Psychedelic Science Research Papers

4 weeks ago • Frontiers in psychiatry

Challenges and priorities in combining methods to assess psychedelic-assisted therapyMethodological fragmentation and integration priorities in psychedelic-assisted therapy assessment: a scoping review.

📖 Top 20% JournalSystematic Review

2 weeks ago • Molecular psychiatry

How Drugs and Other Treatments Influence Dopamine Release in the Movement System: A Meta-Analysis of Brain Imaging StudiesPharmacological and non-pharmacological modulation of striatal dopamine release: a meta-analysis of [11C]raclopride PET studies.

🥈 Top 2% JournalSystematic Review

2 weeks ago • Frontiers in psychiatry

A review of microdosing psilocybin mushrooms and trufflesThe subtle science: a systematic review of psilocybin magic mushroom and truffle microdosing.

📖 Top 20% JournalSystematic Review

3 weeks ago • Journal of clinical medicine

Psilocybin Therapy in Mental Health: How It Works, Uses, and New Findings (2025-2026)Psilocybin-Assisted Therapy in Psychiatry: A Narrative Clinical Review of Mechanisms, Therapeutic Applications, and Emerging Evidence (2025-2026).

📖 Top 20% JournalArticle

3 weeks ago • Psychopharmacology

Comparing high doses of THC, psilocybin, and placebo during a classic psychedelic therapy sessionPilot study comparing the effects of high dose THC to high dose psilocybin and placebo in the set and setting of a classic psychedelic therapy session.

📖 Top 20% JournalArticle

3 weeks ago • Neuroscience of consciousness

Altered consciousness from floatation therapy in people with anxiety and depressionAquahenosis: a non-pharmacological altered state of consciousness induced by floatation-REST in individuals with anxiety and depression.

🎖️ Top 10% JournalArticle

3 weeks ago • Psychopharmacology

Ketamine’s effectiveness and side effects in moderate to severe obsessive-compulsive disorderEfficacy and tolerability of ketamine in moderate to severe obsessive-compulsive disorder: a systematic review.

📖 Top 20% JournalArticle

yesterday • Frontiers in chemistry

Computer modeling of a new remiketamine-like drug and related compounds: how they interact with NMDA receptors and a key metabolic enzymeStructure-based molecular modeling of a novel S-Remiketamine scaffold and derived arylcyclohexanone analogues: NMDA receptor dynamics, MM-GBSA ranking, and CES1-Oriented structural compatibility.

📖 Top 30% JournalArticle

yesterday • Frontiers in psychiatry

Best practice advice for psychiatrists using short-term oral, under-the-skin, and nasal ketamine treatments for depressionShort-term ketamine interventions for depressive disorders: practical best-practice recommendations for psychiatrists using oral, subcutaneous, and nasal formulations.

📖 Top 20% JournalArticle

2 days ago • Molecular psychiatry

Psilocybin improves social curiosity in male mice lacking SAPAP3 and activates thinking and memory brain areasPsilocybin restores social novelty investigation in male SAPAP3 knockout mice and engages prefrontal-hippocampal circuitry.

🥈 Top 2% JournalArticle

3 days ago • Frontiers in psychiatry

How letting go, distancing, and rethinking relate to psilocybin response in hard-to-treat OCDSurrender, disidentification, and reappraisal: a qualitative comparison of psilocybin responders and non-responders in treatment-resistant OCD.

📖 Top 20% JournalArticle

4 days ago • Molecules (Basel, Switzerland)

Comparing the Safety and Effectiveness of Mushroom-Based and Plant-Based Treatments for Mental HealthSafety and Efficacy of Natural and Conventional Psychiatric Treatments: A Comparative Review of Mushroom-Derived Compounds and Medicinal Plants in the Management of Mental Disorders.

📖 Top 20% JournalArticle

4 days ago • Psychopharmacology

How Psychedelic Therapy May Reset Memory Storage to Help Anxiety DisordersResetting the hippocampal buffer: a neurocognitive account of psychedelic therapy for anxiety-related psychopathology.

📖 Top 20% JournalArticle

4 days ago • Scientific reports

Computer study of how dimethyltryptamine attaches to and is detected by metal-doped C20 fullereneIn silico insights into the adsorption and detection of dimethyltryptamine on metal doped C20 fullerene.

