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1 week ago • International journal of biological macromolecules

Modified pullulan improves gene silencing delivery after aerosol treatmentModified pullulan unlocks efficient polyplex-mediated gene silencing following nebulization.

📖 Top 20% JournalArticle

1 week ago • Vaccines

Possible Ways mRNA in Lipid Nanoparticles Breaks Down: A Complete ReviewPossible Mechanisms of mRNA-LNP Degradation: A Comprehensive Review.

📖 Top 20% JournalArticle

1 week ago • Journal of biomedical science

Overview of mRNA Therapy and Methods to Purify mRNA and Remove Double-Stranded RNAThe current landscape of mRNA therapy and the strategies for mRNA purification and dsRNA removal.

🥉 Top 5% JournalArticle

1 week ago • Journal of medical virology

COVID-19 mRNA Vaccines Trigger Neutralizing Antibodies and Change Immune Responses in People with HIVSARS-CoV-2 mRNA Vaccination Induces Neutralizing Antibodies and Type I IFN Changes in People Living With HIV.

Article

1 week ago • Vaccines

Safety and Immune Response to the Pfizer COVID-19 Vaccine in People 2 Years and Older with Weakened ImmunitySafety and Immunogenicity of the BNT162b2 COVID-19 Vaccine in Immunocompromised Participants 2 Years and Older: Results of an Open-Label Phase 2b Study.

📖 Top 20% JournalArticle

1 week ago • Vaccines

Designed mRNA Nanoparticles for Delivery to Lung MucusEngineered mRNA Nanoparticle Platforms for Respiratory Mucosal Delivery.

📖 Top 20% JournalArticle

1 week ago • British journal of pharmacology

Immediate allergic and widespread inflammation effects of Comirnaty in pigs linked to spike protein mRNA and increased inflammatory signalsAcute anaphylactic and multiorgan inflammatory effects of Comirnaty in pigs: evidence of spike protein mRNA transfection and paralleling inflammatory cytokine upregulation.

1 week ago • Infectious diseases and therapy

Immune response, side effects, and safety of the BA.1-adapted BNT162b2 vaccine in 18- to 55-year-olds with or without previous BNT162b2 COVID-19 vaccinationImmunogenicity, Tolerability, and Safety of BA.1-Adapted BNT162b2 Vaccine in 18- to 55-Year-Olds Previously Vaccinated with BNT162b2 or Who Were COVID-19 Vaccine-Naive.

🎖️ Top 10% Journal

1 week ago • Vaccine

Effectiveness of JN.1-adapted regular and self-amplifying mRNA COVID-19 vaccines against symptoms in adults 60 and older in Japan, October 2024-April 2025Interim analysis of effectiveness of JN.1-adapted conventional and self-amplifying mRNA COVID-19 vaccines against symptomatic SARS-CoV-2 infection in adults aged ≥60 years, Japan, October 2024-April 2025.

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1 week ago • Applied biochemistry and biotechnology

Computer-Designed mRNA Vaccine Targeting Multiple Parts of MammarenavirusesComputational Design of a Broad-Spectrum Multi-Epitope mRNA Vaccine Candidate for Mammarenaviruses.

📖 Top 30% Journal

1 week ago • International immunology

Natural immune reactions linked to local and whole-body side effects from mRNA lipid nanoparticle vaccinesInnate immune responses underlying local and systemic adverse reactions to mRNA-lipid nanoparticle vaccines.

🎖️ Top 10% Journal

1 week ago • Discover nano

How mechanical factors control interactions between lipids and tiny particles in nanocarriersMechanical insights into regulation of bio-nano interactions for lipid-based nanocarriers.

📖 Top 30% Journal

1 week ago • Tumori

Early study of bladder cancer treatment using IL-12 mRNA nanoparticles delivered inside the bladderPreliminary study on intravesical instillation of IL-12 mRNA lipid nanoparticles for the treatment of bladder cancer.

📖 Top 50% Journal

1 week ago • Methods and protocols

An Easy Way to Measure the Length of mRNA Tail SequencesA Simple Method to Evaluate the Length of Poly(A) Tails in mRNA.

📖 Top 50% Journal

1 week ago • International journal of oral science

Improving tooth pulp healing by changing metabolism in mature dental stem cells using GLUT1 and HK2 mRNAEnhancing pulp regeneration through metabolic reprogramming of mature dental pulp stem cells mediated by GLUT1/HK2 mRNA delivery.

