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1 week ago • Extracellular vesicles and circulating nucleic acids

Designed tiny cell particles: drug delivery challenges, improvement methods, and potential medical usesEngineered extracellular vesicles: pharmacological barriers, engineering strategies, and translational opportunities.

📖 Top 20% JournalArticle

2 weeks ago • Clinical laboratory

How mRNA Vaccination May Affect the Progression of Chronic Kidney DiseaseEffects of mRNA Vaccination on the Progression of Chronic Kidney Disease.

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2 weeks ago • Preparative biochemistry & biotechnology

Improving plasmid DNA recovery using membrane chromatography with added chemicalsAn additive-enhanced membrane chromatography approach for improved plasmid DNA recovery.

📖 Top 50% JournalArticle

3 weeks ago • Recent advances in drug delivery and formulation

Using Fat-Based Nanoparticles to Deliver RNA Medicines to Specific TargetsTargeted Delivery of RNA-based Therapeutics by Lipid Nanoparticles.

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3 weeks ago • Recent advances in drug delivery and formulation

Flexible Bio-Film Carriers for Delivering Drugs to the Brain through the Lip RouteEmerging Perspectives Bio-Flexi Film Nanocarriers: A Novel Approach for Brain Drug Delivery through the Trans-Vermilion Route.

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2 weeks ago • Science (New York, N.Y.)

The human gut microbiome may prepare the body to develop fever after vaccinationThe human gut microbiome primes fever after vaccination.

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2 weeks ago • Journal of virology

mRNA-lipid nanoparticle vaccine with eight flu proteins triggered broad antibody protection against influenza A in pigsA multivalent mRNA-lipid nanoparticle vaccine containing eight hemagglutinin antigens elicited broad neutralizing antibody responses and protected against influenza A virus challenge in swine.

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1 month ago • bioRxiv : the preprint server for biology

Designed mRNA nanoparticles allow controlled protein production and immune activation for new treatmentsEngineered mRNA nanostructures expand the design space of mRNA therapeutics through programmable protein expression and immune stimulation.

Preprint

2 weeks ago • bioRxiv : the preprint server for biology

Lysophosphatidylserine Nanoparticles Trigger Oral Immune Tolerance Without Relying on TIM-4 or Usual ProcessingLysophosphatidylserine Nanoparticles Induce Oral Tolerance Independent of TIM-4 and Canonical PS Processing.

Preprint

1 month ago • bioRxiv : the preprint server for biology

Timed control of immune sensor activation and RNA delivery separates antibody and cell immune responsesSpatiotemporal control of STING activation and saRNA delivery decouples humoral and cellular immunity.

Preprint

1 month ago • Research square

Comparison of effectiveness, safety, and immune response of two-part versus single-part COVID-19 mRNA booster vaccines in a randomized trialRelative efficacy, safety and immunogenicity of bivalent versus monovalent COVID-19 mRNA booster vaccines: a randomized trial.

Preprint

2 weeks ago • Toxicological sciences : an official journal of the Society of Toxicology

Synthetic mRNA in lipid nanoparticles causes temporary changes in blood cell production through immune responses under high inflammation in animal modelsLipid Nanoparticle-Formulated Synthetic Messenger RNA Induces Reversible Hematopoietic Bias via Type I Interferon Responses Under Upper-Bound Inflammatory Conditions in Preclinical Animal Models.

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2 weeks ago • Biomaterials research

Nasal delivery of Netrin-1 mRNA in tiny vesicles may reduce brain cell death after strokeIntranasal Netrin-1 modRNA-Loaded Extracellular Vesicles Reduce Neuronal Apoptosis after Ischemic Stroke.

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1 week ago • Journal of virology

mRNA nanoparticle delivery of linked nanobodies protects young geese from new goose virus infectionmRNA-LNP delivery of a homo-tandem nanobody protects goslings from novel goose astrovirus infection.

