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3 weeks ago • Stem cell research

Creating a human stem cell line with a specific PKP2 gene mutation using precise DNA editingGeneration of a PKP2 (c.1171-2 A > G) mutant human embryonic stem cell line using adenine base editing.

📖 Top 50% JournalArticle

3 weeks ago • Biosensors & bioelectronics

Controlling the DNA-cutting activity of LbCas12a by adjusting temperatureProgrammable thermoregulation of the nuclease activity of LbCas12a.

🥉 Top 5% JournalArticle

3 weeks ago • bioRxiv : the preprint server for biology

Activation of gene regions by CRISPRa creates lasting chromatin states showing gene-specific memory effectsInduction of hysteretic chromatin states by CRISPRa reveals locus-specific encoding of transcriptional memory.

Preprint

3 weeks ago • bioRxiv : the preprint server for biology

Genes that help Epstein-Barr virus infect human B cells found using a genome-wide CRISPR screenA Human Genome-wide CRISPR-Cas9 Screen Reveals Host Factors That Support Epstein-Barr Virus B cell infection.

Preprint

3 weeks ago • bioRxiv : the preprint server for biology

How plasmid design affects the stability of end DNA repeats in adeno-associated virus vectorsPlasmid architecture determines the stability of inverted terminal repeats in adeno-associated virus vectors.

Preprint

3 weeks ago • Biosensors & bioelectronics

Optimized CRISPR/Cas12a system using split guide RNA for detecting microRNAs without amplificationRationally optimized split crRNA-based CRISPR/Cas12a platform for amplification-free miRNA detection.

🥉 Top 5% JournalArticle

3 weeks ago • iScience

Inducible dCas12a system expands gene control tools for studying malaria parasite Plasmodium falciparumInducible dCas12a system expands CRISPRi/a capabilities for functional genomics in malaria parasite Plasmodium falciparum.

🎖️ Top 10% JournalArticle

3 weeks ago • bioRxiv : the preprint server for biology

Engineering human immune cells to carry gene editing toolsProgramming primary human T cells to deliver gene editing machinery.

Preprint

3 weeks ago • bioRxiv : the preprint server for biology

Using base editing to map chemical and genetic interactions in the MAPK signaling pathwayPathway-wide base editing charts chemical-genetic interactions in MAPK signaling.

Preprint

3 weeks ago • ACS sensors

Portable soil testing for detecting Phytophthora infestans using a CRISPR-based fluorescent strip and microfluidic DNA preparationCentrifugal Microfluidic Soil-to-DNA Preparation for the Portable Detection of Phytophthora infestans Using a CRISPR/Cas12a-Based Quantum Dot Fluorescent Lateral Flow Assay.

🎖️ Top 10% JournalArticle

3 weeks ago • iScience

Loss of SREBF1 disrupts fat signaling and leads to slow muscle fiber breakdownLoss of SREBF1 disrupts lipid signaling and causes slow muscle fiber degeneration.

🎖️ Top 10% JournalArticle

3 weeks ago • DNA and cell biology

Fast Creation of Single and Multiple Gene Knockouts in Human Cells Using CRISPR-Cas9Efficient Generation of Single- and Multigene CRISPR-Cas9 Knockout in Human Cells.

Article

3 weeks ago • Mycology

Precise DNA base editing using CRISPR in the fungus Trichoderma koningiopsisCRISPR/Cas9 nickase-mediated cytosine base editing in Trichoderma koningiopsis.

📖 Top 20% JournalArticle

3 weeks ago • The Yale journal of biology and medicine

Reevaluating Viral Gene Therapy for Brain Cancer: Potential Benefits and ChallengesReassessing Viral Gene Therapy for Glioblastoma: Translational Opportunities and Challenges.

📖 Top 20% JournalArticle

3 weeks ago • Cell proliferation

How DNA Packaging Changes Guide Repair Choices and Improve CRISPR Gene InsertionChromatin Modifications Orchestrate DNA Repair Pathway Choice: Epigenetics Strategies for Enhancing CRISPR-Cas9-Mediated Knock-In Efficiency.

🥉 Top 5% JournalArticle

3 weeks ago • Med (New York, N.Y.)

