Trending mRNA Technology Research Papers

2 days ago • Molecular biomedicine

Using lipid nanoparticles to deliver a gene activator’s instructions for treating fatty liver disease linked to metabolism problemsLipid nanoparticle-mediated transcription factor EB mRNA delivery for the treatment of metabolic dysfunction-associated steatotic liver disease.

🥉 Top 5% JournalArticle

4 days ago • Journal of the Royal Society, Interface

Using multiple goals to design genetic vaccines in a logical wayA multi-objective sequence engineering framework for rational genetic vaccine design.

📖 Top 20% JournalArticle

2 days ago • Journal of pharmaceutical sciences

Measuring how many particles are in mRNA lipid nanoparticles, what affects their production, and why it matters for product qualityParticle occupancy in mRNA lipid nanoparticles: Measurement, manufacturing determinants, and relevance to product quality.

📖 Top 30% JournalArticle

4 days ago • Frontiers in immunology

Alpha-galactosylceramide in mRNA vaccines boosts immune cells against tuberculosis and increases lung T cells with tissue-resident features after a prime-pull approachAlpha-galactosylceramide as mRNA vaccine adjuvant modulates cellular immunity against tuberculosis and contributes to antigen-specific lung-associated T cells with a TRM-associated phenotype following prime-pull strategy.

🥉 Top 5% JournalResearch Support, Non-U.S. Gov't

4 days ago • EMBO molecular medicine

Intramuscular self-amplifying RNA and adenovirus RSV vaccines trigger different body-wide and lung immune responsesIntramuscular self-amplifying RNA and adenoviral RSV vaccines program distinct systemic and respiratory mucosal immune architectures.

🥈 Top 2% JournalArticle

4 days ago • The Journal of clinical investigation

Needle-free combined boosters strengthen naked mRNA vaccines to protect mice from lung virusesJet-injected combinational adjuvants potentiate naked mRNA vaccines for protection against respiratory viral infections in mice.

🥈 Top 2% JournalArticle

5 days ago • Advanced materials (Deerfield Beach, Fla.)

New Lipid Nanoparticle Methods for Delivering RNA Treatments Outside the LiverEmerging Lipid Nanoparticle Targeting Strategies for Extrahepatic Delivery of RNA Therapeutics.

🥇 Top 1% JournalArticle

4 days ago • BioImpacts : BI

RNA Vaccines: Understanding Their Design, How They Are Delivered, and How They Are UsedRNA vaccines in motion: A multidisciplinary exploration of design, delivery, and deployment.

📖 Top 50% JournalArticle

2 days ago • Mucosal immunology

Different control of flu vaccine B cell responses targeting the virus head versus stem in vaccinated and unvaccinated infant African green monkeysDistinct regulation of influenza HA head- versus stem-specific B cell responses in HA mRNA-LNP vaccinated and naïve infant African green monkeys.

🥉 Top 5% JournalArticle

5 days ago • Bioactive materials

Injectable mRNA-made short fibers send timed mechanical and genetic signals to reshape support cell structure for nerve healingInjectable mRNA-engineered short fibers deliver temporally coupled mechano-genetic signals to reprogram Schwann cell cytoskeleton for nerve repair.

🥈 Top 2% JournalArticle

1 week ago • Journal of toxicology

Safety Concerns and Risks of Modified mRNA Vaccine Technology Based on COVID-19 ExperienceToxicological Vulnerabilities and Emerging Safety Signals in Modified mRNA Vaccine Technology: A Narrative Review of the COVID-19 Experience.

📖 Top 30% JournalArticle

4 days ago • Clinical & translational immunology

Using CRISPR to insert large genes into primary human T cells and how they are incorporatedFrom delivery to integration: CRISPR-mediated large insert gene editing in primary human T cells.

🎖️ Top 10% JournalArticle

6 days ago • International journal of pharmaceutics

Lipid-polymer nanoparticles stable for inhalation to deliver mRNA in advanced lab models of the lungsNebulization-stable lipid-polymer hybrid nanoparticles for mRNA delivery in advanced in vitro respiratory models.

📖 Top 20% JournalArticle

5 days ago • Molecular therapy. Nucleic acids

Detailed lab testing and body processing of RNA-made PGT121-LS antibody against HIVRNA-encoded PGT121-LS anti-HIV antibody: Comprehensive preclinical characterization and translational pharmacokinetics.