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1 week ago • The Journal of pharmacy and pharmacology

Using diethylene glycol monoethyl ether as a new solvent for making mRNA lipid nanoparticlesDiethylene glycol monoethyl ether as an alternative solvent for mRNA-LNP manufacture.

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2 weeks ago • Genetics and molecular biology

mRNA therapies: From basic science to medical breakthroughsmRNA-based therapies: From molecular discovery to clinical revolution.

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2 weeks ago • Journal of virology

H5 flu mRNA vaccine in lipid nanoparticles triggers immune responses in Holstein calvesH5 influenza virus mRNA-lipid nanoparticle (LNP) vaccination elicits adaptive immune responses in Holstein calves.

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3 weeks ago • bioRxiv : the preprint server for biology

Ultrasound-activated gene delivery using gas-filled charged nanobubbles without virusesNonviral, ultrasound-triggered gene delivery platform via gas-core cationic nanobubbles.

Preprint

3 weeks ago • bioRxiv : the preprint server for biology

How lipid nanoparticles may disrupt cell recycling compartmentsLipid nanoparticle induced model endosomal membrane disruption.

Preprint

3 weeks ago • bioRxiv : the preprint server for biology

Modeling how PEG-coated lipid nanoparticles move through the space outside cellsA multiscale modeling framework for transport of PEGylated lipid nanoparticle through the extracellular matrix.

Preprint

1 month ago • bioRxiv : the preprint server for biology

Codon pairs influence mRNA stability through their role in protein production beyond individual codon effectsBeyond codon optimality: codon pairs regulate mRNA stability dependent on translation.

Preprint

2 days ago • Journal of controlled release : official journal of the Controlled Release Society

Long-lasting destruction of a key sugar transporter by a targeted molecule causes energy failure and inflammatory cell death in cancerSustained degradation of glucose transporter 1 by an mRNA-encoded lysosome-targeting chimera triggers metabolic collapse and pyroptosis in cancer.

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2 days ago • Journal of controlled release : official journal of the Controlled Release Society

Changing tumor-supporting immune cells with ID3 mRNA to improve immunotherapy for pancreatic cancerReprogramming tumor-associated macrophages via ID3 mRNA delivery for enhanced immunotherapy in pancreatic cancer.

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2 days ago • Journal of controlled release : official journal of the Controlled Release Society

How ionizable lipids affect mRNA vaccine makeup and immune responseIonizable lipid impact on mRNA vaccine formulation properties and immunogenicity.

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1 week ago • The Journal of allergy and clinical immunology

Whole-body allergic reactions to mRNA COVID-19 vaccines in a controlled trialSystemic Allergic Reactions to mRNA COVID-19 Vaccines: A Randomized Placebo-controlled Trial.

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1 week ago • Annals of medicine and surgery (2012)

Potential of mRNA vaccines to fight infectious and chronic diseases in low-income countriesExploring the potential of mRNA vaccines in combatting communicable and non-communicable diseases in low-income and lower-middle-income countries.

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2 weeks ago • Journal of immunology (Baltimore, Md. : 1950)

How Removing Natural Killer Cells May Change Immune Responses to COVID mRNA VaccinesEffects of natural killer cell depletion on innate and adaptive immune responses to COVID mRNA vaccination.

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2 weeks ago • Journal of controlled release : official journal of the Controlled Release Society

Using lipid nanoparticles to deliver human RB1 mRNA and triptolide together for targeted gene therapy of retinoblastomaLipid nanoparticle-mediated co-delivery of human RB1 mRNA and triptolide for localized genetic therapy of retinoblastoma.

Article

2 weeks ago • RSC applied polymers

Creating new charged polymers for delivering mRNA using a four-part chemical processCombinatorial synthesis of novel polycations for mRNA delivery via Ugi 4-component polymerisation.

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2 weeks ago • Journal of controlled release : official journal of the Controlled Release Society

How sugar-coated cell surfaces and protein layers affect mRNA carrier uptake in different cell typesThe role of glycocalyx-protein corona interactions in the cell type-specific uptake of mRNA nanocarriers.

Article

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mRNA Technology Research Papers