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2 weeks ago • Molecular plant pathology

Improved Rice Resistance to Yellow Mottle Virus by Editing a Key Rice Protein Gene Using CRISPREnhanced Rice Yellow Mottle Virus Resistance via CRISPR/Cas9-Targeted Mutagenesis of the Rice eIF(iso)4G Gene.

🎖️ Top 10% Journal

2 weeks ago • Scientific reports

Using CRISPR to disable the white gene in the bluetongue virus carrier, Culicoides sonorensis biting midgesCRISPR-Cas9 mediated knockout of the white gene in the bluetongue virus vector, Culicoides sonorensis (biting midge).

📖 Top 20% Journal

2 weeks ago • Analytical methods : advancing methods and applications

DNA mutation and methylation detected at the same time using a controllable CRISPR-based signal systemSignal logic gate mediated by a controllable CRISPR/Cas12a system for simultaneous detection of DNA mutation and methylation.

📖 Top 50% Journal

3 weeks ago • Nature communications

CAR T-Cell Therapy Targeting IL7 Receptor for T-Cell Acute Lymphoblastic LeukemiaIL7-Receptor-Targeted CAR T-Cell Therapy for T-Cell Acute Lymphoblastic Leukemia.

🥈 Top 2% Journal

3 weeks ago • Plants (Basel, Switzerland)

AI-Guided Genome Editing Without DNA Insertion That Works for All Soybean Types to Improve CropsAI-Guided DNA-Free and Genotype-Independent Genome Editing for Soybean Improvement.

📖 Top 20% Journal

3 weeks ago • International journal of molecular sciences

Tiny Engineered Tools for Gene Therapy: How They Work, Types, and Future PossibilitiesNanoengineering Systems for Gene Therapy: Mechanisms, Modalities, and Future Directions.

📖 Top 20% Journal

3 weeks ago • BMC methods

An Easy Fluorescent Method to Improve Gene Editing in Human Stem CellsA simple and versatile fluorescence-based method to enhance prime editing in human pluripotent stem cells.

3 weeks ago • The Plant cell

Editing the MYB factor APL to change flowering timeThe MYB transcription factor APL is a rational target for base editing to engineer flowering time.

3 weeks ago • Cell death & disease

CRISPR screen finds DCAF4 helps liver cancer resist radiation by activating cell stress defenseCRISPR/Cas9 screen identifies DCAF4 as a novel protector of hepatocellular carcinoma against brachytherapy via stress granule-dependent NRF2 activation.

🥉 Top 5% Journal

3 weeks ago • International journal of biological macromolecules

Increasing or decreasing Engrailed 1 in supportive tissue cells changes their ability to become bone-making cells and heal boneGain- and loss-of-function of Engrailed 1 in mesenchymal stromal cells affect their potential to differentiate into osteoblasts and to repair bone tissue.

📖 Top 20% Journal

3 weeks ago • Stem cell research

Using gene editing to remove FLG in human stem cells to model skin barrier problemsCRISPR/Cpf1-mediated knockout of FLG in human induced pluripotent stem cells generates a model for studying epidermal barrier dysfunction.

📖 Top 50% Journal

3 weeks ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

SiDT1 Controls Plant Shape Similar to Green Revolution Traits in Foxtail MilletSiDT1 Defines Plant Architecture Reminiscent of Green Revolution in Foxtail Millet.

🥈 Top 2% Journal

3 weeks ago • Journal of integrative plant biology

Improving a tiny Fanzor2 tool for better genome editing in plantsOptimization of a hypercompact Fanzor2 system for improved genome editing performance in plants.

🥈 Top 2% Journal

3 weeks ago • Cell genomics

Using engineered virus-like particles together improves precise gene editing and large-scale testingCompound delivery of eVLPs enhances prime editing for targeted genome engineering and high-throughput screening.

🥇 Top 1% Journal

3 weeks ago • Molecular therapy. Nucleic acids

Precise gene editing creates liver cells with PNPLA3-I148M mutation to study fat-related cell damagePrime editing enables isogenic modeling of PNPLA3-I148M-associated lipotoxicity in hepatocytes.

