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2 weeks ago • Nature

CRISPR-Cas controls activity of built-in anti-virus defense systemsCRISPR-Cas regulates expression of embedded anti-phage defence systems.

2 weeks ago • Blood advances

Modifying Stem Cells to Protect Them from Immune Attacks After TransplantEditing Around the Target: Epitope Engineering to Protect Stem Cell Grafts.

🥉 Top 5% Journal

2 weeks ago • Nature protocols

Studying large-scale genome structure by using targeted rearrangements through multiple precise edits in repeated DNA regionsLarge-scale genome structure interrogation via recombinase-mediated rearrangements of multiplexed prime edits in repetitive elements.

🥇 Top 1% Journal

2 weeks ago • Bioresource technology

Increasing natural pigment production in Chlorella sorokiniana by boosting the interaction between ORANGE and PSY proteinsEnhancing carotenoid production in Chlorella sorokiniana through the protein-protein interaction between ORANGE and PSY.

🥉 Top 5% Journal

2 weeks ago • Bioorganic & medicinal chemistry letters

Purifying guide RNA for gene editing without chromatographyNon-chromatographic purification of guide RNA for gene-editing experiments.

📖 Top 50% Journal

2 weeks ago • Cytotherapy

Non-viral gene editing with platinum TALEN helps produce large amounts of cancer-targeting T cellsPlatinum TALEN-mediated nonviral gene editing facilitates clinical-scale production of cancer antigen-reactive T cells.

📖 Top 20% Journal

2 weeks ago • Molecular therapy : the journal of the American Society of Gene Therapy

Using base editors to precisely add and remove genes at the same time to create allo-CAR T cells with fewer DNA rearrangementsRepurposing base editors for targeted knock-in and simultaneous multiplex knockouts to generate allo-CAR T cells with minimal translocations.

🥈 Top 2% Journal

2 weeks ago • Lab on a chip

Low-cost CRISPR test strips with CHA for on-site gene detectionA low-cost CHA-integrated CRISPR/Cas12a-based test strip platform for on-site gene detection.

📖 Top 20% Journal

2 weeks ago • World journal of microbiology & biotechnology

How CRISPR shifts from immune defense to controlling infection in SalmonellaCRISPR rewired: from adaptive immunity to a global virulence control network in Salmonella.

📖 Top 20% Journal

2 weeks ago • STAR protocols

One-step method to create a three-guide RNA CRISPR tool for turning off genes in mouse brain neuronsProtocol for one-step design of a triple sgRNA-based CRISPR/Cas9 construct for neuronal gene knockout in the mouse brain.

📖 Top 20% Journal

2 weeks ago • Biologia futura

Using CRISPR to improve rice's tolerance to cold: recent progress and future possibilitiesCRISPR-Cas systems for enhancing chilling tolerance in rice: recent advances and future prospects.

📖 Top 50% Journal

2 weeks ago • Cancer gene therapy

Blocking RAB27A-related small vesicle release reduces growth and spread of small cell lung cancer in lab and animal modelsTargeting RAB27A-mediated small extracellular vesicle secretion via CRISPR-Cas9 negatively affects proliferation and metastasis in both in vitro and in vivo SCLC models.

🎖️ Top 10% Journal

2 weeks ago • Biosensors & bioelectronics

Highly specific detection of single gene mutations using a Cas12a system without PAM that unwinds double-stranded DNAHigh-specificity gene point mutation detection by PAM-free Cas12a system with double-stranded substrate positioning-unwinding.

🥉 Top 5% Journal

2 weeks ago • Biologia futura

Methods for Producing All-Male Tilapia: Hormones, Biodegradable Tools, and Gene EditingAchieving monosex male tilapia: a critical review of hormonal, biodegradable and genome editing strategies.

📖 Top 50% Journal

2 weeks ago • Biochemical and biophysical research communications

Targeted gene correction of TP53 mutations to restore tumor suppression in colorectal cancerPrecision prime editing of TP53 mutations for functional tumor suppression in colorectal cancer.

