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4 weeks ago • Pharmaceutics

Making and Testing Tiny Lipid-Chitosan Particles Carrying Cyclosporine A for Lung Drug DeliveryMicrofluidic Production and Characterisation of Cyclosporine A-Loaded Lipid-Chitosan Hybrid Nanoparticles as Candidate Pulmonary Drug Delivery Systems.

📖 Top 20% JournalArticle

4 weeks ago • International journal of molecular sciences

Personalized mRNA Cancer Vaccines: Connecting Precise Antigen Choice, Immune System Changes, and Checkpoint TherapyPersonalized mRNA Neoantigen Vaccines in Cancer: Linking Precision Antigen Selection, Immune Remodeling, and Checkpoint Blockade.

📖 Top 20% JournalArticle

4 weeks ago • ACS physical chemistry Au

How pH Changes Affect T7 RNA Polymerase Activity Revealed by Molecular SimulationsMolecular Basis of pH-Dependent Activity in T7 RNA Polymerase Revealed by Constant pH Replica Exchange Molecular Dynamics.

📖 Top 20% JournalArticle

4 weeks ago • Pharmaceutics

Using PSMA-Targeted Liposomes to Deliver Treatment into Prostate Cancer CellsPSMA-Targeted Liposomes for Therapeutic Delivery into a Prostate Cancer Cell Model.

📖 Top 20% JournalArticle

4 weeks ago • Vaccines

mRNA Vaccine Triggers New IgG Antibody Responses Even When Maternal Antibodies Are PresentImmunization with mRNA-LNP Elicits De Novo IgG Responses in the Presence of Maternal Antibody.

📖 Top 20% JournalArticle

4 weeks ago • Vaccines

Development and Future Uses of Circular RNA Vaccines for Viral DiseasesResearch Progress, Application, and Industrialization Prospects of Circular RNA Vaccines in Viral Diseases.

📖 Top 20% JournalArticle

4 weeks ago • Pharmaceutics

Lipid and Vesicle Hybrid Systems for Delivering RNA in Cancer: Types, Delivery Functions, and Practical ChallengesExtracellular Vesicle-Lipid Hybrid Systems for RNA Delivery in Cancer: Structural Classification, Functional Delivery, and Translational Challenges.

📖 Top 20% JournalArticle

4 weeks ago • Pharmaceutics

Using Modified Hyaluronic Acid to Deliver Drugs Inside Cells Through a Cell Surface Receptor and Escape from Cellular ContainersEvaluation of Histidine-Octamer-Modified Hyaluronic Acid as a Cytosolic Drug Delivery Material via CD44-Mediated Cellular Uptake and Endosomal Escape.

📖 Top 20% JournalArticle

4 weeks ago • Molecules (Basel, Switzerland)

Small Activating RNAs: A Organized Database and Guide to Designing ThemSmall Activating RNAs: A Curated Database and an Overview of Rational Design Principles.

📖 Top 20% JournalArticle

4 weeks ago • Pathogens (Basel, Switzerland)

mRNA Vaccine Combining PstS and YidR Protects Against Different Strains of Dangerous Klebsiella pneumoniae Infections, Including Eye InfectionCross-Serotype Protection of a PstS-YidR Fusion mRNA Vaccine Against Systemic Infection and Endogenous Endophthalmitis Caused by Hypervirulent Klebsiella pneumoniae.

📖 Top 20% JournalArticle

4 weeks ago • Vaccines

mRNA Vaccines Targeting the Stable SARS-CoV-2 Fusion Proteins Produce Strong Immunity Against Multiple VariantsmRNA Vaccines Targeting the Conserved SARS-CoV-2 Fusion Machinery Elicit Cross-Variant and Robust Immunity.

📖 Top 20% JournalArticle

4 weeks ago • Vaccines

Immune-Boosting Effects of Human IFN-β mRNA in Primary Human Myeloid Cells Depend on TimingTiming-Dependent Immunostimulatory Activity of Human IFN-β mRNA in Primary Human Myeloid Cells.

📖 Top 20% JournalArticle

4 weeks ago • Current pharmaceutical design

New Developments in Using Emulsomes Nanoparticles for Cancer TreatmentEmulsomes in Cancer Therapy: Emerging Advances in Nanomedicine.

