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2 weeks ago • Neuron

Different types of aging cells in the brain and their links to brain aging and neurodegenerative diseasesSenescent cell heterogeneity in brain aging and neurodegenerative disease.

2 weeks ago • Cardiovascular research

KMT2B increases inflammation and artery disease by controlling cell cleanup in blood vessel lining cellsKMT2B drives inflammation in endothelial cells and promotes atherosclerosis via histone H3 lysine 4 trimethylation-mediated autophagy.

2 weeks ago • Biochemical pharmacology

Higher MYH11 levels may reduce autophagy problems by adjusting ATG4A in fatty liver disease linked to metabolismMYH11 upregulation attenuates autophagy dysfunction through modulation of ATG4A in metabolic dysfunction-associated steatotic liver disease.

2 weeks ago • British journal of pharmacology

β-Nicotinamide mononucleotide reduces liver damage from aflatoxin B1 through gut bacteria, bile acids, and the FXR receptorβ-Nicotinamide mononucleotide reduces aflatoxin B1 induced liver injury via the gut microbiota-bile acid-farnesoid X receptor (FXR/NR1H4) axis.

2 weeks ago • Gene

Common genetic routes and gene interactions in major brain diseases that cause nerve cell lossExploring shared genetic pathways and gene interplay in major neurodegenerative diseases: a comprehensive review.

2 weeks ago • Progress in neuro-psychopharmacology & biological psychiatry

Antidepressants may help treat Alzheimer's and Parkinson's by reducing brain inflammationUnlocking new uses: The promise of antidepressants in treating Alzheimer's and Parkinson's through Neuroinflammation modulation.

2 weeks ago • Cureus

How CPT2 Connects Age-Related Brain Gene Changes to NMN-Driven Gene Activity Recovery in Metabolic OrgansCPT2 as a Convergent Node Linking Age-Associated Neuronal H3K27me3 Remodeling to Nicotinamide Mononucleotide (NMN)-Induced Expression Rescue in Metabolic Tissues.

2 weeks ago • Cureus

DNA Methylation of Key Glutamate Receptor Genes Shows Aging Patterns in Blood After COVID, Linked to Long-COVID Brain and Mood SymptomsDNA Methylation at Core N-Methyl-D-Aspartate (NMDA) Receptor Genes Reveals a Glutamatergic Signature of Aging in Post-COVID Whole Blood With Implications for Long-COVID Neuropsychiatric Sequelae.

2 weeks ago • Biochemical pharmacology

Gut bacteria patterns linked to lifespanMolecular signatures of the gut microbiota that affect longevity.

2 weeks ago • Diabetes, obesity & metabolism

Metformin may improve diabetes-related memory problems by helping cells clear damaged mitochondria through p53 and Parkin pathwaysMetformin Ameliorates Diabetes-Associated Cognitive Dysfunction via p53/Parkin-Mediated Mitophagy.

2 weeks ago • Journal of controlled release : official journal of the Controlled Release Society

Nanozyme-Enhanced Gel Helps Mitochondria Manage Stress to Reduce Inflammation and Damage in Disc DegenerationNanozyme-integrated hydrogel orchestrates mitochondrial quality control to counter inflammatory and oxidative milieu during disc degeneration.

2 weeks ago • International journal of molecular medicine

Fixing lung cell problems in unexplained lung scarring: How it happens and new treatment ideasTargeting alveolar type II cell dysfunction in idiopathic pulmonary fibrosis: Molecular mechanisms and emerging therapeutic strategies (Review).

2 weeks ago • Neurochemistry international

Can Urolithin A Work as a Brain-Boosting Supplement? A Review of How It Acts, Reaches the Brain, and What Is Unknown in Alzheimer’s and Parkinson’s DiseaseIs Urolithin A(UA) a Pharmacologically Credible Neuro-Nutraceutical? A Critical Review of Mechanisms, Brain Exposure, and Evidence Gaps in Alzheimer's and Parkinson's Disease.

2 weeks ago • Biochimica et biophysica acta. Reviews on cancer

The link between cell energy stress and stem cell growth and change, and its role in cancer and aging diseasesROS-mitochondrial nexus in stem cell growth and differentiation and implications in cancer and degenerative diseases.

