Psychedelic Science Research Papers

3 days ago • Depression and anxiety

Oral Esketamine for Hard-to-Treat Depression: Patient Results from an Unapproved Treatment ProgramOral Esketamine Maintenance Treatment for Treatment-Resistant Depression: Clinical Outcomes During an Off-Label Treatment Program.

🥉 Top 5% JournalObservational Study

1 week ago • Frontiers in public health

Group psychedelic therapy for mental health conditions: a combined review of studies and experiencesGroup psychedelic-assisted therapy for mental health conditions: a mixed-methods systematic review.

📖 Top 20% JournalSystematic Review

2 weeks ago • The western journal of emergency medicine

Intravenous Ketamine for Treating Depression and Suicidal Thoughts in Teenagers in the Emergency Room: A Randomized Double-Blind TrialIntravenous Ketamine for Depressed and Suicidal Adolescents in the Emergency Department: A Randomized Double-Blind Trial.

📖 Top 30% JournalRandomized Controlled Trial

4 weeks ago • Translational psychiatry

Short-term effects of ketamine on brain activity linked to reward processingSubacute effects of ketamine on neural correlates of reward processing.

🥉 Top 5% JournalRandomized Controlled Trial

2 weeks ago • JAMA network open

Clinical studies on psilocybin and how they are shown in the media: a systematic reviewClinical Evidence on Psilocybin and Its Representation in Media Reporting: A Systematic Review.

🥈 Top 2% JournalSystematic Review

2 weeks ago • Nature neuroscience

Specific brain receptors in deep thinking neurons support psilocybin’s brain plasticity effects but not its hallucinogenic effects5-HT2A receptors in layer 5 pyramidal neurons mediate the neuroplastic but not the hallucinogenic effects of psilocybin.

🥇 Top 1% JournalArticle

2 weeks ago • Molecules (Basel, Switzerland)

Anxiety- and depression-reducing effects of α,α-Trehalose, a natural compound found in Psilocybe cubensisPreclinical Anxiolytic- and Antidepressant-like Effects of α,α-Trehalose, a Bioactive Compound Identified in Psilocybe cubensis.

📖 Top 20% JournalArticle

3 weeks ago • MycoKeys

Different toxin patterns in two new and one known Inocybe mushroom species from northern ChinaMixed toxin profiles in two new and one known species of Inocybe (Inocybaceae) from northern China.

📖 Top 20% JournalArticle

3 weeks ago • Frontiers in pharmacology

Psilocybin or ethocybin causes lasting stronger avoidance memory in male miceAcute psilocybin or ethocybin leads to a sustained increase in Pavlovian aversion memory in male mice.

📖 Top 20% JournalArticle

3 weeks ago • Communications biology

LSD changes thinking areas by speeding up brain rhythms and increasing complexityLSD reconfigures cortical dynamics through faster brain rhythms and increased fractal dimension.

🥉 Top 5% JournalArticle

1 week ago • Frontiers in public health

New Public Health Ideas Inspired by Traditional Use of PsychedelicsBreaking psychedelic boundaries in public health: emerging ideas with ancient roots.

📖 Top 20% JournalHistorical Article

2 weeks ago • European journal of pharmacology

Ibogaine may support brain cell repair and flexibility by changing cell metabolismExtracellular flux analysis and proteomic profiling indicate ibogaine promotes synaptic plasticity and neural repair by a metabolic preconditioning mechanism.

📖 Top 20% JournalArticle

3 weeks ago • Nature neuroscience

LSD's effects on brain molecules and blood flow in humansInvestigating molecular and hemodynamic effects of LSD in the human brain.

🥇 Top 1% JournalArticle

4 days ago • Translational psychiatry

Genes responding quickly to psychedelics are linked to serotonin receptors and specific brain cell types in the thinking areas of humans and other speciesCross-species mapping of acute psychedelic-responsive genes links HTR2A cortical expression, cell-type enrichment, and human cortical expression modules.

