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1 week ago • Cells

Improved surrounding protein sequences boost immune response and antigen display after mRNA vaccinationOptimized Epitope-Flanking Sequences Enhance Antigen Presentation and T-Cell Responses Following mRNA Vaccination.

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1 week ago • Journal of the Egyptian National Cancer Institute

Cancer nanomedicine and RNA/lipid nanoparticle systems in cancer treatment: development progress, challenges in use, and chances for precise therapiesCancer nanomedicine and RNA/Lipid nanoparticle platforms in oncology: developmental evolution, translational barriers, and precision-therapy opportunities.

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1 week ago • ACS applied materials & interfaces

Nanoparticles that activate only inside target cells when triggeredClickable Turn-On Nanoparticles for Target-Specific Intracellular Activation.

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1 week ago • Clinical pharmacology and therapeutics

Modeling how unconjugated antisense oligonucleotides and GalNAc-linked small interfering RNAs spread in blood and tissues of animals and humansToward a Platform PBPK Model to Characterize the Plasma and Tissue Disposition of Unconjugated Antisense Oligonucleotides and GalNAc-Conjugated Small Interfering RNAs in Preclinical Species and Human.

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1 week ago • Molecular biology reports

Why Delivering siRNA to Treat Brain Diseases Often Fails: Body Barriers, Nanoparticle Design, and Future ApproachesWhy does siRNA delivery still fail in neurodegenerative diseases? Biological barriers, nanocarrier engineering, and future translational directions.

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1 week ago • ACS applied materials & interfaces

Testing many lipid nanoparticles to find the best ones for delivering CRISPR gene-editing toolsHigh-Throughput Screening of a Lipid Nanoparticle (LNP) Library Identifies Lead Formulations for CRISPR-Cas9 Ribonucleoprotein Delivery and Gene Editing.

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1 week ago • Molecules (Basel, Switzerland)

DNA and mRNA Vaccines for Hantaviruses: Designing Targets, Delivery Methods, and Progress Toward UseDNA and mRNA Vaccines Against Hantaviruses: Antigen Design, Delivery Strategies and Translational Progress.

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1 week ago • Trends in pharmacological sciences

Designing monocytes and macrophages to improve medical treatmentsEngineering monocytes and macrophages for therapeutic control.

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1 week ago • Analytica chimica acta

Methods for Measuring How Efficiently mRNA Gets Its Protective CapAnalytical methods for estimation of the mRNA capping efficiency - A comprehensive review.

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1 week ago • Cancer gene therapy

Restoring p53 function with hybrid strontium sulfite nanoparticle-coated lipid particles improves breast cancer treatmentRestoration of p53 function via hybrid strontium sulfite nanoparticles modified LNP improves the antitumor efficacy in breast cancers.

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1 week ago • International journal of dentistry

Cell Growth, Bone Formation, and New Blood Vessel Growth Triggered by Modified mRNA for a Blood Vessel Growth ProteinIn Vitro Cell Proliferation, Osteogenic Differentiation, and In Vivo Angiogenesis Induced by Modified mRNA Encoding Vascular Endothelial Growth Factor-A.

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1 week ago • Molecular oncology

Using LCOR mRNA nanotherapy to change tumor cells and improve immunotherapyReprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy.

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1 week ago • Therapeutic delivery

How the design of tiny fat-based carriers affects their drug releaseMechanistic insights into nanostructured lipid carriers: from lipid architecture to drug release behavior.

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1 week ago • International journal of biological macromolecules

Zein-based hybrid nanoparticles for delivering genes without viruses: A reviewZein-based hybrid nanocarriers for non-viral gene delivery: A review.

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1 week ago • Critical reviews in therapeutic drug carrier systems

Targeted Drug Delivery to Tumors: From Traditional to New TechnologiesTumor Specific Drug Delivery: Conventional to Advanced Technologies.

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1 week ago • Advanced materials (Deerfield Beach, Fla.)

Local mRNA Treatments Delivered to Accessible Body Areas for Targeting DiseasesAnatomically Accessible Local mRNA Therapeutics: From Anatomical Access to Disease-Focused Applications.

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1 week ago • ACS pharmacology & translational science

New RNA Treatments Targeting Inflammation in the Front Part of the Eye: How They Work and Their Medical PromiseEmerging RNA-Based Therapeutic Strategies for Inflammatory Ophthalmic Disorders of the Anterior Segment: Mechanistic Insights and Translational Potential.

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1 week ago • Journal of virology

mRNA nanoparticle delivery of linked nanobodies protects young geese from new goose virus infectionmRNA-LNP delivery of a homo-tandem nanobody protects goslings from novel goose astrovirus infection.

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1 week ago • Current gene therapy

Smart Tiny Carriers That Deliver siRNA and Respond to Signals for Targeted Gene SilencingSMART Nanocarriers for siRNA Delivery: Stimuli-Responsive Platforms for Targeted Gene Silencing.

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1 week ago • ACS chemical biology

Functions of Non-Double-Layer Lipids in Biology, Disease, and Drug DeliveryLipid Chemistry beyond the Bilayer: Roles for Nonbilayer Lipids in Biology, Disease, and Delivery.

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1 week ago • International journal of pharmaceutics

Amorphous trehalose improves long-term high-temperature storage of freeze-dried mRNA-lipid nanoparticlesAmorphous trehalose as a superior lyoprotectant for high-temperature long-term storage of freeze-dried mRNA-lipid nanoparticles.

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1 week ago • Science translational medicine

Engineered antibody parts allow delivery of multiple mRNA-made dual-target antibodies that limit virus evasionOrthogonal Fc engineering enables multiplexed delivery of mRNA-encoded bispecific antibodies that constrain viral escape.

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1 week ago • Frontiers in pharmacology

Circular RNAs in cancer: from disease markers to vaccine-based immune treatmentCircular RNAs in cancer: from biomarkers to vaccine-based immunotherapy.

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1 week ago • Small (Weinheim an der Bergstrasse, Germany)

Using Machine Learning to Design Tiny Programmable Systems from Lipid Bags to DNA Shapes and Mixed VesiclesMachine Learning for Programmable Nanosystems: From Liposome Formulation to DNA Origami and Hybrid Vesicles.

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1 week ago • Human vaccines & immunotherapeutics

Development of mRNA Vaccines for ShinglesDevelopment of mRNA vaccines against herpes zoster.

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1 week ago • The Journal of allergy and clinical immunology

Whole-body allergic reactions to mRNA COVID-19 vaccines in a controlled trialSystemic Allergic Reactions to mRNA COVID-19 Vaccines: A Randomized Placebo-controlled Trial.

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1 week ago • Annals of medicine and surgery (2012)

Potential of mRNA vaccines to fight infectious and chronic diseases in low-income countriesExploring the potential of mRNA vaccines in combatting communicable and non-communicable diseases in low-income and lower-middle-income countries.

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1 week ago • Biomaterials advances

pH-sensitive polymer that changes from water-attracting to water-repelling to help cells take in mRNA using lightPolymer-photosensitizer conjugate exerting pH-responsive hydrophilic-to-hydrophobic conversion for cell-specific photochemical internalization of mRNA.

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1 week ago • Science China. Life sciences

Improving fat-based particles to lower liver buildup and boost mRNA delivery at target sitesOptimization of lipid nanoparticles reduces hepatic accumulation and enhances local delivery of mRNA.

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1 week ago • Biomaterials

Specially designed lipids control RNA assembly in mineral-rich environmentsChemically tailored lipids mediate solid-phase RNA programming of mineralized microenvironments.

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