Trending mRNA Technology Research Papers

yesterday • Biofabrication

Making lipid nanoparticles using gravity and vibrating sharp-tip mixing in microfluidic devicesGravity-driven microfluidic synthesis of lipid nanoparticles via vibrating sharp-tip mixing.

🎖️ Top 10% JournalArticle

5 days ago • RNA (New York, N.Y.)

Efficient production of a self-copying RNA vaccine using a single enzyme from Klebsiella phage 32 starting with its natural RNA codeEfficient production of a self-amplifying RNA vaccine sequence with the single subunit RNA polymerase from Klebsiella phage 32 utilising the native AU initiating dinucleotide.

🥉 Top 5% JournalArticle

yesterday • Human vaccines & immunotherapeutics

Immune response to two different COVID-19 bivalent booster vaccines in US nursing home residentsComparative immunogenicity of mRNA-1273 and BNT162b2 SARS-CoV-2 bivalent booster vaccines in US nursing home residents.

📖 Top 20% JournalComparative Study

2 days ago • Signal transduction and targeted therapy

Boosting blood vessel growth in insulin-producing cells improves islet transplantationβ-cell-targeted RNA activation of vascular endothelial growth factor-A improves islet transplantation.

🥇 Top 1% JournalArticle

yesterday • Acta biochimica et biophysica Sinica

Using a signal to direct proteins inside cells boosts antigen production and release to improve mRNA vaccine effectivenessSignal peptide-mediated endoplasmic reticulum targeting enhances antigen expression and secretion to improve mRNA vaccine efficacy.

📖 Top 20% JournalArticle

2 days ago • Journal of materials chemistry. B

Delivering anti-inflammatory mRNA to the pancreas using lipid nanoparticles reduces acute pancreatitisPancreas-specific lipid nanoparticle-mediated interleukin-10 mRNA delivery ameliorates acute pancreatitis.

📖 Top 20% JournalArticle

2 days ago • Cell reports. Medicine

Including the capsid protein in a chikungunya mRNA vaccine reduces the adaptive immune responseCapsid inclusion in a CHIKV mRNA vaccine impairs adaptive immune responses.

🥈 Top 2% JournalArticle

2 days ago • International journal of biological macromolecules

Gene-activated porous scaffolds carrying SOX9 mRNA nanoparticles promote evenly spread cartilage growth under the skinGene-activated porous scaffolds integrating SOX9 mRNA lipid nanoparticles enable uniformly distributed ectopic chondrogenesis in subcutaneous model.

📖 Top 20% JournalArticle

6 days ago • Molecular therapy : the journal of the American Society of Gene Therapy

Using Tissue-Specific Silencing of Synthetic mRNAs to Identify Vaccination-Active Tissues and Reduce Immune Response to Cas9Tissue-Specific Silencing of Synthetic mRNAs By De-Targeting Elements Maps Vaccination-Competent Tissues, and Allows Cas9 De-Immunization.

🥈 Top 2% JournalArticle

6 days ago • Vaccine

Immune response, side effects, and safety of an mRNA flu and COVID-19 combined vaccine in Japanese adults aged 50 and overImmunogenicity, reactogenicity, and safety of an mRNA-based seasonal influenza and SARS-CoV-2 multicomponent vaccine, mRNA-1083, in adults aged ≥50 years in Japan.

📖 Top 20% JournalArticle

6 days ago • Molecular therapy : the journal of the American Society of Gene Therapy

Self-amplifying mRNA vaccine without a cap protects mice against H5 bird flu virus using lower dosesCapless self-amplifying mRNA vaccine induces dose-sparing protective immunity against HPAI clade 2.3.4.4 H5 virus in mice.

🥈 Top 2% JournalArticle

2 days ago • Drug testing and analysis

Comparing how the body clears lipid nanoparticle-delivered human erythropoietin mRNA to support doping control for mRNA drugsComparative Elimination Analysis of Lipid Nanoparticle-Encapsulated Human Erythropoietin mRNA by Multimodal Approaches Suggests an Effective Doping Control Strategy for mRNA-Based Agents.

📖 Top 30% JournalArticle

4 days ago • Immunologic research

Past progress and future outlook of personalized vaccines and the role of immune-activating cellsPast achievements and future perspectives of personalized vaccines and the role of dendritic cells.

📖 Top 20% JournalArticle

1 week ago • Small science

New Developments in Nano-Sized Drug Carriers Made from PolyethyleneimineAdvances in Polyethyleneimine-Derived Nanoformulations.