📖 Top 50% JournalArticle

4 weeks ago • Current drug delivery

Challenges and Future Approaches for Delivering microRNA Treatments from Lab to ClinicFrom Laboratory to Clinic: Translational Challenges, Lessons, and Future Strategies for microRNA Delivery Systems.

📖 Top 50% JournalArticle

4 weeks ago • Frontiers in genome editing

Using CRISPR-Cas9 Gene Editing for Treating Cancer and Inherited Genetic DiseasesClinical translation of CRISPR-Cas9 therapeutics in cancer and inherited genetic disorders.

🎖️ Top 10% JournalArticle

4 weeks ago • Current pharmaceutical design

mRNA Medicines: Progress, Challenges, and Future Possibilities in HealthcareMessenger RNA (mRNA) Therapeutics: Advances, Challenges, and Future Perspectives in Modern Medicine.

📖 Top 50% JournalArticle

4 weeks ago • Journal of drug targeting

How Individual Building Blocks Help Cell-Penetrating Peptides Cross Cell BarriersOvercoming Cellular Barriers with Cell-Penetrating Peptides: Functional Roles of Individual Amino Acids.

📖 Top 20% JournalArticle

1 month ago • bioRxiv : the preprint server for biology

Timed control of immune sensor activation and RNA delivery separates antibody and cell immune responsesSpatiotemporal control of STING activation and saRNA delivery decouples humoral and cellular immunity.

Preprint

1 month ago • Pharmaceutical research

Computer-Designed mRNA Vaccine Targeting Three Types of Equine Encephalitis VirusesComputational Design of a Trivalent Multi-Epitope mRNA Vaccine Candidate Against Western, Eastern, and Venezuelan Equine Encephalitis Viruses.

📖 Top 20% JournalArticle

1 month ago • bioRxiv : the preprint server for biology

Codon pairs influence mRNA stability through their role in protein production beyond individual codon effectsBeyond codon optimality: codon pairs regulate mRNA stability dependent on translation.

Preprint

1 month ago • Molecular therapy. Nucleic acids

How codon choices in modified mRNA lower immune reactions but keep vaccine effectivenessCodon-dependent translation of N1-ethylpseudouridine-modified mRNA reduces innate immunity while preserving vaccine immunogenicity.

🥉 Top 5% JournalArticle

1 month ago • Medical sciences (Basel, Switzerland)

COVID-19 mRNA Vaccines as Immune Modifiers Beyond Targeting Specific AntigensCOVID-19 mRNA Vaccines as Antigen-Agnostic Immunomodulators: A Repurposing Perspective.

🎖️ Top 10% JournalArticle

1 month ago • Journal of controlled release : official journal of the Controlled Release Society

How protective substances affect the stability of mRNA lipid nanoparticles after freeze-drying and high heat storageUncovering the influence of lyoprotection on stability of mRNA-LNPs after lyophilization and high temperature storage.

Article

1 month ago • bioRxiv : the preprint server for biology

Designed mRNA nanoparticles allow controlled protein production and immune activation for new treatmentsEngineered mRNA nanostructures expand the design space of mRNA therapeutics through programmable protein expression and immune stimulation.

Preprint

1 month ago • Molecular therapy. Nucleic acids

Highly specific gene disruption in living organisms using Cas12a guided by chRDNACas12a chRDNA-mediated in vivo genome editing for high specificity functional gene disruption.

🥉 Top 5% JournalArticle

1 month ago • Cells

mRNA Vaccines as New Immune Treatments for Digestive System CancersmRNA Vaccines as Novel Immunotherapeutic Approaches in Gastrointestinal Cancers.

🎖️ Top 10% JournalArticle

1 month ago • Current opinion in chemical biology

Peptide-based delivery of CRISPR from lab tests to bloodstreamPeptide-mediated CRISPR delivery: From dish to bloodstream.

🥉 Top 5% JournalArticle

1 month ago • Research square

Comparison of effectiveness, safety, and immune response of two-part versus single-part COVID-19 mRNA booster vaccines in a randomized trialRelative efficacy, safety and immunogenicity of bivalent versus monovalent COVID-19 mRNA booster vaccines: a randomized trial.

Preprint

1 month ago • Tropical medicine and infectious disease

Improving Mpox Vaccines with Targeted Antigen Design, New Delivery Methods, and Immune Protection MarkersToward Precision Vaccinology for Mpox: Rational Antigen Design, Next-Generation Platforms, and Immune Correlates of Protection.

📖 Top 30% JournalArticle

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