🥉 Top 5% Journal

3 weeks ago • Cells

Using gene-silencing to lower TERT activity reduces growth of non-small-cell lung cancer cellsCRISPRi-Mediated Epigenetic Suppression of TERT Reduces Cell Growth in Non-Small-Cell Lung Cancer Cells.

🎖️ Top 10% Journal

3 weeks ago • Neurogenetics

CRISPR-Cas9 gene therapies for Huntington's disease and Friedreich's ataxia: how they work, recent progress, and future possibilitiesCRISPR-Cas9-based therapies for Huntington's disease and Friedreich's ataxia: mechanisms, advances, and future perspectives.

📖 Top 30% Journal

3 weeks ago • Autophagy

Genome-wide CRISPR screening reveals how TRIM25 helps break down ribosomes through ribophagyGenome-wide CRISPR-Cas9-based screening revealed the role of ubiquitin ligase TRIM25 in ribosome degradation via ribophagy.

🥈 Top 2% Journal

3 weeks ago • International journal of stem cells

Creating a Patient-Based Stem Cell Model to Study the YARS2 Genetic DiseaseGeneration of a Patient-Derived Inducible Pluripotent Stem Cell Model for Studying the YARS2-Related Genetic Disease.

📖 Top 30% Journal

3 weeks ago • Cellular and molecular life sciences : CMLS

Single-cell analysis and gene editing identify gene activity changes and key genes involved in kidney cell stressSnRNA-seq and genome-wide CRISPR screening define the complete transcriptional trajectory and functional drivers of podocyte stress.

🥉 Top 5% Journal

3 weeks ago • Plant science : an international journal of experimental plant biology

Editing two enzymes at once increases resistant starch and cold-sweetening resistance in Solanum chacoenseMultiplex CRISPR-Cas9 editing of starch branching enzyme II and vacuolar invertase simultaneously enhances resistant starch content and cold-induced sweetening resistance in Solanum chacoense.

📖 Top 20% Journal

3 weeks ago • Applied microbiology and biotechnology

Selective gene editing in the cyanobacterium Cyanothece PCC 7425 using CRISPR/Cas12aTargeted genome editing of the non-model cyanobacterium Cyanothece PCC 7425 via CRISPR/Cas12a.

📖 Top 20% Journal

3 weeks ago • Frontiers in microbiology

Improved gene editing methods for four common Gram-positive bacteriaAdvances in gene editing tools for four typical Gram-positive bacteria.

📖 Top 20% Journal

3 weeks ago • aBIOTECH

AI-designed OpenCRISPR-1 allows precise gene editing and mutations in riceAI-designed OpenCRISPR-1 enables efficient targeted mutagenesis and prime editing in rice.

📖 Top 20% Journal

3 weeks ago • ACS sensors

Light-Activated One-Step DNA Test to Detect a Critically Endangered Species in the EnvironmentOptical-Controlled One-Pot RPA-CRISPR Assay for Environmental DNA Detection of a Critically Endangered Species.

🎖️ Top 10% Journal

3 weeks ago • bioRxiv : the preprint server for biology

Key proteins control how heparan sulfate is modified and binds to other molecules, found using CRISPR activation screensCRISPR activation screens identify core protein-dependent regulation of heparan sulfate sulfation and ligand specificity.

3 weeks ago • Polimery w medycynie

Biotech approaches to fight antibiotic resistanceBiotechnological strategies to combat antibiotic resistance.

📖 Top 50% Journal

3 weeks ago • Molecular therapy : the journal of the American Society of Gene Therapy

Correcting OTC Gene Function by Targeted DNA Integration to Restore Normal Activity and TraitsFunctional Editing of the OTC locus by Targeted Integration with Phenotype Correction and Restoration of Physiological Patterns of Expression.

🥈 Top 2% Journal

3 weeks ago • Nature biotechnology

Designed enzymes allow precise DNA changes from A to GEngineered ADARs enable precision A-to-G base editing of DNA.

🏆 Top 0.1% Journal

3 weeks ago • microPublication biology

Using zebrafish with altered leiomodin 2b gene to model dilated heart diseaseNovel leiomodin 2b crispant zebrafish as a model for dilated cardiomyopathy.

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