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1 week ago • The Journal of pharmacy and pharmacology

Using diethylene glycol monoethyl ether as a new solvent for making mRNA lipid nanoparticlesDiethylene glycol monoethyl ether as an alternative solvent for mRNA-LNP manufacture.

Article

1 week ago • Drug delivery and translational research

Loss of effectiveness from PEG in lipid nanoparticles continues despite formulation changes for mRNA deliveryPEG-associated efficacy loss in lipid nanoparticles persists across formulation modifications for mRNA delivery.

📖 Top 20% JournalArticle

1 week ago • European journal of pharmacology

Survivin mRNA lipid nanoparticles activate killer T cells and memory response for effective oral cancer immunotherapySurvivin mRNA-lipid nanoparticles promote activation of CD8+Granzyme B+ T cells and effector memory formation for effective oral cancer immunotherapy.

📖 Top 20% JournalArticle

1 week ago • International journal of pharmaceutics: X

Distribution of mRNA-carrying lipid nanoparticles in the inner ear of newborn miceExploration of biodistribution of mRNA-delivering lipid nanoparticles in the neonatal mouse inner ear.

📖 Top 20% JournalArticle

1 week ago • Current gene therapy

MicroRNA Treatments in Cancer: Reviewing Their Potential and Challenges for Medical UseMicroRNA Therapeutics in Cancer: Revisiting the Promise and Understanding the Limitations of Clinical Translation.

📖 Top 30% JournalArticle

1 week ago • Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

Lipid-Based Nanomedicines for Inflammatory Diseases: Current Advances and Future OutlookLipid-Based Nanotherapeutics for Inflammatory Disorders: Current Progress and Future Perspectives.

🎖️ Top 10% JournalArticle

1 week ago • Journal of liposome research

Key factors affecting accurate ultrasound creation of fat-based nanoparticlesCritical factors influencing the precise ultrasound-mediated production of lipid nanoparticles.

📖 Top 50% JournalArticle

2 weeks ago • bioRxiv : the preprint server for biology

Lysophosphatidylserine Nanoparticles Trigger Oral Immune Tolerance Without Relying on TIM-4 or Usual ProcessingLysophosphatidylserine Nanoparticles Induce Oral Tolerance Independent of TIM-4 and Canonical PS Processing.

Preprint

2 weeks ago • Toxicological sciences : an official journal of the Society of Toxicology

Synthetic mRNA in lipid nanoparticles causes temporary changes in blood cell production through immune responses under high inflammation in animal modelsLipid Nanoparticle-Formulated Synthetic Messenger RNA Induces Reversible Hematopoietic Bias via Type I Interferon Responses Under Upper-Bound Inflammatory Conditions in Preclinical Animal Models.

Article

2 weeks ago • Journal of immunology (Baltimore, Md. : 1950)

How Removing Natural Killer Cells May Change Immune Responses to COVID mRNA VaccinesEffects of natural killer cell depletion on innate and adaptive immune responses to COVID mRNA vaccination.

Article

2 weeks ago • Bioengineering & translational medicine

How mRNA lipid nanoparticles spread in the body: From drug behavior to medical useMechanisms and determinants of mRNALipid Nanoparticle biodistribution: From pharmacokinetics to clinical translation.

🎖️ Top 10% JournalArticle

2 weeks ago • PLoS pathogens

New mRNA vaccines based on EG95 may provide long-lasting protection against echinococcosisNovel EG95-based mRNA vaccines induce long-term protective immunity against echinococcosis.

🥉 Top 5% JournalArticle

2 weeks ago • Current drug targets

Graphene-based delivery systems carrying self-boosting RNA, circular RNA, and immune activators for cancer immunotherapyStimuli-responsive Graphene Nanoplatforms Co-delivering Self-amplifying RNA, circRNA, and cGAMP for Cancer Immunotherapy: A Narrative Review.

📖 Top 30% JournalArticle

2 weeks ago • Journal of virology

mRNA-lipid nanoparticle vaccine with eight flu proteins triggered broad antibody protection against influenza A in pigsA multivalent mRNA-lipid nanoparticle vaccine containing eight hemagglutinin antigens elicited broad neutralizing antibody responses and protected against influenza A virus challenge in swine.

