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2 weeks ago • Advances in therapy

Ibogaine as a Treatment for Substance Use DisordersIbogaine for Substance Use Disorders.

📖 Top 20% JournalArticle

3 weeks ago • Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Boosting cGMP signaling with psilocybin reduces head twitch behavior and changes synapse proteins while keeping antidepressant effectsEnhancing cGMP signaling with psilocybin reduces head twitch and restructures the synaptic proteome while maintaining antidepressant response.

🥉 Top 5% JournalArticle

3 weeks ago • Journal of affective disorders

Ways to improve IV ketamine treatment in hard-to-treat depression: A review and combined analysisAugmentation strategies for intravenous ketamine in treatment-resistant depression: A systematic review and meta-analysis.

🥉 Top 5% JournalArticle

3 weeks ago • Psychiatry research

Bad reactions to psychedelics in real-life use are linked to current mental health and well-beingAdverse reactions to psychedelics in naturalistic settings are associated with current psychopathology and well-being: A correlational study.

🎖️ Top 10% JournalArticle

3 weeks ago • Contemporary clinical trials

Trial comparing ketamine and midazolam for returning suicidal thoughts in teenagers: study plan and initial resultsRandomized controlled trial of acute ketamine versus midazolam for recurrence of suicidality in adolescents (TASK): Rationale, design, and baseline characteristics.

📖 Top 20% JournalArticle

4 weeks ago • Journal of addiction medicine

Ketamine Addiction and Strongly Fixed Delusional Beliefs: A Case ReportKetamine Use Disorder and Entrenchment of Delusional Beliefs: A Case Report.

📖 Top 20% JournalArticle

2 weeks ago • Drug testing and analysis

Methods to Identify and Distinguish Similar Chemical Isomers of N-(2-Methoxybenzyl)-2-(Trimethoxyphenyl)ethanamines Using Chromatography and Mass SpectrometryAnalytical Strategies for the Identification and Differentiation of Positional Isomers of N-(2-Methoxybenzyl)-2-(trimethoxyphenyl)ethanamines by Chromatography and Mass Spectrometry.

📖 Top 30% JournalArticle

2 weeks ago • CNS & neurological disorders drug targets

How Psilocybin May Affect Brain Cell Loss Disorders Through 5-HT2A Receptors and Their SignalsMechanistic Evaluation of Psilocybin in Neurodegenerative Disorders: Relevance of 5-HT2A Receptors and Downstream Pathways.

📖 Top 30% JournalArticle

2 weeks ago • L'Encephale

French Mental Health Workers' Views on Psychedelic Drugs: A National SurveyFrench psychiatric caregivers' perceptions of psychedelics: A national survey.

📖 Top 50% JournalArticle

2 weeks ago • Canadian family physician Medecin de famille canadien

Therapy Using Psychedelic Drugs: A New ApproachPsychedelic-assisted psychotherapy: Emerging paradigm.

Article

3 days ago • Psychiatry and clinical psychopharmacology

Therapeutic Potential of Traditional Psychedelics and Non-Hallucinogenic Brain-Change Drugs in Mental Health DisordersTherapeutic Potential of Classical Psychedelics and Non-Hallucinogenic Psychoplastogens in Psychiatric Disorders.

Article

1 week ago • Chemistry & biodiversity

Lab and computer tests of new chemical compounds made from a natural plant extract for fighting malariaSynthesis of 1,2,3-Triazole Derivatives of N,N-Dimethyltryptamine Isolated From Mimosa tenuiflora Root Bark: Antiplasmodial Activity In Silico and In Vitro.

📖 Top 50% JournalArticle

3 weeks ago • Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists

Ketamine’s effectiveness in hard-to-treat depression may vary by depression type and childhood trauma historyKetamine administered biomedically or as psychedelic-assisted therapy in treatment-resistant depression: Differing efficacy based on depressive subtype or presence of childhood trauma?

📖 Top 50% JournalArticle

3 weeks ago • medRxiv : the preprint server for health sciences

Use, safety, and mental health benefits of legal psilocybin services in Oregon and ColoradoReal-world use, safety, and mental health efficacy of regulated psilocybin services in Oregon and Colorado.

Preprint

3 weeks ago • bioRxiv : the preprint server for biology

Ongoing unusual perceptions in psychedelic users are linked to learned hallucinations and weaker sensory processingPersisting perceptual abnormalities in psychedelic users are associated with conditioned hallucinations and impaired sensory processing.

