Latest Longevity & Aging Research Papers (Past Year)

yesterday • Cell death & disease

Palbociclib-induced aging-like state does not make pleural mesothelioma cells more sensitive to senolytic drug combinationsPseudo-senescence induced by palbociclib does not sensitise pleural mesothelioma cells to combinations with senolytics

🥉 Top 5% JournalArticle

yesterday • The journal of nutrition, health & aging

Fatigue, muscle weakness, and key signs of aging: a summary reviewFatigue, muscle fatigability, and the Hallmarks of Aging: a narrative review

Article

yesterday • Neurology

Faster Biological Aging Linked to the Presence and Worsening of Small Blood Vessel Disease in the BrainAssociations of Accelerated Biological Aging With the Presence and Longitudinal Progression of Cerebral Small Vessel Disease

🥉 Top 5% JournalArticle

yesterday • bioRxiv : the preprint server for biology

DNA damage leads to a unique aging-related state in nerve cells linked to Alzheimer's diseaseDNA damage drives a unique, Alzheimer’s disease-relevant senescent state in neurons

Preprint

yesterday • The EMBO journal

SenSet identifies cell-type specific aging markers in the human lungSenSet defines cell-type specific senescence signatures in the aged human lung

🥇 Top 1% JournalArticle

yesterday • bioRxiv : the preprint server for biology

Dynamin-2 helps recycle Atg9A from early cell recycling structures during autophagyDynamin-2 promotes Atg9A retrieval from phagophores during autophagy.

Preprint

yesterday • Materials today. Bio

Injectable drug-filled gels reduce tissue scarring and help muscle cell growth by improving energy use and cell movement in lab modelsInjectable antifibrotic drug-loaded hydrogels reduce fibrosis and restore myogenesis by enhancing mitochondrial metabolism and cell mechanics in an in vitro coculture model

🥉 Top 5% JournalArticle

yesterday • Hypertension (Dallas, Tex. : 1979)

How Cell Aging May Contribute to Preeclampsia and Affect Long-Term HealthRole of Senescence in the Pathophysiology of Preeclampsia and Future Health

🥉 Top 5% JournalArticle

yesterday • Placenta

How insulin resistance and cell recycling processes interact in causing miscarriageThe dynamic interplay between insulin resistance and autophagy: Exploring the coordinated regulation of multiple pathways in the pathogenesis of miscarriage

📖 Top 20% JournalArticle

yesterday • Clinical nutrition ESPEN

How the body’s ability to manage metabolism may explain why diet changes work or don’t work in agingWhy dietary interventions fail or succeed in ageing: metabolic resilience as the missing integrative framework

📖 Top 30% JournalArticle

yesterday • Molecular and cellular endocrinology

Lack of glucose reduces heart cell fat tolerance linked to problems with damaged mitochondria cleanupGlucose deprivation impairs lipid tolerance related to mitophagy disorder in cardiomyocytes

📖 Top 20% JournalArticle

yesterday • Biomaterials

A two-part strategy targeting specific cell parts to disrupt communication between energy and protein systems for reducing rheumatoid arthritisA modular design of two-pronged sub-organelle targeting strategy disrupting mitochondria-endoplasmic reticulum crosstalk for mitigating rheumatoid arthritis

🥉 Top 5% JournalArticle

yesterday • Cell biology and toxicology

CK1-driven modification of TERT helps move it to mitochondria to reduce heart cell aging and ease heart injury from blood flow restorationCK1-induced TERT phosphorylation mediates mitochondrial translocation to inhibit cardiomyocyte senescence and alleviate myocardial ischemia–reperfusion injury

Article

yesterday • International immunopharmacology

TRIM27 helps brain immune cells shift to a protective state and supports nerve cell survival through TBK1-controlled cell cleanup after stroke injuryTRIM27 promotes microglial M2 polarization and neuroprotection via TBK1-dependent autophagy in cerebral ischemia–reperfusion injury

Article

yesterday • Nature communications

Protein Making Near Autophagosome Formation During Ongoing Cellular RecyclingTranslation in proximity to forming autophagosomes during sustained autophagy