🥉 Top 5% JournalArticle

1 week ago • China CDC weekly

Two mRNA Approaches for Dog Rabies Vaccines: Progress, Challenges, and Potential Use in the FieldTwo mRNA Platforms for Canine Rabies Vaccines: Advances, Limitations, and Field Application Prospects.

📖 Top 20% JournalArticle

1 week ago • ACS polymers Au

Free Polymers Change Polyplex Solution Behavior and Make It Harder to Understand Their Structure and FunctionFree Polymers Skew Polyplex Solution Properties and Confound the Interpretation of Structure-Function Relationships.

🎖️ Top 10% JournalArticle

4 days ago • Cancer discovery

Cancer Vaccines Targeting Common Tumor Markers Often Fail to WorkShared-Antigen Cancer Vaccines Keep Falling Short.

🥇 Top 1% JournalArticle

6 days ago • International journal of pharmaceutics

Measuring protein production from mRNA-LNPs: how dose and previous exposure affect resultsIVIS assessment of mRNA-LNP protein expression: effects of dosing parameters and prior LNP exposure.

📖 Top 20% JournalArticle

6 days ago • ACS applied materials & interfaces

Improving Cell Delivery for Aptamer-Driven Ubiquitin-Based Breakdown of c-Met ProteinOptimizing Endosomal Escape for Effective Aptamer-Based Ubiquitin-Mediated Degradation of c-Met.

🎖️ Top 10% JournalArticle

1 week ago • International journal of nanomedicine

Using Lipid Nanoparticles to Treat Brain Fungal Infections and Support the Immune ResponseLipid Nanoparticle-Mediated Antifungal and Immunomodulatory Therapy for Neuromycoses.

🎖️ Top 10% JournalArticle

2 days ago • Molecular pharmaceutics

Using Stronger Fat-Based Nanoparticles to Lower PD-L1 Levels in Breast Cancer CellsReinforcement of Solid Lipid Nanoparticles for Targeted PD-L1 Downregulation in Breast Cancer.

📖 Top 20% JournalArticle

2 days ago • Kidney research and clinical practice

Clinical outcomes of third mRNA COVID-19 vaccine doses in patients on hemodialysis across the countryClinical effects of third doses of mRNA COVID-19 vaccines among hemodialysis patients: a nationwide retrospective cohort study.

📖 Top 20% JournalArticle

6 days ago • Bioanalysis

Challenges and possible solutions in analyzing new small-molecule drugs: a European industry perspectiveEuropean Bioanalysis Forum cross-industry perspective on emerging small-molecule modalities: bioanalytical challenges and potential mitigation strategies.

📖 Top 50% JournalArticle

1 week ago • Frontiers in immunology

Combining multiple molecular analyses shows vaccine-specific patterns and timing of COVID-19 immune responsesMulti-omics integration reveals vaccine-specific molecular signatures and temporal dynamics of COVID-19 immune responses.

🥉 Top 5% JournalResearch Support, N.I.H., Extramural

2 days ago • Journal of controlled release : official journal of the Controlled Release Society

Long-lasting destruction of a key sugar transporter by a targeted molecule causes energy failure and inflammatory cell death in cancerSustained degradation of glucose transporter 1 by an mRNA-encoded lysosome-targeting chimera triggers metabolic collapse and pyroptosis in cancer.

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6 days ago • International journal of nanomedicine

Using Peptides to Deliver Active Substances Exactly Inside CellsPeptide-Mediated Precise Intracellular Delivery of Bioactive Substances.

🎖️ Top 10% JournalArticle

2 days ago • Journal of controlled release : official journal of the Controlled Release Society

How ionizable lipids affect mRNA vaccine makeup and immune responseIonizable lipid impact on mRNA vaccine formulation properties and immunogenicity.

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1 week ago • Extracellular vesicles and circulating nucleic acids

Designed tiny cell particles: drug delivery challenges, improvement methods, and potential medical usesEngineered extracellular vesicles: pharmacological barriers, engineering strategies, and translational opportunities.

📖 Top 20% JournalArticle

1 week ago • Frontiers in immunology

How Gut Bacteria and Their Chemicals Affect Vaccine Response and Lasting Immunity Depending on the SituationThe microbiome-metabolite-vaccine axis: context-dependent modulators of immunogenicity and durability.

🥉 Top 5% JournalArticle

2 days ago • Journal of controlled release : official journal of the Controlled Release Society

Changing tumor-supporting immune cells with ID3 mRNA to improve immunotherapy for pancreatic cancerReprogramming tumor-associated macrophages via ID3 mRNA delivery for enhanced immunotherapy in pancreatic cancer.

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