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1 week ago • Analytical chemistry

Highly Sensitive Electrochemical Biosensor Using Multiple CRISPR/Cas12a Cutting UnitsHighly Sensitive Electrochemical Biosensing Strategy Based on Multiple CRISPR/Cas12a Trans-Cleavage Units.

🎖️ Top 10% JournalArticle

1 week ago • Analytical chemistry

Sensitive Tumor Biomarker Detection Using Metal-DNA Nanoparticles to Activate CRISPR-Cas12a in a Microfluidic SystemCascade-Amplified Microfluidic Detection of Tumor Biomarkers via Metal-DNA Nanospheres Activating CRISPR-Cas12a Assay.

🎖️ Top 10% JournalArticle

1 week ago • Biochemistry

Programmable Genome Detection Using RNA Switch and CRISPR with Visual, Fluorescent, and Glucose Meter Readouts in a Cell-Free SystemProgrammable Genome Sensing with Visual, Fluorescence, and Glucometer Readings: Cell-Free In Vitro Translation Approach Using RNA Switch-CRISPR.

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1 week ago • Biochemistry

A DNA Pyramid That Responds to CRISPR-Cas12aA CRISPR-Cas12a-Responsive DNA Tetrahedron.

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1 week ago • Stem cell research

Creating Stem Cell Lines for Spinocerebellar Ataxia 27B and Matching ControlsGeneration of Spinocerebellar Ataxia 27B iPSC Lines and Isogenic Controls.

📖 Top 50% JournalArticle

1 week ago • Journal of agricultural and food chemistry

Improving E. coli’s sugar-making process to efficiently produce Lacto-N-tetraoseEngineering the Metabolic Pathway of Escherichia coli for Efficient Biosynthesis of Lacto-N-tetraose.

📖 Top 20% JournalArticle

1 week ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Redesigning RNA Structures to Reduce Leakage in CRISPR/Cas12a Systems for More Accurate Genetic TestingScaffold RNA Reengineering for a Leakage-Suppressed CRISPR/Cas12a Cascade System Toward Precise Nucleic Acid Diagnostics.

🥈 Top 2% JournalArticle

1 week ago • International journal of biological macromolecules

Rapid test combining DNA amplification and CRISPR to detect antibiotic-resistant Klebsiella pneumoniaeOne-pot dual RPA-CRISPR/Cas12a lateral flow biosensor for rapid detection of carbapenemase-producing Klebsiella pneumoniae.

📖 Top 20% JournalArticle

1 week ago • ACS infectious diseases

Rapid CRISPR Test for ALV-J Virus with Wide Detection and Lower Leftover DNARPA-CRISPR/Cas12a Assay for ALV-J with Broad-Spectrum Detection and Reduced Residual Amplicon Load.

📖 Top 20% JournalArticle

1 week ago • Journal of pharmaceutical and biomedical analysis

Using higher temperatures to improve and speed up CRISPR detection of SARS-CoV-2 and its Omicron variantLeveraging high temperature for enhanced and faster detection of SARS-CoV-2 and its Omicron variant with CRISPR-AsCas12a.

📖 Top 30% JournalArticle

1 week ago • Nature communications

A phage DUF669 protein helps fix DNA after cutting to resist host CRISPR defenseA phage DUF669 protein mediates post-cleavage DNA repair against host CRISPR immunity.

🥈 Top 2% JournalResearch Support, Non-U.S. Gov't

1 week ago • Cell host & microbe

A virus-made small RNA that mimics guide RNA to block CRISPR-Cas9A phage-encoded small RNA that mimics chimeric guide to inhibit CRISPR-Cas9.

🥇 Top 1% JournalArticle

1 week ago • Synthetic and systems biotechnology

A gene-editing and selection system for connecting epigenetic controllers to inactive natural product genes in Aspergillus nidulansA base-editing and auxotrophic selection platform for linking epigenetic regulators to silent biosynthetic gene clusters in Aspergillus nidulans.

📖 Top 20% JournalArticle

1 week ago • Science translational medicine

Reducing repeated DNA sections with Cas9 nickase is linked to symptom improvements in a Huntington’s disease mouse modelCas9 nickase-mediated contraction of CAG/CTG repeats is associated with phenotypic improvements in a Huntington's disease mouse model.

