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2 weeks ago • Journal of translational medicine

CD73-coated nanoparticles boost anti-cancer T-cell response by enhancing immune-activating dendritic cells through TLR3CD73-LNPs promote antitumor T-cell immunity via amplifying TLR3-mediated immunostimulatory dendritic cell activation.

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2 weeks ago • NPJ Regenerative medicine

Lipid nanoparticle therapy delivering HGF mRNA helps heal the uterus after cesarean in miceHGF mRNA LNP therapy promotes uterine repair after cesarean section in a mouse model.

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2 weeks ago • Cancer letters

Circular RNA Vaccine Triggers Strong Tumor-Targeted Immune Response and Changes Tumor Environment in Lung CancerCircular RNA-based therapeutic vaccine elicits potent antigen-specific antitumor immunity and remodels tumor microenvironment in lung cancer.

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2 weeks ago • International journal of nanomedicine

Safe and Effective Gene Therapy Using Non-Viral Nanoparticle DeliveryToward Safe and Effective Gene Therapy: Non-Viral Nanostructured Delivery Systems.

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2 weeks ago • NPJ vaccines

Strong T-cell responses to SARS-CoV-2 despite weak antibody immunity in children with very low B-cell levelsPreserved SARS-CoV-2 T-cell responses despite impaired humoral immunity in children with profound B-cell lymphopenia.

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2 weeks ago • STAR protocols

Method for delivering mRNA inside fat-based particles directly into live mouse testiclesProtocol for in vivo transfection of mRNA-encapsulated lipid nanoparticles in mouse testis.

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2 weeks ago • International journal of pharmaceutics

Microneedles carrying tiny particles for skin delivery: stability, spreading, movement at skin surface, and skin absorptionColloid-loaded microneedles for transdermal delivery: formulation stability, redispersion, biointerfacial transport, and dermal fate.

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2 weeks ago • Clinical and translational science

Antibodies from mRNA COVID-19 vaccines may interfere with lab tests measuring pegylated drug levelsAnti-PEG Antibodies From mRNA COVID-19 Vaccines Affect In Vitro Measurements of Pegylated Drug Levels.

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2 weeks ago • Molecular cancer

RNA changes in cancer linked to tumor growth and treatment responseRNA modifications in cancer: regulators of tumor evolution and therapeutic response.

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2 weeks ago • Antiviral research

Scientific and Technological Advances to Develop Vaccines for Diseases Without Effective ProtectionBridging the Vaccine Gap: Scientific and Technological Advances for Diseases Lacking Effective Vaccines.

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2 weeks ago • Journal of nanobiotechnology

Kidney-targeted fat nanoparticles carrying ANXA2 may reduce kidney injury by blocking cell death through CHMP2AKidney‑enriched lipid nanoparticles delivering ANXA2 alleviate renal ischemia-reperfusion injury via CHMP2A-mediated necroptosis inhibition.

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2 weeks ago • Current opinion in microbiology

Design, Use, and Future Potential of Antisense Oligonucleotides in MicrobiologyAntisense oligonucleotides: design, implementation and future perspectives in microbiology.

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2 weeks ago • Nature reviews. Chemistry

Polymers with precise sequences for reliable gene deliverySequence-defined polymers for predictable gene delivery.

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2 weeks ago • ACS nano

Lung Delivery of Self-Amplifying RNA: Finding a Balance Between Inflammation and Lasting Gene ActivityPulmonary Delivery of Self-Amplifying RNA: Balancing Inflammation and Durable Transgene Expression.

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2 weeks ago • ACS chemical biology

Ionizable Silyl Lipids with Different Membrane Flexibility and mRNA Delivery EffectsIonizable Silyl Lipids with Distinct Membrane Fluidity and mRNA Delivery Profiles.

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2 weeks ago • Nature biomedical engineering

Using RModBlock antisense oligonucleotides to precisely and efficiently block RNA modificationsRModBlock antisense oligonucleotides as a universal tool for precise and efficient inhibition of RNA modifications.