Article

2 weeks ago • Journal of controlled release : official journal of the Controlled Release Society

Using lipid nanoparticles to deliver human RB1 mRNA and triptolide together for targeted gene therapy of retinoblastomaLipid nanoparticle-mediated co-delivery of human RB1 mRNA and triptolide for localized genetic therapy of retinoblastoma.

Article

2 weeks ago • Genetics and molecular biology

mRNA therapies: From basic science to medical breakthroughsmRNA-based therapies: From molecular discovery to clinical revolution.

Article

2 weeks ago • Nanomedicine (London, England)

mRNA nanomedicine for healing diabetic wounds: progress in delivery, immune response, and tissue repairmRNA-based nanomedicine for diabetic wound repair: advances in LNP delivery, immune modulation, and regenerative pathways.

📖 Top 50% JournalArticle

2 weeks ago • Current opinion in chemical biology

Fluorescent tagging methods for genetic material and their use in studying RNA deliveryFluorescence labelling strategies for nucleic acids and current applications in studying RNA delivery.

🥉 Top 5% JournalArticle

2 weeks ago • Frontiers in bioinformatics

Design of a multi-part mRNA vaccine targeting the main types of hepatitis E virus that infect peopleImmunoinformatics-based design of a multi-epitope mRNA vaccine candidate targeting the major human-infecting hepatitis E virus genotypes 1-4.

📖 Top 20% JournalArticle

2 weeks ago • Journal of virology

H5 flu mRNA vaccine in lipid nanoparticles triggers immune responses in Holstein calvesH5 influenza virus mRNA-lipid nanoparticle (LNP) vaccination elicits adaptive immune responses in Holstein calves.

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2 weeks ago • Science (New York, N.Y.)

The human gut microbiome may prepare the body to develop fever after vaccinationThe human gut microbiome primes fever after vaccination.

Article

2 weeks ago • Vaccine

Circular RNA Vaccines for Pvs25 Trigger Antibodies That May Block Malaria TransmissionCircular RNA vaccines encoding Pvs25 induce antibodies that block Plasmodium vivax transmission.

📖 Top 20% JournalArticle

2 weeks ago • Vaccine

SARS-CoV-2 mRNA vaccine immune response over time in inflammatory bowel disease patients, linked to anti-TNF treatment and ageLongitudinal SARS-CoV-2 mRNA vaccine immunogenicity in inflammatory bowel disease in relation to anti-TNF therapy and age: a prospective cohort study.

📖 Top 20% JournalArticle

2 weeks ago • Frontiers in pharmacology

Using gene function data to identify MED12 as a potential RNA-targeting weakness in acute myeloid leukemia and testing a targeted siRNA delivery methodFunctional-genomic prioritization identifies MED12 as a candidate RNAi vulnerability in acute myeloid leukemia: evaluation of a T22 peptide-functionalized LNP-siRNA formulation.

📖 Top 20% JournalArticle

2 weeks ago • Clinical laboratory

How mRNA Vaccination May Affect the Progression of Chronic Kidney DiseaseEffects of mRNA Vaccination on the Progression of Chronic Kidney Disease.

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2 weeks ago • RSC applied polymers

Creating new charged polymers for delivering mRNA using a four-part chemical processCombinatorial synthesis of novel polycations for mRNA delivery via Ugi 4-component polymerisation.

Article

2 weeks ago • Lab on a chip

Designing microfluidic channels for mRNA lipid nanoparticles: review of mixing methods, particle structures, and biological resultsMicrofluidic channel engineering for mRNA-LNPs: a systematic review of mixing strategies, nanostructures, and biological performance.

📖 Top 20% JournalArticle

2 weeks ago • FEBS open bio

Using Fluorine to Adjust How Molecules and Tiny Systems Interact with Living ThingsFluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter.

📖 Top 20% JournalArticle

2 weeks ago • Signal transduction and targeted therapy

Bioengineering methods to boost the immune response of mRNA vaccinesBioengineering strategies for improving the immunogenicity of mRNA vaccines.

🥇 Top 1% JournalArticle

2 weeks ago • Cell reports. Medicine

Zika mRNA vaccine with fusion-loop changes triggers focused B cell response that separates protection from antibody-related enhancement in macaquesFusion-loop-engineered Zika mRNA vaccine elicits convergent B cell immunodominance to uncouple protection from ADE in macaques.

🥈 Top 2% JournalArticle

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