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2 weeks ago • ACS chemical biology

Ionizable Silyl Lipids with Different Membrane Flexibility and mRNA Delivery EffectsIonizable Silyl Lipids with Distinct Membrane Fluidity and mRNA Delivery Profiles.

🎖️ Top 10% Journal

2 weeks ago • Proceedings of the National Academy of Sciences of the United States of America

Fast production of personalized cancer vaccines using lab-made RNA that makes proteins without cell-based methodsIVT-free, chemically synthesized protein-encoding RNA oligonucleotides for rapid production of personalized cancer vaccines.

2 weeks ago • ACS nano

Using Nanopores to Precisely Build mRNA Lipid Nanoparticles for COVID-19 VaccinesNanopore-Mediated Assembly Enables Precise and Continuous Synthesis of mRNA-Encapsulated Lipid Nanoparticles for COVID-19 Vaccines.

🥈 Top 2% Journal

2 weeks ago • International journal of biological macromolecules

Hydrogel carrying gene-silencing nanoparticles targeting interleukin-11 for scar-free wound healingChitosan quaternary ammonium/sodium alginate double-network hydrogel loaded with interleukin-11-targeting siRNA-lipid nanoparticles for scarless wound healing.

📖 Top 20% Journal

2 weeks ago • ACS applied materials & interfaces

Making Negatively Charged mRNA Lipid Nanoparticles More Stable Using Breakable Cholesterol LinksStabilizing Anionic mRNA Lipid Nanoparticles by Cleavable Crosslinking of Cholesterol.

🎖️ Top 10% Journal

2 weeks ago • Molecular pharmaceutics

Lipid Nanoparticles Targeting Fibroblasts to Deliver Genes into Tumor Support TissueFibroblast-Selective Lipid Nanoparticles for Tumor Stromal Transfection.

📖 Top 20% Journal

3 weeks ago • Molecular cell

SMD2 recognizes RNA modifications to control mRNA processing and support tumor growthSMD2 reads pseudouridines to regulate mRNA splicing and promote tumorigenesis.

3 weeks ago • Scientific reports

Antibody responses to different COVID-19 variants after booster shots and breakthrough infectionsVariant-specific and cross-reactive antibody responses following COVID-19 booster vaccinations and SARS-CoV-2 breakthrough infections.

📖 Top 20% Journal

3 weeks ago • Science China. Life sciences

Plant-based microRNA 152 delivered by lipid nanoparticles may boost doxorubicin treatment in breast cancer immunotherapyPlant-derived CTLA-4-targeting miR152 via lipid nanoparticles potentiates doxorubicin efficacy in breast cancer immunochemotherapy.

🥉 Top 5% Journal

3 weeks ago • MedComm

Methods for Delivering Gene Editing Treatments: Challenges, New Advances, and Future OutlookDelivery Systems for Therapeutic Genome Editing: Challenges, Innovations, and Future Perspectives.

🥉 Top 5% Journal

3 weeks ago • Journal of molecular biology

How Long Epitranscriptome Marks Last: Measuring Their Persistence Over TimeThe Half-Life of a Mark: Dwell Time and the Missing Time Axis of the Epitranscriptome.

🥉 Top 5% Journal

3 weeks ago • Drug delivery and translational research

Synthetic miRNA carriers targeted to blood vessel and iron transport proteins with potential stroke therapyE-selectin and transferrin receptor functionalized synthetic miRNA nanoshuttles with therapeutic potential in stroke.

📖 Top 20% Journal

3 weeks ago • Journal of controlled release : official journal of the Controlled Release Society

Improved methods for delivering RNA to tissues and cells outside the liverAdvances in RNA delivery to extrahepatic tissues and cells.

3 weeks ago • ACS applied materials & interfaces

Immune-Targeting Nanoparticles Carrying Cisplatin for Combined Chemotherapy and Immunotherapy in Pancreatic CancerImmunoregulatory Dendritic Lipopeptide Nanoparticles for High-Capacity Cisplatin Delivery and Pancreatic Cancer Chemo-Immunotherapy.

🎖️ Top 10% Journal

3 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Improved lipid nanoparticles with modified fats for safer mRNA deliveryOptimized Lipid Nanoparticles with Tail-Modified Ionizable Lipids for Safer mRNA Delivery.