🥉 Top 5% JournalArticle

5 days ago • Frontiers in psychiatry

Participant experiences and suggestions for psychedelic clinical trials and future treatments from expert advocatesParticipant experiences and recommendations for psychedelic clinical trials and future treatment delivery: a qualitative study with experts by experience from the Psychedelic Participant Advocacy Network.

📖 Top 20% JournalArticle

1 week ago • International journal of molecular sciences

📖 Top 20% JournalArticle

1 week ago • Psychopharmacology

Differences between men and women in responses to psilocybin or escitalopramSex-related differences in outcomes following psilocybin or escitalopram: a Bayesian secondary analysis.

📖 Top 20% JournalArticle

1 week ago • Frontiers in psychiatry

How cancer patients’ awareness of internal body sensations relates to getting ready for psilocybin therapyPreparing the body for psilocybin therapy: receptive and generative interoception in cancer patients.

📖 Top 20% JournalArticle

1 week ago • Frontiers in public health

Using Ayahuasca in Community Care to Support Indigenous Mental Health in the Yaqui Medicine Clinic in Sonora, MexicoIntercultural pathways to indigenous mental health: the integration of ayahuasca in community care in the Yaqui intercultural medicine clinic in Sonora, Mexico.

📖 Top 20% JournalArticle

1 week ago • Biogerontology

LSD may lengthen lifespan in a type of wormLysergic acid diethylamide extends lifespan in Caenorhabditis elegans.

📖 Top 20% JournalArticle

1 week ago • Frontiers in pharmacology

Activation of serotonin 5-HT2A receptors causes long-lasting presynaptic inhibition in the reward system depending on cannabinoid CB1 receptors5-HT2A receptor activation induces CB1-dependent presynaptic inhibitory long-term depression in the nucleus accumbens core.

📖 Top 20% JournalArticle

2 weeks ago • Frontiers in psychiatry

Careful Consideration of Psychedelics from Medical and Practical Use PerspectivesCaution before canonisation: a clinical and implementation science perspective on psychedelics.

📖 Top 20% JournalArticle

2 weeks ago • Nature neuroscience

Changes in the timing and location of activity in the brain's emotion control area mark the start of depression-like behaviorsSpatiotemporal remodeling in habenula marks the onset of depression-related phenotypes.

🥇 Top 1% JournalArticle

2 weeks ago • Psychopharmacology

How Combining Meditation and Psychoactive Substances Relates to Well-BeingBeyond psychedelic exceptionalism: how people combine meditation with psychoactive substances, and how this relates to well-being.

📖 Top 20% JournalArticle

2 weeks ago • Frontiers in psychiatry

Long-lasting ketamine abstinence after ibogaine treatment: a case reportCorrection: Sustained abstinence in severe ketamine use disorder following ibogaine treatment case report.

📖 Top 20% JournalPublished Erratum

2 weeks ago • Frontiers in pharmacology

Using flashing light to study and test how psilocybin affects the brainStroboscopic light stimulation as a controllable probe of the psilocybin state: a mechanistic framework and a falsifiable prediction.

📖 Top 20% JournalArticle

2 weeks ago • Epigenetics

Changes in blood DNA methylation over time after ketamine-assisted therapy in major depressionLongitudinal peripheral DNA methylation remodeling following ketamine-assisted psychotherapy in major depressive disorder.

📖 Top 20% JournalArticle

2 weeks ago • The oncologist

Personal Control and Psychedelic Therapy in Advanced Cancer: Ethical Lessons from Patient CasesAspirational autonomy and psychedelic-assisted therapy in advanced cancer: ethical lessons from clinical cases.

🥉 Top 5% JournalArticle

2 weeks ago • Frontiers in public health

Creating a system to evaluate ways to reduce psychedelic harm at events using mixed research methodsDesigning evaluation infrastructure for psychedelic harm reduction at events: a methodological framework with formative mixed-methods field application.

📖 Top 20% JournalArticle

2 weeks ago • BMC medical ethics

Feeling Safe: Understanding Vulnerability in (Es)Ketamine TreatmentFeeling safe: an empirical-ethical analysis of vulnerability in (es)ketamine treatment.

📖 Top 20% JournalArticle

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