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2 weeks ago • Molecular pharmaceutics

Lipid Nanoparticles Targeting Fibroblasts to Deliver Genes into Tumor Support TissueFibroblast-Selective Lipid Nanoparticles for Tumor Stromal Transfection.

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2 weeks ago • ACS applied materials & interfaces

Making Negatively Charged mRNA Lipid Nanoparticles More Stable Using Breakable Cholesterol LinksStabilizing Anionic mRNA Lipid Nanoparticles by Cleavable Crosslinking of Cholesterol.

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2 weeks ago • International journal of biological macromolecules

Hydrogel carrying gene-silencing nanoparticles targeting interleukin-11 for scar-free wound healingChitosan quaternary ammonium/sodium alginate double-network hydrogel loaded with interleukin-11-targeting siRNA-lipid nanoparticles for scarless wound healing.

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3 weeks ago • Journal of molecular biology

How Long Epitranscriptome Marks Last: Measuring Their Persistence Over TimeThe Half-Life of a Mark: Dwell Time and the Missing Time Axis of the Epitranscriptome.

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3 weeks ago • Science China. Life sciences

Plant-based microRNA 152 delivered by lipid nanoparticles may boost doxorubicin treatment in breast cancer immunotherapyPlant-derived CTLA-4-targeting miR152 via lipid nanoparticles potentiates doxorubicin efficacy in breast cancer immunochemotherapy.

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3 weeks ago • Molecular therapy : the journal of the American Society of Gene Therapy

Recent Advances in Designing mRNA VaccinesRecent Progress in the Rational Design of mRNA Vaccines.

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3 weeks ago • ACS applied materials & interfaces

Immune-Targeting Nanoparticles Carrying Cisplatin for Combined Chemotherapy and Immunotherapy in Pancreatic CancerImmunoregulatory Dendritic Lipopeptide Nanoparticles for High-Capacity Cisplatin Delivery and Pancreatic Cancer Chemo-Immunotherapy.

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3 weeks ago • ACS biomaterials science & engineering

Designing Fat-Based Nano Carriers for Cancer Treatments: From Chemotherapy Drugs to mRNA TherapiesPharmaceutical Engineering of Lipid-Based Nanocarriers for Cancer Nanomedicines: From Doxorubicin to mRNA Platforms.

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3 weeks ago • Macromolecular bioscience

Lipoic acid-based nanoparticles improve mRNA delivery by helping cells take it in through sulfur-based uptakeLipoic Acid Derivative/PEI Composite Nanoparticles Enable Efficient mRNA Delivery via Thiol-Mediated Cellular Uptake.

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3 weeks ago • Biomaterials

Adding signaling proteins to targeted lipid nanoparticles improves T cell engineering in living organismsCytokine co-presentation on targeted lipid nanoparticles enhances in vivo T cell engineering.

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3 weeks ago • Molecular therapy. Nucleic acids

mRNA nanoparticles delivered through the bloodstream enter main and spreading liver tumorsSystemically delivered mRNA-LNPs transfect primary and secondary liver tumors.

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3 weeks ago • Angewandte Chemie (International ed. in English)

Using Targeted Molecules to Redirect Liver-Directed Lipid Nanoparticles for Lung-Selective mRNA DeliveryLigand-Mediated Reprogramming Redirects Liver-Tropic Ionizable Lipid Nanoparticles for Lung-Selective mRNA Delivery.

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3 weeks ago • ACS nano

How Lipid Nanoparticles Carry RNA: Detailed Images Reveal Their Structure and FunctionFrom Morphology to Mechanism: Cryo-Electron Microscopy Insights into Lipid Nanoparticles for RNA Delivery.

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3 weeks ago • Regulatory toxicology and pharmacology : RTP

Comparing Safety Tests of COVID-19 Vaccines in Laboratory and Human StudiesComparative analysis of non-clinical and clinical safety assessment of COVID 19 vaccines.

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