🥉 Top 5% Journal

1 week ago • Nanomedicine (London, England)

New stealth fat-based carriers: improvements in PEG coating and new amide polymer optionsNext-generation stealth lipid-based nanocarriers: advances in PEGylation and emerging amide-containing polymer alternatives.

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1 week ago • Drug metabolism and bioanalysis

Using Tiny Fat Particles to Improve Diabetes TreatmentLipid Nanoparticles: A New Frontier in Diabetes Treatment.

1 week ago • Frontiers in immunology

How RNA Modifications Help Tumors Avoid the Immune System: Mechanisms, Different Situations, and Treatment PossibilitiesRNA epitranscriptomic regulation of tumor immune evasion: mechanisms, context-dependent roles, and therapeutic implications.

🥉 Top 5% Journal

1 week ago • Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

pH-sensitive lipid nanocarriers designed for coordinated delivery and combined treatment of triple-negative breast cancerTailoring pH-responsive charge-conversional interfaces in ionizable lipid-based nanoliposomes for synchronized co-delivery and synergistic therapy of triple-negative breast cancer.

🎖️ Top 10% Journal

1 week ago • Molecular therapy. Advances

Restoring eye cell function in choroideremia by delivering mRNA to the retinamRNA delivery to the retina restores REP1 function in choroideremia.

1 week ago • Current pharmaceutical biotechnology

Using Positively Charged Lipid Nanoparticles to Deliver miR-34A to Lung Cancer Cells: Comparing DNA and RNA FormulationsCationic Lipid Nanoparticles for miR-34A Delivery to Lung Cancer Cells: Comparative Evaluation of Plasmid DNA and Oligonucleotide Formulations.

📖 Top 50% Journal

1 week ago • Small (Weinheim an der Bergstrasse, Germany)

Changing the Fat and Connector Parts of PEG-Lipids Helps mRNA Nanoparticles Target Muscle Cells More PreciselyHydrophobic Tail and Linker Diversification of PEG-Lipids Unlocks Precise Muscle Tropism of mRNA-Lipid Nanoparticles.

🥈 Top 2% Journal

1 week ago • Small (Weinheim an der Bergstrasse, Germany)

Using Proton Channels to Change pH and Help siRNA Escape from Cell CompartmentsActive pH Modulation by Proton Channel-Peptide Nucleic Acid Complex for Effective siRNA Endosomal Escape.

🥈 Top 2% Journal

1 week ago • ACS applied materials & interfaces

Designing Polymer Carriers for Nucleic Acid Vaccines and Overcoming Biological BarriersPolymeric Delivery Vehicles for Nucleic Acid Vaccines: Design Strategies and Biological Barriers.

🎖️ Top 10% Journal

1 week ago • Carbohydrate polymers

Improved sustainable sugar-based gene-delivery systems using free polyethyleneimine chainsSustainable polysaccharide-poly(2-oxazoline) gene-delivery platforms enhanced by free polyethyleneimine chains.

🥉 Top 5% Journal

1 week ago • ACS applied bio materials

Making Antibody-Modified mRNA Nanoparticles Using Two Post-Loading MethodsPreparation of Antibody-Modified mRNA-LNPs via a Combination of Post-Encapsulation and Post-Insertion.

📖 Top 20% Journal

2 weeks ago • Open forum infectious diseases

Safety and Immune Response to the BNT162b2 Vaccine in People With HIV on Antiretroviral TreatmentSafety and Immunogenicity of BNT162b2 in Antiretroviral Therapy-Treated People With HIV.

🎖️ Top 10% Journal

2 weeks ago • Vaccine

Real-world safety and effectiveness of protein-based and mRNA COVID-19 vaccinesReal-world effectiveness and safety of protein-based and mRNA COVID-19 vaccines (BEEHIVE trial).

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2 weeks ago • Frontiers in pharmacology

mRNA Cancer Vaccines: How They Are Delivered, Influence the Immune System, and Move Toward Medical UsemRNA cancer vaccines: delivery strategies, immune modulation, and clinical translation.

📖 Top 20% Journal

2 weeks ago • The Lancet. Microbe

mRNA Vaccines Against Drug-Resistant Bacteria: Potential, Challenges, and Approaches Based on the MicrobiomemRNA vaccines for multidrug-resistant bacteria: promise, challenges, and microbiome-informed strategies.

🥇 Top 1% Journal

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