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1 week ago • Vaccines

Possible Ways mRNA in Lipid Nanoparticles Breaks Down: A Complete ReviewPossible Mechanisms of mRNA-LNP Degradation: A Comprehensive Review.

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1 week ago • Vaccines

A new tiny particle system that improves poultry vaccinesA Novel Effective Nanoadjuvant System for Poultry Vaccines.

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1 week ago • Vaccines

Designed mRNA Nanoparticles for Delivery to Lung MucusEngineered mRNA Nanoparticle Platforms for Respiratory Mucosal Delivery.

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1 week ago • Vaccines

Safety and Immune Response to the Pfizer COVID-19 Vaccine in People 2 Years and Older with Weakened ImmunitySafety and Immunogenicity of the BNT162b2 COVID-19 Vaccine in Immunocompromised Participants 2 Years and Older: Results of an Open-Label Phase 2b Study.

📖 Top 20% JournalArticle

1 week ago • Journal of biomedical science

Overview of mRNA Therapy and Methods to Purify mRNA and Remove Double-Stranded RNAThe current landscape of mRNA therapy and the strategies for mRNA purification and dsRNA removal.

🥉 Top 5% JournalArticle

1 week ago • International immunology

Natural immune reactions linked to local and whole-body side effects from mRNA lipid nanoparticle vaccinesInnate immune responses underlying local and systemic adverse reactions to mRNA-lipid nanoparticle vaccines.

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1 week ago • Frontiers in immunology

How RNA Modifications Help Tumors Avoid the Immune System: Mechanisms, Different Situations, and Treatment PossibilitiesRNA epitranscriptomic regulation of tumor immune evasion: mechanisms, context-dependent roles, and therapeutic implications.

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1 week ago • Small (Weinheim an der Bergstrasse, Germany)

Using Proton Channels to Change pH and Help siRNA Escape from Cell CompartmentsActive pH Modulation by Proton Channel-Peptide Nucleic Acid Complex for Effective siRNA Endosomal Escape.

🥈 Top 2% Journal

1 week ago • ACS applied bio materials

Making Antibody-Modified mRNA Nanoparticles Using Two Post-Loading MethodsPreparation of Antibody-Modified mRNA-LNPs via a Combination of Post-Encapsulation and Post-Insertion.

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2 weeks ago • Open forum infectious diseases

Safety and Immune Response to the BNT162b2 Vaccine in People With HIV on Antiretroviral TreatmentSafety and Immunogenicity of BNT162b2 in Antiretroviral Therapy-Treated People With HIV.

🎖️ Top 10% Journal

2 weeks ago • Frontiers in pharmacology

mRNA Cancer Vaccines: How They Are Delivered, Influence the Immune System, and Move Toward Medical UsemRNA cancer vaccines: delivery strategies, immune modulation, and clinical translation.

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2 weeks ago • Advanced materials (Deerfield Beach, Fla.)

Understanding Differences in Targeted Lipid Nanoparticles Using Liquid-Based Physical TestsResolving Heterogeneity of Targeted Lipid Nanoparticles Through Solution-Based Biophysical Analyses.

🥇 Top 1% Journal

2 weeks ago • Nature communications

Special lipid carriers use cell release pathways to boost natural killer cells against solid tumorsDual compartment lipid carriers hijack exocytosis to empower natural killer cells against solid tumours.

🥈 Top 2% Journal

2 weeks ago • ACS nano

Using Nanopores to Precisely Build mRNA Lipid Nanoparticles for COVID-19 VaccinesNanopore-Mediated Assembly Enables Precise and Continuous Synthesis of mRNA-Encapsulated Lipid Nanoparticles for COVID-19 Vaccines.

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3 weeks ago • Scientific reports

Antibody responses to different COVID-19 variants after booster shots and breakthrough infectionsVariant-specific and cross-reactive antibody responses following COVID-19 booster vaccinations and SARS-CoV-2 breakthrough infections.

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3 weeks ago • Drug delivery and translational research

Synthetic miRNA carriers targeted to blood vessel and iron transport proteins with potential stroke therapyE-selectin and transferrin receptor functionalized synthetic miRNA nanoshuttles with therapeutic potential in stroke.

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3 weeks ago • MedComm

Methods for Delivering Gene Editing Treatments: Challenges, New Advances, and Future OutlookDelivery Systems for Therapeutic Genome Editing: Challenges, Innovations, and Future Perspectives.

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3 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Improved lipid nanoparticles with modified fats for safer mRNA deliveryOptimized Lipid Nanoparticles with Tail-Modified Ionizable Lipids for Safer mRNA Delivery.

🥈 Top 2% Journal

3 weeks ago • Advanced materials (Deerfield Beach, Fla.)

Using Lipid Nanoparticles to Deliver mRNA and a Drug Together for Oral Cancer ChemoimmunotherapyLipid Nanoparticle Co-Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy.

🥇 Top 1% Journal

3 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Parkin reduces cell damage and bone loss caused by steroids by modifying a fat-processing proteinUbiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid-Induced Bone Loss.

🥈 Top 2% Journal

3 weeks ago • Microbiology spectrum

Different immune reactions to two SFTSV mRNA vaccines in mice and dogsDifferential immune responses to SFTSV Gn and Gc mRNA vaccines in mice and dogs.

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3 weeks ago • Clinical epigenetics

Advances in epigenetic editing: AI-based design, improved delivery methods, and progress toward medical useEpigenetic editing approaches maturity: AI-driven precision design, delivery innovation, and the road to clinical translation.

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4 weeks ago • Communications biology

Engineered carriers deliver mRNA to skin for healing and regenerationBiologically engineered vectors enable topical mRNA delivery for skin regeneration.

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4 weeks ago • ACS applied bio materials

Improved Gene Delivery Using Aminated Collagen-Chitosan Non-Viral CarriersMatrix-Enhanced Non-Viral Vectors: Aminated Collagen-Chitosan for Improved Gene Delivery.

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1 month ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

mRNA Lipid Nanoparticle Vaccines Help Treat Autoimmune Disease in Animal ModelsAutoantigen mRNA-LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity.

🥈 Top 2% Journal

1 week ago • Current issues in molecular biology

Creating and Testing a Protected mRNA for Human Growth HormoneDesign, Synthesis, and Proof-of-Concept Bioassay of an Encapsulated mRNA for Human Growth Hormone.

📖 Top 30% JournalArticle

1 week ago • Diseases (Basel, Switzerland)

Development of mRNA Vaccines for Diseases Other Than COVID-19: A Review of Clinical and Laboratory StudiesFrom Pandemic Innovation to Platform Diversification: A Systematic Review of Clinical and Preclinical Development of Non-SARS-CoV-2 mRNA Vaccines.

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1 week ago • Methods and protocols

An Easy Way to Measure the Length of mRNA Tail SequencesA Simple Method to Evaluate the Length of Poly(A) Tails in mRNA.

📖 Top 50% Journal

4 weeks ago • Nucleosides, nucleotides & nucleic acids

Partial pairing between the ends of synthetic mRNA controls its expression levelsPartial base pairing between 5' and 3' UTRs artificially regulates IVT mRNA expression levels.

yesterday • Acta biochimica et biophysica Sinica

Using a signal to direct proteins inside cells boosts antigen production and release to improve mRNA vaccine effectivenessSignal peptide-mediated endoplasmic reticulum targeting enhances antigen expression and secretion to improve mRNA vaccine efficacy.

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