🥈 Top 2% Journal

3 weeks ago • Molecular therapy : the journal of the American Society of Gene Therapy

Recent Advances in Designing mRNA VaccinesRecent Progress in the Rational Design of mRNA Vaccines.

🥈 Top 2% Journal

3 weeks ago • Advanced materials (Deerfield Beach, Fla.)

Using Lipid Nanoparticles to Deliver mRNA and a Drug Together for Oral Cancer ChemoimmunotherapyLipid Nanoparticle Co-Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy.

🥇 Top 1% Journal

3 weeks ago • ACS biomaterials science & engineering

Designing Fat-Based Nano Carriers for Cancer Treatments: From Chemotherapy Drugs to mRNA TherapiesPharmaceutical Engineering of Lipid-Based Nanocarriers for Cancer Nanomedicines: From Doxorubicin to mRNA Platforms.

📖 Top 20% Journal

3 weeks ago • Biomaterials

Adding signaling proteins to targeted lipid nanoparticles improves T cell engineering in living organismsCytokine co-presentation on targeted lipid nanoparticles enhances in vivo T cell engineering.

🥉 Top 5% Journal

3 weeks ago • Central nervous system agents in medicinal chemistry

Lipid Nanoparticles That Respond to Stimuli for Targeted Brain Disease Treatment: Current Challenges and Future ProspectsStimuli-responsive Lipid-based Nanoplatforms for Targeted Therapy of Brain Diseases: Current Challenges and Future Directions.

📖 Top 50% Journal

3 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Parkin reduces cell damage and bone loss caused by steroids by modifying a fat-processing proteinUbiquitination of ACSL4 by Parkin Suppresses Ferroptosis and Rescues Glucocorticoid-Induced Bone Loss.

🥈 Top 2% Journal

3 weeks ago • Macromolecular bioscience

Lipoic acid-based nanoparticles improve mRNA delivery by helping cells take it in through sulfur-based uptakeLipoic Acid Derivative/PEI Composite Nanoparticles Enable Efficient mRNA Delivery via Thiol-Mediated Cellular Uptake.

📖 Top 20% Journal

3 weeks ago • Mass spectrometry (Tokyo, Japan)

Using the Peptide Barcode Method to Quickly Screen mRNA Control SequencesUse of the Peptide Barcode Method for Efficient Screening of mRNA Expression Control Sequence.

3 weeks ago • Human vaccines & immunotherapeutics

Seasonal flu mRNA vaccines show safety and stronger immune response in phase 2 trialOptimized seasonal influenza mRNA vaccine compositions demonstrate safety and enhanced immunogenicity in a phase 2 study.

📖 Top 20% Journal

3 weeks ago • Molecular therapy. Nucleic acids

mRNA nanoparticles delivered through the bloodstream enter main and spreading liver tumorsSystemically delivered mRNA-LNPs transfect primary and secondary liver tumors.

🥉 Top 5% Journal

3 weeks ago • Journal of controlled release : official journal of the Controlled Release Society

A new mRNA vaccine targeting two cancer markers removes liver cancer in miceA novel bivalent neoantigen vaccine based on mRNA-loaded lipid nanoparticles eradicates hepatocellular carcinoma in mice.

3 weeks ago • Journal of controlled release : official journal of the Controlled Release Society

Design and early testing of non-viral, non-fat-based nanoparticles for RNA treatmentsNon-viral and non-lipid nanoparticles for RNA therapeutics: Design, applications, and preclinical studies.

3 weeks ago • Angewandte Chemie (International ed. in English)

Using Targeted Molecules to Redirect Liver-Directed Lipid Nanoparticles for Lung-Selective mRNA DeliveryLigand-Mediated Reprogramming Redirects Liver-Tropic Ionizable Lipid Nanoparticles for Lung-Selective mRNA Delivery.

🥇 Top 1% Journal

3 weeks ago • ACS nano

How Lipid Nanoparticles Carry RNA: Detailed Images Reveal Their Structure and FunctionFrom Morphology to Mechanism: Cryo-Electron Microscopy Insights into Lipid Nanoparticles for RNA Delivery.

🥈 Top 2% Journal

3 weeks ago • Microbiology spectrum

Different immune reactions to two SFTSV mRNA vaccines in mice and dogsDifferential immune responses to SFTSV Gn and Gc mRNA vaccines in mice and dogs.

📖 Top 20% Journal

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