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1 week ago • NAR cancer

xNNPCD finds key controllers of programmed cell death by combining gene changes after treatment with cancer cell survival dataxNNPCD identifies regulators of programmed cell death by integrating perturbation transcriptomes with cancer dependency profiles.

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1 week ago • Molecular therapy. Oncology

Gene Therapy as a New Cellular Approach to Treat CancerGene therapy as an upcoming technique in the treatment of cancer: A cellular solution to a cellular problem.

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1 week ago • Current opinion in chemical biology

Using CRISPR to test the roles of noncoding gene control regionsCRISPR-based functional screening of noncoding regulatory elements.

🥉 Top 5% JournalArticle

1 week ago • Talanta

Light-activated DNA nanorobot for ultra-sensitive one-step detection of two microRNAs in triple-negative breast cancerCascade DNA walker-driven photo-controlled CRISPR/Cas12a nanorobot enabling ultrasensitive one-pot detection of dual miRNAs in triple-negative breast cancer.

📖 Top 20% JournalArticle

1 week ago • Molecular therapy. Nucleic acids

Genetic screening finds factors that affect CAR T cell survival in different tumor environmentsGenome-wide CRISPRa screens identify modulators of CAR T survival across diverse tumor cytokine milieus.

🥉 Top 5% JournalArticle

1 week ago • iScience

Truncated plakophilin-2 mutations cause heart rhythm problems like arrhythmogenic cardiomyopathy in adult zebrafishStable truncating mutations in plakophilin-2 induce arrhythmogenic cardiomyopathy-like phenotypes in adult zebrafish.

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1 week ago • Molecular therapy. Nucleic acids

Precise and adjustable base editing with inactive Cas12b proteins that cause minimal DNA changesMinimal indel-inducing and window-adjustable base editing using inactive Cas12b effectors.

🥉 Top 5% JournalArticle

1 week ago • ACS measurement science au

Sensitive Nucleic Acid Detection Using CRISPR and Amplified Signal Boosted by Catalytic Hairpin AssemblyCatalytic Hairpin Assembly-Aided CRISPR/Cas-SERS for Nucleic Acid Detection Enhanced by Multiple Catalytic Amplification.

📖 Top 20% JournalArticle

1 week ago • Methods (San Diego, Calif.)

A method to efficiently disable genes in heart and skeletal muscle cells without using DNAA DNA-free CRISPR-Cas9 ribonucleoprotein electroporation protocol for efficient knockout generation in cardiac and skeletal muscle cell lines.

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1 week ago • Biosensors & bioelectronics

DNAzyme-activated guide RNA allows CRISPR-Cas12a to detect alkaline phosphatase and Staphylococcus aureusA DNAzyme-activated engineered crRNA enables CRISPR-Cas12a biosensing of ALP and S. aureus.

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1 week ago • Analytical chemistry

Portable sensor using CRISPR and aptamers for detecting antibiotic resistance in waterRPA-CRISPR/Cas12a and Aptamer-Based Electrochemical Biosensing Duplex Platform for On-Site Monitoring of Antimicrobial Resistance in Water.

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1 week ago • Nano letters

Lack of GCLC Protein Increases Cell Intake of BNCT Drugs Through Stress-Triggered Cell DrinkingGCLC Deficiency Enhances Cellular Uptake of BNCT Agents via Oxidative Stress-Induced Macropinocytosis.

🥉 Top 5% JournalArticle

1 week ago • Talanta

Highly sensitive detection of aflatoxin B1 using a self-sustaining DNA-based sensor powered by CRISPR/Cas12aCRISPR/Cas12a-powered self-sustaining catalytic nucleic acid circuit for highly sensitive detection of aflatoxin B1.

📖 Top 20% JournalArticle

1 week ago • Nature neuroscience

Genes linked to behavior show Creld1 helps control different types of body sensationBehavioral genomics identifies Creld1 as a cross-modal regulator of somatosensation.

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1 week ago • Analytical chemistry

Programmable Cas9 System with AI for Detecting Two Proteins and Classifying Tumor Small VesiclesCHAI-sEV: A Programmable Hairpin-Driven Cas9 Platform with AI Integration for Dual-Protein Profiling and Intelligent Classification of Tumor-Derived Small Extracellular Vesicles.

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1 week ago • Nature plants

Changing wheat chromosomes by targeting their central regionsRewriting wheat karyotypes through centromere-targeted chromosome engineering.