📖 Top 20% JournalArticle

1 week ago • Frontiers in psychiatry

Adding rapamycin to long-term ketamine use may improve various symptomsNon-randomized rapamycin augmentation of chronic self-administered ketamine provides subjective improvement in diverse phenotypes.

📖 Top 20% JournalArticle

2 weeks ago • Frontiers in nutrition

Appetite changes during ketamine treatment in hard-to-treat mood disordersAppetite measures during ketamine administration in treatment-resistant mood disorders: a naturalistic study.

📖 Top 20% JournalArticle

2 weeks ago • Nature communications

How the connection between thinking, memory, and emotion areas relates to brain changes in antidepressant responseThe mPFC-reuniens-hippocampus pathway links brain circuitry and neural plasticity in antidepressant response.

🥈 Top 2% JournalArticle

3 weeks ago • Annals of neurology

Ketamine's potential to treat sudden muscle weakness in Narcolepsy Type 1: Evidence from a patient and mouse studyTherapeutic Prospects of Ketamine for Cataplexy in Narcolepsy Type 1: Evidence from a Human Case and a Murine Model.

🥈 Top 2% JournalArticle

3 weeks ago • Frontiers in psychiatry

Using active imagination and participation to support healing after psychedelic experiencesPsychedelic integration beyond the verbal: participatory-imaginal processing as a hypothesis-generating therapeutic framework.

📖 Top 20% JournalArticle

3 weeks ago • Life (Basel, Switzerland)

Safety and clinical effects of psychedelics across different use patternsPsychedelic Safety and Clinical Outcomes Across Exposure Patterns: A Structured Narrative Review.

📖 Top 30% JournalArticle

4 weeks ago • Frontiers in public health

Key public health needs for psychedelics: education, trained workers, and information in a fast-changing environmentPriorities for public health preparedness for psychedelics: education, workforce readiness, and strategic information needs in a rapidly changing landscape.

📖 Top 20% JournalArticle

4 weeks ago • Neuroscience of consciousness

Low-dose LSD changes how people see visuals without affecting visual contrast processingLow-dose lysergic acid diethylamide alters subjective visual perception but not visual contrast surround suppression.

🎖️ Top 10% JournalArticle

2 weeks ago • Nature communications

Serotonin-based psychedelics cause unique changes in energy use and coordination in rat brain systemsSerotonergic psychedelics induce distinct patterns of metabolic activity and covariance within biologically informed rat brain networks.

🥈 Top 2% JournalResearch Support, Non-U.S. Gov't

3 weeks ago • The Journal of legal medicine

Comparing State Rules to Find the Best Way to Regulate PsilocybinToward an Optimal Framework for Psilocybin Regulation: A Comparison of State Regulatory Approaches Across Key Dimensions.

Article

3 days ago • Frontiers in neuroscience

What Brain Flexibility Means in Mental Health and How Psychedelic Therapy May Relate to ItOn the meaning of "plasticity" in neuroscience and mental health research and its relation to the action of psychedelic therapy.

📖 Top 20% JournalArticle

1 week ago • HEC forum : an interdisciplinary journal on hospitals' ethical and legal issues

Ketamine-caused Dissociation as a Meaningful Sign, Not Just a Side Effect: How Context Guides Ethical Medical ResponsibilitiesKetamine-Induced Dissociation as an Ethical Signal, Not a Side Effect: Context as the Determinant of Clinical Duties Under Beneficence and Non-maleficence.

📖 Top 50% JournalArticle

3 weeks ago • Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater

S-ketamine as a treatment for suicidal thoughts and hard-to-treat depression in teens with early psychosisCase report of S-ketamine as treatment option for suicidal ideation and treatment-resistant depression in adolescents with early-onset psychosis.

📖 Top 50% JournalArticle

2 days ago • Nature communications

How Activation of 5-HT2A Receptors Differs from 5-HT2B ReceptorsMechanistic Basis for 5-HT2AR Over 5-HT2BR Activation.

🥈 Top 2% JournalArticle

2 days ago • Nature communications

Designing psychedelic-like compounds that selectively target specific brain receptor typesStructure-based design of subtype-selective psychedelic analogs.

🥈 Top 2% JournalArticle

3 days ago • JAMA psychiatry

Why Stronger Blinding Is Needed in Psychedelic Drug StudiesThe Case for More Aggressive Masking in Psychedelic Trials.

🥇 Top 1% JournalArticle

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