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3 weeks ago • Nature biotechnology

Efficient cytosine base editing inside living cells using virus-like particles that block uracil DNA repairEfficient in vivo cytosine base editing using virus-like particles with uracil DNA glycosylase inhibition.

🏆 Top 0.1% Journal

3 weeks ago • IUBMB life

Using Drug Lifespan to Target Short-Lived Long Noncoding RNAs with Antisense MoleculesHalf-Life as a Therapeutic Design Axis: Targeting Short-Lived lncRNAs With Antisense Oligonucleotides.

📖 Top 20% Journal

3 weeks ago • ACS omega

Smart Polyethylenimine-Based Carriers for Delivering siRNA: Current Approaches and Future DirectionsStimuli-Responsive Polyethylenimine Derivatives as Carriers for siRNA Delivery: Current Solutions and Future Perspectives.

📖 Top 30% Journal

3 weeks ago • Journal of chromatography. A

Detecting charged fats in horse blood to monitor mRNA drug useDetection of ionisable lipids in equine plasma by supported liquid extraction and liquid chromatography-high-resolution tandem mass spectrometry for doping control of mRNA agents.

📖 Top 30% Journal

3 weeks ago • Advanced materials (Deerfield Beach, Fla.)

Self-Boosting RNA Vaccine Reduces Immune Resistance by Dendritic Cells to Improve Cell Therapy for Solid TumorsSelf-Cooperative RNA Vaccine Mitigates Dendritic Cell-Mediated Acquired Immune Resistance to Potentiate Cell Therapy for Solid Tumors.

🥇 Top 1% Journal

3 weeks ago • Advanced drug delivery reviews

Lipid nanoparticles that release medicine in response to cell oxidationRedox-responsive LNPs for therapeutics delivery.

🥈 Top 2% Journal

4 weeks ago • The Journal of investigative dermatology

The past and future of RNA-based medicinesHistory and future of RNA medicines.

🎖️ Top 10% Journal

4 weeks ago • Journal of the American Chemical Society

Ionizable Lipid Nanoparticles Activated by Tumor Acidity for Targeted Cancer TherapyTumor Acidity-Activatable Ionizable Lipid Nanoparticles for Selective Oncolytic Therapy.

🥇 Top 1% Journal

4 weeks ago • Communications medicine

The role of mRNA vaccine technology in helping Africa become independent in public healthThe strategic importance of mRNA vaccine technologies in Africa for achieving public health independence.

🥉 Top 5% Journal

4 weeks ago • Journal of materials chemistry. B

Carefully designed tiny capsules for steady release of mRNA lipid nanoparticlesPrecise microfluidic engineering of mRNA lipid nanoparticle-loaded polycaprolactone microcapsules for sustained delivery.

📖 Top 20% Journal

4 weeks ago • ACS nano

A Lung-Directed T Cell Nanovaccine Links Lung Immune Activation to Bodywide Anti-Cancer Response in Non-Small-Cell Lung CancerA Lung-Targeted γδ T Cell Nanovaccine Couples Pulmonary Immune Priming to Systemic Antitumor Immunity in Non-Small-Cell Lung Cancer.

🥈 Top 2% Journal

1 month ago • NPJ vaccines

Immune response to the LP.8.1-adapted BNT162b2 COVID-19 vaccine in animal studiesPreclinical immunogenicity of the LP.8.1-adapted BNT162b2 COVID-19 vaccine.

🥉 Top 5% Journal

1 month ago • Journal of hematology & oncology

Design, cell delivery, and potential uses of antibody-linked DNA moleculesAntibody-oligonucleotide conjugates: design principles, intracellular delivery, and translational opportunities.

🥇 Top 1% Journal

1 month ago • Molecular therapy. Nucleic acids

Improving human protein production using advanced AI methods for genetic code optimizationEnhancing protein expression in humans through codon optimization with transformer and contrastive learning.

🥉 Top 5% Journal

1 month ago • International journal of pharmaceutics

Using tiny technology to deliver gene-editing tools to the brain for controlling genes in Parkinson's diseaseProgrammable gene modulation networks for Parkinson's disease using nanotechnology enabled CRISPR/Cas brain delivery.