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1 week ago • ACS synthetic biology

Automated Small Bioreactors Show Time-Based Molecular Responses to Gene Suppression in Pseudomonas putidaAutomated Mini-Bioreactors Reveal the Temporal Dynamics and Multi-Omics Responses of CRISPRi Knockdowns in Pseudomonas putida.

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1 week ago • Analytical chemistry

Using Split Cas12a Design for Highly Specific Detection of DNA Strands Without a PAM SequenceSplit Cas12a Protospacer Engineering Enables Ultraspecific Recognition of a PAM-Less DNA Strand via an External PAM-Proximal Duplex.

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1 week ago • Analytical chemistry

Sensitive Tumor Biomarker Detection Using Metal-DNA Nanoparticles to Activate CRISPR-Cas12a in a Microfluidic SystemCascade-Amplified Microfluidic Detection of Tumor Biomarkers via Metal-DNA Nanospheres Activating CRISPR-Cas12a Assay.

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1 week ago • Analytical chemistry

A CRISPR-Based Test Without PAM Requirements to Detect the katG Ser315Thr Mutation Linked to Isoniazid Resistance in TuberculosisAn XNA-CRISPR Platform for PAM-Free Detection of the katG Ser315Thr Mutation Associated with Isoniazid Resistance in Tuberculosis.

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1 week ago • Analytical chemistry

Highly Sensitive Electrochemical Biosensor Using Multiple CRISPR/Cas12a Cutting UnitsHighly Sensitive Electrochemical Biosensing Strategy Based on Multiple CRISPR/Cas12a Trans-Cleavage Units.

🎖️ Top 10% JournalArticle

1 week ago • Journal of agricultural and food chemistry

Improving E. coli’s sugar-making process to efficiently produce Lacto-N-tetraoseEngineering the Metabolic Pathway of Escherichia coli for Efficient Biosynthesis of Lacto-N-tetraose.

📖 Top 20% JournalArticle

1 week ago • ACS infectious diseases

Rapid CRISPR Test for ALV-J Virus with Wide Detection and Lower Leftover DNARPA-CRISPR/Cas12a Assay for ALV-J with Broad-Spectrum Detection and Reduced Residual Amplicon Load.

📖 Top 20% JournalArticle

1 week ago • International journal of biological macromolecules

Rapid test combining DNA amplification and CRISPR to detect antibiotic-resistant Klebsiella pneumoniaeOne-pot dual RPA-CRISPR/Cas12a lateral flow biosensor for rapid detection of carbapenemase-producing Klebsiella pneumoniae.

📖 Top 20% JournalArticle

1 week ago • Science translational medicine

Reducing repeated DNA sections with Cas9 nickase is linked to symptom improvements in a Huntington’s disease mouse modelCas9 nickase-mediated contraction of CAG/CTG repeats is associated with phenotypic improvements in a Huntington's disease mouse model.

🥇 Top 1% JournalArticle

1 week ago • Cell host & microbe

A virus-made small RNA that mimics guide RNA to block CRISPR-Cas9A phage-encoded small RNA that mimics chimeric guide to inhibit CRISPR-Cas9.

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1 week ago • Synthetic and systems biotechnology

A gene-editing and selection system for connecting epigenetic controllers to inactive natural product genes in Aspergillus nidulansA base-editing and auxotrophic selection platform for linking epigenetic regulators to silent biosynthetic gene clusters in Aspergillus nidulans.

📖 Top 20% JournalArticle

2 weeks ago • RSC advances

Low-cost device using aptamer-CRISPR method for detecting multiple small molecules at oncePaper integrated aptamer-CRISPR sensing enables multiplexed small-molecule sensing in a low-cost device.

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2 weeks ago • Nature biotechnology

Designed human Argonaute 2 protein for precise RNA editing from C to UEngineered human Argonaute 2 for targeted C-to-U RNA base editing.

🏆 Top 0.1% JournalArticle

2 weeks ago • Leukemia

Blocking a key mitochondrial protein boosts FLT3 inhibitor effects in acute myeloid leukemia with FLT3 mutationsTargeting the mitochondrial complex I subunit NDUFS2 potentiates FLT3 inhibition in acute myeloid leukaemia with FLT3 internal tandem duplication.

🥈 Top 2% JournalArticle

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CRISPR Gene Editing Research Papers