🥉 Top 5% JournalArticle

1 week ago • Journal of pharmacokinetics and pharmacodynamics

Whole-body model to study how lipid nanoparticle mRNA medicines spread and act inside cellsConstruction of a translational whole-body physiologically based pharmacokinetic model to investigate the biodistribution of lipid nanoparticle-based mRNA therapeutics for intracellular protein targets.

📖 Top 20% JournalArticle

6 days ago • Vaccine

Strong early immune reactions reduce T cell response to mRNA COVID-19 vaccinesOver-induction of innate immune responses suppresses T cell response to mRNA SARS-CoV-2 vaccination.

📖 Top 20% JournalArticle

1 week ago • Small (Weinheim an der Bergstrasse, Germany)

Lipid Nanoparticles Using Protein Coating to Capture Inflammatory Molecules for Combined Immune TherapyReverse-Engineered Lipid Nanoparticles Harness Protein Corona Formation for Cytokine Sequestration and Combination Immunomodulatory Therapy.

🥈 Top 2% JournalArticle

4 days ago • bioRxiv : the preprint server for biology

Loading RNA into fat-based nanoparticle carriersPost-loading ribonucleic acid into lipid nanoparticle carriers.

Preprint

1 week ago • Artificial cells, nanomedicine, and biotechnology

Recent progress in CRISPR gene editing tools and delivery methodsRecent advances of CRISPR-based gene editing technologies and delivery strategies.

📖 Top 30% JournalArticle

4 days ago • Nanomedicine (London, England)

Progression of peptide-based delivery systems for siRNA from early designs to advanced platformsEvolution of peptide-mediated siRNA delivery - from early design to next generation platform.

📖 Top 50% JournalArticle

6 days ago • Small (Weinheim an der Bergstrasse, Germany)

Lipid nanoparticles that restore iron supply and use RNA interference to trigger iron-dependent cell death for cancer treatmentA Ferrous-Supply-Regenerating Lipid Nanoparticle Integrating RNAi Induces Ferroptosis for Cancer Therapy.

🥈 Top 2% JournalArticle

6 days ago • Frontiers in cell and developmental biology

Tiny cell membranes that connect organelles influence their movement and cell survivalNanoscale biointerfaces in inter-organelle communication: membrane contact sites, organelle trafficking, and cell fate control.

🎖️ Top 10% JournalArticle

1 week ago • Journal of applied genetics

A new mRNA vaccine targeting multiple parts of E. coli designed using computer methodsA novel multi-epitope mRNA vaccine against Escherichia coli using an in silico reverse vaccinology approach.

📖 Top 50% JournalArticle

5 days ago • Acta tropica

Levels of COVID-19 antibodies and related factors after a different mRNA booster in people first vaccinated with an inactivated vaccineAnti-SARS-CoV-2 receptor-binding domain IgG titers and associated factors after heterologous mRNA booster vaccination in individuals primed with the inactivated vaccine.

📖 Top 30% JournalArticle

1 week ago • Research square

Improving HPV16 E6/E7 mRNA Vaccine by Adding HSV-1 gD Epitope and Immune-Boosting Agents in StepsStepwise Enhancement of HPV16 E6/E7 mRNA Vaccine Efficacy Using HSV-1 gD Epitope Incorporation and Immune-Modulating Agents.

Preprint

6 days ago • Cell genomics

PUS7 changes RNA by modifying specific letters based on RNA sequence, shape, and cell typePUS7 mRNA pseudouridylation is driven by RNA sequence, structure, and cell-type-specific features.

🥇 Top 1% JournalArticle

1 week ago • bioRxiv : the preprint server for biology

mRNA Nanoparticles Producing a Key Bacterial Protein Trigger Wide-Ranging Systemic and Mucosal Antibodies Against Drug-Resistant GonorrheaAn mRNA-Lipid Nanoparticle Platform Encoding the Conserved Outer Membrane Protein BamA Elicits Broadly Cross-Reactive Systemic and Mucosal Antibodies Against Antimicrobial-Resistant Neisseria gonorrhoeae.

Preprint

1 week ago • bioRxiv : the preprint server for biology

Peptides change lipid nanoparticles and improve gene delivery to lung cells without serumPeptide additives reprogram the lipid nanoparticle corona and enhance gene delivery in a serum-free environment for lung epithelium.

Preprint

5 days ago • DNA and cell biology

Current and Future Advances in Using Molecular Replacement to Treat DiseasesMolecular Restoration Through Replacement Therapies: Current Advances and Future Directions in Treating Diseases.

Article

5 days ago • Advances in colloid and interface science

Using tiny fat-based carriers to deliver genetic material for protecting plants and crops by applying medical nanotechnology ideasLipid nanocarriers for nucleic acid delivery in plants and crop protection: bridging nanomedicine concepts with agricultural applications.

Article