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2 weeks ago • Vaccine

mRNA vaccine for hepatitis C targeting p7 protein produces stronger antibody responsemRNA-LNP hepatitis C vaccine encoding p7 elicits improved humoral immunogenicity.

📖 Top 20% Journal

2 weeks ago • Signal transduction and targeted therapy

Personalized Cancer Vaccines: Combining Immune Therapy and Precision Medicine for Advanced TreatmentsPersonalized cancer vaccines: bridging immune-oncology and precision medicine for advanced therapeutics.

🥇 Top 1% Journal

2 weeks ago • Nature communications

Special lipid carriers use cell release pathways to boost natural killer cells against solid tumorsDual compartment lipid carriers hijack exocytosis to empower natural killer cells against solid tumours.

🥈 Top 2% Journal

2 weeks ago • Journal of translational medicine

CD73-coated nanoparticles boost anti-cancer T-cell response by enhancing immune-activating dendritic cells through TLR3CD73-LNPs promote antitumor T-cell immunity via amplifying TLR3-mediated immunostimulatory dendritic cell activation.

🥉 Top 5% Journal

2 weeks ago • Journal of controlled release : official journal of the Controlled Release Society

The often overlooked later steps in making lipid nanoparticlesThe hidden half of lipid nanoparticle manufacturing: Downstream processing.

2 weeks ago • NPJ Regenerative medicine

Lipid nanoparticle therapy delivering HGF mRNA helps heal the uterus after cesarean in miceHGF mRNA LNP therapy promotes uterine repair after cesarean section in a mouse model.

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2 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Using Sterol Changes to Guide mRNA Lipid Nanoparticles for Improved Targeting and Stronger Immunity in the SpleenMolecular Dynamics-Guided Sterol Engineering of mRNA-Lipid Nanoparticles Reprograms Biodistribution and Enhances Spleen-Selective Immunity.

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2 weeks ago • Advanced materials (Deerfield Beach, Fla.)

Understanding Differences in Targeted Lipid Nanoparticles Using Liquid-Based Physical TestsResolving Heterogeneity of Targeted Lipid Nanoparticles Through Solution-Based Biophysical Analyses.

🥇 Top 1% Journal

2 weeks ago • World journal of microbiology & biotechnology

Self-amplifying mRNA vaccine combining multiple targets against Staphylococcus aureus using computer-based design and structure modelingSelf-amplifying mRNA vaccine cocktail against Staphylococcus aureus: A multi-epitope immunoinformatics and structural simulation framework.

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2 weeks ago • NPJ vaccines

Strong T-cell responses to SARS-CoV-2 despite weak antibody immunity in children with very low B-cell levelsPreserved SARS-CoV-2 T-cell responses despite impaired humoral immunity in children with profound B-cell lymphopenia.

🥉 Top 5% Journal

2 weeks ago • Cancer letters

Circular RNA Vaccine Triggers Strong Tumor-Targeted Immune Response and Changes Tumor Environment in Lung CancerCircular RNA-based therapeutic vaccine elicits potent antigen-specific antitumor immunity and remodels tumor microenvironment in lung cancer.

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2 weeks ago • International journal of nanomedicine

Safe and Effective Gene Therapy Using Non-Viral Nanoparticle DeliveryToward Safe and Effective Gene Therapy: Non-Viral Nanostructured Delivery Systems.

🎖️ Top 10% Journal

2 weeks ago • Cell

Viral enzyme-triggered cell self-destruction as a universal antiviral mRNA treatmentViral protease-initiated lytic cell death as a universal antiviral mRNA therapy.

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2 weeks ago • STAR protocols

Method for delivering mRNA inside fat-based particles directly into live mouse testiclesProtocol for in vivo transfection of mRNA-encapsulated lipid nanoparticles in mouse testis.

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2 weeks ago • Clinical and translational science

Antibodies from mRNA COVID-19 vaccines may interfere with lab tests measuring pegylated drug levelsAnti-PEG Antibodies From mRNA COVID-19 Vaccines Affect In Vitro Measurements of Pegylated Drug Levels.

