥇 Top 1% Journal

1 week ago • Frontiers in psychiatry

Real-world results of nasal esketamine and intravenous ketamine treatments for hard-to-treat depression in a community clinicReal-world outcomes of intranasal esketamine and intravenous ketamine induction therapy for treatment-resistant depression in a community clinic: a retrospective cohort study.

📖 Top 20% Journal

1 week ago • Molecular psychiatry

How fast-acting antidepressants affect lab-grown brain cells over time from people with treatment-resistant depression and healthy individualsTime-dependent effects of rapid-acting antidepressants in iPSC-derived neurons from treatment-resistant depression and healthy volunteers.

🥈 Top 2% Journal

2 weeks ago • Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Psilocybin causes stronger immediate effects and sex-specific long-term improvements in sensory processing in a mouse model of schizophrenia lacking mGlu5Psilocybin produces amplified acute responses and sex-specific long-term increases in sensorimotor gating in the mGlu5 knockout mouse model of schizophrenia.

🥉 Top 5% Journal

3 weeks ago • Neuroscience of consciousness

Detailed experience of feeling immersed and sensing presence while under DMTMicro-phenomenology of immersion and perceived presences under DMT.

🎖️ Top 10% Journal

3 weeks ago • Translational psychiatry

Psilocybin's effects on brain cell connection changes in humansPsilocybin's effect on human brain synaptic plasticity.

🥉 Top 5% Journal

4 weeks ago • Molecular psychiatry

Increased serotonin 1B receptor binding after ketamine and electroconvulsive therapy across multiple centersConvergent increases in serotonin 1B receptor binding following ketamine and electroconvulsive therapy: a multi-centre bayesian re-analysis of PET data.

🥈 Top 2% Journal

6 days ago • Communications medicine

Safety, practicality, and early results of psilocybin therapy for veterans with severe, hard-to-treat PTSDSafety, feasibility, and preliminary clinical outcomes of psilocybin-assisted therapy for veterans with severe, treatment-resistant PTSD: an open-label pilot clinical trial.

🥉 Top 5% JournalArticle

1 week ago • iScience

Social rank influences behavior and gene activity responses to long-term stress and ketamine in male miceSocial hierarchy shapes behavioral and transcriptional responses to chronic stress and ketamine in male mice.

🎖️ Top 10% Journal

2 weeks ago • Science signaling

A new psychedelic quipazine-like drug designed for therapy with possibly fewer side effectsDesign of a new psychedelic quipazine analog with therapeutic efficacy and potentially fewer side effects.

🥉 Top 5% Journal

2 weeks ago • The British journal of psychiatry : the journal of mental science

UK's different rules for psychedelics versus assisted suicide drugsUK's regulatory and legislative double standards in the treatment of psychedelics and drugs for assisted suicide.

🥉 Top 5% Journal

3 weeks ago • JAMA psychiatry

Lessons from GHB for Developing Psychedelic MedicinesFrom Schedule I to the Clinic-Insights Into Psychedelic Drug Development From GHB.

🥇 Top 1% Journal

2 days ago • Addiction (Abingdon, England)

Mental changes in alcohol use disorder linked to 5-MeO-DMT and cognitive behavioral therapyPsychological change processes in alcohol use disorder: A qualitative study of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) with cognitive behavioural therapy.

🥉 Top 5% JournalArticle

6 days ago • Frontiers in psychiatry

How psychedelic drugs affect male and female rodents differently: a review of studiesSex-dependent effects of psychedelics: review of evidence from rodent models.

📖 Top 20% JournalArticle

1 week ago • Biomedicines

Psilocybin: Current Knowledge, Safety Concerns, and Challenges in Studying Its Possible Effects on Multiple OrgansPsilocibin: Current Evidence, Safety Signals, and Challenges in Assessing Potential Multi-Organ Effects.

