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2 weeks ago • PLoS pathogens

New mRNA vaccines based on EG95 may provide long-lasting protection against echinococcosisNovel EG95-based mRNA vaccines induce long-term protective immunity against echinococcosis.

🥉 Top 5% JournalArticle

2 weeks ago • Frontiers in bioinformatics

Design of a multi-part mRNA vaccine targeting the main types of hepatitis E virus that infect peopleImmunoinformatics-based design of a multi-epitope mRNA vaccine candidate targeting the major human-infecting hepatitis E virus genotypes 1-4.

📖 Top 20% JournalArticle

2 weeks ago • Frontiers in pharmacology

Using gene function data to identify MED12 as a potential RNA-targeting weakness in acute myeloid leukemia and testing a targeted siRNA delivery methodFunctional-genomic prioritization identifies MED12 as a candidate RNAi vulnerability in acute myeloid leukemia: evaluation of a T22 peptide-functionalized LNP-siRNA formulation.

📖 Top 20% JournalArticle

2 weeks ago • Advanced materials (Deerfield Beach, Fla.)

Positively Charged Lipid Nanoparticles Carry Platinum-Based Nanocages for Cancer Treatment in Living OrganismsCharge-Reversed Lipid Nanoparticles Enable Encapsulation of Pt2L4 Nanocages for In vivo Anti-Cancer Treatment.

🥇 Top 1% JournalArticle

2 weeks ago • Bioengineering & translational medicine

HER2-targeted mRNA vaccine combined with radiation slows lung tumor growth in mice and how it worksCombined HER2-targeted mRNA-LNP vaccine and radiotherapy suppress Lewis lung carcinoma growth in mice: Efficacy and mechanistic insights.

🎖️ Top 10% JournalArticle

2 weeks ago • Angewandte Chemie (International ed. in English)

A Specific tRNA Modification Helps RNA Bind to LipidsThe tRNA-Modification Geranyl-2-Thiouridine Enables RNA-Lipid Association.

🥇 Top 1% JournalArticle

3 weeks ago • Frontiers in immunology

Using AI to design a COVID-19 spike protein that may protect against many related coronavirusesAI-guided epitope engineering of a SARS-CoV-2 spike antigen for broad sarbecovirus neutralization.

🥉 Top 5% JournalArticle

3 weeks ago • Frontiers in immunology

mRNA vaccine targeting a malaria surface protein produces versatile antibodiesTargeting a malaria merozoite surface protein with mRNA vaccine generates multifunctional antibodies.

🥉 Top 5% JournalArticle

3 weeks ago • Frontiers in genome editing

Using lysine-based lipid nanoparticles to improve delivery of large all-in-one CRISPR/Cas9 gene-editing toolsOvercoming delivery barriers of large all-in-one CRISPR/Cas9 plasmids using lysine-based lipid nanoparticles.

🎖️ Top 10% JournalArticle

3 weeks ago • Experimental & molecular medicine

Using patient-derived tumor models to test cell therapy and gene editing for restoring dystrophinPatient-derived teratomas as a humanized platform for dystrophin restoration by ex vivo cell therapy and in vivo base editing.

🥈 Top 2% JournalArticle

3 weeks ago • National science review

Step-by-step polymer system delivers proteins into cells without leftovers and blocks cell cleanup to improve cancer treatmentStepwise-coordinated polymeric nanoplatform enables traceless cytosolic protein delivery and autophagy blockade for enhanced tumor therapy.

🥉 Top 5% JournalArticle

3 weeks ago • Frontiers in immunology

Overview of immune response, effectiveness, and safety of mRNA flu vaccinesmRNA-based seasonal influenza vaccines: an overview of immunogenicity, efficacy, and safety.

🥉 Top 5% JournalArticle

3 weeks ago • APL bioengineering

Design of a wireless probe for controlled gene delivery using electrical pulsesEngineering of a wireless single capacitive discharge conductivity-clamped gene electrotransfer probe for naked nucleic acid therapeutics.

📖 Top 20% JournalArticle

3 weeks ago • RSC advances

Hybrid lipid-based nanogels for delivering mRNAHybrid lipid-nanogels: nanolipogels for mRNA delivery.

📖 Top 30% JournalArticle

3 weeks ago • Advanced materials (Deerfield Beach, Fla.)

More mRNA inside lipid nanoparticles increases gene delivery effectivenessIncreasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency.

🥇 Top 1% JournalArticle

3 weeks ago • Molecular biomedicine

Current status, challenges, and future outlook of mRNA vaccines using fat-based particlesmRNA lipid nanoparticle vaccines: current status, challenges and future prospects.