📖 Top 30% Journal

2 weeks ago • Talanta

Highly sensitive detection of methylated DNA using gene-editing enzymes combined with organic electrochemical sensorsCRISPR/Cas12a-coupled organic electrochemical transistors for highly sensitive detection of methylated DNA.

📖 Top 20% Journal

2 weeks ago • Molecular therapy : the journal of the American Society of Gene Therapy

One Base Editing System for Multipurpose Genetic Engineering of Immune CellsA Singular Base Editing Platform for Polyfunctional Multiplex Engineering of Immune Cells.

🥈 Top 2% Journal

2 weeks ago • Molecular therapy : the journal of the American Society of Gene Therapy

Accurate liver gene editing of ASGR1 leads to strong and lasting cholesterol lowering without relying on LDL receptorsPrecise hepatic base editing of ASGR1 enables robust and durable LDLR-independent lipid lowering in vivo.

🥈 Top 2% Journal

2 weeks ago • Methods in molecular biology (Clifton, N.J.)

Producing Rice Plants with Only One Set of Genes by Removing a Protein Active in Egg CellsIn Vivo Rice Haploid-Induction System by an Egg Cell-Specific Peptidase Knockout.

📖 Top 50% Journal

2 weeks ago • ACS nano

Designing Guide DNA for Accurate RNA Targeting by Cas12aSequence Engineering of Guide DNA for Precise RNA Targeting by Cas12a.

🥈 Top 2% Journal

2 weeks ago • Discover oncology

Using gene editing to understand and treat pancreatic ductal adenocarcinomaCRISPR guided gene knockout in pancreatic ductal adenocarcinoma molecular mechanisms and therapeutic strategies.

📖 Top 20% Journal

2 weeks ago • bioRxiv : the preprint server for biology

Improved β-thalassemia treatment using protected blood stem cell transplant with toxin-free preparation and natural selection inside the bodyCD117 epitope-shielded hematopoietic stem cell transplantation with toxin-free conditioning and in vivo selection ameliorates a β-thalassemia model.

2 weeks ago • Advanced genetics (Hoboken, N.J.)

Small Cas12 Tools for Editing Multiple Plant Systems That Handle Environmental StressCompact Cas12 Systems for Multiplex Engineering of Plant Abiotic-Stress Networks.

2 weeks ago • bioRxiv : the preprint server for biology

Design and Analysis of CRISPR Gene Editing Tests Focused on Specific Genome Areas Using FRACTELRegion-Level Design and Analysis of CRISPR Perturbation Screens with FRACTEL.

2 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

SOX5 May Drive Cancer Progression by Changing Gene Control in MYC-Driven B-Cell LymphomaSOX5 Orchestrates Malignant Evolution via Promoter-Centric Chromatin Remodeling in MYC-Driven B-Cell Lymphoma.

🥈 Top 2% Journal

2 weeks ago • Frontiers in plant science

Using CRISPR-Cas to detect, monitor, and protect plants from virusesCRISPR-Cas systems for plant virus management: detection, surveillance, and host resistance.

📖 Top 20% Journal

2 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Gene Editing to Treat Alzheimer's Disease by Changing APOE4 Using Prime Editor 7Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7.

🥈 Top 2% Journal

2 weeks ago • Pediatric research

Advances in children's gene therapy using CRISPR, artificial intelligence, and personalized treatmentThe future of pediatric gene therapy: CRISPR-Cas9, AI, and personalized medicine.

📖 Top 20% Journal

2 weeks ago • Functional & integrative genomics

Using CRISPR to improve plant resistance to environmental and biological stresses: a detailed reviewCRISPR-enabled functional genomics for bolstering plant tolerance to abiotic and biotic stress; a comprehensive review.

📖 Top 30% Journal

2 weeks ago • Molecular cell

CRISPR-Cas12a2 kills cells by recognizing specific RNAProgrammable cell killer: CRISPR-Cas12a2 eliminates cells via RNA identity.

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Latest CRISPR Gene Editing Research Papers