📖 Top 20% Journal

2 days ago • Drug testing and analysis

Comparing how the body clears lipid nanoparticle-delivered human erythropoietin mRNA to support doping control for mRNA drugsComparative Elimination Analysis of Lipid Nanoparticle-Encapsulated Human Erythropoietin mRNA by Multimodal Approaches Suggests an Effective Doping Control Strategy for mRNA-Based Agents.

📖 Top 30% JournalArticle

4 days ago • Immunologic research

Past progress and future outlook of personalized vaccines and the role of immune-activating cellsPast achievements and future perspectives of personalized vaccines and the role of dendritic cells.

📖 Top 20% JournalArticle

4 days ago • Nanomedicine (London, England)

Progression of peptide-based delivery systems for siRNA from early designs to advanced platformsEvolution of peptide-mediated siRNA delivery - from early design to next generation platform.

📖 Top 50% JournalArticle

1 week ago • Journal of pharmacokinetics and pharmacodynamics

Whole-body model to study how lipid nanoparticle mRNA medicines spread and act inside cellsConstruction of a translational whole-body physiologically based pharmacokinetic model to investigate the biodistribution of lipid nanoparticle-based mRNA therapeutics for intracellular protein targets.

📖 Top 20% JournalArticle

1 week ago • Advances in medical sciences

How RNA chemical changes relate to cancer growth and resistance to platinum drugsEpitranscriptomic regulation in the progression of cancer and platinum resistance.

📖 Top 30% JournalArticle

1 week ago • Clinics and research in hepatology and gastroenterology

Personalized CRISPR gene editing tailored for rare genetic liver diseasesFrom one-size-fits-all to on-demand: personalized crispr gene editing for rare genetic liver diseases.

📖 Top 30% JournalArticle

1 week ago • Current pharmaceutical design

Using Fat-Based Nanoparticles for Skin Cancer Treatment: Drug Delivery, Gene Therapies, and Clinical ProgressHarnessing Lipid-Based Nanocarriers for Skin Cancer Therapy: A Comprehensive Review of Drug Delivery, Gene-Based Strategies, and Clinical Translation.

📖 Top 50% JournalArticle

1 week ago • Applied biochemistry and biotechnology

Computer-Designed mRNA Vaccine Targeting Multiple Parts of MammarenavirusesComputational Design of a Broad-Spectrum Multi-Epitope mRNA Vaccine Candidate for Mammarenaviruses.

📖 Top 30% Journal

1 week ago • Discover nano

How mechanical factors control interactions between lipids and tiny particles in nanocarriersMechanical insights into regulation of bio-nano interactions for lipid-based nanocarriers.

📖 Top 30% Journal

1 week ago • Tumori

Early study of bladder cancer treatment using IL-12 mRNA nanoparticles delivered inside the bladderPreliminary study on intravesical instillation of IL-12 mRNA lipid nanoparticles for the treatment of bladder cancer.

📖 Top 50% Journal

1 week ago • Nanomedicine (London, England)

New stealth fat-based carriers: improvements in PEG coating and new amide polymer optionsNext-generation stealth lipid-based nanocarriers: advances in PEGylation and emerging amide-containing polymer alternatives.

📖 Top 50% Journal

1 week ago • Current pharmaceutical biotechnology

Using Positively Charged Lipid Nanoparticles to Deliver miR-34A to Lung Cancer Cells: Comparing DNA and RNA FormulationsCationic Lipid Nanoparticles for miR-34A Delivery to Lung Cancer Cells: Comparative Evaluation of Plasmid DNA and Oligonucleotide Formulations.

📖 Top 50% Journal

2 weeks ago • World journal of microbiology & biotechnology

Self-amplifying mRNA vaccine combining multiple targets against Staphylococcus aureus using computer-based design and structure modelingSelf-amplifying mRNA vaccine cocktail against Staphylococcus aureus: A multi-epitope immunoinformatics and structural simulation framework.

📖 Top 20% Journal

3 weeks ago • Human vaccines & immunotherapeutics

Seasonal flu mRNA vaccines show safety and stronger immune response in phase 2 trialOptimized seasonal influenza mRNA vaccine compositions demonstrate safety and enhanced immunogenicity in a phase 2 study.

📖 Top 20% Journal

3 weeks ago • Nanomedicine (London, England)

How Tiny Particles Reach and Move Within the Brain in Nervous System Diseases: A Guide for TreatmentsBrain targeting and trafficking of extracellular vesicles in central nervous system diseases: a therapeutic roadmap.

📖 Top 50% Journal

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