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1 week ago • Journal of virology

mRNA nanoparticle delivery of linked nanobodies protects young geese from new goose virus infectionmRNA-LNP delivery of a homo-tandem nanobody protects goslings from novel goose astrovirus infection.

Article

1 week ago • The Journal of pharmacy and pharmacology

Using diethylene glycol monoethyl ether as a new solvent for making mRNA lipid nanoparticlesDiethylene glycol monoethyl ether as an alternative solvent for mRNA-LNP manufacture.

Article

2 weeks ago • Genetics and molecular biology

mRNA therapies: From basic science to medical breakthroughsmRNA-based therapies: From molecular discovery to clinical revolution.

Article

2 weeks ago • Journal of virology

H5 flu mRNA vaccine in lipid nanoparticles triggers immune responses in Holstein calvesH5 influenza virus mRNA-lipid nanoparticle (LNP) vaccination elicits adaptive immune responses in Holstein calves.

Article

3 weeks ago • bioRxiv : the preprint server for biology

Ultrasound-activated gene delivery using gas-filled charged nanobubbles without virusesNonviral, ultrasound-triggered gene delivery platform via gas-core cationic nanobubbles.

Preprint

3 weeks ago • bioRxiv : the preprint server for biology

How lipid nanoparticles may disrupt cell recycling compartmentsLipid nanoparticle induced model endosomal membrane disruption.

Preprint

3 weeks ago • bioRxiv : the preprint server for biology

Modeling how PEG-coated lipid nanoparticles move through the space outside cellsA multiscale modeling framework for transport of PEGylated lipid nanoparticle through the extracellular matrix.

Preprint

1 month ago • bioRxiv : the preprint server for biology

Codon pairs influence mRNA stability through their role in protein production beyond individual codon effectsBeyond codon optimality: codon pairs regulate mRNA stability dependent on translation.

Preprint

yesterday • The journal of physical chemistry. B

RNA Interactions Shape the Structure and Behavior of Lipid NanoparticlesRNA-Lipid Interactions Control Structure and Dynamics of Lipid Nanoparticles.

Article

yesterday • Molecular therapy. Advances

pSIM: A new lab test to measure mRNA strengthpSIM: A next generation in vitro mRNA potency assay.

Article

yesterday • Expert opinion on drug delivery

siRNA treatments: moving from liver delivery to targeting other organssiRNA therapeutics: from hepatic delivery to extrahepatic targeting.

Article

2 days ago • Journal of controlled release : official journal of the Controlled Release Society

Long-lasting destruction of a key sugar transporter by a targeted molecule causes energy failure and inflammatory cell death in cancerSustained degradation of glucose transporter 1 by an mRNA-encoded lysosome-targeting chimera triggers metabolic collapse and pyroptosis in cancer.

Article

2 days ago • Journal of controlled release : official journal of the Controlled Release Society

Changing tumor-supporting immune cells with ID3 mRNA to improve immunotherapy for pancreatic cancerReprogramming tumor-associated macrophages via ID3 mRNA delivery for enhanced immunotherapy in pancreatic cancer.

Article

2 days ago • Journal of controlled release : official journal of the Controlled Release Society

How ionizable lipids affect mRNA vaccine makeup and immune responseIonizable lipid impact on mRNA vaccine formulation properties and immunogenicity.

Article

1 week ago • The Journal of allergy and clinical immunology

Whole-body allergic reactions to mRNA COVID-19 vaccines in a controlled trialSystemic Allergic Reactions to mRNA COVID-19 Vaccines: A Randomized Placebo-controlled Trial.

Article

1 week ago • Annals of medicine and surgery (2012)

Potential of mRNA vaccines to fight infectious and chronic diseases in low-income countriesExploring the potential of mRNA vaccines in combatting communicable and non-communicable diseases in low-income and lower-middle-income countries.

Article

2 weeks ago • Journal of immunology (Baltimore, Md. : 1950)

How Removing Natural Killer Cells May Change Immune Responses to COVID mRNA VaccinesEffects of natural killer cell depletion on innate and adaptive immune responses to COVID mRNA vaccination.

Article

2 weeks ago • Journal of controlled release : official journal of the Controlled Release Society

Using lipid nanoparticles to deliver human RB1 mRNA and triptolide together for targeted gene therapy of retinoblastomaLipid nanoparticle-mediated co-delivery of human RB1 mRNA and triptolide for localized genetic therapy of retinoblastoma.

Article

2 weeks ago • RSC applied polymers

Creating new charged polymers for delivering mRNA using a four-part chemical processCombinatorial synthesis of novel polycations for mRNA delivery via Ugi 4-component polymerisation.

Article

2 weeks ago • Journal of controlled release : official journal of the Controlled Release Society

How sugar-coated cell surfaces and protein layers affect mRNA carrier uptake in different cell typesThe role of glycocalyx-protein corona interactions in the cell type-specific uptake of mRNA nanocarriers.

Article

2 weeks ago • Journal of controlled release : official journal of the Controlled Release Society

Lung surfactants in lipid nanoparticles for delivering mRNA to the lungsLung surfactants as a component of lipid nanoparticles for pulmonary mRNA delivery.

Article

2 weeks ago • Biological & pharmaceutical bulletin

Using Fat-Based Nanoparticles to Disrupt Blood Vessels in Lung Cancer SpreadLipid Nanoparticle-Mediated Vascular-Disrupting Therapy for Lung Metastasis.

Article

3 weeks ago • Journal of controlled release : official journal of the Controlled Release Society

Vaccine using two glycolipids allows choice of delivery method to target lung tumor spreadDual-glycolipid engineered vaccine platform empowers delivery route customization to intercept tumor lung metastasis.

Article

3 weeks ago • Journal of controlled release : official journal of the Controlled Release Society

A nanomaterial that stays local to improve mRNA immune treatment without entering the bloodstreamA systemic-absorption-blocked (SEAL) nanoplatform for mRNA-based local immunotherapy.

Article

3 weeks ago • Journal of controlled release : official journal of the Controlled Release Society

Improved cancer-fighting effects of PD-1 blocking antibody using liposome delivery and immune cell targetingAntitumor efficacy of PD-1 blocking antibody is enhanced through liposomal delivery and myeloid immune modulation.

Article

3 weeks ago • Biophysical journal

Wrapping Non-Enveloped Virus Shells with Fatty Layers in the LabIn Vitro Wrapping of Non-Enveloped Viral Capsids with Lipid Bilayers.

Article

3 weeks ago • Journal of controlled release : official journal of the Controlled Release Society

How protein production changes over time from mRNA, saRNA, and pDNA delivered alone or together in the same lipid nanoparticleProtein expression kinetics of mRNA, saRNA, and pDNA as individual or co-delivered payloads using a common lipid nanoparticle formulation.

Article

3 weeks ago • Advances in colloid and interface science

How Tumor Cells Take In Nanoparticles: Processes, Advances, and ChallengesDecoding the uptake pathway of nanoparticles in tumor cells: mechanisms, developments and challenges.

Article

1 month ago • Journal of controlled release : official journal of the Controlled Release Society

How protective substances affect the stability of mRNA lipid nanoparticles after freeze-drying and high heat storageUncovering the influence of lyoprotection on stability of mRNA-LNPs after lyophilization and high temperature storage.

Article

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mRNA Technology Research Papers