mRNA Technology Research Papers

4 weeks ago • PloS one

A Piezoelectric Device for Improved Delivery of RNA Vaccines Without CarriersA piezoelectric electroporator (Piezopen) for enhanced "naked" RNA vaccine delivery.

📖 Top 30% Journal

5 days ago • RNA (New York, N.Y.)

Efficient production of a self-copying RNA vaccine using a single enzyme from Klebsiella phage 32 starting with its natural RNA codeEfficient production of a self-amplifying RNA vaccine sequence with the single subunit RNA polymerase from Klebsiella phage 32 utilising the native AU initiating dinucleotide.

🥉 Top 5% JournalArticle

2 weeks ago • Cell

Viral enzyme-triggered cell self-destruction as a universal antiviral mRNA treatmentViral protease-initiated lytic cell death as a universal antiviral mRNA therapy.

🏆 Top 0.1% Journal

2 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Using Sterol Changes to Guide mRNA Lipid Nanoparticles for Improved Targeting and Stronger Immunity in the SpleenMolecular Dynamics-Guided Sterol Engineering of mRNA-Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen-Selective Immunity.

🥈 Top 2% Journal

2 weeks ago • Small (Weinheim an der Bergstrasse, Germany)

Understanding how lipid makeup affects immune response to design nanoparticles with controlled immunityDefining Composition-Cytokine Relationships Enables the Design of Lipid Nanoparticles with Programmed Immunogenicity.

🥈 Top 2% Journal

2 weeks ago • Angewandte Chemie (International ed. in English)

Glutathione-Triggered Chemical Changes to Activate RNA and Extend Protein ProductionGlutathione-Responsive Acyl-Modifications for Targeted RNA Decaging and Prolonged Protein Synthesis.

🥇 Top 1% Journal

6 days ago • Vaccine

Immune response, side effects, and safety of an mRNA flu and COVID-19 combined vaccine in Japanese adults aged 50 and overImmunogenicity, reactogenicity, and safety of an mRNA-based seasonal influenza and SARS-CoV-2 multicomponent vaccine, mRNA-1083, in adults aged ≥50 years in Japan.

📖 Top 20% JournalArticle

1 week ago • Small (Weinheim an der Bergstrasse, Germany)

Changing the Fat and Connector Parts of PEG-Lipids Helps mRNA Nanoparticles Target Muscle Cells More PreciselyHydrophobic Tail and Linker Diversification of PEG-Lipids Unlocks Precise Muscle Tropism of mRNA-Lipid Nanoparticles.

🥈 Top 2% Journal

2 weeks ago • Molecular pharmaceutics

Targeted mRNA Delivery Using Antibody-Linked Lipid NanoparticlesTargeted mRNA Delivery Using Bispecific Antibody-Lipid Nanoparticle Complexes.

📖 Top 20% JournalArticle

2 weeks ago • Science advances

A unique process of showing vaccine parts triggers strong T cell immune response in mRNA vaccines using lipid nanoparticlesA distinct antigen presentation pathway drives potent T cell immunity in lipid nanoparticle-based mRNA vaccines.

🥈 Top 2% Journal

3 weeks ago • Biomaterials

Targeted delivery of optimized mRNA nanoparticles to lymph nodes for COVID-19 vaccinationLymph node-targeted mRNA delivery of fine-tuned peptide-nanocomplexes for SARS-CoV-2 Vaccination.

🥉 Top 5% Journal

3 weeks ago • Molecular therapy : the journal of the American Society of Gene Therapy

How Gene Code Changes Affect Self-Replicating RNA’s Ability to Copy ItselfTransgene Sequence Codon Optimization and Composition Determines Replication Competence of Self-Amplifying RNA.

🥈 Top 2% Journal

4 weeks ago • Nature communications

Lung-delivered mRNA nanoparticle vaccines for fast and lasting protection against bacterial infectionsPulmonary mRNA-LNP vaccines for rapid and durable protection against bacterial infection.

🥈 Top 2% Journal

2 days ago • Signal transduction and targeted therapy

Boosting blood vessel growth in insulin-producing cells improves islet transplantationβ-cell-targeted RNA activation of vascular endothelial growth factor-A improves islet transplantation.

🥇 Top 1% JournalArticle

1 week ago • Small (Weinheim an der Bergstrasse, Germany)

Lipid Nanoparticles Using Protein Coating to Capture Inflammatory Molecules for Combined Immune TherapyReverse-Engineered Lipid Nanoparticles Harness Protein Corona Formation for Cytokine Sequestration and Combination Immunomodulatory Therapy.