📖 Top 20% JournalArticle

1 week ago • Frontiers in psychiatry

How psychedelic research reveals healing processes in brain systems linked to mental healthSystems-based psychiatry: insights from psychedelic research on mechanisms of healing.

📖 Top 20% JournalArticle

1 week ago • Molecular psychiatry

Shared brain-immune signaling linked to fast antidepressant effects of ketamine and psychedelicsConvergent neuroimmune signaling underlying rapid antidepressant response to ketamine and psychedelics.

🥈 Top 2% JournalArticle

1 week ago • Pharmaceuticals (Basel, Switzerland)

Assessing the Brain Toxicity of NBOH Chemical VariantsEvaluation of Neurotoxicity of NBOH Derivatives.

📖 Top 20% JournalArticle

1 week ago • Biomolecules

A Six-Point Guide to the Evidence, Safety, and Benefits of Natural Psilocybin for Therapy and PolicyNaturally Derived Psilocybin for Therapeutic Use: A Six-Criterion Framework for Evidence, Safety, and Benefit-Risk Considerations in Policy and Clinical Development.

🎖️ Top 10% JournalArticle

1 week ago • Frontiers in psychiatry

Using the addictive drug ketamine to treat addiction: revisiting the ketamine paradoxTreating addiction with an addictive drug: the ketamine paradox revisited.

📖 Top 20% Journal

3 weeks ago • International journal of molecular sciences

Ion Balance Problems in Major Depression: How Ion Channels and Brain Excitation-Inhibition Imbalance May Guide Targeted TreatmentsIonic Homeostasis Failure in Major Depressive Disorder: Ion Channel Mechanisms, Excitation-Inhibition Imbalance, and Precision Therapeutics.

📖 Top 20% Journal

3 weeks ago • Psychopharmacology

Combined DMT and harmine reduce negative self-focused feelings during social self-evaluation in healthy volunteersCombined DMT-harmine formulation reduces negative self-referential emotions during social self-evaluation: a randomized placebo-controlled trial in healthy volunteers.

📖 Top 20% Journal

3 weeks ago • Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Psychedelics long-lastingly increase reward response in male ratsPsychedelics produce enduring enhancement of reward responsiveness in male rats.

🥉 Top 5% Journal

3 weeks ago • Frontiers in psychiatry

Participants' experiences with ketamine-assisted therapy for methamphetamine addictionNavigating 'k-land': a qualitative exploration of participants' experiences of ketamine-assisted psychotherapy for methamphetamine use disorder.

📖 Top 20% Journal

1 month ago • BMJ open

MDMA-assisted therapy combined with exposure treatment for people with both PTSD and alcohol use disorder: study plan for a double-blind outpatient trialMDMA-assisted PTSD and Alcohol Therapy Trial (MPATHY): study protocol for a double-blind, randomised, controlled outpatient trial of MDMA-assisted integrated exposure-based therapy for comorbid post-traumatic stress disorder and alcohol use disorder.

📖 Top 20% Journal

1 month ago • The British journal of psychiatry : the journal of mental science

Effectiveness and safety of repeated under-the-skin ketamine for hard-to-treat depression and how past ketamine use may affect resultsEffectiveness and safety of repeat dose subcutaneous ketamine for treatment-resistant depression, and the impact of prior ketamine treatment: open label extension of the KADS study.

🥉 Top 5% Journal

1 month ago • The international journal of neuropsychopharmacology

Ketamine's effects on brain activity and therapy links vary in treatment-resistant depression, PTSD, and OCDKetamine effects on EEG and their links to therapy differ across treatment-resistant major depression, post-traumatic stress disorder, and obsessive-compulsive disorder.

🎖️ Top 10% Journal

3 weeks ago • Drug testing and analysis

Using Drug Testing and Wastewater Analysis to Understand Illegal and New Psychoactive Drug Use in AustraliaUnderstanding Consumption of Illicit Drugs and New Psychoactive Substances in Australia by Triangulating Drug Checking and Wastewater-Based Epidemiology.

📖 Top 30% Journal

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