2 weeks ago • American journal of physiology. Cell physiology

Muscle Stem Cells and AgingMuscle Satellite Cells and Aging.

3 weeks ago • Experimental and therapeutic medicine

Resveratrol may reduce type 2 diabetes by improving cell energy production and fat metabolism through Sirtuin 1[Retracted] Resveratrol attenuates type 2 diabetes mellitus by mediating mitochondrial biogenesis and lipid metabolism via Sirtuin type 1.

3 weeks ago • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Chemical exposure worsens amyloid-beta toxicity in Alzheimer's model worms through impaired cell cleanup and increased oxidative stressDi(2-ethylhexyl) phthalate exposure aggravates amyloid-beta-induced toxicity in transgenic AD Caenorhabditis elegans via lysosomal dysfunction and oxidative stress.

3 weeks ago • Mechanisms of ageing and development

How ABO Blood Types Are Linked to Aging-Related Health OutcomesABO blood groups and ageing-related outcomes: Insights from a narrative review.

3 weeks ago • Genes & development

SMARCAL1 as a potential treatment target for tumors using alternative lengthening of telomeresSMARCAL1 is a candidate therapeutic target for ALT-positive tumors.

3 weeks ago • International immunopharmacology

Grx may reduce diabetic cataracts by boosting cell cleaning through a specific energy and recycling pathway in lens cellsGrx attenuates diabetes cataract by activating AMPK/BNIP3/BNIP3L-mediated mitophagy in lens epithelial cells.

3 weeks ago • Autophagy reports

New roles of the Arp2/3 complex and WHAMM in cell cleanup and recycling systemsDamage control: new functions for the Arp2/3 complex and WHAMM in autophagy and lysosomal homeostasis.

3 weeks ago • Biochimica et biophysica acta. Molecular basis of disease

Neuroglobin lowers stress-related cell damage and amyloid buildup in 3D human nerve cell culturesNeuroglobin reduces stress-induced oxidative damage and amyloid burden in a three-dimensional human neuroblastoma cell culture.

3 weeks ago • Neurobiology of disease

Noise exposure triggers immune response in the brain and affects thinking abilities depending on context in rats with long-term hearing lossNoise exposure induces microglial reactivity and context-dependent cognitive vulnerability in chronic noise-induced hearing loss rats.

3 weeks ago • Acta diabetologica

Using single-cell machine learning to find how PINK1-related mitochondrial recycling affects metabolism in type 2 diabetesInterpretable single-cell machine learning identifies PINK1-centred mitophagy as a determinant of metabolic fitness in type 2 diabetes.

3 weeks ago • Journal of controlled release : official journal of the Controlled Release Society

Improving insulin sensitivity by lowering fat cell aging with targeted nanoparticles in obese mice on a high-fat dietEnhancing insulin sensitivity by reducing adipocyte senescence using uPAR-targeted nanoparticles in high-fat-diet-induced obese mice.

3 weeks ago • Journal of controlled release : official journal of the Controlled Release Society

Using Nanoparticles to Remove Aging Cells in Brain Blood VesselsNanoparticles as an efficient strategy to eliminate senescent brain endothelial cells.

3 weeks ago • The journals of gerontology. Series A, Biological sciences and medical sciences

Tracking Aging Patterns Over Time Using Urine Metabolism Measured by Detailed NMRUrinary Metabolic Age from High-Resolution NMR Reveals Longitudinal Aging Patterns.

3 weeks ago • Chinese medical journal

Understanding tiny cell particles in age-related long-term lung diseasesInsights into extracellular vesicles in senescence-associated chronic lung diseases.

3 weeks ago • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

PFDA exposure may speed up heart aging and scarring by over-activating the MTORC1 signaling pathwayPFDA exposure promotes myocardial aging and fibrosis via hyperactivation of the MTORC1 signaling axis.

3 weeks ago • Journal of controlled release : official journal of the Controlled Release Society

Tiny particles from hairyvein agrimony in microneedles kill hidden bacteria and reverse cell aging to heal diabetic foot bone infectionsHairyvein agrimony-derived nanovesicles in microneedles eradicate intracellular bacteria and reverse senescence to heal diabetic foot osteomyelitis.

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Longevity & Aging Research Papers