🥉 Top 5% JournalArticle

3 weeks ago • Experimental dermatology

Using mRNA Treatments to Refresh Aging Skin: From Aging Studies to Patient CaremRNA Therapeutics for Skin Rejuvenation: From Aging Atlases to Clinical Translation.

📖 Top 20% JournalArticle

3 weeks ago • Nature communications

Using N1-methylpseudouridine changes to improve mRNA vaccine designRecoding by N1-methylpseudouridine guides rational mRNA vaccine design.

🥈 Top 2% JournalArticle

3 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Adding an Immune Checkpoint Blocker to Lipid Nanoparticles Helps Target Lymph Nodes and Boosts mRNA Vaccine EffectivenessImmune Checkpoint Inhibitor as a Fifth Component of Lipid Nanoparticles Enables Lymph Node-Targeting and Augments mRNA Vaccine Efficacy.

🥈 Top 2% JournalArticle

4 weeks ago • Pharmaceutics

New Developments in Non-Viral Methods for Delivering Genes, from Fat-Based Particles to Modified Cell MessengersRecent Advances in Non-Viral Vectors for Gene Therapy and Gene Delivery: From Lipid Nanoparticles to Engineered Extracellular Vesicles.

📖 Top 20% JournalArticle

4 weeks ago • International journal of molecular sciences

Personalized mRNA Cancer Vaccines: Connecting Precise Antigen Choice, Immune System Changes, and Checkpoint TherapyPersonalized mRNA Neoantigen Vaccines in Cancer: Linking Precision Antigen Selection, Immune Remodeling, and Checkpoint Blockade.

📖 Top 20% JournalArticle

4 weeks ago • Vaccines

mRNA Vaccine Triggers New IgG Antibody Responses Even When Maternal Antibodies Are PresentImmunization with mRNA-LNP Elicits De Novo IgG Responses in the Presence of Maternal Antibody.

📖 Top 20% JournalArticle

4 weeks ago • Pharmaceutics

A targeted peptide that helps deliver gene-silencing molecules to brain tumor cellsAn EGFR-Targeted Fusogenic Tandem Peptide for siRNA Delivery in Glioblastoma.

📖 Top 20% JournalArticle

4 weeks ago • Pharmaceutics

Using PSMA-Targeted Liposomes to Deliver Treatment into Prostate Cancer CellsPSMA-Targeted Liposomes for Therapeutic Delivery into a Prostate Cancer Cell Model.

📖 Top 20% JournalArticle

4 weeks ago • Vaccines

mRNA Vaccines Targeting the Stable SARS-CoV-2 Fusion Proteins Produce Strong Immunity Against Multiple VariantsmRNA Vaccines Targeting the Conserved SARS-CoV-2 Fusion Machinery Elicit Cross-Variant and Robust Immunity.

📖 Top 20% JournalArticle

4 weeks ago • Pharmaceutics

Making and Testing Tiny Lipid-Chitosan Particles Carrying Cyclosporine A for Lung Drug DeliveryMicrofluidic Production and Characterisation of Cyclosporine A-Loaded Lipid-Chitosan Hybrid Nanoparticles as Candidate Pulmonary Drug Delivery Systems.

📖 Top 20% JournalArticle

4 weeks ago • Veterinary sciences

A Lipid Nanoparticle mRNA Vaccine Triggers PRRS Virus-Specific Antibody and Immune Cell Responses in MiceA Lipid Nanoparticle-Formulated GP5-mRNA Vaccine Induces PRRSV-Specific Humoral and Cellular Immune Responses in BALB/c Mice.

📖 Top 30% JournalArticle

4 weeks ago • Pathogens (Basel, Switzerland)

mRNA Vaccine Combining PstS and YidR Protects Against Different Strains of Dangerous Klebsiella pneumoniae Infections, Including Eye InfectionCross-Serotype Protection of a PstS-YidR Fusion mRNA Vaccine Against Systemic Infection and Endogenous Endophthalmitis Caused by Hypervirulent Klebsiella pneumoniae.

📖 Top 20% JournalArticle

4 weeks ago • Pharmaceutics

Lipid and Vesicle Hybrid Systems for Delivering RNA in Cancer: Types, Delivery Functions, and Practical ChallengesExtracellular Vesicle-Lipid Hybrid Systems for RNA Delivery in Cancer: Structural Classification, Functional Delivery, and Translational Challenges.

📖 Top 20% JournalArticle

4 weeks ago • Pharmaceutics

Using Modified Hyaluronic Acid to Deliver Drugs Inside Cells Through a Cell Surface Receptor and Escape from Cellular ContainersEvaluation of Histidine-Octamer-Modified Hyaluronic Acid as a Cytosolic Drug Delivery Material via CD44-Mediated Cellular Uptake and Endosomal Escape.

📖 Top 20% JournalArticle

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