🥈 Top 2% JournalArticle

yesterday • International immunopharmacology

How Gut Bacteria May Link Inflammation and Aging Immune Cells to OsteoarthritisThe gut–joint axis in osteoarthritis: integrating microbiota-driven metaflammation and immunosenescence

Article

yesterday • Renal failure

Resveratrol reduces kidney damage in diabetes by lowering oxidative stress, inflammation, and cell death after blood flow loss and restorationResveratrol inhibits renal ischemia and reperfusion injury in diabetes via reducing oxidative stress, inflammation, and apoptosis

📖 Top 30% JournalArticle

yesterday • FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Lysosomal Membrane Proteins as Important Controllers of Sugar Metabolism and Related DiseasesLysosomal Membrane Proteins: Key Regulators of Glucose Metabolism and Its Associated Diseases

Systematic Review

yesterday • bioRxiv : the preprint server for biology

Rab12 controls the removal of damaged mitochondria and maintains mitochondrial healthRab12 is a regulator of mitophagy and mitochondrial homeostasis.

Preprint

2 days ago • Radiology. Cardiothoracic imaging

Estimating Biological Age Using Automated Organ Measurements from Chest X-RaysExplainable Biological Age from Automated Chest Radiography–based Organ Quantifications: qCXR-bioage

🎖️ Top 10% JournalArticle

2 days ago • Frontiers in cell and developmental biology

Key factors in bone aging: how cell aging, low estrogen, and gut health contribute and potential treatmentsThe triangular drivers of bone aging: mechanistic insights and therapeutic targets in cellular senescence, estrogen deficiency, and gut microenvironment dysregulation

🎖️ Top 10% JournalFulltext (Open License)Article

2 days ago • Scientific reports

Synthetic circular RNA may improve heart cell function by targeting key microRNAsSynthetically designed circRNA can be used to target cardiovascular relevant microRNAs to improve cellular function

📖 Top 20% JournalArticle

2 days ago • BMC medicine

Understanding and treating aging-related immune decline in lung diseasesTargeting immunosenescence in lung diseases: mechanistic insights and clinical interventions

🥉 Top 5% JournalArticle

2 days ago • American journal of physiology. Cell physiology

Measuring Mitochondrial Damage in Human Airway Muscle Cells Using FluorescenceFluorescence-Based Quantification of Mitochondrial Damage in Human Airway Smooth Muscle Cells

Article

2 days ago • The journals of gerontology. Series A, Biological sciences and medical sciences

The ISG15 Pathway: A Key Driver and Treatment Target in Blood Vessel Aging and InflammationThe ISG15 Axis: A Central Mediator and Therapeutic Target in Vascular Inflammaging

Article

2 days ago • Life sciences

Disrupting the OPTN-TBK1 pathway reduces cell cleanup in prion diseaseDisruption of the OPTN-TBK1 axis impairs autophagosome formation in prion disease

Article

2 days ago • The Journal of biological chemistry

Where and how mammal cells form autophagosomesWhere and how do mammalian cells shape autophagosomes?

🎖️ Top 10% JournalArticle

2 days ago • Materials today. Bio

Cell-membrane-coated nanoparticles may reduce spine disc wear by lowering oxidative stress and boosting cell cleanupMembrane-camouflaged nanoparticle alleviates intervertebral disc degeneration via oxidative stress suppression and autophagy activation

🥉 Top 5% JournalArticle

2 days ago • Cell biochemistry and function

High Blood Sugar May Cause Immune Cell Aging by Damaging Energy Factories and Blocking Their Cleanup ProcessHigh Glucose Triggers Macrophage Senescence Through Mitochondrial Dysfunction and Mitophagy Impairment

📖 Top 30% JournalArticle

2 days ago • Aging cell

Human cGAS Activates LINE-1 to Trigger MAVS-Dependent Cell AgingHuman c GAS Drives LINE ‐1 Transcriptional Activation to Trigger MAVS ‐Dependent Cellular Senescence

🥉 Top 5% JournalArticle

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