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1 week ago • Expert opinion on investigational drugs

Gene therapy using CRISPR-Cas9 to treat hereditary angioedemaLonvoguran ziclumeran: a CRISPR-CAS9-based gene therapy for the treatment of hereditary angioedema.

📖 Top 20% JournalArticle

1 week ago • The CRISPR journal

Creating and Testing RNA-Guided Modular Base Editors Using Staphylococcus aureus Cas9 Variants and New EnzymesDevelopment and Characterization of RNA Aptamer-Mediated Modular Base Editors Containing Staphylococcus aureus Cas9 Derivatives and Novel Deaminase Orthologs.

🎖️ Top 10% Journal

2 weeks ago • ACS sensors

Color-based detection of viral and non-coding RNAs using CRISPR and zinc finger-guided gold nanoparticle assemblyCut-and-Bind Colorimetric Detection of Viral and Non-Coding RNAs Using CRISPR/Cas12a with Zinc Finger-Facilitated Gold Nanoparticle Assembly.

🎖️ Top 10% Journal

2 weeks ago • Biosensors & bioelectronics

Improved RNA detection using CRISPR/Cas12a with chemical additivesChemical additives-enhanced CRISPR/Cas12a-based RNA detection.

🥉 Top 5% Journal

2 weeks ago • Blood advances

Modifying Stem Cells to Protect Them from Immune Attacks After TransplantEditing Around the Target: Epitope Engineering to Protect Stem Cell Grafts.

🥉 Top 5% Journal

2 weeks ago • Nature protocols

Studying large-scale genome structure by using targeted rearrangements through multiple precise edits in repeated DNA regionsLarge-scale genome structure interrogation via recombinase-mediated rearrangements of multiplexed prime edits in repetitive elements.

🥇 Top 1% Journal

2 weeks ago • STAR protocols

One-step method to create a three-guide RNA CRISPR tool for turning off genes in mouse brain neuronsProtocol for one-step design of a triple sgRNA-based CRISPR/Cas9 construct for neuronal gene knockout in the mouse brain.

📖 Top 20% Journal

2 weeks ago • Bioresource technology

Increasing natural pigment production in Chlorella sorokiniana by boosting the interaction between ORANGE and PSY proteinsEnhancing carotenoid production in Chlorella sorokiniana through the protein-protein interaction between ORANGE and PSY.

🥉 Top 5% Journal

2 weeks ago • Cytotherapy

Non-viral gene editing with platinum TALEN helps produce large amounts of cancer-targeting T cellsPlatinum TALEN-mediated nonviral gene editing facilitates clinical-scale production of cancer antigen-reactive T cells.

📖 Top 20% Journal

2 weeks ago • Lab on a chip

Low-cost CRISPR test strips with CHA for on-site gene detectionA low-cost CHA-integrated CRISPR/Cas12a-based test strip platform for on-site gene detection.

📖 Top 20% Journal

2 weeks ago • Cancer gene therapy

Blocking RAB27A-related small vesicle release reduces growth and spread of small cell lung cancer in lab and animal modelsTargeting RAB27A-mediated small extracellular vesicle secretion via CRISPR-Cas9 negatively affects proliferation and metastasis in both in vitro and in vivo SCLC models.

🎖️ Top 10% Journal

2 weeks ago • Biosensors & bioelectronics

Highly specific detection of single gene mutations using a Cas12a system without PAM that unwinds double-stranded DNAHigh-specificity gene point mutation detection by PAM-free Cas12a system with double-stranded substrate positioning-unwinding.

🥉 Top 5% Journal

2 weeks ago • ACS nano

Designing Guide DNA for Accurate RNA Targeting by Cas12aSequence Engineering of Guide DNA for Precise RNA Targeting by Cas12a.

🥈 Top 2% Journal

2 weeks ago • Talanta

Highly sensitive detection of methylated DNA using gene-editing enzymes combined with organic electrochemical sensorsCRISPR/Cas12a-coupled organic electrochemical transistors for highly sensitive detection of methylated DNA.

📖 Top 20% Journal

2 weeks ago • Pediatric research

Advances in children's gene therapy using CRISPR, artificial intelligence, and personalized treatmentThe future of pediatric gene therapy: CRISPR-Cas9, AI, and personalized medicine.

