mRNA Technology Research Papers

3 weeks ago • Human vaccines & immunotherapeutics

Side effects of 2023-2024 XBB.1.5 mRNA and protein-based COVID-19 vaccines in real-world use from the BEEHIVE trialReal-world evaluation of 2023-2024 XBB.1.5 mRNA and protein-based COVID-19 vaccine reactogenicity from the randomized BEEHIVE trial.

📖 Top 20% JournalRandomized Controlled Trial

1 week ago • Cells

Improved surrounding protein sequences boost immune response and antigen display after mRNA vaccinationOptimized Epitope-Flanking Sequences Enhance Antigen Presentation and T-Cell Responses Following mRNA Vaccination.

🎖️ Top 10% JournalArticle

3 weeks ago • Nature communications

A viral protein boosts self-replicating RNA by adjusting cell immune defenseTuning intracellular immunity by Nodamura virus B2 protein enhances self-amplifying RNA activity.

🥈 Top 2% JournalArticle

4 days ago • Frontiers in immunology

Alpha-galactosylceramide in mRNA vaccines boosts immune cells against tuberculosis and increases lung T cells with tissue-resident features after a prime-pull approachAlpha-galactosylceramide as mRNA vaccine adjuvant modulates cellular immunity against tuberculosis and contributes to antigen-specific lung-associated T cells with a TRM-associated phenotype following prime-pull strategy.

🥉 Top 5% JournalResearch Support, Non-U.S. Gov't

1 week ago • Frontiers in immunology

Combining multiple molecular analyses shows vaccine-specific patterns and timing of COVID-19 immune responsesMulti-omics integration reveals vaccine-specific molecular signatures and temporal dynamics of COVID-19 immune responses.

🥉 Top 5% JournalResearch Support, N.I.H., Extramural

1 week ago • ACS applied materials & interfaces

Testing many lipid nanoparticles to find the best ones for delivering CRISPR gene-editing toolsHigh-Throughput Screening of a Lipid Nanoparticle (LNP) Library Identifies Lead Formulations for CRISPR-Cas9 Ribonucleoprotein Delivery and Gene Editing.

🎖️ Top 10% JournalArticle

1 week ago • International journal of pharmaceutics

Amorphous trehalose improves long-term high-temperature storage of freeze-dried mRNA-lipid nanoparticlesAmorphous trehalose as a superior lyoprotectant for high-temperature long-term storage of freeze-dried mRNA-lipid nanoparticles.

📖 Top 20% JournalArticle

1 week ago • Science translational medicine

Engineered antibody parts allow delivery of multiple mRNA-made dual-target antibodies that limit virus evasionOrthogonal Fc engineering enables multiplexed delivery of mRNA-encoded bispecific antibodies that constrain viral escape.

🥇 Top 1% JournalArticle

2 weeks ago • Cell reports. Medicine

Zika mRNA vaccine with fusion-loop changes triggers focused B cell response that separates protection from antibody-related enhancement in macaquesFusion-loop-engineered Zika mRNA vaccine elicits convergent B cell immunodominance to uncouple protection from ADE in macaques.

🥈 Top 2% JournalArticle

2 weeks ago • Molecular therapy. Nucleic acids

Segmented mRNA tail regions with microRNA sites allow tissue-specific control for mRNA therapiesSegmented poly(A) tails with microRNA target sites confer tissue-specific regulation for mRNA therapeutics.

🥉 Top 5% JournalArticle

3 weeks ago • Cell reports. Medicine

Improved liver healing by delivering mRNA to partly reprogram cells inside the bodyEnhanced liver regeneration via targeted mRNA delivery for partial in vivo reprogramming.

🥈 Top 2% JournalArticle

3 weeks ago • Molecular therapy : the journal of the American Society of Gene Therapy

Separating side effects from effectiveness to create safer mRNA vaccines, gene therapies, and gene editing treatmentsDecoupling reactogenicity from efficacy enables safer mRNA vaccines, AAV gene delivery, and in vivo base editing.

🥈 Top 2% JournalArticle

3 weeks ago • Nature biotechnology

Improved lipid nanoparticles for delivering large RNA and targeting tissues to boost genome editing in living organismsLipid nanoparticles optimized for large RNA cargo and tissue targeting enhance in vivo genome editing.

🏆 Top 0.1% JournalArticle

1 month ago • Molecular therapy. Nucleic acids

Highly specific gene disruption in living organisms using Cas12a guided by chRDNACas12a chRDNA-mediated in vivo genome editing for high specificity functional gene disruption.

