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2 weeks ago • Trends in biotechnology

From Changing Genes to Reshaping Chromosomes in PlantsFrom genome editing to chromosome engineering in plants.

🥉 Top 5% JournalArticle

2 weeks ago • Biosensors & bioelectronics

Sensitive detection of osteopontin using a probe-activated CRISPR method for assessing bone cancer and treatment responseUnipoint-anchored cascade amplification strategy integrating FUSE probe-activated CRISPR-Cas12a for dual mode osteopontin detection toward osteosarcoma assessment and therapeutic response evaluation.

🥉 Top 5% JournalArticle

2 weeks ago • STAR protocols

Using engineered virus-like particles to deliver gene editing tools in pancreatic cancer cellsProtocol for eVLP-mediated CRISPR-Cas9 and prime editing in pancreatic cancer cell lines.

📖 Top 20% JournalArticle

2 weeks ago • The New phytologist

Adding uORFs in wheat increases tolerance to environmental stress without affecting growthEngineering uORFs in wheat improves abiotic stress tolerance without growth penalties.

🥈 Top 2% JournalArticle

2 weeks ago • Trends in molecular medicine

Improved models of chromosome changes to recreate genome rearrangementsAdvances in modeling chromosomal aberrations to recapitulate genomic rearrangements.

🥈 Top 2% JournalArticle

3 weeks ago • Cancer research

A mouse brain tumor model mimics key molecular, immune, and functional traits of human glioblastoma to support treatment researchA syngeneic murine glioma model recapitulates key molecular, immunologic, and functional features of human glioblastoma to enable therapeutic development.

🥈 Top 2% JournalArticle

3 weeks ago • Transgenic research

CRISPR gene editing in food and feed crops: patent issues, worldwide access, and views from IndiaCRISPR genome editing in food and feed crops: intellectual property challenges, global accessibility, and the Indian perspective.

📖 Top 50% JournalArticle

3 weeks ago • Cellular & molecular immunology

Activating an alternative NF-κB pathway to improve cancer-killing by engineered T cellsCRISPRa screen unveils noncanonical NF-κB to boost the antitumor activity of TCR-based CAR-T cells.

🥇 Top 1% JournalArticle

3 weeks ago • Ear and hearing

New Gene Editing Treatments for Inherited DeafnessEmerging Therapies for Genetic Deafness: The Rise of Precision Gene Editing.

📖 Top 20% JournalArticle

3 weeks ago • Zoological research

Improved gGBE tool allows reliable G-to-Y DNA changes in mammal cells and zebrafish embryosOptimized gGBE enables robust G-to-Y conversion in mammalian cells and zebrafish embryos.

📖 Top 20% JournalArticle

3 weeks ago • Renal failure

Genes that affect kidney filter cell survival under oxidative stress, found by genome-wide CRISPR screensGenome-wide CRISPR screens identify shared and context-specific regulators of podocyte resistance to oxidative injury.

📖 Top 30% JournalArticle

3 weeks ago • Plant cell reports

mTREX2 increases large DNA deletions during CRISPR editing of complex sugarcane genomemTREX2 co-expression promotes large deletions in CRISPR/Cas12a editing of the highly polyploid sugarcane genome.

🎖️ Top 10% JournalArticle

3 weeks ago • Biosensors & bioelectronics

Controlling the DNA-cutting activity of LbCas12a by adjusting temperatureProgrammable thermoregulation of the nuclease activity of LbCas12a.

🥉 Top 5% JournalArticle

3 weeks ago • Biosensors & bioelectronics

Optimized CRISPR/Cas12a system using split guide RNA for detecting microRNAs without amplificationRationally optimized split crRNA-based CRISPR/Cas12a platform for amplification-free miRNA detection.

🥉 Top 5% JournalArticle

3 weeks ago • iScience

Inducible dCas12a system expands gene control tools for studying malaria parasite Plasmodium falciparumInducible dCas12a system expands CRISPRi/a capabilities for functional genomics in malaria parasite Plasmodium falciparum.

🎖️ Top 10% JournalArticle

3 weeks ago • ACS sensors

Portable soil testing for detecting Phytophthora infestans using a CRISPR-based fluorescent strip and microfluidic DNA preparationCentrifugal Microfluidic Soil-to-DNA Preparation for the Portable Detection of Phytophthora infestans Using a CRISPR/Cas12a-Based Quantum Dot Fluorescent Lateral Flow Assay.

