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3 weeks ago • bioRxiv : the preprint server for biology

Modeling how PEG-coated lipid nanoparticles move through the space outside cellsA multiscale modeling framework for transport of PEGylated lipid nanoparticle through the extracellular matrix.

Preprint

3 weeks ago • Experimental & molecular medicine

Using patient-derived tumor models to test cell therapy and gene editing for restoring dystrophinPatient-derived teratomas as a humanized platform for dystrophin restoration by ex vivo cell therapy and in vivo base editing.

🥈 Top 2% JournalArticle

3 weeks ago • Recent advances in drug delivery and formulation

Flexible Bio-Film Carriers for Delivering Drugs to the Brain through the Lip RouteEmerging Perspectives Bio-Flexi Film Nanocarriers: A Novel Approach for Brain Drug Delivery through the Trans-Vermilion Route.

Article

3 weeks ago • Cell reports

Genetic differences in immune system and blood cell genes influence antibody protection from COVID-19 mRNA vaccinesGenetic variation in HLA, IGKV, and HHEX loci influences mRNA vaccine-induced humoral protection against COVID-19.

🥈 Top 2% JournalArticle

3 weeks ago • National science review

Step-by-step polymer system delivers proteins into cells without leftovers and blocks cell cleanup to improve cancer treatmentStepwise-coordinated polymeric nanoplatform enables traceless cytosolic protein delivery and autophagy blockade for enhanced tumor therapy.

🥉 Top 5% JournalArticle

3 weeks ago • Human vaccines & immunotherapeutics

Side effects of 2023-2024 XBB.1.5 mRNA and protein-based COVID-19 vaccines in real-world use from the BEEHIVE trialReal-world evaluation of 2023-2024 XBB.1.5 mRNA and protein-based COVID-19 vaccine reactogenicity from the randomized BEEHIVE trial.

📖 Top 20% JournalRandomized Controlled Trial

3 weeks ago • Seminars in cancer biology

RNA changes and metabolism in cancer: how they interact and what this means for treatmentRNA modifications and metabolism in cancer: mechanisms, cross-talk and therapeutic implications.

🥈 Top 2% JournalArticle

3 weeks ago • ACS applied materials & interfaces

A Brain-Targeted Nanoparticle System to Reduce Brain Inflammation After Stroke Using Combined Antioxidant and Anti-Inflammatory ActionsA Brain-Targeted Nanozyme System for Alleviating Poststroke Neuroinflammation via Synergistic Antioxidant and Anti-inflammatory Mechanisms.

🎖️ Top 10% JournalArticle

3 weeks ago • APL bioengineering

Design of a wireless probe for controlled gene delivery using electrical pulsesEngineering of a wireless single capacitive discharge conductivity-clamped gene electrotransfer probe for naked nucleic acid therapeutics.

📖 Top 20% JournalArticle

3 weeks ago • Frontiers in immunology

Overview of immune response, effectiveness, and safety of mRNA flu vaccinesmRNA-based seasonal influenza vaccines: an overview of immunogenicity, efficacy, and safety.

🥉 Top 5% JournalArticle

3 weeks ago • Molecular therapy : the journal of the American Society of Gene Therapy

Separating side effects from effectiveness to create safer mRNA vaccines, gene therapies, and gene editing treatmentsDecoupling reactogenicity from efficacy enables safer mRNA vaccines, AAV gene delivery, and in vivo base editing.

🥈 Top 2% JournalArticle

3 weeks ago • Biomaterials advances

Using lab-made nanoparticle carriers to restore function in aged donor liversThe application of engineered exosome-mimetic lipid nanoparticles in the hepatic rejuvenation of aged donor livers.

📖 Top 20% JournalArticle

3 weeks ago • RSC advances

Hybrid lipid-based nanogels for delivering mRNAHybrid lipid-nanogels: nanolipogels for mRNA delivery.

📖 Top 30% JournalArticle

3 weeks ago • Nature biotechnology

Faster finding of heat-resistant mRNA vaccine nanoparticles using efficient AIAccelerated discovery of thermostable mRNA-lipid nanoparticle vaccines using data-efficient AI.

🏆 Top 0.1% JournalArticle

3 weeks ago • Nature biotechnology

Improved lipid nanoparticles for delivering large RNA and targeting tissues to boost genome editing in living organismsLipid nanoparticles optimized for large RNA cargo and tissue targeting enhance in vivo genome editing.