Preprint

3 days ago • Methods in molecular biology (Clifton, N.J.)

Measuring Tryptamine Compounds in Body SamplesDetermination of Tryptamines in Biological Specimens.

📖 Top 50% JournalArticle

2 weeks ago • Health affairs scholar

Who qualifies for psilocybin therapy? A secret shopper study of Oregon mushroom service centers"Am I a candidate for magic mushrooms?" A mystery shopper study of Oregon psilocybin service centers.

Article

2 weeks ago • Journal of psychoactive drugs

How Psychedelic Drug Use Relates to Romantic Relationship HealthPsychedelic Drug Use and Romantic Relationship Functioning.

Article

4 weeks ago • Progress in neuro-psychopharmacology & biological psychiatry

A review of drug, clinical, and research evidence on three compounds: N,N-dimethyltryptamine, 5-methoxy-N,N-dimethyltryptamine, and zalsupindolePharmacological, clinical, and translational evidence for N,N-dimethyltryptamine, 5-methoxy-N,N-dimethyltryptamine, and zalsupindole: a systematic review.

Article

yesterday • Journal of psychopharmacology (Oxford, England)

Ongoing mental health problems after using classic psychedelics: Stories from people seeking helpPersisting psychological complications following the use of classic psychedelics: A qualitative study of help-seeking experiences.

Article

4 days ago • Journal of psychopharmacology (Oxford, England)

Effectiveness and safety of LSD for treating depression symptoms: A combined review and analysisEfficacy, safety, and tolerability of lysergic acid diethylamide for the treatment of depressive symptoms: A meta-analysis and systematic review.

Article

4 weeks ago • Psychological medicine

Psilocybin use, mental health care use, and unmet treatment needs in US adults with depressionPsilocybin use, mental health treatment utilization, and unmet treatment need among US individuals with depression.

Article

1 week ago • bioRxiv : the preprint server for biology

Ketamine changes natural opioid signals and lowers heroin-seeking behavior in male ratsKetamine Modulates Endogenous Opioid Peptide Signaling and Reduces Heroin-Seeking in Male Long-Evans Rats.

Preprint

4 days ago • Journal of psychiatric research

Fast antidepressant effects of ketamine combined with common antidepressants: How they work and future possibilitiesRapid antidepressant effects of ketamine combined with selective serotonin reuptake inhibitors: Mechanisms and outlook.

Article

4 days ago • Alcohol (Fayetteville, N.Y.)

MDMA-Assisted Therapy and Clinical Results for Veterans with Both PTSD and Alcohol Use Disorder in an Initial Open-Label TrialMDMA-Assisted Therapy for Veterans with Comorbid Posttraumatic Stress Disorder and Alcohol Use Disorder: Clinical Outcomes from the First Open-Label Pilot Trial.

Article

1 week ago • Journal of psychopharmacology (Oxford, England)

Psychedelics and psychosis: A review of recent studies from 1984 to 2025Psychedelics and psychosis: A systematic review of recent-era studies (1984-2025).

Article

1 week ago • In silico pharmacology

Computer study of Desmodium gangeticum compounds as dual regulators of MAO-B and 5-HT2A in Parkinson's diseaseIn silico characterization of Desmodium gangeticum compounds as dual modulators of MAO-B and 5-HT2A in Parkinson's disease: an integrated approach combining molecular docking, ADMET profiling, MM-GBSA, QSAR modeling, and molecular dynamics simulation.

Article

1 week ago • JAMA

Single Dose of the Psychedelic Mebufotenin by Nose for Hard-to-Treat Depression: A Randomized Clinical TrialSingle Intranasal Administration of the Psychedelic Mebufotenin for Treatment-Resistant Depression: A Randomized Clinical Trial.

Article

1 week ago • The journal of physical chemistry. B

How Terahertz Waves May Change Psychedelic Effects on Serotonin ReceptorsModulating the Thermodynamics and Kinetics of Psychedelics at Serotonin Receptors via Terahertz Waves.

Article

1 week ago • Psychiatric services (Washington, D.C.)

Cost-effectiveness of Ketamine Compared to Electroconvulsive Therapy for Nonpsychotic Treatment-Resistant DepressionKetamine Versus Electroconvulsive Therapy for Nonpsychotic Treatment-Resistant Depression: A Cost-Effectiveness Analysis.

Article

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Psychedelic Science Research Papers