🥈 Top 2% JournalArticle

1 week ago • Small science

New Developments in Nano-Sized Drug Carriers Made from PolyethyleneimineAdvances in Polyethyleneimine-Derived Nanoformulations.

🥉 Top 5% JournalArticle

1 week ago • Animals : an open access journal from MDPI

A New ORFV F1L mRNA Vaccine: Development, Immune Response, and Comparison with a Commercial Live VaccineAn ORFV F1L mRNA Vaccine Candidate: Preparation, Immunogenicity, and Comparison with a Commercial Live Vaccine.

📖 Top 30% JournalArticle

1 week ago • Pharmaceutics

Improving delivery of therapeutic mRNA to the lungs to prevent lung scarringOptimization of Therapeutic modRNA Delivery to the Lung for Prevention of Pulmonary Fibrosis.

📖 Top 20% JournalArticle

1 week ago • International journal of molecular sciences

COVID-19 mRNA Vaccines Linked to Lower Immune Cell Death in Patients with Solid TumorsSARS-CoV-2 mRNA Vaccination Induces Reduced T-Cell Apoptosis in Patients with Solid Tumors.

📖 Top 20% JournalArticle

1 week ago • International journal of molecular sciences

Molecular methods for RNA and epigenome editing therapies beyond permanent gene changesBeyond Permanent Genome Editing: Molecular Delivery Strategies for RNA Editing and Epigenome-Editing Therapeutics.

📖 Top 20% JournalArticle

1 week ago • Pharmaceutics

Immune responses to PEG in mRNA lipid vaccines show changes across the populationAnti-PEG Immunogenicity of mRNA-LNP Vaccines in Humans: Evidence for Population-Level Changes in the Anti-PEG Antibody Repertoire.

📖 Top 20% JournalArticle

1 week ago • Pharmaceutics

Analysis and Stability of RNA-Based VaccinesAnalytical Characterization and Stability Assessment of RNA-Based Vaccines.

📖 Top 20% JournalArticle

1 week ago • Biomolecules

Shared Tumor-Specific Targets Based on Genetic Sequences for Ready-Made mRNA Cancer Vaccines Matched to Patient Immune Types Across Multiple CancersSequence-Anchored Shared Tumor-Specific Epitopes for Pre-Manufactured HLA-Matched mRNA Cancer Vaccine Libraries: A Pan-Cancer Framework.

🎖️ Top 10% JournalArticle

1 week ago • Pharmaceutics

Using Artificial Intelligence to Design and Develop Nanomedicine from Drug Formulation to Clinical UseArtificial Intelligence-Driven Nanomedicine: From Drug Formulation and Nanocarrier Design to Clinical Translation.

📖 Top 20% JournalArticle

1 week ago • Vaccines

Fast measurement of mRNA vaccine cap quality using precise RNA cutting and improved chromatographyRapid LC-MS Quantification of mRNA Vaccine Capping Efficiency via High-Specificity RNase H Cleavage and Metal Adduct Suppressed Chromatography.

📖 Top 20% JournalArticle

1 week ago • Advanced materials (Deerfield Beach, Fla.)

Using Continuous Microfluidics to Explore and Build Lipid NanostructuresNavigating Lipid Nanostructure Design Space Through Continuous Microfluidic Automation.

🥇 Top 1% JournalArticle

1 week ago • Vaccines

Minicircle DNA Vaccines and How They Improve Delivery and Protein Production for Advanced ImmunizationMinicircle DNA Vaccines: Overcoming Delivery and Expression Barriers in Next-Generation Immunization.

📖 Top 20% JournalArticle

1 week ago • Vaccines

Possible Ways mRNA in Lipid Nanoparticles Breaks Down: A Complete ReviewPossible Mechanisms of mRNA-LNP Degradation: A Comprehensive Review.

📖 Top 20% JournalArticle

1 week ago • Vaccines

A new tiny particle system that improves poultry vaccinesA Novel Effective Nanoadjuvant System for Poultry Vaccines.

📖 Top 20% JournalArticle

1 week ago • Vaccines

Designed mRNA Nanoparticles for Delivery to Lung MucusEngineered mRNA Nanoparticle Platforms for Respiratory Mucosal Delivery.

📖 Top 20% JournalArticle

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