Latest CRISPR Gene Editing Research Papers | Page 5 | OpenScience.ink

3 weeks ago • bioRxiv : the preprint server for biology

Detailed CRISPR Study of the WAVE Complex Finds Drugs That Affect Movement of Brain Immune Cells Linked to Alzheimer’sDense CRISPR Mapping of the WAVE Complex Identifies Pharmacological Modulators of AD-Linked Myeloid Migration.

3 weeks ago • bioRxiv : the preprint server for biology

Blocking a key recycling process slows pancreatic cancer growth and makes it more sensitive to mTORC1-targeted treatmentVertical inhibition of the autophagy pathway impairs growth and enhances sensitivity to mTORC1 inhibition in pancreatic ductal adenocarcinoma.

3 weeks ago • Molecular biology reports

Designing cell-made delivery packages for gene therapy: new genetic approaches and future possibilitiesEngineering extracellular vesicle biogenesis for therapeutic gene delivery: emerging genetic programming strategies and translational prospects.

📖 Top 30% Journal

3 weeks ago • Nature biotechnology

Efficient cytosine base editing inside living cells using virus-like particles that block uracil DNA repairEfficient in vivo cytosine base editing using virus-like particles with uracil DNA glycosylase inhibition.

🏆 Top 0.1% Journal

3 weeks ago • Molecular biology reports

CRISPR-Cas9 gene editing in Leishmania parasites: methods, uses, challenges, and future possibilitiesA comprehensive review of CRISPR-Cas9-mediated genome editing in Leishmania strains: methodologies, applications, challenges and future directions.

📖 Top 30% Journal

3 weeks ago • Immunity

Using CRISPR to quickly add large human antibody genes into mouse embryosCRISPR-mediated precise large fragment insertion in zygotes enables rapid generation of humanized immunoglobulin heavy-chain mice.

🥇 Top 1% Journal

4 weeks ago • Science advances

Low ALDH6A1 levels change valine metabolism and may promote stomach cancer spreadReprogramming of valine metabolism mediated by abnormally low ALDH6A1 expression promotes invasive metastasis of gastric cancer.

🥈 Top 2% Journal

4 weeks ago • Nature genetics

Finding important lysine sites in mammal histone H3 using advanced CRISPR editingIdentifying critical lysines in mammalian histone H3 with high-throughput CRISPR prime editing.

🏆 Top 0.1% Journal

4 weeks ago • Nature

Safe cell transplantation and selection inside the body using targeted surface marker changesNon-genotoxic transplantation and in vivo selection through epitope editing.

4 weeks ago • Methods in molecular biology (Clifton, N.J.)

Designing Switchable Guide RNAs to Control Gene ActivityDesign of Conditional Guide RNAs for the Logical Regulation of Gene Expression.

📖 Top 50% Journal

4 weeks ago • Methods in molecular biology (Clifton, N.J.)

Using CRISPRi Between Cells to Build Distributed Genetic CircuitsIntercellular CRISPRi for Distributed Genetic Circuits.

📖 Top 50% Journal

4 weeks ago • Methods in molecular biology (Clifton, N.J.)

Designing Synthetic Gene Control Systems Using CRISPRi in BacteriaDesign of CRISPRi-Based Synthetic Gene Circuits in Bacteria.

📖 Top 50% Journal

4 weeks ago • Methods in molecular biology (Clifton, N.J.)

Building a Genetic Switch in Bacteria to Reduce Protein ProductionConstruction of a Tl-CRISPRi Genetic Circuit in Bacteria for Translation-Level Gene Knockdown.

📖 Top 50% Journal

4 weeks ago • Mikrochimica acta

Using two linked DNA reactions to boost CRISPR/Cas12a biosensor sensitivity for detecting tiny amounts of microRNAsAn integrated signal amplification strategy based on catalytic hairpin assembly and hybridization chain reaction for driving a CRISPR/Cas12a biosensor toward ultrasensitive detection of microRNAs.

📖 Top 30% Journal

4 weeks ago • Methods in molecular biology (Clifton, N.J.)

Using CRISPRi Competition to Build Multi-Part Controllers for Managing Resources in Genetic CircuitsHarnessing CRISPRi Competition to Develop Multimodule Controllers for Resource-Aware Circuit Design.

📖 Top 50% Journal

4 weeks ago • Bioinformatics (Oxford, England)

CROP: A context-aware method to predict CRISPR-Cas9 gene editing errors without relying on specific DNA featuresCROP: a feature-independent context-aware method for CRISPR-Cas9 frameshift prediction.

🥉 Top 5% Journal

4 weeks ago • eLife

Improved genome editing methods for precise DNA changes using prime editors in zebrafishOptimised genome editing for precise DNA insertion and substitution using prime editors in zebrafish.

🥈 Top 2% Journal

4 weeks ago • STAR protocols

Method for creating pig fetal cells with multiple precise genetic editsProtocol for generating multiplexed prime-edited monoclonal cell lines in porcine fetal fibroblasts.

📖 Top 20% Journal

4 weeks ago • Life sciences

Gene-edited heart cells modeling short QT syndrome type 3 show electrical differences and varied drug responsesPrime-edited isogenic hiPSC-derived cardiomyocyte model of short QT syndrome type 3 reveals electrophysiological phenotypes and differential drug responses.

1 month ago • The Plant journal : for cell and molecular biology

Efficient gene editing of plants without added genes using virus-based deliveryEfficient CRISPR-Cas9 delivery and transgene-free multiplex genome editing in plants using cymbidium mosaic virus-derived vectors.

1 month ago • Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Fixing a Gene Improves Dopamine Cell Therapy in a Monkey Model of Parkinson's DiseaseGene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease.

🥈 Top 2% Journal

1 month ago • Scientific reports

A CRISPR-based fluorescent method to detect EGFR mutations in non-small cell lung cancerA "turn-on" CRISPR-mediated method using enhanced fluorescent bimetallic DNA nanoclusters for EGFR mutation detection in non-small cell lung cancer.

📖 Top 20% Journal

1 month ago • Molecular therapy. Nucleic acids

Improving twin prime editing tools for gene editing and treatment of spinocerebellar ataxia type 3Optimizing twin prime editing components for scalable genome editing and therapy in spinocerebellar ataxia type 3.

🥉 Top 5% Journal

1 month ago • Journal of integrative plant biology

Creating watermelon that resists glyphosate using precise gene editingEngineering glyphosate-resistant watermelon by prime editing.

🥈 Top 2% Journal

1 month ago • International journal of pharmaceutics

Using tiny technology to deliver gene-editing tools to the brain for controlling genes in Parkinson's diseaseProgrammable gene modulation networks for Parkinson's disease using nanotechnology enabled CRISPR/Cas brain delivery.

📖 Top 20% Journal

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