🎖️ Top 10% JournalArticle

3 weeks ago • iScience

Loss of SREBF1 disrupts fat signaling and leads to slow muscle fiber breakdownLoss of SREBF1 disrupts lipid signaling and causes slow muscle fiber degeneration.

🎖️ Top 10% JournalArticle

3 weeks ago • Mycology

Precise DNA base editing using CRISPR in the fungus Trichoderma koningiopsisCRISPR/Cas9 nickase-mediated cytosine base editing in Trichoderma koningiopsis.

📖 Top 20% JournalArticle

3 weeks ago • The Yale journal of biology and medicine

Reevaluating Viral Gene Therapy for Brain Cancer: Potential Benefits and ChallengesReassessing Viral Gene Therapy for Glioblastoma: Translational Opportunities and Challenges.

📖 Top 20% JournalArticle

3 weeks ago • Plant physiology and biochemistry : PPB

Removing IBH1 gene with CRISPR adjusts growth hormone levels and changes plant shape and grain traits in durum wheatCRISPR-Cas9 knockout of IBH1 fine-tunes brassinosteroid metabolism and modulates plant architecture and grain traits in durum wheat.

🎖️ Top 10% JournalArticle

3 weeks ago • Cold Spring Harbor perspectives in medicine

"Cultural Lag" and Managing Risks in Life Science ResearchWhat's New Is Old: "Cultural Lag" and Governance of Risk in the Life Sciences.

🥉 Top 5% JournalArticle

3 weeks ago • Angewandte Chemie (International ed. in English)

How Substrate Access and Position Affect Cas12a Protein Cutting SpeedAccessibility and Alignment of Trans-Cleavage Substrates Modulate the Kinetics of Cas12a Ribonucleoprotein.

🥇 Top 1% JournalArticle

3 weeks ago • Advanced materials (Deerfield Beach, Fla.)

Using CRISPR-Enhanced Nanocatalysts to Trigger Iron-Dependent Cell Death in Triple-Negative Breast CancerCRISPR Nanomachinery-Sensitized Nanocatalytic Tumor Ferroptosis in Triple-Negative Breast Cancer.

🥇 Top 1% JournalArticle

3 weeks ago • Nucleic acids research

A flexible control point in CRISPR-Cas9 that helps ensure accurate DNA targetingA dynamically frustrated allosteric checkpoint consistent with conformational proofreading in CRISPR-Cas9.

🥇 Top 1% JournalArticle

4 weeks ago • Cell reports

Genome-wide CRISPR screening found a non-neuron receptor called hemojuvelin for botulinum toxins A and CGenome-wide CRISPR screening identified hemojuvelin as a non-neuronal receptor for the botulinum neurotoxin serotypes A and C.

🥈 Top 2% JournalArticle

4 weeks ago • Nucleic acids research

Using gene-silencing linked to adaptation to find genes that increase antibiotic sensitivity and create a new plasmid selection markerAdaptation-coupled CRISPRi identifies antibiotic-sensitizing genes leading to a novel plasmid selection marker.

🥇 Top 1% JournalArticle

4 weeks ago • American journal of hematology

Genes Important for Red Blood Cell Development Identified by a Large Genetic ScreenA Pooled CRISPR Screen Reveals Genes Critical for Erythroblast Enucleation.

🥉 Top 5% JournalArticle

4 weeks ago • The Journal of chemical physics

Computer simulation of the molecular structure and interaction of the IscB protein with its guide RNAMolecular dynamics simulation and QM/MM study of IscB-ωRNA complex.

📖 Top 30% JournalArticle

4 weeks ago • Cancer research

Blocking SLC38A5 May Help Immunotherapy Work Better by Reducing Glutamine Competition Between Brain Tumor Cells and Immune T CellsTargeting SLC38A5 Overcomes αPD-1 Immunotherapy Resistance by Alleviating Glutamine Competition Between Glioblastoma Cells and T Cells.

🥈 Top 2% JournalArticle

4 days ago • Molecular genetics and genomics : MGG

Advances in fixing genetic diseases by prime editing inside the bodyResearch progress of gene correction for genetic diseases via in vivo prime editing.

📖 Top 50% JournalArticle

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CRISPR Gene Editing Research Papers