📖 Top 20% Journal

2 weeks ago • Molecular plant pathology

Improved Rice Resistance to Yellow Mottle Virus by Editing a Key Rice Protein Gene Using CRISPREnhanced Rice Yellow Mottle Virus Resistance via CRISPR/Cas9-Targeted Mutagenesis of the Rice eIF(iso)4G Gene.

🎖️ Top 10% Journal

3 weeks ago • Nature communications

CAR T-Cell Therapy Targeting IL7 Receptor for T-Cell Acute Lymphoblastic LeukemiaIL7-Receptor-Targeted CAR T-Cell Therapy for T-Cell Acute Lymphoblastic Leukemia.

🥈 Top 2% Journal

3 weeks ago • International journal of biological macromolecules

Increasing or decreasing Engrailed 1 in supportive tissue cells changes their ability to become bone-making cells and heal boneGain- and loss-of-function of Engrailed 1 in mesenchymal stromal cells affect their potential to differentiate into osteoblasts and to repair bone tissue.

📖 Top 20% Journal

3 weeks ago • Journal of integrative plant biology

Improving a tiny Fanzor2 tool for better genome editing in plantsOptimization of a hypercompact Fanzor2 system for improved genome editing performance in plants.

🥈 Top 2% Journal

3 weeks ago • Molecular therapy. Nucleic acids

Precise gene editing creates liver cells with PNPLA3-I148M mutation to study fat-related cell damagePrime editing enables isogenic modeling of PNPLA3-I148M-associated lipotoxicity in hepatocytes.

🥉 Top 5% Journal

3 weeks ago • Cellular and molecular life sciences : CMLS

Single-cell analysis and gene editing identify gene activity changes and key genes involved in kidney cell stressSnRNA-seq and genome-wide CRISPR screening define the complete transcriptional trajectory and functional drivers of podocyte stress.

🥉 Top 5% Journal

3 weeks ago • Autophagy

Genome-wide CRISPR screening reveals how TRIM25 helps break down ribosomes through ribophagyGenome-wide CRISPR-Cas9-based screening revealed the role of ubiquitin ligase TRIM25 in ribosome degradation via ribophagy.

🥈 Top 2% Journal

3 weeks ago • Plant science : an international journal of experimental plant biology

Editing two enzymes at once increases resistant starch and cold-sweetening resistance in Solanum chacoenseMultiplex CRISPR-Cas9 editing of starch branching enzyme II and vacuolar invertase simultaneously enhances resistant starch content and cold-induced sweetening resistance in Solanum chacoense.

📖 Top 20% Journal

3 weeks ago • ACS sensors

Light-Activated One-Step DNA Test to Detect a Critically Endangered Species in the EnvironmentOptical-Controlled One-Pot RPA-CRISPR Assay for Environmental DNA Detection of a Critically Endangered Species.

🎖️ Top 10% Journal

3 weeks ago • aBIOTECH

AI-designed OpenCRISPR-1 allows precise gene editing and mutations in riceAI-designed OpenCRISPR-1 enables efficient targeted mutagenesis and prime editing in rice.

📖 Top 20% Journal

3 weeks ago • Molecular therapy : the journal of the American Society of Gene Therapy

Correcting OTC Gene Function by Targeted DNA Integration to Restore Normal Activity and TraitsFunctional Editing of the OTC locus by Targeted Integration with Phenotype Correction and Restoration of Physiological Patterns of Expression.

🥈 Top 2% Journal

3 weeks ago • Nature biotechnology

Efficient cytosine base editing inside living cells using virus-like particles that block uracil DNA repairEfficient in vivo cytosine base editing using virus-like particles with uracil DNA glycosylase inhibition.

🏆 Top 0.1% Journal

3 weeks ago • Nature biotechnology

Designed enzymes allow precise DNA changes from A to GEngineered ADARs enable precision A-to-G base editing of DNA.

🏆 Top 0.1% Journal

4 weeks ago • Mikrochimica acta

Using two linked DNA reactions to boost CRISPR/Cas12a biosensor sensitivity for detecting tiny amounts of microRNAsAn integrated signal amplification strategy based on catalytic hairpin assembly and hybridization chain reaction for driving a CRISPR/Cas12a biosensor toward ultrasensitive detection of microRNAs.

📖 Top 30% Journal

4 weeks ago • STAR protocols

Method for creating pig fetal cells with multiple precise genetic editsProtocol for generating multiplexed prime-edited monoclonal cell lines in porcine fetal fibroblasts.

📖 Top 20% Journal

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CRISPR Gene Editing Research Papers