Gene editing for inherited angioedema: a major trial and remaining questionsGenome editing for hereditary angioedema: A landmark trial and important unanswered questions.

🥈 Top 2% JournalArticle

3 weeks ago • Die Ophthalmologie

Gene-based treatments for Stargardt disease[Genetic therapies for Stargardt disease].

English Abstract

3 weeks ago • bioRxiv : the preprint server for biology

Measuring how dCas9 finds DNA to identify what affects guide RNA effectivenessQuantitative profiling of intrinsic dCas9-DNA recognition reveals key determinants of guide RNA performance.

Preprint

3 weeks ago • Plant physiology and biochemistry : PPB

Removing IBH1 gene with CRISPR adjusts growth hormone levels and changes plant shape and grain traits in durum wheatCRISPR-Cas9 knockout of IBH1 fine-tunes brassinosteroid metabolism and modulates plant architecture and grain traits in durum wheat.

🎖️ Top 10% JournalArticle

3 weeks ago • Frontiers in genome editing

Using CRISPR tools that target both RNA and DNA to better reduce hepatitis B virus gene activityCombined RNA- and DNA-targeting CRISPR ribonucleoproteins enhance suppression of HBV transcripts.

🎖️ Top 10% JournalArticle

3 weeks ago • bioRxiv : the preprint server for biology

A gene-editing method for human liver cells allows testing and confirming factors that affect hepatitis B virusA CRISPR-Cas9 platform for primary human hepatocytes enables arrayed screening and in vivo validation of HBV host factors.

Preprint

3 weeks ago • bioRxiv : the preprint server for biology

Genome-wide activation map of surface protein levels in human helper T cellsA genome-wide CRISPR activation map of surface protein expression in human CD4 T cells.

Preprint

3 weeks ago • Archivos de la Sociedad Espanola de Oftalmologia

New gene-editing treatments for the front part of the eye using CRISPR-Cas9Advances in precision medicine for the anterior segment: therapeutic applications using CRISPR-Cas9.

Article

3 weeks ago • Angewandte Chemie (International ed. in English)

How Substrate Access and Position Affect Cas12a Protein Cutting SpeedAccessibility and Alignment of Trans-Cleavage Substrates Modulate the Kinetics of Cas12a Ribonucleoprotein.

🥇 Top 1% JournalArticle

3 weeks ago • Cold Spring Harbor perspectives in medicine

"Cultural Lag" and Managing Risks in Life Science ResearchWhat's New Is Old: "Cultural Lag" and Governance of Risk in the Life Sciences.

🥉 Top 5% JournalArticle

4 weeks ago • Nature communications

How Cattle Establish Pregnancy Without Embryo Signaling Protein Interferon TauPregnancy establishment in cattle without embryonic interferon tau.

🥈 Top 2% JournalResearch Support, Non-U.S. Gov't

4 weeks ago • Frontiers in genome editing

Genome-edited sheep created by delivering prime editing proteins into fertilized eggs using electric pulsesGenome edited sheep generated by zygote electroporation of prime editor ribonucleoproteins.

🎖️ Top 10% JournalArticle

4 weeks ago • Blood research

Targeting a specific viral protein triggers inflammatory cell death and may offer a new treatment for acute myeloid leukemiaCorrespondence on: "Targeting the HERV-K102 envelope elicits pyroptosis and represents a novel therapeutic strategy for acute myeloid leukemia".

📖 Top 30% JournalComment

4 weeks ago • Advanced materials (Deerfield Beach, Fla.)

Using CRISPR-Enhanced Nanocatalysts to Trigger Iron-Dependent Cell Death in Triple-Negative Breast CancerCRISPR Nanomachinery-Sensitized Nanocatalytic Tumor Ferroptosis in Triple-Negative Breast Cancer.

🥇 Top 1% JournalArticle

4 weeks ago • Journal of visualized experiments : JoVE

Computer Modeling of Gene Editing to Restore Factor VII Production in Inherited DeficiencyIn Silico CRISPR Restoration of F7 Promoter Activity in Hereditary Factor VII Deficiency.

📖 Top 50% JournalVideo-Audio Media

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Latest CRISPR Gene Editing Research Papers