🥇 Top 1% JournalArticle

2 weeks ago • Nature biotechnology

Designed human Argonaute 2 protein for precise RNA editing from C to UEngineered human Argonaute 2 for targeted C-to-U RNA base editing.

🏆 Top 0.1% JournalArticle

2 weeks ago • RSC advances

Low-cost device using aptamer-CRISPR method for detecting multiple small molecules at oncePaper integrated aptamer-CRISPR sensing enables multiplexed small-molecule sensing in a low-cost device.

📖 Top 30% JournalArticle

2 weeks ago • eLife

Using CRISPRi to reveal a gene activity switch between KLF activators and repressors in the developing thinking areas of the brainMultiplexed CRISPRi reveals a transcriptional switch between KLF activators and repressors in the maturing neocortex.

🥈 Top 2% JournalArticle

2 weeks ago • Frontiers in immunology

CRISPR-Cas systems in Helicobacter pylori and gut bacteria as regulators of gut cancer riskThe emerging role of CRISPR-Cas systems in helicobacter pylori and the gut microbiota as regulators of gastrointestinal cancer risk.

🥉 Top 5% JournalArticle

2 weeks ago • Trends in biotechnology

From Changing Genes to Reshaping Chromosomes in PlantsFrom genome editing to chromosome engineering in plants.

🥉 Top 5% JournalArticle

2 weeks ago • Frontiers in plant science

DNA-free genome editing methods for improving cropsGenome editing beyond transgenes: DNA-free technologies in crop improvement.

📖 Top 20% JournalArticle

2 weeks ago • Leukemia

Blocking a key mitochondrial protein boosts FLT3 inhibitor effects in acute myeloid leukemia with FLT3 mutationsTargeting the mitochondrial complex I subunit NDUFS2 potentiates FLT3 inhibition in acute myeloid leukaemia with FLT3 internal tandem duplication.

🥈 Top 2% JournalArticle

2 weeks ago • The New phytologist

Adding uORFs in wheat increases tolerance to environmental stress without affecting growthEngineering uORFs in wheat improves abiotic stress tolerance without growth penalties.

🥈 Top 2% JournalArticle

2 weeks ago • Biosensors & bioelectronics

Sensitive detection of osteopontin using a probe-activated CRISPR method for assessing bone cancer and treatment responseUnipoint-anchored cascade amplification strategy integrating FUSE probe-activated CRISPR-Cas12a for dual mode osteopontin detection toward osteosarcoma assessment and therapeutic response evaluation.

🥉 Top 5% JournalArticle

2 weeks ago • STAR protocols

Using engineered virus-like particles to deliver gene editing tools in pancreatic cancer cellsProtocol for eVLP-mediated CRISPR-Cas9 and prime editing in pancreatic cancer cell lines.

📖 Top 20% JournalArticle

2 weeks ago • Plant direct

Testing a flexible gene editing method called Free-BE in moss, maize, and wheatValidation of a Modular Base Editing Strategy, Free-BE, in Physcomitrium patens, Maize, and Wheat.

📖 Top 30% JournalArticle

2 weeks ago • Cureus

A review of personalized and platform-specific gene-editing studies in clinical records across 148 casesIndividualized and Platform-Designated Gene-Editing Studies in the Registered Clinical Record: A Case-by-Case Census Against 148 Eligible Studies.

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2 weeks ago • Nature communications

cPRIME allows natural mapping of genetic variant effects on RNAcPRIME enables endogenous mapping of genetic variant effects at RNA level.

🥈 Top 2% JournalResearch Support, Non-U.S. Gov't

2 weeks ago • Planta

Using CRISPR-dCas9 tools to change gene activity for climate-resilient cropsThe CRISPR-dCas9 epigenetic toolbox: prospects for modulating gene expression in climate-resilient crops.

Article

2 weeks ago • Plants (Basel, Switzerland)

Recent Progress and Uses of Genome Editing for Precise Crop BreedingAdvances and Applications of Genome Editing in Precision Crop Breeding.

📖 Top 20% JournalArticle

2 weeks ago • Trends in molecular medicine

Improved models of chromosome changes to recreate genome rearrangementsAdvances in modeling chromosomal aberrations to recapitulate genomic rearrangements.

🥈 Top 2% JournalArticle

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