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2 weeks ago • Molecular pharmaceutics

Targeted mRNA Delivery Using Antibody-Linked Lipid NanoparticlesTargeted mRNA Delivery Using Bispecific Antibody-Lipid Nanoparticle Complexes.

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2 weeks ago • Small (Weinheim an der Bergstrasse, Germany)

Understanding how lipid makeup affects immune response to design nanoparticles with controlled immunityDefining Composition-Cytokine Relationships Enables the Design of Lipid Nanoparticles with Programmed Immunogenicity.

🥈 Top 2% Journal

2 weeks ago • International journal of pharmaceutics

Microneedles carrying tiny particles for skin delivery: stability, spreading, movement at skin surface, and skin absorptionColloid-loaded microneedles for transdermal delivery: formulation stability, redispersion, biointerfacial transport, and dermal fate.

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2 weeks ago • Molecular cancer

RNA changes in cancer linked to tumor growth and treatment responseRNA modifications in cancer: regulators of tumor evolution and therapeutic response.

🥇 Top 1% Journal

2 weeks ago • Journal of controlled release : official journal of the Controlled Release Society

A ready-to-use delivery system targeting specific immune cells for personalized mRNA cancer vaccines with strong immune response in primatesNanoReady: A ready-made DC-selective delivery platform for personalized mRNA cancer vaccines with strong NHP immunogenicity.

2 weeks ago • Journal of nanobiotechnology

Kidney-targeted fat nanoparticles carrying ANXA2 may reduce kidney injury by blocking cell death through CHMP2AKidney‑enriched lipid nanoparticles delivering ANXA2 alleviate renal ischemia-reperfusion injury via CHMP2A-mediated necroptosis inhibition.

🥉 Top 5% Journal

2 weeks ago • Antiviral research

Scientific and Technological Advances to Develop Vaccines for Diseases Without Effective ProtectionBridging the Vaccine Gap: Scientific and Technological Advances for Diseases Lacking Effective Vaccines.

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2 weeks ago • Science advances

A unique process of showing vaccine parts triggers strong T cell immune response in mRNA vaccines using lipid nanoparticlesA distinct antigen presentation pathway drives potent T cell immunity in lipid nanoparticle-based mRNA vaccines.

🥈 Top 2% Journal

2 weeks ago • medRxiv : the preprint server for health sciences

COVID-19 mRNA Vaccines May Lower the Risk of Guillain-Barré Syndrome in a Large Long-Term StudyCOVID-19 mRNA Vaccination Reduces Guillain-Barré Syndrome Risk: Evidence from a Large Longitudinal Cohort Study.

2 weeks ago • Journal of immunology (Baltimore, Md. : 1950)

T-cell microRNA-155 influences response to tumor-targeting mRNA vaccines in a mouse model of acute leukemiaT-cell miR-155 regulates the response to tumor-specific mRNA vaccines in a murine model of acute myeloid leukemia.

2 weeks ago • Angewandte Chemie (International ed. in English)

Glutathione-Triggered Chemical Changes to Activate RNA and Extend Protein ProductionGlutathione-Responsive Acyl-Modifications for Targeted RNA Decaging and Prolonged Protein Synthesis.

🥇 Top 1% Journal

2 weeks ago • ACS nano

Lung Delivery of Self-Amplifying RNA: Finding a Balance Between Inflammation and Lasting Gene ActivityPulmonary Delivery of Self-Amplifying RNA: Balancing Inflammation and Durable Transgene Expression.

🥈 Top 2% Journal

2 weeks ago • Nature reviews. Chemistry

Polymers with precise sequences for reliable gene deliverySequence-defined polymers for predictable gene delivery.

🥇 Top 1% Journal

2 weeks ago • Current opinion in microbiology

Design, Use, and Future Potential of Antisense Oligonucleotides in MicrobiologyAntisense oligonucleotides: design, implementation and future perspectives in microbiology.

🥉 Top 5% Journal

2 weeks ago • Nature biomedical engineering

Using RModBlock antisense oligonucleotides to precisely and efficiently block RNA modificationsRModBlock antisense oligonucleotides as a universal tool for precise and efficient inhibition of RNA modifications.

🥇 Top 1% Journal

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