🏆 Top 0.1% JournalArticle

3 weeks ago • Nature communications

A viral protein boosts self-replicating RNA by adjusting cell immune defenseTuning intracellular immunity by Nodamura virus B2 protein enhances self-amplifying RNA activity.

🥈 Top 2% JournalArticle

3 weeks ago • Nature communications

Using N1-methylpseudouridine changes to improve mRNA vaccine designRecoding by N1-methylpseudouridine guides rational mRNA vaccine design.

🥈 Top 2% JournalArticle

3 weeks ago • Molecular biomedicine

Current status, challenges, and future outlook of mRNA vaccines using fat-based particlesmRNA lipid nanoparticle vaccines: current status, challenges and future prospects.

🥉 Top 5% JournalArticle

3 weeks ago • Advanced materials (Deerfield Beach, Fla.)

More mRNA inside lipid nanoparticles increases gene delivery effectivenessIncreasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency.

🥇 Top 1% JournalArticle

3 weeks ago • Experimental dermatology

Using mRNA Treatments to Refresh Aging Skin: From Aging Studies to Patient CaremRNA Therapeutics for Skin Rejuvenation: From Aging Atlases to Clinical Translation.

📖 Top 20% JournalArticle

3 weeks ago • Trends in biotechnology

Improving mRNA treatments from creation to deliveryAdvancing mRNA therapeutics from design to delivery.

🥉 Top 5% JournalArticle

3 weeks ago • Journal of controlled release : official journal of the Controlled Release Society

How protein production changes over time from mRNA, saRNA, and pDNA delivered alone or together in the same lipid nanoparticleProtein expression kinetics of mRNA, saRNA, and pDNA as individual or co-delivered payloads using a common lipid nanoparticle formulation.

Article

3 weeks ago • International journal of pharmaceutics

Dual-drug linked ionizable lipids for delivering genetic material and targeted treatment of brain tumorsDual-drug conjugated ionizable lipids for nucleic acid delivery and multidimensional targeted therapy of brain tumors.

📖 Top 20% JournalArticle

3 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Adding an Immune Checkpoint Blocker to Lipid Nanoparticles Helps Target Lymph Nodes and Boosts mRNA Vaccine EffectivenessImmune Checkpoint Inhibitor as a Fifth Component of Lipid Nanoparticles Enables Lymph Node-Targeting and Augments mRNA Vaccine Efficacy.

🥈 Top 2% JournalArticle

3 weeks ago • International journal of pharmaceutics

Physical, chemical, and biological testing of a pharmaceutical-grade lipid for reliable large-scale production of RNA-loaded lipid nanoparticlesPhysicochemical and biological evaluation of a GMP‑grade ionizable lipid for robust and scalable manufacturing of siRNA- and mRNA-loaded lipid nanoparticles.

📖 Top 20% JournalArticle

3 weeks ago • Advances in colloid and interface science

How Tumor Cells Take In Nanoparticles: Processes, Advances, and ChallengesDecoding the uptake pathway of nanoparticles in tumor cells: mechanisms, developments and challenges.

Article

4 weeks ago • Pharmaceutics

A targeted peptide that helps deliver gene-silencing molecules to brain tumor cellsAn EGFR-Targeted Fusogenic Tandem Peptide for siRNA Delivery in Glioblastoma.

📖 Top 20% JournalArticle

4 weeks ago • Pharmaceutics

New Developments in Non-Viral Methods for Delivering Genes, from Fat-Based Particles to Modified Cell MessengersRecent Advances in Non-Viral Vectors for Gene Therapy and Gene Delivery: From Lipid Nanoparticles to Engineered Extracellular Vesicles.

📖 Top 20% JournalArticle

4 weeks ago • Micromachines

Combining Artificial Intelligence and Microfluidics for Drug DeliveryIntegration of Artificial Intelligence and Microfluidics for Drug Delivery Applications.

📖 Top 50% JournalArticle

4 weeks ago • Veterinary sciences

A Lipid Nanoparticle mRNA Vaccine Triggers PRRS Virus-Specific Antibody and Immune Cell Responses in MiceA Lipid Nanoparticle-Formulated GP5-mRNA Vaccine Induces PRRSV-Specific Humoral and Cellular Immune Responses in BALB/c Mice.

📖 Top 30% JournalArticle

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