🥉 Top 5% JournalArticle

2 days ago • Molecular biomedicine

Using lipid nanoparticles to deliver a gene activator’s instructions for treating fatty liver disease linked to metabolism problemsLipid nanoparticle-mediated transcription factor EB mRNA delivery for the treatment of metabolic dysfunction-associated steatotic liver disease.

🥉 Top 5% JournalArticle

4 days ago • Journal of the Royal Society, Interface

Using multiple goals to design genetic vaccines in a logical wayA multi-objective sequence engineering framework for rational genetic vaccine design.

📖 Top 20% JournalArticle

4 days ago • EMBO molecular medicine

Intramuscular self-amplifying RNA and adenovirus RSV vaccines trigger different body-wide and lung immune responsesIntramuscular self-amplifying RNA and adenoviral RSV vaccines program distinct systemic and respiratory mucosal immune architectures.

🥈 Top 2% JournalArticle

4 days ago • The Journal of clinical investigation

Needle-free combined boosters strengthen naked mRNA vaccines to protect mice from lung virusesJet-injected combinational adjuvants potentiate naked mRNA vaccines for protection against respiratory viral infections in mice.

🥈 Top 2% JournalArticle

4 days ago • Clinical & translational immunology

Using CRISPR to insert large genes into primary human T cells and how they are incorporatedFrom delivery to integration: CRISPR-mediated large insert gene editing in primary human T cells.

🎖️ Top 10% JournalArticle

1 week ago • ACS polymers Au

Free Polymers Change Polyplex Solution Behavior and Make It Harder to Understand Their Structure and FunctionFree Polymers Skew Polyplex Solution Properties and Confound the Interpretation of Structure-Function Relationships.

🎖️ Top 10% JournalArticle

1 week ago • Frontiers in immunology

How Gut Bacteria and Their Chemicals Affect Vaccine Response and Lasting Immunity Depending on the SituationThe microbiome-metabolite-vaccine axis: context-dependent modulators of immunogenicity and durability.

🥉 Top 5% JournalArticle

1 week ago • ACS applied materials & interfaces

Nanoparticles that activate only inside target cells when triggeredClickable Turn-On Nanoparticles for Target-Specific Intracellular Activation.

🎖️ Top 10% JournalArticle

1 week ago • Molecules (Basel, Switzerland)

DNA and mRNA Vaccines for Hantaviruses: Designing Targets, Delivery Methods, and Progress Toward UseDNA and mRNA Vaccines Against Hantaviruses: Antigen Design, Delivery Strategies and Translational Progress.

📖 Top 20% JournalArticle

1 week ago • Cancer gene therapy

Restoring p53 function with hybrid strontium sulfite nanoparticle-coated lipid particles improves breast cancer treatmentRestoration of p53 function via hybrid strontium sulfite nanoparticles modified LNP improves the antitumor efficacy in breast cancers.

🎖️ Top 10% JournalArticle

1 week ago • Molecular oncology

Using LCOR mRNA nanotherapy to change tumor cells and improve immunotherapyReprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy.

🥉 Top 5% JournalArticle

1 week ago • International journal of dentistry

Cell Growth, Bone Formation, and New Blood Vessel Growth Triggered by Modified mRNA for a Blood Vessel Growth ProteinIn Vitro Cell Proliferation, Osteogenic Differentiation, and In Vivo Angiogenesis Induced by Modified mRNA Encoding Vascular Endothelial Growth Factor-A.

📖 Top 30% JournalArticle

1 week ago • Small (Weinheim an der Bergstrasse, Germany)

Using Machine Learning to Design Tiny Programmable Systems from Lipid Bags to DNA Shapes and Mixed VesiclesMachine Learning for Programmable Nanosystems: From Liposome Formulation to DNA Origami and Hybrid Vesicles.

🥈 Top 2% JournalArticle

1 week ago • Frontiers in pharmacology

Circular RNAs in cancer: from disease markers to vaccine-based immune treatmentCircular RNAs in cancer: from biomarkers to vaccine-based immunotherapy.

📖 Top 20% JournalArticle

1 week ago • Drug delivery and translational research

Loss of effectiveness from PEG in lipid nanoparticles continues despite formulation changes for mRNA deliveryPEG-associated efficacy loss in lipid nanoparticles persists across formulation modifications for mRNA delivery.

📖 Top 20% JournalArticle

2 weeks ago • Bioengineering & translational medicine

How mRNA lipid nanoparticles spread in the body: From drug behavior to medical useMechanisms and determinants of mRNALipid Nanoparticle biodistribution: From pharmacokinetics to clinical translation.

🎖️ Top 10% JournalArticle

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